{"id":"https://openalex.org/W4414306234","doi":"https://doi.org/10.3389/fncom.2025.1612314","title":"Effects of AC induced electric fields on neuronal firing sensitivity and activity patterns","display_name":"Effects of AC induced electric fields on neuronal firing sensitivity and activity patterns","publication_year":2025,"publication_date":"2025-09-18","ids":{"openalex":"https://openalex.org/W4414306234","doi":"https://doi.org/10.3389/fncom.2025.1612314","pmid":"https://pubmed.ncbi.nlm.nih.gov/41049356"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2025.1612314","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2025.1612314","pdf_url":"https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2025.1612314/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2025.1612314/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103921011","display_name":"Chunhua Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I116036724","display_name":"Shenyang Ligong University","ror":"https://ror.org/03m20nr07","country_code":"CN","type":"education","lineage":["https://openalex.org/I116036724"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhua Yuan","raw_affiliation_strings":["School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang, China","institution_ids":["https://openalex.org/I116036724"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rupei Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I116036724","display_name":"Shenyang Ligong University","ror":"https://ror.org/03m20nr07","country_code":"CN","type":"education","lineage":["https://openalex.org/I116036724"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rupei Chen","raw_affiliation_strings":["School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang, China","institution_ids":["https://openalex.org/I116036724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460308","display_name":"Xiangyu Li","orcid":"https://orcid.org/0000-0001-9903-9797"},"institutions":[{"id":"https://openalex.org/I116036724","display_name":"Shenyang Ligong University","ror":"https://ror.org/03m20nr07","country_code":"CN","type":"education","lineage":["https://openalex.org/I116036724"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangyu Li","raw_affiliation_strings":["School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang, China","institution_ids":["https://openalex.org/I116036724"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101871120","display_name":"Yueyang Zhao","orcid":"https://orcid.org/0009-0006-5807-707X"},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yueyang Zhao","raw_affiliation_strings":["Shengjing Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shengjing Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100460308","https://openalex.org/A5101871120"],"corresponding_institution_ids":["https://openalex.org/I116036724","https://openalex.org/I91656880"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.2652,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.80097858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"19","issue":null,"first_page":"1612314","last_page":"1612314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.40950000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.40950000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.2199999988079071,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.18000000715255737,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.8425999879837036},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.6863999962806702},{"id":"https://openalex.org/keywords/neural-activity","display_name":"Neural activity","score":0.5976999998092651},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5389000177383423},{"id":"https://openalex.org/keywords/premovement-neuronal-activity","display_name":"Premovement neuronal activity","score":0.4611999988555908},{"id":"https://openalex.org/keywords/neuronal-firing","display_name":"Neuronal firing","score":0.42969998717308044},{"id":"https://openalex.org/keywords/electric-field","display_name":"Electric field","score":0.4180000126361847},{"id":"https://openalex.org/keywords/local-field-potential","display_name":"Local field potential","score":0.41269999742507935}],"concepts":[{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.8425999879837036},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6863999962806702},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6676999926567078},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.5976999998092651},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5389000177383423},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.4611999988555908},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.44839999079704285},{"id":"https://openalex.org/C3019868978","wikidata":"https://www.wikidata.org/wiki/Q194277","display_name":"Neuronal firing","level":3,"score":0.42969998717308044},{"id":"https://openalex.org/C60799052","wikidata":"https://www.wikidata.org/wiki/Q46221","display_name":"Electric field","level":2,"score":0.4180000126361847},{"id":"https://openalex.org/C117838684","wikidata":"https://www.wikidata.org/wiki/Q533483","display_name":"Local field potential","level":2,"score":0.41269999742507935},{"id":"https://openalex.org/C28843909","wikidata":"https://www.wikidata.org/wiki/Q177625","display_name":"Electromagnetic field","level":2,"score":0.40049999952316284},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.39739999175071716},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3808000087738037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3357999920845032},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.3165000081062317},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31369999051094055},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.31299999356269836},{"id":"https://openalex.org/C3020056645","wikidata":"https://www.wikidata.org/wiki/Q1327643","display_name":"Electric stimulation","level":3,"score":0.29440000653266907},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.2709999978542328},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.2623000144958496}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fncom.2025.1612314","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2025.1612314","pdf_url":"https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2025.1612314/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:41049356","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41049356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:doaj.org/article:d4f73c148cf54068b46625c4eea80bae","is_oa":true,"landing_page_url":"https://doaj.org/article/d4f73c148cf54068b46625c4eea80bae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 19 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11299292","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12488696","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12488696","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12488696/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Comput Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fncom.2025.1612314","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2025.1612314","pdf_url":"https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2025.1612314/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2116199857","display_name":null,"funder_award_id":"JYTMS20230215","funder_id":"https://openalex.org/F4320327799","funder_display_name":"Scientific Research Fund of Liaoning Provincial Education Department"},{"id":"https://openalex.org/G667799849","display_name":null,"funder_award_id":"62173073","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8887564192","display_name":null,"funder_award_id":"62173073","funder_id":"https://openalex.org/F4320327799","funder_display_name":"Scientific Research Fund of Liaoning Provincial Education Department"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324560","display_name":"Department of Education of Liaoning Province","ror":"https://ror.org/0022v2454"},{"id":"https://openalex.org/F4320327799","display_name":"Scientific Research Fund of Liaoning Provincial Education Department","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414306234.pdf","grobid_xml":"https://content.openalex.org/works/W4414306234.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1980618916","https://openalex.org/W1997483562","https://openalex.org/W2052115153","https://openalex.org/W2107281753","https://openalex.org/W2132480629","https://openalex.org/W2425755063","https://openalex.org/W2768096625","https://openalex.org/W2789980339","https://openalex.org/W2900005990","https://openalex.org/W2903380895","https://openalex.org/W2913827938","https://openalex.org/W3014659950","https://openalex.org/W3023848433","https://openalex.org/W3041284834","https://openalex.org/W3044495418","https://openalex.org/W3084009508","https://openalex.org/W3140837773","https://openalex.org/W3159135914","https://openalex.org/W3183975923","https://openalex.org/W3198211391","https://openalex.org/W4292071050","https://openalex.org/W4367318261","https://openalex.org/W4386134054","https://openalex.org/W4388347794","https://openalex.org/W4392129762","https://openalex.org/W4399476154","https://openalex.org/W4400457455","https://openalex.org/W4404515118","https://openalex.org/W4407565959"],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"Understanding":[1],"how":[2,206],"neurons":[3],"respond":[4],"to":[5,121,129],"time-varying":[6],"electric":[7,28],"fields":[8,29],"is":[9],"essential":[10],"for":[11,107,174,217],"both":[12,221],"basic":[13],"neuroscience":[14],"and":[15,34,66,73,123,135,223],"the":[16,22,85,92,110,124],"development":[17],"of":[18,62,97],"neuromodulation":[19,219],"strategies.":[20],"However,":[21],"mechanisms":[23],"by":[24,119,190],"which":[25,191],"alternating-current":[26],"induced":[27],"(AC-IEF)":[30],"influence":[31],"neuronal":[32,194],"sensitivity":[33,83,125],"firing":[35,56,81,116,150],"remain":[36],"unclear.":[37],"Methods:":[38],"We":[39],"developed":[40],"a":[41,59,163,187],"modified":[42],"two-compartment":[43],"Pinsky-Rinzel":[44],"(PR)":[45],"neuron":[46],"model":[47],"incorporating":[48],"AC-IEF":[49,192],"stimulation.":[50],"Using":[51],"systematic":[52],"simulations,":[53],"we":[54],"examined":[55],"responses":[57],"across":[58],"wide":[60],"range":[61,127],"field":[63,86],"frequencies,":[64],"amplitudes,":[65],"intrinsic":[67],"membrane":[68,94],"parameters,":[69],"including":[70],"inter-compartmental":[71,156],"conductance":[72,98],"potassium":[74,176],"reversal":[75,100,177],"potential.":[76,101],"Results:":[77],"Neurons":[78],"exhibited":[79],"no":[80],"or":[82,99],"when":[84,109],"amplitude":[87,111,143],"was":[88],"less":[89],"than":[90,201],"twice":[91],"baseline":[93],"potential,":[95],"regardless":[96],"Sensitivity":[102],"increased":[103],"markedly":[104],"with":[105,139],"amplitude:":[106],"example,":[108],"exceeded":[112],"0.5":[113],"mV/cm,":[114],"maximum":[115],"rates":[117],"rose":[118],"up":[120],"45%":[122],"frequency":[126],"extended":[128],"10-50":[130],"Hz.":[131],"Phase-locking":[132],"phenomena":[133],"(1:1":[134],"2:1)":[136],"were":[137],"observed,":[138],"bandwidths":[140],"widening":[141],"as":[142],"increased.":[144],"For":[145],"amplitudes":[146,159],"below":[147],"30":[148],"mV,":[149],"pattern":[151],"transitions":[152,172],"depended":[153],"strongly":[154],"on":[155],"conductance,":[157],"whereas":[158],"\u226530":[160],"mV":[161],"produced":[162],"consistent":[164],"progression":[165],"ending":[166],"in":[167,220],"subthreshold":[168],"oscillations.":[169],"Similar":[170],"parameter-dependent":[171,188],"occurred":[173],"different":[175],"potentials,":[178],"converging":[179],"at":[180],"high":[181],"amplitudes.":[182],"Discussion:":[183],"These":[184],"results":[185],"reveal":[186],"mechanism":[189],"modulate":[193],"excitability.":[195],"The":[196],"findings":[197],"provide":[198],"qualitative":[199],"rather":[200],"strictly":[202],"quantitative":[203],"insights":[204],"into":[205],"external":[207],"electromagnetic":[208],"environments":[209],"can":[210],"shape":[211],"neural":[212],"activity,":[213],"offering":[214],"new":[215],"directions":[216],"targeted":[218],"health":[222],"disease.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}