{"id":"https://openalex.org/W4365148696","doi":"https://doi.org/10.3389/fncom.2023.1169288","title":"Spike timing-dependent plasticity under imbalanced excitation and inhibition reduces the complexity of neural activity","display_name":"Spike timing-dependent plasticity under imbalanced excitation and inhibition reduces the complexity of neural activity","publication_year":2023,"publication_date":"2023-04-12","ids":{"openalex":"https://openalex.org/W4365148696","doi":"https://doi.org/10.3389/fncom.2023.1169288","pmid":"https://pubmed.ncbi.nlm.nih.gov/37122995"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2023.1169288","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2023.1169288","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1169288/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1169288/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100767275","display_name":"Jihoon Park","orcid":"https://orcid.org/0000-0003-3582-204X"},"institutions":[{"id":"https://openalex.org/I90023481","display_name":"National Institute of Information and Communications Technology","ror":"https://ror.org/016bgq349","country_code":"JP","type":"facility","lineage":["https://openalex.org/I90023481"]},{"id":"https://openalex.org/I98285908","display_name":"Osaka University","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Jihoon Park","raw_affiliation_strings":["Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita, Japan","Symbiotic Intelligent Systems Research Center, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan"],"affiliations":[{"raw_affiliation_string":"Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita, Japan","institution_ids":["https://openalex.org/I90023481"]},{"raw_affiliation_string":"Symbiotic Intelligent Systems Research Center, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019038638","display_name":"Yuji Kawai","orcid":"https://orcid.org/0000-0002-9976-4195"},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"Osaka University","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Kawai","raw_affiliation_strings":["Symbiotic Intelligent Systems Research Center, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan"],"affiliations":[{"raw_affiliation_string":"Symbiotic Intelligent Systems Research Center, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044985800","display_name":"Minoru Asada","orcid":"https://orcid.org/0000-0001-9506-6333"},"institutions":[{"id":"https://openalex.org/I90023481","display_name":"National Institute of Information and Communications Technology","ror":"https://ror.org/016bgq349","country_code":"JP","type":"facility","lineage":["https://openalex.org/I90023481"]},{"id":"https://openalex.org/I4528725","display_name":"Osaka International University","ror":"https://ror.org/02dqf3w62","country_code":"JP","type":"education","lineage":["https://openalex.org/I4528725"]},{"id":"https://openalex.org/I98285908","display_name":"Osaka University","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]},{"id":"https://openalex.org/I184937672","display_name":"Chubu University","ror":"https://ror.org/02sps0775","country_code":"JP","type":"education","lineage":["https://openalex.org/I184937672"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Asada","raw_affiliation_strings":["Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita, Japan","Chubu University Academy of Emerging Sciences/Center for Mathematical Science and Artificial Intelligence, Chubu University, Kasugai, Japan","International Professional University of Technology in Osaka, Osaka, Japan","Symbiotic Intelligent Systems Research Center, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan"],"affiliations":[{"raw_affiliation_string":"Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita, Japan","institution_ids":["https://openalex.org/I90023481"]},{"raw_affiliation_string":"Chubu University Academy of Emerging Sciences/Center for Mathematical Science and Artificial Intelligence, Chubu University, Kasugai, Japan","institution_ids":["https://openalex.org/I184937672"]},{"raw_affiliation_string":"International Professional University of Technology in Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I4528725"]},{"raw_affiliation_string":"Symbiotic Intelligent Systems Research Center, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100767275"],"corresponding_institution_ids":["https://openalex.org/I90023481","https://openalex.org/I98285908"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.3484,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55340225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"17","issue":null,"first_page":"1169288","last_page":"1169288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.7774715423583984},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.7771729230880737},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7626060843467712},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.6463697552680969},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.5603506565093994},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5089061260223389},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48512229323387146},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"Neuroplasticity","score":0.43635979294776917},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.41152191162109375},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3324659466743469},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27417314052581787},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20268428325653076}],"concepts":[{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7774715423583984},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7771729230880737},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7626060843467712},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.6463697552680969},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5603506565093994},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5089061260223389},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48512229323387146},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.43635979294776917},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.41152191162109375},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3324659466743469},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27417314052581787},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20268428325653076},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fncom.2023.1169288","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2023.1169288","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1169288/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:37122995","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37122995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10130424","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10130424","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10130424/pdf/fncom-17-1169288.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Comput Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d1be2ac3baa741a6a4ab6c3fd4a9badb","is_oa":true,"landing_page_url":"https://doaj.org/article/d1be2ac3baa741a6a4ab6c3fd4a9badb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 17 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncom.2023.1169288","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2023.1169288","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1169288/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1069223013","display_name":null,"funder_award_id":"JSPS KAKENHI","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2792802287","display_name":null,"funder_award_id":"KAKENHI","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"},{"id":"https://openalex.org/G3282004645","display_name":null,"funder_award_id":"JPMJCR","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"},{"id":"https://openalex.org/G3315487872","display_name":"Constructive understanding of inhibitory systems in the brain for motor function development and aging, through computational modeling and fMRI analysis","funder_award_id":"22K15622","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4155471703","display_name":null,"funder_award_id":"JPMJCR17A4","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4636223006","display_name":null,"funder_award_id":"JSPS KAK","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5506463476","display_name":null,"funder_award_id":"JP22K1","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6718509927","display_name":null,"funder_award_id":"CREST","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7604265505","display_name":null,"funder_award_id":"JPMJCR17A4","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"},{"id":"https://openalex.org/G7728667633","display_name":null,"funder_award_id":"JP22K15622","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7823066605","display_name":null,"funder_award_id":"JPMJCR17A4","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4365148696.pdf"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1129581376","https://openalex.org/W1191860829","https://openalex.org/W1541267199","https://openalex.org/W1613369435","https://openalex.org/W1918284089","https://openalex.org/W1964190792","https://openalex.org/W1975412204","https://openalex.org/W1975628461","https://openalex.org/W1989910778","https://openalex.org/W1999107021","https://openalex.org/W2001309356","https://openalex.org/W2049517487","https://openalex.org/W2054390925","https://openalex.org/W2059851411","https://openalex.org/W2060584452","https://openalex.org/W2063032535","https://openalex.org/W2063094367","https://openalex.org/W2066805606","https://openalex.org/W2072652550","https://openalex.org/W2089516943","https://openalex.org/W2091038318","https://openalex.org/W2092939357","https://openalex.org/W2093266575","https://openalex.org/W2102582359","https://openalex.org/W2107433900","https://openalex.org/W2113693127","https://openalex.org/W2117561082","https://openalex.org/W2126050517","https://openalex.org/W2128239595","https://openalex.org/W2128432504","https://openalex.org/W2132748057","https://openalex.org/W2142937846","https://openalex.org/W2146052710","https://openalex.org/W2152502378","https://openalex.org/W2158463114","https://openalex.org/W2164653071","https://openalex.org/W2170527455","https://openalex.org/W2171693726","https://openalex.org/W2172294131","https://openalex.org/W2292351724","https://openalex.org/W2294392975","https://openalex.org/W2320983896","https://openalex.org/W2434132484","https://openalex.org/W2503929286","https://openalex.org/W2801709363","https://openalex.org/W2805469146","https://openalex.org/W2810213456","https://openalex.org/W2908731397","https://openalex.org/W2916484570","https://openalex.org/W2938949210","https://openalex.org/W2999524883","https://openalex.org/W3105461111","https://openalex.org/W3163695510","https://openalex.org/W4231081240","https://openalex.org/W4249787363","https://openalex.org/W6675555054"],"related_works":["https://openalex.org/W2791883561","https://openalex.org/W2950596497","https://openalex.org/W2436760910","https://openalex.org/W4303432678","https://openalex.org/W2043066229","https://openalex.org/W2082329602","https://openalex.org/W2023878078","https://openalex.org/W2142526561","https://openalex.org/W2974163011","https://openalex.org/W2106951973"],"abstract_inverted_index":{"Excitatory":[0],"and":[1,10,19,39,70,102,135,156,159],"inhibitory":[2,100,104],"neurons":[3,101],"are":[4,14],"fundamental":[5],"components":[6],"of":[7,35,67,99,113,132,162],"the":[8,33,36,58,63,84,91,97,103,130,151,166],"brain,":[9],"healthy":[11],"neural":[12,54,68,78,93,133],"circuits":[13],"well":[15],"balanced":[16],"between":[17,139,153],"excitation":[18],"inhibition":[20],"(E/I":[21],"balance).":[22],"However,":[23],"it":[24],"is":[25],"not":[26],"clear":[27],"how":[28,48],"an":[29,145],"E/I":[30,51,124],"imbalance":[31],"affects":[32,53],"self-organization":[34],"network":[37,79],"structure":[38],"function":[40],"in":[41,107,142,165],"general.":[42],"In":[43,73],"this":[44],"study,":[45],"we":[46,149],"examined":[47],"locally":[49,122],"altered":[50],"balance":[52],"dynamics":[55],"such":[56],"as":[57],"connectivity":[59],"by":[60],"activity-dependent":[61],"formation,":[62],"complexity":[64,131,161],"(multiscale":[65],"entropy)":[66],"activity,":[69,134],"information":[71,137],"transmission.":[72],"our":[74,154],"simulation,":[75],"a":[76,108,121],"spiking":[77],"model":[80],"was":[81],"used":[82],"with":[83],"spike-timing":[85],"dependent":[86],"plasticity":[87],"rule":[88],"to":[89,144],"explore":[90],"above":[92],"dynamics.":[94],"We":[95],"controlled":[96],"number":[98],"synaptic":[105],"weights":[106],"single":[109],"neuron":[110,115,140],"group":[111],"out":[112],"multiple":[114],"groups.":[116],"The":[117],"results":[118,155],"showed":[119],"that":[120],"increased":[123],"ratio":[125],"strengthens":[126],"excitatory":[127],"connections,":[128],"reduces":[129],"decreases":[136],"transmission":[138],"groups":[141],"response":[143],"external":[146],"input.":[147],"Finally,":[148],"argued":[150],"relationship":[152],"excessive":[157],"connections":[158],"low":[160],"brain":[163,168],"activity":[164],"neuropsychiatric":[167],"disorders.":[169]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
