{"id":"https://openalex.org/W4315433921","doi":"https://doi.org/10.3389/fncom.2022.1095676","title":"A computational approach based on weighted gene co-expression network analysis for biomarkers analysis of Parkinson\u2019s disease and construction of diagnostic model","display_name":"A computational approach based on weighted gene co-expression network analysis for biomarkers analysis of Parkinson\u2019s disease and construction of diagnostic model","publication_year":2023,"publication_date":"2023-01-10","ids":{"openalex":"https://openalex.org/W4315433921","doi":"https://doi.org/10.3389/fncom.2022.1095676","pmid":"https://pubmed.ncbi.nlm.nih.gov/36704228"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2022.1095676","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2022.1095676","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2022.1095676/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncom.2022.1095676/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028264427","display_name":"Zhaoping Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoping Wu","raw_affiliation_strings":["Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031818289","display_name":"Zhiping Hu","orcid":"https://orcid.org/0000-0001-5672-9683"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiping Hu","raw_affiliation_strings":["Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088070359","display_name":"Yunchun Gao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210123733","display_name":"The First People's Hospital of Changde","ror":"https://ror.org/02h2ywm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210123733"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunchun Gao","raw_affiliation_strings":["Department of Neurology, The First People's Hospital of Changde City, Changde, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First People's Hospital of Changde City, Changde, Hunan, China","institution_ids":["https://openalex.org/I4210123733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091627874","display_name":"Yuechong Xia","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuechong Xia","raw_affiliation_strings":["Department of Respiratory Medicine, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462484","display_name":"Xiaobo Zhang","orcid":"https://orcid.org/0000-0003-0222-2515"},"institutions":[{"id":"https://openalex.org/I4210123733","display_name":"The First People's Hospital of Changde","ror":"https://ror.org/02h2ywm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210123733"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobo Zhang","raw_affiliation_strings":["Department of Neurology, The First People's Hospital of Changde City, Changde, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First People's Hospital of Changde City, Changde, Hunan, China","institution_ids":["https://openalex.org/I4210123733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015346170","display_name":"Zheng Jiang","orcid":"https://orcid.org/0000-0001-7160-4512"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zheng Jiang","raw_affiliation_strings":["Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015346170"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.7545,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.8459663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"1095676","last_page":"1095676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7204999923706055,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7204999923706055,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.11209999769926071,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.6321663856506348},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"Gene co-expression network","score":0.6199555993080139},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.6086210608482361},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.6035939455032349},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5797635912895203},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5148741006851196},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4772636592388153},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.46591734886169434},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.44797223806381226},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.44457584619522095},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3512341380119324},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34044748544692993},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3279772400856018},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31958723068237305},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29708123207092285},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21632066369056702},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.17475605010986328},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14754247665405273}],"concepts":[{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6321663856506348},{"id":"https://openalex.org/C2778022302","wikidata":"https://www.wikidata.org/wiki/Q18207329","display_name":"Gene co-expression network","level":5,"score":0.6199555993080139},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6086210608482361},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.6035939455032349},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5797635912895203},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5148741006851196},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4772636592388153},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.46591734886169434},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.44797223806381226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44457584619522095},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3512341380119324},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34044748544692993},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3279772400856018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31958723068237305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29708123207092285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21632066369056702},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.17475605010986328},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14754247665405273},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fncom.2022.1095676","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2022.1095676","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2022.1095676/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:36704228","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36704228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9873349","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9873349","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Comput Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c3b9ba025abb4035b2cf8b0732b2f8b2","is_oa":true,"landing_page_url":"https://doaj.org/article/c3b9ba025abb4035b2cf8b0732b2f8b2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 16 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncom.2022.1095676","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2022.1095676","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2022.1095676/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8544064025","display_name":null,"funder_award_id":"81974213","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4315433921.pdf"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W192435104","https://openalex.org/W1525787712","https://openalex.org/W1966327575","https://openalex.org/W1974924674","https://openalex.org/W1979565835","https://openalex.org/W1982207977","https://openalex.org/W1996863275","https://openalex.org/W2006617902","https://openalex.org/W2014182955","https://openalex.org/W2029786514","https://openalex.org/W2033669048","https://openalex.org/W2035618305","https://openalex.org/W2050781983","https://openalex.org/W2056493327","https://openalex.org/W2062417009","https://openalex.org/W2062899306","https://openalex.org/W2075856383","https://openalex.org/W2080092217","https://openalex.org/W2097939227","https://openalex.org/W2116634113","https://openalex.org/W2149476546","https://openalex.org/W2159096710","https://openalex.org/W2161703366","https://openalex.org/W2162429758","https://openalex.org/W2169353806","https://openalex.org/W2172071810","https://openalex.org/W2413106361","https://openalex.org/W2755552661","https://openalex.org/W2810892887","https://openalex.org/W2821171282","https://openalex.org/W2898208708","https://openalex.org/W2913212062","https://openalex.org/W2958067187","https://openalex.org/W2972355844","https://openalex.org/W2999246652","https://openalex.org/W3000784938","https://openalex.org/W3015873948","https://openalex.org/W3037753076","https://openalex.org/W3042580583","https://openalex.org/W3046401125","https://openalex.org/W3084329562","https://openalex.org/W3094738391","https://openalex.org/W3096667083","https://openalex.org/W3096763885","https://openalex.org/W3107715620","https://openalex.org/W3117645897","https://openalex.org/W3125287040","https://openalex.org/W3161075586","https://openalex.org/W4200451722","https://openalex.org/W4206663729","https://openalex.org/W4294124554","https://openalex.org/W4304892986","https://openalex.org/W6607795100"],"related_works":["https://openalex.org/W2796636403","https://openalex.org/W2015700328","https://openalex.org/W2364565895","https://openalex.org/W2767847608","https://openalex.org/W2911678823","https://openalex.org/W2152648570","https://openalex.org/W2183420549","https://openalex.org/W2039699813","https://openalex.org/W2081507994","https://openalex.org/W1972696957"],"abstract_inverted_index":{"Background:":[0],"Parkinson's":[1],"disease":[2],"(PD)":[3],"is":[4,12,32,48],"a":[5,136,220,272],"common":[6],"age-related":[7],"chronic":[8],"neurodegenerative":[9],"disease.":[10],"There":[11],"currently":[13],"no":[14],"affordable,":[15],"effective,":[16],"and":[17,28,86,105,144,186,198,206,229,250,267],"less":[18],"invasive":[19],"test":[20],"for":[21,39,224,276],"PD":[22,56,66,96,225],"diagnosis.":[23],"Metabolite":[24],"profiling":[25],"in":[26,118,226,243],"blood":[27],"blood-based":[29],"gene":[30,60,84],"transcripts":[31],"thought":[33],"to":[34,49,81,113,134,153,172,208],"be":[35],"an":[36],"ideal":[37],"method":[38],"diagnosing":[40],"PD.":[41,126,277],"Aim:":[42],"In":[43],"this":[44],"study,":[45],"the":[46,51,88,98,115,119,145,155,158,161,174,203,216,227,234,244,253],"objective":[47],"identify":[50,87,114],"potential":[52,273],"diagnostic":[53,137,210,217,222,274],"biomarkers":[54],"of":[55,63,157,233,247],"by":[57],"analyzing":[58],"microarray":[59],"expression":[61,246],"data":[62],"samples":[64],"from":[65,97,202],"patients.":[67],"Methods:":[68],"A":[69],"computational":[70],"approach,":[71],"namely,":[72],"Weighted":[73],"Gene":[74],"Co-expression":[75],"Network":[76],"Analysis":[77],"(WGCNA)":[78],"was":[79,111,170],"used":[80,133,152,171,207],"construct":[82,135,209],"co-expression":[83],"networks":[85],"key":[89,120,181],"modules":[90,121,182,205],"that":[91,215,238],"were":[92,131,151,200,240],"highly":[93],"correlated":[94],"with":[95,122,125,184],"GSE99039":[99,162],"dataset.":[100,163],"The":[101,127,258],"Least":[102],"Absolute":[103],"Shrinkage":[104],"Selection":[106],"Operator":[107],"(LASSO)":[108],"regression":[109,142],"analysis":[110,213],"performed":[112],"hub":[116,129,175,190,255],"genes":[117,130],"strong":[123],"association":[124],"selected":[128],"then":[132],"model":[138,159,218],"based":[139],"on":[140],"logistic":[141],"analysis,":[143],"Receiver":[146],"Operating":[147],"Characteristic":[148],"(ROC)":[149],"curves":[150],"evaluate":[154],"efficacy":[156],"using":[160],"Finally,":[164],"Reverse":[165],"Transcription-Polymerase":[166],"Chain":[167],"Reaction":[168],"(RT-PCR)":[169],"validate":[173],"genes.":[176,256],"Results:":[177],"WGCNA":[178],"identified":[179,201],"two":[180,204],"associated":[183],"inflammation":[185],"immune":[187],"response.":[188],"Seven":[189],"genes,":[191],"LILRB1,":[192,248],"LSP1,":[193,249,262],"SIPA1,":[194,263],"SLC15A3,":[195,264],"MBOAT7,":[196,265],"RNF24,":[197,266],"TLE3":[199],"models.":[211],"ROC":[212],"showed":[214,237],"had":[219],"good":[221],"performance":[223],"training":[228],"testing":[230],"datasets.":[231],"Results":[232],"RT-PCR":[235],"experiments":[236],"there":[239],"significant":[241],"differences":[242],"mRNA":[245],"MBOAT7":[251],"among":[252],"seven":[254],"Conclusion:":[257],"7-gene":[259],"panel":[260],"(LILRB1,":[261],"TLE3)":[268],"will":[269],"serve":[270],"as":[271],"signature":[275]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
