{"id":"https://openalex.org/W4323316856","doi":"https://doi.org/10.3389/fncom.2023.1108346","title":"A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning","display_name":"A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning","publication_year":2023,"publication_date":"2023-03-06","ids":{"openalex":"https://openalex.org/W4323316856","doi":"https://doi.org/10.3389/fncom.2023.1108346","pmid":"https://pubmed.ncbi.nlm.nih.gov/36950506"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2023.1108346","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2023.1108346","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1108346/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1108346/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109334962","display_name":"Matthew Ricci","orcid":null},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Ricci","raw_affiliation_strings":["Carney Institute for Brain Sciences, Brown University, Providence, RI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carney Institute for Brain Sciences, Brown University, Providence, RI, United States","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I1314596251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030116523","display_name":"Junkyung Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junkyung Kim","raw_affiliation_strings":["Carney Institute for Brain Sciences, Brown University, Providence, RI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carney Institute for Brain Sciences, Brown University, Providence, RI, United States","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I1314596251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090246850","display_name":"Fredrik Johansson","orcid":"https://orcid.org/0000-0001-5942-0606"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Fredrik Johansson","raw_affiliation_strings":["Department of Experimental Medical Science, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medical Science, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090246850"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2652,"currency":"EUR","value_usd":2860},"fwci":0.2258,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52930095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":null,"first_page":"1108346","last_page":"1108346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/purkinje-cell","display_name":"Purkinje cell","score":0.9115800857543945},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7779295444488525},{"id":"https://openalex.org/keywords/eyeblink-conditioning","display_name":"Eyeblink conditioning","score":0.7082468271255493},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.531423807144165},{"id":"https://openalex.org/keywords/cerebellar-cortex","display_name":"Cerebellar cortex","score":0.47049427032470703},{"id":"https://openalex.org/keywords/cerebellum","display_name":"Cerebellum","score":0.46499693393707275},{"id":"https://openalex.org/keywords/conditioning","display_name":"Conditioning","score":0.44894668459892273},{"id":"https://openalex.org/keywords/classical-conditioning","display_name":"Classical conditioning","score":0.4412245750427246},{"id":"https://openalex.org/keywords/interstimulus-interval","display_name":"Interstimulus interval","score":0.4198932647705078},{"id":"https://openalex.org/keywords/parallel-fiber","display_name":"Parallel fiber","score":0.41158610582351685},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.2505815029144287},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2388538122177124},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.06418192386627197}],"concepts":[{"id":"https://openalex.org/C2778472085","wikidata":"https://www.wikidata.org/wiki/Q1570272","display_name":"Purkinje cell","level":3,"score":0.9115800857543945},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7779295444488525},{"id":"https://openalex.org/C2781081984","wikidata":"https://www.wikidata.org/wiki/Q5422751","display_name":"Eyeblink conditioning","level":4,"score":0.7082468271255493},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.531423807144165},{"id":"https://openalex.org/C2992333117","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellar cortex","level":3,"score":0.47049427032470703},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.46499693393707275},{"id":"https://openalex.org/C45262634","wikidata":"https://www.wikidata.org/wiki/Q5159291","display_name":"Conditioning","level":2,"score":0.44894668459892273},{"id":"https://openalex.org/C39617858","wikidata":"https://www.wikidata.org/wiki/Q212737","display_name":"Classical conditioning","level":3,"score":0.4412245750427246},{"id":"https://openalex.org/C138370407","wikidata":"https://www.wikidata.org/wiki/Q16944465","display_name":"Interstimulus interval","level":3,"score":0.4198932647705078},{"id":"https://openalex.org/C2778058767","wikidata":"https://www.wikidata.org/wiki/Q5064084","display_name":"Parallel fiber","level":4,"score":0.41158610582351685},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2505815029144287},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2388538122177124},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06418192386627197},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fncom.2023.1108346","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2023.1108346","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1108346/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:36950506","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36950506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10025386","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10025386","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10025386/pdf/fncom-17-1108346.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Comput Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1673ad98a8e946a1abe5712d6b8c9bdc","is_oa":true,"landing_page_url":"https://doaj.org/article/1673ad98a8e946a1abe5712d6b8c9bdc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 17 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncom.2023.1108346","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2023.1108346","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1108346/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8351625759","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"1644760","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321761","display_name":"Crafoordska Stiftelsen","ror":"https://ror.org/02hwwbr17"},{"id":"https://openalex.org/F4320322168","display_name":"Hj\u00e4rnfonden","ror":"https://ror.org/014btj409"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4323316856.pdf"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W133568568","https://openalex.org/W1502963283","https://openalex.org/W1518056784","https://openalex.org/W1528959312","https://openalex.org/W1550824444","https://openalex.org/W1582681335","https://openalex.org/W1596241641","https://openalex.org/W1693262811","https://openalex.org/W1937980604","https://openalex.org/W1965741585","https://openalex.org/W1975023995","https://openalex.org/W1994919683","https://openalex.org/W1995249750","https://openalex.org/W1995952358","https://openalex.org/W1997328693","https://openalex.org/W2011825691","https://openalex.org/W2012198383","https://openalex.org/W2015816821","https://openalex.org/W2021000234","https://openalex.org/W2031402048","https://openalex.org/W2031714533","https://openalex.org/W2037593288","https://openalex.org/W2041545661","https://openalex.org/W2046889372","https://openalex.org/W2051690980","https://openalex.org/W2055850746","https://openalex.org/W2055914072","https://openalex.org/W2060694206","https://openalex.org/W2069333865","https://openalex.org/W2074202447","https://openalex.org/W2082164815","https://openalex.org/W2090286775","https://openalex.org/W2090876232","https://openalex.org/W2106614622","https://openalex.org/W2113364987","https://openalex.org/W2127398100","https://openalex.org/W2136879066","https://openalex.org/W2137345241","https://openalex.org/W2144367924","https://openalex.org/W2204225291","https://openalex.org/W2212196805","https://openalex.org/W2270773227","https://openalex.org/W2320347944","https://openalex.org/W2329491027","https://openalex.org/W2512047319","https://openalex.org/W2618157844","https://openalex.org/W2954287947","https://openalex.org/W3005435558","https://openalex.org/W3158487872","https://openalex.org/W4239749396","https://openalex.org/W4284883196","https://openalex.org/W6813633774"],"related_works":["https://openalex.org/W2147033427","https://openalex.org/W2059448612","https://openalex.org/W2783288149","https://openalex.org/W2040618151","https://openalex.org/W2035934691","https://openalex.org/W2896701575","https://openalex.org/W4232461937","https://openalex.org/W2054352874","https://openalex.org/W2753969824","https://openalex.org/W2135146585"],"abstract_inverted_index":{"The":[0,141],"cerebellar":[1,24],"Purkinje":[2,25,70,105,133,150],"cell":[3,26,106,134,151],"controlling":[4],"eyeblinks":[5],"can":[6],"learn,":[7],"remember,":[8],"and":[9,66,135,156],"reproduce":[10],"the":[11,23,48,54,63,69,92,103,126,132],"interstimulus":[12],"interval":[13],"in":[14,57,91,98],"a":[15,34,80,122],"classical":[16,154],"conditioning":[17,75,155],"paradigm.":[18],"Given":[19],"temporally":[20],"separated":[21],"inputs,":[22],"learns":[27],"to":[28,89,115,131,138],"pause":[29],"its":[30],"tonic":[31],"inhibition":[32],"of":[33,79,95,125],"motor":[35],"pathway":[36],"with":[37,145],"high":[38],"temporal":[39,93],"precision":[40],"so":[41],"that":[42,102],"an":[43],"overt":[44],"blink":[45],"occurs":[46],"at":[47],"right":[49],"time.":[50],"Most":[51],"models":[52,86],"place":[53],"passage-of-time":[55,127],"representation":[56],"upstream":[58,64],"network":[59,65,85],"effects.":[60],"Yet,":[61],"bypassing":[62],"directly":[67],"stimulating":[68],"cell's":[71],"pre-synaptic":[72],"fibers":[73],"during":[74,153],"still":[76],"causes":[77],"acquisition":[78],"well-timed":[81],"response.":[82],"Additionally,":[83],"while":[84],"are":[87],"sensitive":[88],"variance":[90],"structure":[94],"probe":[96,139],"stimulation,":[97],"vivo":[99],"findings":[100,111],"suggest":[101],"acquired":[104],"response":[107],"is":[108,129,136,143],"not.":[109],"Such":[110],"motivate":[112],"alternative":[113],"approaches":[114],"modeling":[116],"neural":[117],"function.":[118],"Here,":[119],"we":[120],"present":[121],"proof-of-principle":[123],"model":[124,142],"which":[128],"internal":[130],"invariant":[137],"structure.":[140],"consistent":[144],"puzzling":[146],"findings,":[147],"accurately":[148],"recapitulates":[149],"firing":[152],"makes":[157],"testable":[158],"electrophysiological":[159],"predictions.":[160],"1":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2025-10-10T00:00:00"}