{"id":"https://openalex.org/W4416758530","doi":"https://doi.org/10.3389/fdgth.2025.1708067","title":"UpSMART: five years of digital innovation in cancer clinical research\u2014achievements, challenges, and recommendations","display_name":"UpSMART: five years of digital innovation in cancer clinical research\u2014achievements, challenges, and recommendations","publication_year":2025,"publication_date":"2025-11-27","ids":{"openalex":"https://openalex.org/W4416758530","doi":"https://doi.org/10.3389/fdgth.2025.1708067","pmid":"https://pubmed.ncbi.nlm.nih.gov/41395630"},"language":"en","primary_location":{"id":"doi:10.3389/fdgth.2025.1708067","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdgth.2025.1708067","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2025.1708067/pdf","source":{"id":"https://openalex.org/S4210170686","display_name":"Frontiers in Digital Health","issn_l":"2673-253X","issn":["2673-253X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Digital Health","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2025.1708067/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015115681","display_name":"Paul O\u2019Regan","orcid":"https://orcid.org/0000-0002-0231-5028"},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paul O\u2019Regan","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022954270","display_name":"Fouziah Butt","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fouziah Butt","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033090749","display_name":"Louise Carter","orcid":"https://orcid.org/0000-0002-9854-2304"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise Carter","raw_affiliation_strings":["Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom","The Christie NHS Foundation Trust, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"The Christie NHS Foundation Trust, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022848214","display_name":"Donna M. Graham","orcid":"https://orcid.org/0000-0001-6500-8140"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Donna M. Graham","raw_affiliation_strings":["Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom","The Christie NHS Foundation Trust, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"The Christie NHS Foundation Trust, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049413258","display_name":"Anja Le Blanc","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anja Le Blanc","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","Research IT, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]},{"raw_affiliation_string":"Research IT, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052251827","display_name":"Richard Hoskins","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Hoskins","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","Research IT, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]},{"raw_affiliation_string":"Research IT, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055901329","display_name":"Laura Stephenson","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura Stephenson","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084599253","display_name":"Akshita Patil","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Akshita Patil","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046792481","display_name":"Malik Shahzad Shabbir","orcid":"https://orcid.org/0000-0003-1393-2897"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Muhammad Shabbir","raw_affiliation_strings":["Research IT, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research IT, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120523411","display_name":"Dilan Eken","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dilan Eken","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029480443","display_name":"Subir Singh","orcid":"https://orcid.org/0000-0002-1355-3750"},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Subir Singh","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","The Christie NHS Foundation Trust, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]},{"raw_affiliation_string":"The Christie NHS Foundation Trust, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103229972","display_name":"Andrea Villa","orcid":"https://orcid.org/0009-0002-6319-0684"},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Villa","raw_affiliation_strings":["Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014295233","display_name":"Luca Agnelli","orcid":"https://orcid.org/0000-0003-0582-6170"},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Agnelli","raw_affiliation_strings":["Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067671428","display_name":"Silvia Damian","orcid":"https://orcid.org/0000-0001-9560-1092"},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Damian","raw_affiliation_strings":["Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001721232","display_name":"Christopher Grave","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher Grave","raw_affiliation_strings":["Research IT, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research IT, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001575096","display_name":"G. Pretelli","orcid":"https://orcid.org/0000-0002-5550-1211"},"institutions":[{"id":"https://openalex.org/I122544976","display_name":"Hebron University","ror":"https://ror.org/04wwgp209","country_code":"PS","type":"education","lineage":["https://openalex.org/I122544976"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127641"]},{"id":"https://openalex.org/I4210151726","display_name":"CIBBIM-Nanomedicine","ror":"https://ror.org/04xezgr31","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4210127641","https://openalex.org/I4210151726","https://openalex.org/I4387153040"]}],"countries":["ES","PS"],"is_corresponding":false,"raw_author_name":"Giulia Pretelli","raw_affiliation_strings":["Department of Medical Oncology, Vall D'Hebron University Hospital (HUVH), Barcelona, Spain","Early Drug Development, Vall D'Hebron Institute of Oncology (VHIO), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Vall D'Hebron University Hospital (HUVH), Barcelona, Spain","institution_ids":["https://openalex.org/I122544976","https://openalex.org/I4210127641"]},{"raw_affiliation_string":"Early Drug Development, Vall D'Hebron Institute of Oncology (VHIO), Barcelona, Spain","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I4210151726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110059556","display_name":"Elena Garralda","orcid":null},"institutions":[{"id":"https://openalex.org/I122544976","display_name":"Hebron University","ror":"https://ror.org/04wwgp209","country_code":"PS","type":"education","lineage":["https://openalex.org/I122544976"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127641"]},{"id":"https://openalex.org/I4210151726","display_name":"CIBBIM-Nanomedicine","ror":"https://ror.org/04xezgr31","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4210127641","https://openalex.org/I4210151726","https://openalex.org/I4387153040"]}],"countries":["ES","PS"],"is_corresponding":false,"raw_author_name":"Elena Garralda","raw_affiliation_strings":["Department of Medical Oncology, Vall D'Hebron University Hospital (HUVH), Barcelona, Spain","Early Drug Development, Vall D'Hebron Institute of Oncology (VHIO), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Vall D'Hebron University Hospital (HUVH), Barcelona, Spain","institution_ids":["https://openalex.org/I122544976","https://openalex.org/I4210127641"]},{"raw_affiliation_string":"Early Drug Development, Vall D'Hebron Institute of Oncology (VHIO), Barcelona, Spain","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I4210151726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019524414","display_name":"Hannah Frost","orcid":"https://orcid.org/0000-0002-4398-0382"},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hannah Frost","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009935310","display_name":"Filippo de Braud","orcid":"https://orcid.org/0000-0003-0103-730X"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo de Braud","raw_affiliation_strings":["Department of Hemato-Oncology, University of Milan, Milan, Italy","Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemato-Oncology, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andre Freitas","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I7495430","display_name":"Idiap Research Institute","ror":"https://ror.org/05932h694","country_code":"CH","type":"facility","lineage":["https://openalex.org/I7495430"]}],"countries":["CH","GB"],"is_corresponding":false,"raw_author_name":"Andre Freitas","raw_affiliation_strings":["Department of Computer Science, The University of Manchester, Manchester, United Kingdom","IDIAP Research Institute, Martigny, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"IDIAP Research Institute, Martigny, Switzerland","institution_ids":["https://openalex.org/I7495430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039337111","display_name":"Caroline Dive","orcid":"https://orcid.org/0000-0002-1726-8850"},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210157630","display_name":"National Computing Centre (United Kingdom)","ror":"https://ror.org/05gptew44","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210157630"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Caroline Dive","raw_affiliation_strings":["Cancer Research UK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210157630","https://openalex.org/I4210129527"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015029955","display_name":"Harriet Unsworth","orcid":"https://orcid.org/0000-0002-1427-6783"},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harriet Unsworth","raw_affiliation_strings":["Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Cancer Research Team, CRUK National Biomarker Centre, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210129527"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":22,"corresponding_author_ids":["https://openalex.org/A5015115681"],"corresponding_institution_ids":["https://openalex.org/I4210129527"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51615551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":"1708067","last_page":"1708067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11446","display_name":"Mobile Health and mHealth Applications","score":0.06859999895095825,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11446","display_name":"Mobile Health and mHealth Applications","score":0.06859999895095825,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12027","display_name":"Social Media in Health Education","score":0.06679999828338623,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.065700002014637,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidisciplinary-approach","display_name":"Multidisciplinary approach","score":0.7565000057220459},{"id":"https://openalex.org/keywords/digital-health","display_name":"Digital health","score":0.5422999858856201},{"id":"https://openalex.org/keywords/data-collection","display_name":"Data collection","score":0.44780001044273376},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.41620001196861267},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.38339999318122864},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.37119999527931213},{"id":"https://openalex.org/keywords/medline","display_name":"MEDLINE","score":0.2904999852180481}],"concepts":[{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.7565000057220459},{"id":"https://openalex.org/C2780433410","wikidata":"https://www.wikidata.org/wiki/Q5276090","display_name":"Digital health","level":3,"score":0.5422999858856201},{"id":"https://openalex.org/C133462117","wikidata":"https://www.wikidata.org/wiki/Q4929239","display_name":"Data collection","level":2,"score":0.44780001044273376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4262000024318695},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.41620001196861267},{"id":"https://openalex.org/C39549134","wikidata":"https://www.wikidata.org/wiki/Q133080","display_name":"Public relations","level":1,"score":0.39899998903274536},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38339999318122864},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.37119999527931213},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.366100013256073},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.36090001463890076},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.3312999904155731},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.314300000667572},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C202645933","wikidata":"https://www.wikidata.org/wiki/Q4930","display_name":"eHealth","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.27730000019073486},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.2728999853134155},{"id":"https://openalex.org/C2989236134","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Patient care","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C2779318504","wikidata":"https://www.wikidata.org/wiki/Q1438035","display_name":"Research design","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C66204764","wikidata":"https://www.wikidata.org/wiki/Q219416","display_name":"Sustainability","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C2779891985","wikidata":"https://www.wikidata.org/wiki/Q46994","display_name":"Telemedicine","level":3,"score":0.2574000060558319},{"id":"https://openalex.org/C2780877353","wikidata":"https://www.wikidata.org/wiki/Q2518253","display_name":"Health services research","level":3,"score":0.2549000084400177}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fdgth.2025.1708067","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdgth.2025.1708067","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2025.1708067/pdf","source":{"id":"https://openalex.org/S4210170686","display_name":"Frontiers in Digital Health","issn_l":"2673-253X","issn":["2673-253X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Digital Health","raw_type":"journal-article"},{"id":"pmid:41395630","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41395630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in digital health","raw_type":null},{"id":"pmh:oai:doaj.org/article:35d3318767e84c4ea4723c31e73e231c","is_oa":true,"landing_page_url":"https://doaj.org/article/35d3318767e84c4ea4723c31e73e231c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Digital Health, Vol 7 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12697062","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12697062/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Digit Health","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fdgth.2025.1708067","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdgth.2025.1708067","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2025.1708067/pdf","source":{"id":"https://openalex.org/S4210170686","display_name":"Frontiers in Digital Health","issn_l":"2673-253X","issn":["2673-253X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Digital Health","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6976145177","display_name":null,"funder_award_id":"100001","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320333687","display_name":"Manchester Biomedical Research Centre","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4416758530.pdf"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2112747875","https://openalex.org/W2370981871","https://openalex.org/W2904154481","https://openalex.org/W2938864889","https://openalex.org/W2982580298","https://openalex.org/W3046739387","https://openalex.org/W3105429526","https://openalex.org/W4210401110","https://openalex.org/W4225303670","https://openalex.org/W4281401029","https://openalex.org/W4283734208","https://openalex.org/W4317472763","https://openalex.org/W4377046748","https://openalex.org/W4386491559","https://openalex.org/W4386833262","https://openalex.org/W4387328031","https://openalex.org/W4395691451","https://openalex.org/W4399150199","https://openalex.org/W4403095177","https://openalex.org/W4404061126","https://openalex.org/W4405537915","https://openalex.org/W4408197148","https://openalex.org/W4410188253"],"related_works":[],"abstract_inverted_index":{"UpSMART,":[0,35],"a":[1],"research":[2,17,65],"programme":[3],"involving":[4],"24":[5],"European":[6],"cancer":[7],"centres,":[8],"aimed":[9],"to":[10,67],"promote":[11],"digital":[12,28],"innovation":[13],"in":[14,20],"early-phase":[15],"clinical":[16],"addressing":[18],"challenges":[19],"recruitment,":[21],"data":[22],"collection":[23],"and":[24,38,43,59,61],"analysis.":[25],"Several":[26],"open-source":[27],"healthcare":[29],"products":[30],"(DHPs)":[31],"were":[32],"developed":[33],"through":[34],"including":[36],"eTARGET":[37],"trialFinder":[39],"for":[40,46],"trial":[41],"matching,":[42],"PROACT":[44],"2.0":[45],"patient-reported":[47],"data.":[48],"Lessons":[49],"learned":[50],"highlight":[51],"the":[52,64],"importance":[53],"of":[54],"multidisciplinary":[55],"teams,":[56],"sustainable":[57],"funding":[58],"deployment,":[60],"engagement":[62],"with":[63],"community":[66],"maximise":[68],"impact.":[69]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-11-28T00:00:00"}