{"id":"https://openalex.org/W4391261228","doi":"https://doi.org/10.3389/fdgth.2024.1336050","title":"A framework towards digital twins for type 2 diabetes","display_name":"A framework towards digital twins for type 2 diabetes","publication_year":2024,"publication_date":"2024-01-26","ids":{"openalex":"https://openalex.org/W4391261228","doi":"https://doi.org/10.3389/fdgth.2024.1336050","pmid":"https://pubmed.ncbi.nlm.nih.gov/38343907"},"language":"en","primary_location":{"id":"doi:10.3389/fdgth.2024.1336050","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdgth.2024.1336050","pdf_url":"https://www.frontiersin.org/articles/10.3389/fdgth.2024.1336050/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210170686","display_name":"Frontiers in Digital Health","issn_l":"2673-253X","issn":["2673-253X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Digital Health","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fdgth.2024.1336050/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069771612","display_name":"Y Zhang","orcid":"https://orcid.org/0000-0001-6533-5563"},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Zhang","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, United States","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039544050","display_name":"Guangrong Qin","orcid":"https://orcid.org/0000-0001-8836-1246"},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangrong Qin","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, United States","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091465954","display_name":"Boris Aguilar","orcid":"https://orcid.org/0000-0002-9840-5908"},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris Aguilar","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, United States","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058043043","display_name":"Noa Rappaport","orcid":"https://orcid.org/0000-0001-8643-2055"},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noa Rappaport","raw_affiliation_strings":["Center for Phenomic Health, Buck Institute for Research on Aging, Novato, CA, United States","Institute for Systems Biology, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Phenomic Health, Buck Institute for Research on Aging, Novato, CA, United States","institution_ids":["https://openalex.org/I1337826666"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, United States","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082126398","display_name":"James T. Yurkovich","orcid":"https://orcid.org/0000-0002-9403-509X"},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]},{"id":"https://openalex.org/I4210165057","display_name":"ProNAi Therapeutics (United States)","ror":"https://ror.org/05rzyfd75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165057"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. Yurkovich","raw_affiliation_strings":["Center for Phenomic Health, Buck Institute for Research on Aging, Novato, CA, United States","Phenome Health, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Phenomic Health, Buck Institute for Research on Aging, Novato, CA, United States","institution_ids":["https://openalex.org/I1337826666"]},{"raw_affiliation_string":"Phenome Health, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210165057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060853762","display_name":"Lance Pflieger","orcid":"https://orcid.org/0000-0003-2237-5674"},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]},{"id":"https://openalex.org/I4210165057","display_name":"ProNAi Therapeutics (United States)","ror":"https://ror.org/05rzyfd75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165057"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance Pflieger","raw_affiliation_strings":["Center for Phenomic Health, Buck Institute for Research on Aging, Novato, CA, United States","Phenome Health, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Phenomic Health, Buck Institute for Research on Aging, Novato, CA, United States","institution_ids":["https://openalex.org/I1337826666"]},{"raw_affiliation_string":"Phenome Health, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210165057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019206785","display_name":"Sui Huang","orcid":"https://orcid.org/0000-0002-3545-4665"},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sui Huang","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, United States","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085306431","display_name":"Leroy Hood","orcid":"https://orcid.org/0000-0001-7158-3678"},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I4210165057","display_name":"ProNAi Therapeutics (United States)","ror":"https://ror.org/05rzyfd75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165057"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leroy Hood","raw_affiliation_strings":["Center for Phenomic Health, Buck Institute for Research on Aging, Novato, CA, United States","Institute for Systems Biology, Seattle, WA, United States","Phenome Health, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Phenomic Health, Buck Institute for Research on Aging, Novato, CA, United States","institution_ids":["https://openalex.org/I1337826666"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, United States","institution_ids":["https://openalex.org/I3148997608"]},{"raw_affiliation_string":"Phenome Health, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210165057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061460061","display_name":"Ilya Shmulevich","orcid":"https://orcid.org/0000-0002-4410-8780"},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ilya Shmulevich","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, United States","institution_ids":["https://openalex.org/I3148997608"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061460061"],"corresponding_institution_ids":["https://openalex.org/I3148997608"],"apc_list":{"value":2125,"currency":"USD","value_usd":2125},"apc_paid":{"value":2125,"currency":"USD","value_usd":2125},"fwci":8.9914,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.98202271,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"6","issue":null,"first_page":"1336050","last_page":"1336050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.19689999520778656,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.19689999520778656,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10763","display_name":"Digital Transformation in Industry","score":0.07989999651908875,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7274566888809204},{"id":"https://openalex.org/keywords/grasp","display_name":"GRASP","score":0.7090535163879395},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5846894383430481},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.510796070098877},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.5019557476043701},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.49888062477111816},{"id":"https://openalex.org/keywords/human\u2013computer-interaction","display_name":"Human\u2013computer interaction","score":0.3468147814273834},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16210860013961792},{"id":"https://openalex.org/keywords/software-engineering","display_name":"Software engineering","score":0.09754455089569092}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7274566888809204},{"id":"https://openalex.org/C171268870","wikidata":"https://www.wikidata.org/wiki/Q1486676","display_name":"GRASP","level":2,"score":0.7090535163879395},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5846894383430481},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.510796070098877},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.5019557476043701},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49888062477111816},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.3468147814273834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16210860013961792},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.09754455089569092},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fdgth.2024.1336050","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdgth.2024.1336050","pdf_url":"https://www.frontiersin.org/articles/10.3389/fdgth.2024.1336050/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210170686","display_name":"Frontiers in Digital Health","issn_l":"2673-253X","issn":["2673-253X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Digital Health","raw_type":"journal-article"},{"id":"pmid:38343907","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38343907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in digital health","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10853398","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10853398","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10853398/pdf/fdgth-06-1336050.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Digit Health","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:42febbed3fe641b9be4078e0077dd232","is_oa":true,"landing_page_url":"https://doaj.org/article/42febbed3fe641b9be4078e0077dd232","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Digital Health, Vol 6 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fdgth.2024.1336050","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdgth.2024.1336050","pdf_url":"https://www.frontiersin.org/articles/10.3389/fdgth.2024.1336050/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210170686","display_name":"Frontiers in Digital Health","issn_l":"2673-253X","issn":["2673-253X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Digital Health","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7072544879","display_name":null,"funder_award_id":"R01 CA270210","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4391261228.pdf"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W44929223","https://openalex.org/W229097380","https://openalex.org/W1994751336","https://openalex.org/W2017771330","https://openalex.org/W2053870136","https://openalex.org/W2062533676","https://openalex.org/W2064186732","https://openalex.org/W2089259629","https://openalex.org/W2098000380","https://openalex.org/W2124168655","https://openalex.org/W2151053450","https://openalex.org/W2338627428","https://openalex.org/W2605973178","https://openalex.org/W2624021832","https://openalex.org/W2790272775","https://openalex.org/W2810503494","https://openalex.org/W2886504687","https://openalex.org/W2903357856","https://openalex.org/W2942628179","https://openalex.org/W2991821439","https://openalex.org/W2997591727","https://openalex.org/W3005059200","https://openalex.org/W3010152544","https://openalex.org/W3012041784","https://openalex.org/W3081655479","https://openalex.org/W3091428250","https://openalex.org/W3092065440","https://openalex.org/W3118305256","https://openalex.org/W3136213531","https://openalex.org/W3159064895","https://openalex.org/W3215822628","https://openalex.org/W4211058450","https://openalex.org/W4212942915","https://openalex.org/W4225304474","https://openalex.org/W4281481995","https://openalex.org/W4306176357","https://openalex.org/W4318250042","https://openalex.org/W4318983406","https://openalex.org/W4319813194","https://openalex.org/W4328048668","https://openalex.org/W4386303479","https://openalex.org/W4389674515","https://openalex.org/W6608852248"],"related_works":["https://openalex.org/W2163296013","https://openalex.org/W2743859443","https://openalex.org/W2326995835","https://openalex.org/W165915117","https://openalex.org/W2059402478","https://openalex.org/W2123347777","https://openalex.org/W4387804363","https://openalex.org/W2477150073","https://openalex.org/W2019547100","https://openalex.org/W2515493494"],"abstract_inverted_index":{"Introduction:":[0],"A":[1],"digital":[2,38,121],"twin":[3,39,122],"is":[4],"a":[5,9,37,60,120],"virtual":[6],"representation":[7],"of":[8,22,26,31,127,133],"patient's":[10],"disease,":[11],"facilitating":[12],"real-time":[13],"monitoring,":[14],"analysis,":[15],"and":[16,29,55,63,83,88,129],"simulation.":[17],"This":[18],"enables":[19],"the":[20,131],"prediction":[21],"disease":[23,74,97],"progression,":[24],"optimization":[25],"care":[27],"delivery,":[28],"improvement":[30],"outcomes.":[32],"Methods:":[33],"Here,":[34],"we":[35,66],"introduce":[36],"framework":[40],"for":[41],"type":[42],"2":[43],"diabetes":[44],"(T2D)":[45],"that":[46],"integrates":[47],"machine":[48,69],"learning":[49,70],"with":[50],"multiomic":[51,62],"data,":[52],"knowledge":[53,77],"graphs,":[54],"mechanistic":[56],"models.":[57],"By":[58],"analyzing":[59],"substantial":[61],"clinical":[64],"dataset,":[65],"constructed":[67],"predictive":[68],"models":[71],"to":[72,81],"forecast":[73],"progression.":[75],"Furthermore,":[76],"graphs":[78],"were":[79],"employed":[80],"elucidate":[82],"contextualize":[84],"multiomic-disease":[85],"relationships.":[86],"Results":[87],"discussion:":[89],"Our":[90],"findings":[91],"not":[92],"only":[93],"reaffirm":[94],"known":[95],"targetable":[96],"components":[98,111],"but":[99],"also":[100],"spotlight":[101],"novel":[102],"ones,":[103],"unveiled":[104],"through":[105],"this":[106,114],"integrated":[107],"approach.":[108],"The":[109],"versatile":[110],"presented":[112],"in":[113],"study":[115],"can":[116],"be":[117],"incorporated":[118],"into":[119],"system,":[123],"enhancing":[124],"our":[125],"grasp":[126],"diseases":[128],"propelling":[130],"advancement":[132],"precision":[134],"medicine.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":4}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
