{"id":"https://openalex.org/W4398138092","doi":"https://doi.org/10.3389/fdata.2024.1390467","title":"Big data and its impact on the 3Rs: a home cage monitoring oriented review","display_name":"Big data and its impact on the 3Rs: a home cage monitoring oriented review","publication_year":2024,"publication_date":"2024-05-20","ids":{"openalex":"https://openalex.org/W4398138092","doi":"https://doi.org/10.3389/fdata.2024.1390467","pmid":"https://pubmed.ncbi.nlm.nih.gov/38831953"},"language":"en","primary_location":{"id":"doi:10.3389/fdata.2024.1390467","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdata.2024.1390467","pdf_url":"https://www.frontiersin.org/articles/10.3389/fdata.2024.1390467/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210201220","display_name":"Frontiers in Big Data","issn_l":"2624-909X","issn":["2624-909X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Big Data","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fdata.2024.1390467/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061294740","display_name":"Sara Fuochi","orcid":"https://orcid.org/0000-0001-9491-6930"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Sara Fuochi","raw_affiliation_strings":["Experimental Animal Center, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Animal Center, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046078977","display_name":"Mara Rigamonti","orcid":"https://orcid.org/0000-0002-3913-4458"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mara Rigamonti","raw_affiliation_strings":["Tecniplast S.p.A, Varese, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tecniplast S.p.A, Varese, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033805566","display_name":"Eoin C. O\u2019Connor","orcid":"https://orcid.org/0000-0002-7810-1915"},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Eoin C. O'Connor","raw_affiliation_strings":["Neuroscience and Rare Diseases, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience and Rare Diseases, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047680210","display_name":"Paolo de Girolamo","orcid":"https://orcid.org/0000-0003-1557-4763"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo De Girolamo","raw_affiliation_strings":["Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069018340","display_name":"Livia D\u2019Angelo","orcid":"https://orcid.org/0000-0001-5050-642X"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Livia D'Angelo","raw_affiliation_strings":["Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061294740","https://openalex.org/A5069018340"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I71267560"],"apc_list":{"value":1285,"currency":"USD","value_usd":1285},"apc_paid":{"value":2393,"currency":"EUR","value_usd":2580},"fwci":1.1142,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73390239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"7","issue":null,"first_page":"1390467","last_page":"1390467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9434999823570251,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.942300021648407,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6028167009353638},{"id":"https://openalex.org/keywords/baseline","display_name":"Baseline (sea)","score":0.5858415365219116},{"id":"https://openalex.org/keywords/big-data","display_name":"Big data","score":0.5752009749412537},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.5037958025932312},{"id":"https://openalex.org/keywords/term","display_name":"Term (time)","score":0.47208282351493835},{"id":"https://openalex.org/keywords/location-data","display_name":"Location data","score":0.4248822033405304},{"id":"https://openalex.org/keywords/psychological-intervention","display_name":"Psychological intervention","score":0.4166383147239685},{"id":"https://openalex.org/keywords/cage","display_name":"Cage","score":0.4129282236099243},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.2932090163230896},{"id":"https://openalex.org/keywords/real-time-computing","display_name":"Real-time computing","score":0.2256225049495697},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1900162398815155},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1658238172531128}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6028167009353638},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.5858415365219116},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.5752009749412537},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5037958025932312},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.47208282351493835},{"id":"https://openalex.org/C2988186277","wikidata":"https://www.wikidata.org/wiki/Q5915793","display_name":"Location data","level":2,"score":0.4248822033405304},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.4166383147239685},{"id":"https://openalex.org/C160272327","wikidata":"https://www.wikidata.org/wiki/Q841007","display_name":"Cage","level":2,"score":0.4129282236099243},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2932090163230896},{"id":"https://openalex.org/C79403827","wikidata":"https://www.wikidata.org/wiki/Q3988","display_name":"Real-time computing","level":1,"score":0.2256225049495697},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1900162398815155},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1658238172531128},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fdata.2024.1390467","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdata.2024.1390467","pdf_url":"https://www.frontiersin.org/articles/10.3389/fdata.2024.1390467/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210201220","display_name":"Frontiers in Big Data","issn_l":"2624-909X","issn":["2624-909X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Big Data","raw_type":"journal-article"},{"id":"pmid:38831953","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38831953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in big data","raw_type":null},{"id":"pmh:oai:boris.unibe.ch:197552","is_oa":true,"landing_page_url":"https://boris.unibe.ch/197552/","pdf_url":"https://boris.unibe.ch/197552/","source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fuochi, Sara; Rigamonti, Mara; O'Connor, Eoin C; De Girolamo, Paolo; D'Angelo, Livia (2024). Big data and its impact on the 3Rs: a home cage monitoring oriented review. Frontiers in big data, 7(1390467), p. 1390467. Frontiers 10.3389/fdata.2024.1390467 <http://dx.doi.org/10.3389/fdata.2024.1390467>","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11144903","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11144903","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11144903/pdf/fdata-07-1390467.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Big Data","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a5c23adf63aa441298d9034393b9caee","is_oa":false,"landing_page_url":"https://doaj.org/article/a5c23adf63aa441298d9034393b9caee","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Big Data, Vol 7 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fdata.2024.1390467","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdata.2024.1390467","pdf_url":"https://www.frontiersin.org/articles/10.3389/fdata.2024.1390467/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210201220","display_name":"Frontiers in Big Data","issn_l":"2624-909X","issn":["2624-909X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Big Data","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310992","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4398138092.pdf"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W223176005","https://openalex.org/W1655460658","https://openalex.org/W2175070379","https://openalex.org/W2277932823","https://openalex.org/W2323492951","https://openalex.org/W2339403798","https://openalex.org/W2626454026","https://openalex.org/W2750126764","https://openalex.org/W2914848079","https://openalex.org/W2926611844","https://openalex.org/W2950480439","https://openalex.org/W3014640853","https://openalex.org/W3082897316","https://openalex.org/W3095703932","https://openalex.org/W3097294022","https://openalex.org/W3118523093","https://openalex.org/W3156137178","https://openalex.org/W3174838700","https://openalex.org/W3209933378","https://openalex.org/W4207033818","https://openalex.org/W4212903839","https://openalex.org/W4281567696","https://openalex.org/W4283829342","https://openalex.org/W4290720059","https://openalex.org/W4322773380","https://openalex.org/W4378174156","https://openalex.org/W4383264819","https://openalex.org/W4384111647","https://openalex.org/W4390538933","https://openalex.org/W4392381774","https://openalex.org/W6608823504","https://openalex.org/W6854725931","https://openalex.org/W6945265090"],"related_works":["https://openalex.org/W2118997044","https://openalex.org/W4211098594","https://openalex.org/W2017210895","https://openalex.org/W2383111961","https://openalex.org/W2365952365","https://openalex.org/W2095616489","https://openalex.org/W4390608645","https://openalex.org/W2352448290","https://openalex.org/W2120024554","https://openalex.org/W2380820513"],"abstract_inverted_index":{"Undisturbed":[0],"home":[1,102],"cage":[2,103],"recording":[3],"of":[4,51,65,78,97,118,128],"mouse":[5],"activity":[6],"and":[7,30,42,60,85,125],"behavior":[8],"has":[9],"received":[10],"increasing":[11],"attention":[12],"in":[13,23,44,63,130],"recent":[14],"years.":[15],"In":[16,89],"parallel,":[17],"several":[18],"technologies":[19],"have":[20],"been":[21],"developed":[22],"a":[24,49,75],"bid":[25],"to":[26,33],"automate":[27],"data":[28,80,106],"collection":[29],"interpretation.":[31],"Thanks":[32],"these":[34],"expanding":[35],"technologies,":[36],"massive":[37],"datasets":[38,70],"can":[39,71,82,114],"be":[40,83],"recorded":[41],"saved":[43],"the":[45,95,116,119],"long":[46],"term,":[47],"providing":[48],"wealth":[50],"information":[52],"concerning":[53],"animal":[54],"wellbeing,":[55],"clinical":[56],"status,":[57],"baseline":[58],"activity,":[59],"subsequent":[61],"deviations":[62],"case":[64],"experimental":[66],"interventions.":[67],"Such":[68],"large":[69],"also":[72],"serve":[73],"as":[74],"long-term":[76],"reservoir":[77],"scientific":[79],"that":[81],"reanalyzed":[84],"repurposed":[86],"upon":[87],"need.":[88],"this":[90],"review,":[91],"we":[92],"present":[93],"how":[94],"impact":[96],"Big":[98],"Data":[99],"deriving":[100],"from":[101],"monitoring":[104],"(HCM)":[105],"acquisition,":[107],"particularly":[108],"through":[109],"Digital":[110],"Ventilated":[111],"Cages":[112],"(DVCs),":[113],"support":[115],"application":[117],"3Rs":[120],"by":[121],"enhancing":[122],"Refinement,":[123],"Reduction,":[124],"even":[126],"Replacement":[127],"research":[129],"animals.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}