{"id":"https://openalex.org/W4411041924","doi":"https://doi.org/10.3389/fncom.2025.1564932","title":"A new method for community-based intelligent screening of early Alzheimer\u2019s disease populations based on digital biomarkers of the writing process","display_name":"A new method for community-based intelligent screening of early Alzheimer\u2019s disease populations based on digital biomarkers of the writing process","publication_year":2025,"publication_date":"2025-06-04","ids":{"openalex":"https://openalex.org/W4411041924","doi":"https://doi.org/10.3389/fncom.2025.1564932","pmid":"https://pubmed.ncbi.nlm.nih.gov/40534727"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2025.1564932","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2025.1564932","pdf_url":"https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2025.1564932/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2025.1564932/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002661571","display_name":"Shuwu Li","orcid":"https://orcid.org/0000-0003-0127-6597"},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuwu Li","raw_affiliation_strings":["School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077051963","display_name":"Kai Li","orcid":"https://orcid.org/0000-0003-3519-8814"},"institutions":[{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Li","raw_affiliation_strings":["School of Information Engineering, Hangzhou Medical College, Hangzhou, China","Zhejiang Engineering Research Center for Brain Cognition and Brain Diseases Digital Medical Instruments, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Engineering, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Zhejiang Engineering Research Center for Brain Cognition and Brain Diseases Digital Medical Instruments, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070426597","display_name":"Jiakang Liu","orcid":"https://orcid.org/0009-0002-7565-2700"},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiakang Liu","raw_affiliation_strings":["School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038549281","display_name":"Shouqiang Huang","orcid":"https://orcid.org/0000-0002-0612-6574"},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shouqiang Huang","raw_affiliation_strings":["School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337510","display_name":"Chen Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Wang","raw_affiliation_strings":["School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuting Tu","orcid":null},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Tu","raw_affiliation_strings":["School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003139287","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0001-5606-8555"},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Wang","raw_affiliation_strings":["School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684254","display_name":"Pengpeng Zhang","orcid":"https://orcid.org/0000-0003-1488-265X"},"institutions":[{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengpeng Zhang","raw_affiliation_strings":["School of Information Engineering, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Engineering, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101768611","display_name":"Yi Luo","orcid":"https://orcid.org/0000-0003-4470-220X"},"institutions":[{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuntian Luo","raw_affiliation_strings":["School of Information Engineering, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Engineering, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435005","display_name":"Yanli Zhang","orcid":"https://orcid.org/0000-0001-8173-2024"},"institutions":[{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanli Zhang","raw_affiliation_strings":["School of Information Engineering, Hangzhou Medical College, Hangzhou, China","Zhejiang Engineering Research Center for Brain Cognition and Brain Diseases Digital Medical Instruments, Hangzhou Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Engineering, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Zhejiang Engineering Research Center for Brain Cognition and Brain Diseases Digital Medical Instruments, Hangzhou Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101460256","display_name":"Tong Chen","orcid":"https://orcid.org/0000-0002-0250-227X"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tong Chen","raw_affiliation_strings":["Department of Neurology, Second Medical Center of Chinese PLA General Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Second Medical Center of Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5077051963","https://openalex.org/A5100435005","https://openalex.org/A5101460256"],"corresponding_institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210165441"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.2197,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.87148522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"19","issue":null,"first_page":"1564932","last_page":"1564932"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.4505999982357025,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.4505999982357025,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12488","display_name":"Mental Health via Writing","score":0.2603999972343445,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10465","display_name":"Neurobiology of Language and Bilingualism","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.6395393013954163},{"id":"https://openalex.org/keywords/neuropsychology","display_name":"Neuropsychology","score":0.5912879705429077},{"id":"https://openalex.org/keywords/montreal-cognitive-assessment","display_name":"Montreal Cognitive Assessment","score":0.5726863741874695},{"id":"https://openalex.org/keywords/handwriting","display_name":"Handwriting","score":0.4975302517414093},{"id":"https://openalex.org/keywords/neuropsychological-assessment","display_name":"Neuropsychological assessment","score":0.4658656120300293},{"id":"https://openalex.org/keywords/confidence-interval","display_name":"Confidence interval","score":0.4408244490623474},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4216499626636505},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3851653039455414},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.37259525060653687},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3670274317264557},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2586160898208618},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2391178011894226},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.22601228952407837}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6395393013954163},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.5912879705429077},{"id":"https://openalex.org/C2776632958","wikidata":"https://www.wikidata.org/wiki/Q6906262","display_name":"Montreal Cognitive Assessment","level":4,"score":0.5726863741874695},{"id":"https://openalex.org/C2779386606","wikidata":"https://www.wikidata.org/wiki/Q2393642","display_name":"Handwriting","level":2,"score":0.4975302517414093},{"id":"https://openalex.org/C536788834","wikidata":"https://www.wikidata.org/wiki/Q7002588","display_name":"Neuropsychological assessment","level":4,"score":0.4658656120300293},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4408244490623474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4216499626636505},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3851653039455414},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.37259525060653687},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3670274317264557},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2586160898208618},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2391178011894226},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.22601228952407837}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fncom.2025.1564932","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2025.1564932","pdf_url":"https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2025.1564932/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:40534727","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40534727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:doaj.org/article:8088454f8e71453aa7ef8ef462bbca6f","is_oa":true,"landing_page_url":"https://doaj.org/article/8088454f8e71453aa7ef8ef462bbca6f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 19 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12174119","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12174119","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Comput Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fncom.2025.1564932","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2025.1564932","pdf_url":"https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2025.1564932/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8899999856948853,"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education"}],"awards":[{"id":"https://openalex.org/G1699285692","display_name":null,"funder_award_id":"2022C03064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411041924.pdf","grobid_xml":"https://content.openalex.org/works/W4411041924.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W179914360","https://openalex.org/W1556037442","https://openalex.org/W1965086680","https://openalex.org/W1967507630","https://openalex.org/W2038681740","https://openalex.org/W2051590969","https://openalex.org/W2054004786","https://openalex.org/W2056985030","https://openalex.org/W2068078453","https://openalex.org/W2085125680","https://openalex.org/W2087924155","https://openalex.org/W2103154862","https://openalex.org/W2110655398","https://openalex.org/W2111117051","https://openalex.org/W2124517301","https://openalex.org/W2132175842","https://openalex.org/W2136388544","https://openalex.org/W2156102858","https://openalex.org/W2274424338","https://openalex.org/W2291931977","https://openalex.org/W2575016110","https://openalex.org/W2582524520","https://openalex.org/W2591652352","https://openalex.org/W2605570095","https://openalex.org/W2763922694","https://openalex.org/W2798054687","https://openalex.org/W2808741319","https://openalex.org/W2894357926","https://openalex.org/W2909260055","https://openalex.org/W2951499911","https://openalex.org/W2963584229","https://openalex.org/W2967444033","https://openalex.org/W2971598158","https://openalex.org/W2990861132","https://openalex.org/W3093463175","https://openalex.org/W3135232379","https://openalex.org/W3204829872","https://openalex.org/W4211036635","https://openalex.org/W4211081781","https://openalex.org/W4220814050","https://openalex.org/W4221000532","https://openalex.org/W4281684307","https://openalex.org/W4285007550","https://openalex.org/W4288722279","https://openalex.org/W4328049732","https://openalex.org/W4386144530","https://openalex.org/W4386606089","https://openalex.org/W4387364653","https://openalex.org/W4401560172"],"related_works":["https://openalex.org/W2480208912","https://openalex.org/W2505185432","https://openalex.org/W1600510083","https://openalex.org/W4235872100","https://openalex.org/W1986283048","https://openalex.org/W2561897638","https://openalex.org/W2963713644","https://openalex.org/W4388325710","https://openalex.org/W4250661259","https://openalex.org/W1488488265"],"abstract_inverted_index":{"Background:":[0],"In":[1],"response":[2],"to":[3,60,90,109,131,194,204],"the":[4,7,43,49,78,87,126,152,164,181,188],"shortcomings":[5],"of":[6,26,52,86,97,121,140,147,191,215],"current":[8],"Alzheimer's":[9],"disease":[10],"(AD)":[11],"early":[12,213,216],"populations":[13,133,196,218],"assessment,":[14],"which":[15,201],"is":[16,202],"based":[17,41,124,179],"on":[18,33,42,125,180],"neuropsychological":[19],"scales":[20],"with":[21,54],"high":[22],"subjectivity,":[23],"low":[24],"accuracy":[25],"repeated":[27],"measurements,":[28],"tedious":[29],"process":[30,45,89,129,183],"and":[31,74,82,105,142,163,186,212],"dependence":[32],"physicians,":[34],"it":[35],"was":[36,149],"found":[37],"that":[38],"digital":[39,67,84,122,177],"biomarkers":[40,85,123,178],"writing":[44,68,88,128,182],"can":[46,184],"effectively":[47],"characterize":[48,185],"cognitive":[50,56,93,189],"deficits":[51],"patients":[53],"mild":[55],"impairment":[57],"(MCI)":[58],"due":[59,108,130,193],"AD.":[61],"Methods:":[62],"This":[63],"study":[64],"designed":[65],"a":[66,143,198,206,220],"assessment":[69,80],"paradigm,":[70],"extracted":[71],"dynamic":[72],"handwriting":[73],"image":[75],"data":[76],"during":[77],"paradigm":[79],"process,":[81],"analyzed":[83],"assess":[91],"subjects'":[92],"functions.":[94],"A":[95],"total":[96],"72":[98],"subjects,":[99],"including":[100],"34":[101],"health":[102],"controls":[103],"(HC)":[104],"38":[106],"MCI":[107,127,192],"AD,":[110],"were":[111],"enrolled":[112],"in":[113,219],"this":[114],"study.":[115],"Results:":[116],"Their":[117],"combined":[118],"screening":[119,211],"efficacy":[120],"AD":[132,195,217],"having":[134],"an":[135],"area":[136],"under":[137],"curve":[138],"(AUC)":[139],"0.918,":[141],"confidence":[144],"interval":[145],"(CI)":[146],"0.854-0.982,":[148],"higher":[150],"than":[151],"Montreal":[153],"Cognitive":[154],"Assessment":[155],"Scale":[156,168],"(AUC":[157,169],"=":[158,161,170,173],"0.859,":[159],"CI":[160,172],"0.772-0.947)":[162],"Mini-mental":[165],"State":[166],"Examination":[167],"0.783,":[171],"0.678-0.888).":[174],"Conclusion:":[175],"Therefore,":[176],"quantify":[187],"function":[190],"at":[197],"fine-grained":[199],"level,":[200],"expected":[203],"be":[205],"new":[207],"method":[208],"for":[209],"intelligent":[210],"warning":[214],"community-based":[221],"physician-free":[222],"setting.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-05-21T09:19:25.381259","created_date":"2025-10-10T00:00:00"}