{"id":"https://openalex.org/W4319039813","doi":"https://doi.org/10.3389/fncom.2023.1017075","title":"Noise-modulated multistable synapses in a Wilson-Cowan-based model of plasticity","display_name":"Noise-modulated multistable synapses in a Wilson-Cowan-based model of plasticity","publication_year":2023,"publication_date":"2023-02-02","ids":{"openalex":"https://openalex.org/W4319039813","doi":"https://doi.org/10.3389/fncom.2023.1017075","pmid":"https://pubmed.ncbi.nlm.nih.gov/36817317"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2023.1017075","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2023.1017075","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1017075/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1017075/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040514719","display_name":"Caroline Lea\u2010Carnall","orcid":"https://orcid.org/0000-0001-6814-3356"},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Caroline A. Lea-Carnall","raw_affiliation_strings":["School of Health Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Health Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003206781","display_name":"Lisabel I. Tanner","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lisabel I. Tanner","raw_affiliation_strings":["School of Health Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Health Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089716242","display_name":"Marcelo A. Montemurro","orcid":"https://orcid.org/0000-0003-0893-8530"},"institutions":[{"id":"https://openalex.org/I204136569","display_name":"The Open University","ror":"https://ror.org/05mzfcs16","country_code":"GB","type":"education","lineage":["https://openalex.org/I204136569"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Marcelo A. Montemurro","raw_affiliation_strings":["School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, United Kingdom","institution_ids":["https://openalex.org/I204136569"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040514719","https://openalex.org/A5089716242"],"corresponding_institution_ids":["https://openalex.org/I204136569","https://openalex.org/I2799725268","https://openalex.org/I28407311"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.0504,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7387943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"17","issue":null,"first_page":"1017075","last_page":"1017075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasticity","display_name":"Plasticity","score":0.6456596851348877},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.6364570260047913},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"Synaptic plasticity","score":0.6164682507514954},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5841590166091919},{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.530394434928894},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.4993007183074951},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"Neuroplasticity","score":0.49084049463272095},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.47250044345855713},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3483041226863861},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34801149368286133},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.29322779178619385},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24270132184028625},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.12551864981651306}],"concepts":[{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.6456596851348877},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.6364570260047913},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.6164682507514954},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5841590166091919},{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.530394434928894},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4993007183074951},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.49084049463272095},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.47250044345855713},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3483041226863861},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34801149368286133},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29322779178619385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24270132184028625},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12551864981651306},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fncom.2023.1017075","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2023.1017075","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1017075/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:36817317","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36817317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/7972d1cd-12ed-44fe-8e6a-dab828b25f95","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/7972d1cd-12ed-44fe-8e6a-dab828b25f95","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lea-Carnall, C A, Tanner, L I & Montemurro, M A 2023, 'Noise-modulated multistable synapses in a Wilson-Cowan-based model of plasticity', Frontiers in Computational Neuroscience, vol. 17. https://doi.org/10.3389/fncom.2023.1017075","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:oro.open.ac.uk:87301","is_oa":true,"landing_page_url":"https://oro.open.ac.uk/view/person/mam777.html","pdf_url":"https://oro.open.ac.uk/87301/1/fncom-17-1017075.pdf","source":{"id":"https://openalex.org/S4306401187","display_name":"Open Research Online (The Open University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204136569","host_organization_name":"The Open University","host_organization_lineage":["https://openalex.org/I204136569"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:pubmedcentral.nih.gov:9931909","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9931909","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9931909/pdf/fncom-17-1017075.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Comput Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:43865ac3790a4d518f4c5cb6580ca77d","is_oa":true,"landing_page_url":"https://doaj.org/article/43865ac3790a4d518f4c5cb6580ca77d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 17 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncom.2023.1017075","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2023.1017075","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2023.1017075/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G150590730","display_name":null,"funder_award_id":"MR/P014445/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4319039813.pdf"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W111157985","https://openalex.org/W1552141811","https://openalex.org/W1970113884","https://openalex.org/W1985579243","https://openalex.org/W1985616013","https://openalex.org/W1987430298","https://openalex.org/W1992476998","https://openalex.org/W1994718873","https://openalex.org/W1997290576","https://openalex.org/W2007190359","https://openalex.org/W2012183985","https://openalex.org/W2015173963","https://openalex.org/W2016354087","https://openalex.org/W2021104507","https://openalex.org/W2028722600","https://openalex.org/W2036956268","https://openalex.org/W2037135555","https://openalex.org/W2039128518","https://openalex.org/W2039281962","https://openalex.org/W2055264244","https://openalex.org/W2061979338","https://openalex.org/W2067565862","https://openalex.org/W2085497225","https://openalex.org/W2104731571","https://openalex.org/W2105801075","https://openalex.org/W2115810652","https://openalex.org/W2138351621","https://openalex.org/W2144247213","https://openalex.org/W2145137020","https://openalex.org/W2147336335","https://openalex.org/W2152002666","https://openalex.org/W2157280774","https://openalex.org/W2171904973","https://openalex.org/W2172306290","https://openalex.org/W2218991028","https://openalex.org/W2275018691","https://openalex.org/W2481263544","https://openalex.org/W2483809583","https://openalex.org/W2521922003","https://openalex.org/W2567032455","https://openalex.org/W2578308616","https://openalex.org/W2738159159","https://openalex.org/W2740752047","https://openalex.org/W2789322388","https://openalex.org/W2791677105","https://openalex.org/W2795067400","https://openalex.org/W2796227472","https://openalex.org/W2819218734","https://openalex.org/W2887715873","https://openalex.org/W2896350660","https://openalex.org/W2896501945","https://openalex.org/W2902817509","https://openalex.org/W2950462296","https://openalex.org/W2951401594","https://openalex.org/W2962791540","https://openalex.org/W3017220423","https://openalex.org/W3033642508","https://openalex.org/W3092564561","https://openalex.org/W3105012889","https://openalex.org/W4281606193","https://openalex.org/W4283120220","https://openalex.org/W6677510898"],"related_works":["https://openalex.org/W4224217224","https://openalex.org/W3118640947","https://openalex.org/W4388308731","https://openalex.org/W2042003698","https://openalex.org/W1964519618","https://openalex.org/W1969697984","https://openalex.org/W3048730783","https://openalex.org/W1992416820","https://openalex.org/W3094197880","https://openalex.org/W2183786486"],"abstract_inverted_index":{"Frequency-dependent":[0],"plasticity":[1,107,120,216],"refers":[2],"to":[3,10,19,70,82],"changes":[4],"in":[5,8,23,33,52,85,100,122,134,141,211],"synaptic":[6,106,161,177],"strength":[7,162,178],"response":[9],"different":[11,97],"stimulation":[12,60,138],"frequencies.":[13],"Resonance":[14],"is":[15,41,66,169,206],"a":[16,67,123,136,154,170,180,207],"factor":[17,210],"known":[18],"be":[20,164],"of":[21,30,75,88,94,126,144,146,157,172,194,215],"importance":[22],"such":[24],"frequency":[25],"dependence,":[26],"however,":[27],"the":[28,34,39,72,86,91,96,101,142,158,187,190,195,213],"role":[29],"neural":[31,76,128],"noise":[32,145,159,173,184,205],"process":[35],"remains":[36],"elusive.":[37],"Considering":[38],"brain":[40,59],"an":[42],"inherently":[43],"noisy":[44],"system,":[45],"understanding":[46],"its":[47],"effects":[48],"may":[49],"prove":[50],"beneficial":[51],"shaping":[53],"therapeutic":[54],"interventions":[55],"based":[56],"on":[57],"non-invasive":[58],"protocols.":[61],"The":[62,149],"Wilson-Cowan":[63],"(WC)":[64],"model":[65,69,103,125],"well-established":[68],"describe":[71],"average":[73],"dynamics":[74,121],"populations":[77,110,129],"and":[78],"has":[79,112],"been":[80,115],"shown":[81],"exhibit":[83],"bistability":[84],"presence":[87,143],"noise.":[89],"However,":[90],"important":[92],"question":[93],"how":[95],"stable":[98,196],"regimes":[99],"WC":[102],"can":[104,163],"affect":[105],"when":[108],"cortical":[109],"interact":[111],"not":[113],"yet":[114],"addressed.":[116],"Therefore,":[117],"we":[118],"investigated":[119],"WC-based":[124],"interacting":[127],"coupled":[130],"with":[131],"activity-dependent":[132],"synapses":[133],"which":[135,176],"periodic":[137],"was":[139],"applied":[140],"controlled":[147],"intensity.":[148],"results":[150,202],"indicate":[151],"that":[152,189,204],"for":[153,175],"narrow":[155],"range":[156],"variance,":[160],"optimized.":[165],"In":[166],"particular,":[167],"there":[168],"regime":[171],"intensity":[174,185],"presents":[179],"triple-stable":[181],"state.":[182],"Regulating":[183],"affects":[186],"probability":[188],"system":[191],"chooses":[192],"one":[193],"states,":[197],"thereby":[198],"controlling":[199],"plasticity.":[200],"These":[201],"suggest":[203],"highly":[208],"influential":[209],"determining":[212],"outcome":[214],"induced":[217],"by":[218],"stimulation.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}