{"id":"https://openalex.org/W4396777893","doi":"https://doi.org/10.3389/fncom.2024.1327986","title":"Computational modeling to study the impact of changes in Nav1.8 sodium channel on neuropathic pain","display_name":"Computational modeling to study the impact of changes in Nav1.8 sodium channel on neuropathic pain","publication_year":2024,"publication_date":"2024-05-09","ids":{"openalex":"https://openalex.org/W4396777893","doi":"https://doi.org/10.3389/fncom.2024.1327986","pmid":"https://pubmed.ncbi.nlm.nih.gov/38784679"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2024.1327986","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2024.1327986","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2024.1327986/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncom.2024.1327986/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049975919","display_name":"Peter Kan","orcid":"https://orcid.org/0000-0002-5060-5118"},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter Kan","raw_affiliation_strings":["Department of Health Sciences, McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064877688","display_name":"Yong Fang Zhu","orcid":"https://orcid.org/0000-0002-3113-1965"},"institutions":[{"id":"https://openalex.org/I177485205","display_name":"Redeemer University","ror":"https://ror.org/04qx1zg28","country_code":"CA","type":"education","lineage":["https://openalex.org/I177485205"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yong Fang Zhu","raw_affiliation_strings":["Department of Health Sciences, Redeemer University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Redeemer University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I177485205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008764604","display_name":"Junling Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Junling Ma","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Victoria, Victoria, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Victoria, Victoria, BC, Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048880303","display_name":"Gurmit Singh","orcid":"https://orcid.org/0000-0002-6256-5790"},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gurmit Singh","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada","Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.7346,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69143456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"18","issue":null,"first_page":"1327986","last_page":"1327986"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"Neuropathic pain","score":0.8809477090835571},{"id":"https://openalex.org/keywords/nav1","display_name":"NAV1","score":0.855925977230072},{"id":"https://openalex.org/keywords/sodium-channel","display_name":"Sodium channel","score":0.7509986758232117},{"id":"https://openalex.org/keywords/sodium-channel-blocker","display_name":"Sodium channel blocker","score":0.4865230917930603},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3847231864929199},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3223174512386322},{"id":"https://openalex.org/keywords/sodium","display_name":"Sodium","score":0.2980268895626068},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.2848667800426483},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2281494438648224},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1764313280582428}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.8809477090835571},{"id":"https://openalex.org/C2777589315","wikidata":"https://www.wikidata.org/wiki/Q18048105","display_name":"NAV1","level":4,"score":0.855925977230072},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.7509986758232117},{"id":"https://openalex.org/C2776414672","wikidata":"https://www.wikidata.org/wiki/Q7553303","display_name":"Sodium channel blocker","level":4,"score":0.4865230917930603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3847231864929199},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3223174512386322},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.2980268895626068},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2848667800426483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2281494438648224},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1764313280582428},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fncom.2024.1327986","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2024.1327986","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2024.1327986/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:38784679","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38784679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11111952","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11111952","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11111952/pdf/fncom-18-1327986.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Comput Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:efe486c18d7f4315b02e09338b574211","is_oa":true,"landing_page_url":"https://doaj.org/article/efe486c18d7f4315b02e09338b574211","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncom.2024.1327986","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2024.1327986","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2024.1327986/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6600000262260437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396777893.pdf"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1494525315","https://openalex.org/W1520866342","https://openalex.org/W1617355594","https://openalex.org/W1700165191","https://openalex.org/W1966337493","https://openalex.org/W1980908861","https://openalex.org/W1981715847","https://openalex.org/W1987439527","https://openalex.org/W1997333327","https://openalex.org/W1997480818","https://openalex.org/W2004413159","https://openalex.org/W2004938469","https://openalex.org/W2013173477","https://openalex.org/W2018809272","https://openalex.org/W2020634817","https://openalex.org/W2027820788","https://openalex.org/W2030893345","https://openalex.org/W2031102231","https://openalex.org/W2042301702","https://openalex.org/W2049139575","https://openalex.org/W2050646098","https://openalex.org/W2052851214","https://openalex.org/W2054229783","https://openalex.org/W2057408859","https://openalex.org/W2059715474","https://openalex.org/W2065611170","https://openalex.org/W2066796908","https://openalex.org/W2071595010","https://openalex.org/W2076923772","https://openalex.org/W2082309778","https://openalex.org/W2082451911","https://openalex.org/W2105493663","https://openalex.org/W2117259350","https://openalex.org/W2147142375","https://openalex.org/W2157916066","https://openalex.org/W2162723169","https://openalex.org/W2275157848","https://openalex.org/W2318070250","https://openalex.org/W2630522640","https://openalex.org/W2884379645","https://openalex.org/W2950613784","https://openalex.org/W2950982422","https://openalex.org/W2957971038","https://openalex.org/W3001451127","https://openalex.org/W4304606578","https://openalex.org/W4323031799","https://openalex.org/W4391648790"],"related_works":["https://openalex.org/W1481443370","https://openalex.org/W2740465963","https://openalex.org/W2065689638","https://openalex.org/W2368500567","https://openalex.org/W2379660239","https://openalex.org/W1994504221","https://openalex.org/W2783055853","https://openalex.org/W2072634365","https://openalex.org/W2067045529","https://openalex.org/W2074149198"],"abstract_inverted_index":{"Objective":[0],"Nav1.8":[1,33,56,83,110,160,263],"expression":[2,13],"is":[3,52,161,181,197,240],"restricted":[4],"to":[5,25,34,53,244,258,271],"sensory":[6,60,147,222],"neurons;":[7],"it":[8],"was":[9],"hypothesized":[10],"that":[11,108,159,256],"aberrant":[12],"and":[14,65,127,168,174,196,205,217],"function":[15],"of":[16,22,32,49,78,89,105,141,152,170,191,193,208,221,248,262],"this":[17,50,194,201,252],"channel":[18,82,195,260],"at":[19],"the":[20,29,76,95,113,129,166,188,246,259,265],"site":[21],"injury":[23],"contributed":[24],"pathological":[26],"pain.":[27,46,72,250,273],"However,":[28],"specific":[30],"contributions":[31],"neuropathic":[35,71,153,226,272],"pain":[36,154],"are":[37],"not":[38],"as":[39,41],"clear":[40],"its":[42],"role":[43],"in":[44,58,80,136,149,187,224],"inflammatory":[45],"The":[47,176],"aim":[48],"study":[51,75],"understand":[54,245],"how":[55],"present":[57],"peripheral":[59],"neurons":[61,91,148,223],"regulate":[62],"neuronal":[63,106,172],"excitability":[64,179],"induce":[66],"various":[67],"electrophysiological":[68],"features":[69],"on":[70,139,235],"Methods":[73],"To":[74],"effect":[77],"changes":[79,257],"sodium":[81],"kinetics,":[84],"Hodgkin\u2013Huxley":[85],"type":[86],"conductance-based":[87],"models":[88,151,228],"spiking":[90],"were":[92],"constructed":[93,101],"using":[94],"NEURON":[96],"v8.2":[97],"simulation":[98],"software.":[99],"We":[100,124,157],"a":[102,184,241],"single-compartment":[103],"model":[104,130],"soma":[107,140],"contained":[109],"channels":[111],"with":[112,131],"ionic":[114],"mechanisms":[115],"adapted":[116],"from":[117,135],"some":[118],"existing":[119],"small":[120,142,266],"DRG":[121,267],"neuron":[122,268],"models.":[123],"then":[125],"validated":[126],"compared":[128],"our":[132,225],"experimental":[133],"data":[134],"vivo":[137],"recordings":[138],"dorsal":[143],"root":[144],"ganglion":[145],"(DRG)":[146],"animal":[150,227],"(NEP).":[155],"Results":[156],"show":[158],"an":[162],"important":[163],"parameter":[164],"for":[165],"generation":[167,247],"maintenance":[169],"abnormal":[171],"electrogenesis":[173],"hyperexcitability.":[175],"typical":[177],"increased":[178,218],"seen":[180],"dominated":[182],"by":[183,200,232],"left":[185],"shift":[186],"steady":[189,206],"state":[190,207],"activation":[192],"further":[198],"modulated":[199],"channel\u2019s":[202],"maximum":[203],"conductance":[204],"inactivation.":[209],"Therefore,":[210],"modified":[211],"action":[212],"potential":[213],"shape,":[214],"decreased":[215],"threshold,":[216],"repetitive":[219],"firing":[220],"may":[229,269],"be":[230],"orchestrated":[231],"these":[233],"modulations":[234],"Nav1.8.":[236],"Conclusion":[237],"Computational":[238],"modeling":[239],"novel":[242],"strategy":[243],"chronic":[249],"In":[251],"study,":[253],"we":[254],"highlight":[255],"functions":[261],"within":[264],"contribute":[270]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
