{"id":"https://openalex.org/W2517419569","doi":"https://doi.org/10.3389/fncom.2016.00086","title":"The Dynamics of Voluntary Force Production in Afferented Muscle Influence Involuntary Tremor","display_name":"The Dynamics of Voluntary Force Production in Afferented Muscle Influence Involuntary Tremor","publication_year":2016,"publication_date":"2016-08-18","ids":{"openalex":"https://openalex.org/W2517419569","doi":"https://doi.org/10.3389/fncom.2016.00086","mag":"2517419569","pmid":"https://pubmed.ncbi.nlm.nih.gov/27594832"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2016.00086","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2016.00086","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2016.00086/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncom.2016.00086/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078698490","display_name":"Christopher M. Laine","orcid":"https://orcid.org/0000-0001-5054-7811"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Laine","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern CaliforniaLos Angeles, CA, USA; Division of Biokinesiology and Physical Therapy, University of Southern CaliforniaLos Angeles, CA, USA","Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA","Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern CaliforniaLos Angeles, CA, USA; Division of Biokinesiology and Physical Therapy, University of Southern CaliforniaLos Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054326530","display_name":"Akira Nagamori","orcid":"https://orcid.org/0000-0003-4699-1260"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akira Nagamori","raw_affiliation_strings":["Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles, CA, USA","Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011153285","display_name":"Francisco J. Valero\u2010Cuevas","orcid":"https://orcid.org/0000-0002-2611-7923"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Francisco J. Valero-Cuevas","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern CaliforniaLos Angeles, CA, USA; Division of Biokinesiology and Physical Therapy, University of Southern CaliforniaLos Angeles, CA, USA","Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern CaliforniaLos Angeles, CA, USA; Division of Biokinesiology and Physical Therapy, University of Southern CaliforniaLos Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011153285"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.026,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.86410242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isometric-exercise","display_name":"Isometric exercise","score":0.8691009283065796},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.48717302083969116},{"id":"https://openalex.org/keywords/electromyography","display_name":"Electromyography","score":0.4713529944419861},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.43082284927368164},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42725250124931335},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4247647523880005},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3974018394947052},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.36130291223526},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2423551380634308},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.1701631247997284},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.15944373607635498},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15484854578971863},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.12498283386230469}],"concepts":[{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.8691009283065796},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.48717302083969116},{"id":"https://openalex.org/C2777515770","wikidata":"https://www.wikidata.org/wiki/Q507369","display_name":"Electromyography","level":2,"score":0.4713529944419861},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.43082284927368164},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42725250124931335},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4247647523880005},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3974018394947052},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.36130291223526},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2423551380634308},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.1701631247997284},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.15944373607635498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15484854578971863},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12498283386230469},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fncom.2016.00086","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2016.00086","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2016.00086/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:27594832","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27594832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:doaj.org/article:d847e6b3b97f4ce9b3a97c0dcb3648b8","is_oa":true,"landing_page_url":"https://doaj.org/article/d847e6b3b97f4ce9b3a97c0dcb3648b8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 10 (2016)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4990560","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4990560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Comput Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fncom.2016.00086","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2016.00086","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncom.2016.00086/pdf","source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1705725886","display_name":null,"funder_award_id":"R01 AR-052345","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2595256972","display_name":null,"funder_award_id":"R01 AR-050520","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2517419569.pdf","grobid_xml":"https://content.openalex.org/works/W2517419569.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W288272089","https://openalex.org/W1562465373","https://openalex.org/W1565371978","https://openalex.org/W1586810339","https://openalex.org/W1772854098","https://openalex.org/W1964796831","https://openalex.org/W1974001496","https://openalex.org/W1981336856","https://openalex.org/W1987737534","https://openalex.org/W1989458918","https://openalex.org/W1993266190","https://openalex.org/W1999635151","https://openalex.org/W2000248734","https://openalex.org/W2005995324","https://openalex.org/W2006127388","https://openalex.org/W2008222794","https://openalex.org/W2008232105","https://openalex.org/W2011134828","https://openalex.org/W2013427209","https://openalex.org/W2023230692","https://openalex.org/W2023287718","https://openalex.org/W2027187284","https://openalex.org/W2029080852","https://openalex.org/W2030302597","https://openalex.org/W2033817519","https://openalex.org/W2042560285","https://openalex.org/W2046932463","https://openalex.org/W2047281269","https://openalex.org/W2056991487","https://openalex.org/W2058608931","https://openalex.org/W2059009913","https://openalex.org/W2060522808","https://openalex.org/W2063714243","https://openalex.org/W2064834200","https://openalex.org/W2065064872","https://openalex.org/W2068485163","https://openalex.org/W2090092911","https://openalex.org/W2093615513","https://openalex.org/W2100611943","https://openalex.org/W2101388623","https://openalex.org/W2107910247","https://openalex.org/W2118568634","https://openalex.org/W2118893544","https://openalex.org/W2131051077","https://openalex.org/W2138452398","https://openalex.org/W2142416079","https://openalex.org/W2142831289","https://openalex.org/W2148085313","https://openalex.org/W2151503300","https://openalex.org/W2153815554","https://openalex.org/W2154667763","https://openalex.org/W2160054543","https://openalex.org/W2165346682","https://openalex.org/W2166089952","https://openalex.org/W2166178334","https://openalex.org/W2166714154","https://openalex.org/W2168029749","https://openalex.org/W2169508341","https://openalex.org/W2185222181","https://openalex.org/W2259642456","https://openalex.org/W2260794900","https://openalex.org/W2334528915","https://openalex.org/W2403560496","https://openalex.org/W4240144299","https://openalex.org/W6683552350","https://openalex.org/W6684540548"],"related_works":["https://openalex.org/W2340005245","https://openalex.org/W1547508840","https://openalex.org/W2052773812","https://openalex.org/W2428872210","https://openalex.org/W2181360123","https://openalex.org/W2322261446","https://openalex.org/W2017681254","https://openalex.org/W2423632980","https://openalex.org/W2391009298","https://openalex.org/W1558657480"],"abstract_inverted_index":{"Voluntary":[0],"control":[1,167,287],"of":[2,10,48,80,110,133,164,177,188,213,229,264,269,280],"force":[3,50,64,85,147,286],"is":[4,30],"always":[5],"marked":[6],"by":[7],"some":[8],"degree":[9],"error":[11],"and":[12,16,38,69,89,101,131,199,221,282,290],"unsteadiness.":[13],"Both":[14],"neural":[15,281],"mechanical":[17,244,283],"factors":[18],"contribute":[19],"to":[20,27,53,61,73,125,173,180,218,251,285],"these":[21],"fluctuations,":[22],"but":[23],"how":[24],"they":[25],"interact":[26],"produce":[28,62,174],"them":[29],"poorly":[31],"understood.":[32],"In":[33,137],"this":[34,201],"study,":[35],"we":[36],"identify":[37],"characterize":[39],"a":[40,75,108,152,158,165,214,255],"previously":[41],"undescribed":[42],"neuromechanical":[43,259],"interaction":[44],"where":[45],"the":[46,66,93,117,129,134,170,186,206,211,262],"dynamics":[47],"voluntary":[49,84],"production":[51],"suffice":[52],"generate":[54],"involuntary":[55],"tremor.":[56,202],"Specifically,":[57],"participants":[58],"were":[59,99],"asked":[60],"isometric":[63],"with":[65,146,273],"index":[67],"finger":[68],"use":[70],"visual":[71],"feedback":[72,190],"track":[74],"sinusoidal":[76],"target":[77,111,135],"spanning":[78],"5-9%":[79],"each":[81],"individual's":[82],"maximal":[83],"level.":[86],"Force":[87,113],"fluctuations":[88],"EMG":[90,142],"activity":[91,143],"over":[92],"flexor":[94],"digitorum":[95],"superficialis":[96],"(FDS)":[97],"muscle":[98,192],"recorded":[100],"their":[102],"frequency":[103,122],"content":[104],"was":[105,144,161,194],"analyzed":[106],"as":[107,233],"function":[109],"phase.":[112],"variability":[114],"in":[115,156,183,288],"either":[116],"1-5":[118],"or":[119,243],"6-15":[120],"Hz":[121],"ranges":[123],"tended":[124],"be":[126],"largest":[127],"at":[128],"peaks":[130],"valleys":[132],"sinusoid.":[136],"those":[138],"same":[139],"periods,":[140],"FDS":[141],"synchronized":[145],"fluctuations.":[148],"We":[149,203],"then":[150],"constructed":[151],"physiologically-realistic":[153],"computer":[154],"simulation":[155],"which":[157],"muscle-tendon":[159,216],"complex":[160],"set":[162],"inside":[163],"feedback-driven":[166],"loop.":[168],"Surprisingly,":[169],"model":[171],"sufficed":[172],"phase-dependent":[175],"modulation":[176],"tremor":[178,208,230,253],"similar":[179],"that":[181,205,257],"observed":[182],"humans.":[184],"Further,":[185],"gain":[187],"afferent":[189],"from":[191,254],"spindles":[193],"critical":[195],"for":[196],"appropriately":[197],"amplifying":[198],"shaping":[200],"suggest":[204],"experimentally-induced":[207],"may":[209],"represent":[210],"response":[212],"viscoelastic":[215],"system":[217],"dynamic":[219],"drive,":[220,236],"therefore":[222],"does":[223],"not":[224],"fall":[225],"into":[226],"known":[227],"categories":[228],"generation,":[231],"such":[232],"tremorogenic":[234],"descending":[235],"stretch-reflex":[237],"loop":[238],"oscillations,":[239],"motor":[240],"unit":[241],"behavior,":[242],"resonance.":[245],"Our":[246],"findings":[247],"motivate":[248],"future":[249],"efforts":[250],"understand":[252],"perspective":[256],"considers":[258],"coupling":[260],"within":[261],"context":[263],"closed-loop":[265],"control.":[266],"The":[267],"strategy":[268],"combining":[270],"experimental":[271],"recordings":[272],"physiologically-sound":[274],"simulations":[275],"will":[276],"enable":[277],"thorough":[278],"exploration":[279],"contributions":[284],"health":[289],"disease.":[291]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}