{"id":"https://openalex.org/W3166615618","doi":"https://doi.org/10.3389/fdata.2021.672460","title":"Comprehensive Data Integration Approach to Assess Immune Responses and Correlates of RTS,S/AS01-Mediated Protection From Malaria Infection in Controlled Human Malaria Infection Trials","display_name":"Comprehensive Data Integration Approach to Assess Immune Responses and Correlates of RTS,S/AS01-Mediated Protection From Malaria Infection in Controlled Human Malaria Infection Trials","publication_year":2021,"publication_date":"2021-06-15","ids":{"openalex":"https://openalex.org/W3166615618","doi":"https://doi.org/10.3389/fdata.2021.672460","mag":"3166615618","pmid":"https://pubmed.ncbi.nlm.nih.gov/34212134"},"language":"en","primary_location":{"id":"doi:10.3389/fdata.2021.672460","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdata.2021.672460","pdf_url":null,"source":{"id":"https://openalex.org/S4210201220","display_name":"Frontiers in Big Data","issn_l":"2624-909X","issn":["2624-909X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Big Data","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fdata.2021.672460","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035661716","display_name":"William C. Young","orcid":"https://orcid.org/0000-0002-3368-052X"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Chad Young","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085762412","display_name":"Lindsay N. Carpp","orcid":"https://orcid.org/0000-0003-0333-5925"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay N. Carpp","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089946703","display_name":"Sidhartha Chaudhury","orcid":"https://orcid.org/0000-0001-9513-6688"},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sidhartha Chaudhury","raw_affiliation_strings":["Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050338720","display_name":"Jason A. Regules","orcid":"https://orcid.org/0000-0001-9928-221X"},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason A. Regules","raw_affiliation_strings":["Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090960821","display_name":"Elke S. Bergmann\u2010Leitner","orcid":"https://orcid.org/0000-0002-8571-8956"},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elke S. Bergmann-Leitner","raw_affiliation_strings":["Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059907819","display_name":"Christian F. Ockenhouse","orcid":null},"institutions":[{"id":"https://openalex.org/I4210107484","display_name":"U.S. President's Malaria Initiative","ror":"https://ror.org/012rb2c33","country_code":"US","type":"other","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I2801582665","https://openalex.org/I4210107484"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Ockenhouse","raw_affiliation_strings":["PATH Malaria Vaccine Initiative, Washington, DC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PATH Malaria Vaccine Initiative, Washington, DC, United States","institution_ids":["https://openalex.org/I4210107484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066583780","display_name":"Ulrike Wille-Reece","orcid":null},"institutions":[{"id":"https://openalex.org/I4210107484","display_name":"U.S. President's Malaria Initiative","ror":"https://ror.org/012rb2c33","country_code":"US","type":"other","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I2801582665","https://openalex.org/I4210107484"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulrike Wille-Reece","raw_affiliation_strings":["PATH Malaria Vaccine Initiative, Washington, DC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PATH Malaria Vaccine Initiative, Washington, DC, United States","institution_ids":["https://openalex.org/I4210107484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031000479","display_name":"Allan C. deCamp","orcid":"https://orcid.org/0000-0003-1404-4322"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan C. deCamp","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062131922","display_name":"Ellis Hughes","orcid":"https://orcid.org/0000-0003-0637-4436"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellis Hughes","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083432152","display_name":"Celia R. Mahoney","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celia Mahoney","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024777848","display_name":"Suresh Pallikkuth","orcid":"https://orcid.org/0000-0003-4451-8859"},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh Pallikkuth","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002278563","display_name":"Savita Pahwa","orcid":"https://orcid.org/0000-0002-4470-4216"},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Savita Pahwa","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967835","display_name":"S. Moses Dennison","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Moses Dennison","raw_affiliation_strings":["Center for Human Systems Immunology, Duke University, Durham, NC, United States","Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","Duke Human Vaccine Institute, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Systems Immunology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010048942","display_name":"Sarah V. Mudrak","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah V. Mudrak","raw_affiliation_strings":["Center for Human Systems Immunology, Duke University, Durham, NC, United States","Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","Duke Human Vaccine Institute, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Systems Immunology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027270152","display_name":"S. Munir Alam","orcid":"https://orcid.org/0000-0003-0941-0703"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Munir Alam","raw_affiliation_strings":["Center for Human Systems Immunology, Duke University, Durham, NC, United States","Department of Pathology, Duke University, Durham, NC, United States","Duke Human Vaccine Institute, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Systems Immunology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Pathology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002215161","display_name":"Kelly E. Seaton","orcid":"https://orcid.org/0000-0002-2009-3270"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly E. Seaton","raw_affiliation_strings":["Center for Human Systems Immunology, Duke University, Durham, NC, United States","Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","Duke Human Vaccine Institute, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Systems Immunology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040104802","display_name":"Rachel L. Spreng","orcid":"https://orcid.org/0000-0003-1254-0760"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel L. Spreng","raw_affiliation_strings":["Center for Human Systems Immunology, Duke University, Durham, NC, United States","Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","Duke Human Vaccine Institute, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Systems Immunology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113918737","display_name":"Jon Fallon","orcid":null},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Fallon","raw_affiliation_strings":["Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States","institution_ids":["https://openalex.org/I2802422659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043801034","display_name":"Ashlin R. Michell","orcid":"https://orcid.org/0000-0002-7563-4345"},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashlin Michell","raw_affiliation_strings":["Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States","institution_ids":["https://openalex.org/I2802422659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027764835","display_name":"Fernando Ulloa\u2010Montoya","orcid":null},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fernando Ulloa-Montoya","raw_affiliation_strings":["GSK, Rixensart, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Rixensart, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017382489","display_name":"Margherita Coccia","orcid":"https://orcid.org/0000-0003-1947-4735"},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Margherita Coccia","raw_affiliation_strings":["GSK, Rixensart, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Rixensart, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011882174","display_name":"Erik Jongert","orcid":null},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erik Jongert","raw_affiliation_strings":["GSK, Rixensart, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Rixensart, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059371880","display_name":"Galit Alter","orcid":"https://orcid.org/0000-0002-7680-9215"},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galit Alter","raw_affiliation_strings":["Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States","institution_ids":["https://openalex.org/I2802422659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034536696","display_name":"Georgia D. Tomaras","orcid":"https://orcid.org/0000-0001-8076-1931"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgia D. Tomaras","raw_affiliation_strings":["Center for Human Systems Immunology, Duke University, Durham, NC, United States","Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","Duke Human Vaccine Institute, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Systems Immunology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Departments of Surgery, Immunology, and Molecular Genetics and Microbiology, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005741024","display_name":"Rapha\u00ebl Gottardo","orcid":"https://orcid.org/0000-0002-3867-0232"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raphael Gottardo","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":25,"corresponding_author_ids":["https://openalex.org/A5005741024"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":1150,"currency":"USD","value_usd":1150},"apc_paid":{"value":1150,"currency":"USD","value_usd":1150},"fwci":1.0586,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75889579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"4","issue":null,"first_page":"672460","last_page":"672460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria-vaccine","display_name":"Malaria vaccine","score":0.7774287462234497},{"id":"https://openalex.org/keywords/malaria","display_name":"Malaria","score":0.7733016014099121},{"id":"https://openalex.org/keywords/parasitemia","display_name":"Parasitemia","score":0.6153391003608704},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5665125250816345},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5530484914779663},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5225617289543152},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"Vaccine efficacy","score":0.5020384788513184},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"Immunogenicity","score":0.500084638595581},{"id":"https://openalex.org/keywords/vaccination","display_name":"Vaccination","score":0.4734708368778229},{"id":"https://openalex.org/keywords/vaccine-trial","display_name":"Vaccine trial","score":0.4256497621536255},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.4251921772956848},{"id":"https://openalex.org/keywords/regimen","display_name":"Regimen","score":0.41761448979377747},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.3727480173110962},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3636040687561035},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.27795273065567017}],"concepts":[{"id":"https://openalex.org/C2781034427","wikidata":"https://www.wikidata.org/wiki/Q6741353","display_name":"Malaria vaccine","level":4,"score":0.7774287462234497},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.7733016014099121},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.6153391003608704},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5665125250816345},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5530484914779663},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5225617289543152},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.5020384788513184},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.500084638595581},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4734708368778229},{"id":"https://openalex.org/C2778190748","wikidata":"https://www.wikidata.org/wiki/Q7907956","display_name":"Vaccine trial","level":3,"score":0.4256497621536255},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4251921772956848},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.41761448979377747},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.3727480173110962},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3636040687561035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27795273065567017}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fdata.2021.672460","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdata.2021.672460","pdf_url":null,"source":{"id":"https://openalex.org/S4210201220","display_name":"Frontiers in Big Data","issn_l":"2624-909X","issn":["2624-909X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Big Data","raw_type":"journal-article"},{"id":"pmid:34212134","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34212134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in big data","raw_type":null},{"id":"pmh:oai:doaj.org/article:3a278326c7e94b59825dbc56352b388d","is_oa":true,"landing_page_url":"https://doaj.org/article/3a278326c7e94b59825dbc56352b388d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Big Data, Vol 4 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8239149","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8239149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Big Data","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fdata.2021.672460","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdata.2021.672460","pdf_url":null,"source":{"id":"https://openalex.org/S4210201220","display_name":"Frontiers in Big Data","issn_l":"2624-909X","issn":["2624-909X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Big Data","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"awards":[{"id":"https://openalex.org/G1309067393","display_name":null,"funder_award_id":"U19AI057266","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2356833817","display_name":"Duke University - to support the production of proteins for the Collaboration for AIDS Vaccine Discovery (CAVD) central service facilities, CAVD grantees, and others...","funder_award_id":"OPP1066832","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G2387849103","display_name":null,"funder_award_id":"U19AI128914","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2597303791","display_name":null,"funder_award_id":"U19AI090023 U19AI057266","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2739226184","display_name":null,"funder_award_id":"OPP1151372","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G358553234","display_name":null,"funder_award_id":"OPP12109388","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G3926501084","display_name":null,"funder_award_id":"U19AI090023","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6659301337","display_name":null,"funder_award_id":"INV-008576/OPP1154739 OPP1151372 OPP12109388 OPP12109388 OPP1087783 OPP1066832","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G6807843741","display_name":null,"funder_award_id":"INV-008576/OPP1154739","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G7183410437","display_name":null,"funder_award_id":"U19AI090023","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G741654985","display_name":"IUCRC RAPID: Collaborative Research: Rapid Detection & Systems Modeling for Containment and  Casualty Mitigation in Ebola Outbreak","funder_award_id":"1516074","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7601075659","display_name":"Fred Hutchinson Cancer Center - to provide statistical support to generate novel analytic methods and tools, and clinical and pre-clinical trial design and analysis","funder_award_id":"INV-008576","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G7741159374","display_name":null,"funder_award_id":"OPP1087783","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G8209219023","display_name":null,"funder_award_id":"U19AI128914","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8405245891","display_name":null,"funder_award_id":"U19AI057266","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G972733634","display_name":"I/UCRC:  Center for Health Organization Transformation","funder_award_id":"1361532","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320313818","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W65828984","https://openalex.org/W278308212","https://openalex.org/W798958370","https://openalex.org/W1242484266","https://openalex.org/W1817614869","https://openalex.org/W1860505696","https://openalex.org/W1964162643","https://openalex.org/W1969218538","https://openalex.org/W2016679437","https://openalex.org/W2021408631","https://openalex.org/W2058400042","https://openalex.org/W2070197170","https://openalex.org/W2073300038","https://openalex.org/W2075901113","https://openalex.org/W2082572922","https://openalex.org/W2085769219","https://openalex.org/W2087804239","https://openalex.org/W2097360283","https://openalex.org/W2108476551","https://openalex.org/W2108868448","https://openalex.org/W2145860712","https://openalex.org/W2150932450","https://openalex.org/W2163861382","https://openalex.org/W2164153211","https://openalex.org/W2177094957","https://openalex.org/W2181213627","https://openalex.org/W2214074259","https://openalex.org/W2229789789","https://openalex.org/W2232693424","https://openalex.org/W2244674613","https://openalex.org/W2346100156","https://openalex.org/W2414241210","https://openalex.org/W2436449558","https://openalex.org/W2547858404","https://openalex.org/W2588086300","https://openalex.org/W2604445430","https://openalex.org/W2744836284","https://openalex.org/W2754894339","https://openalex.org/W2758186654","https://openalex.org/W2799521111","https://openalex.org/W2884623540","https://openalex.org/W2898154893","https://openalex.org/W2906693047","https://openalex.org/W2909149114","https://openalex.org/W2924721436","https://openalex.org/W2946248791","https://openalex.org/W2964828448","https://openalex.org/W2976620503","https://openalex.org/W3017483958","https://openalex.org/W3021855507","https://openalex.org/W3031654458","https://openalex.org/W3044993434","https://openalex.org/W3115162871","https://openalex.org/W3139121890","https://openalex.org/W4254848468","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W2145001694","https://openalex.org/W2037900651","https://openalex.org/W3142450751","https://openalex.org/W2966479367","https://openalex.org/W2571217953","https://openalex.org/W2066729340","https://openalex.org/W2133838934","https://openalex.org/W2102187250","https://openalex.org/W1998968974","https://openalex.org/W4307374353"],"abstract_inverted_index":{"RTS,S/AS01":[0,56,83,108,160,168,219,271],"(GSK)":[1],"is":[2],"the":[3,16,30,55,158,166,171,191,199],"world's":[4],"first":[5,17],"malaria":[6,50,150,290],"vaccine.":[7],"However,":[8],"despite":[9],"initial":[10],"efficacy":[11,22,65],"of":[12,20,29,54,102,116,186,196,214,232,245,302],"almost":[13],"70%":[14],"over":[15,24],"6":[18],"months":[19],"follow-up,":[21],"waned":[23],"time.":[25],"A":[26],"deeper":[27],"understanding":[28],"immune":[31,123,139],"features":[32],"that":[33,144,188,289],"contribute":[34],"to":[35,72,137,180,190,228],"RTS,S/AS01-mediated":[36],"protection":[37,148],"could":[38,145],"be":[39],"beneficial":[40],"for":[41,283],"further":[42],"vaccine":[43,57,64,87,291],"development.":[44],"In":[45,105,210],"two":[46],"recent":[47],"controlled":[48],"human":[49],"infection":[51],"(CHMI)":[52],"trials":[53,293],"in":[58,90,249,259,262,266],"malaria-na\u00efve":[59],"adults,":[60],"MAL068":[61,155],"and":[62,76,121,170,184,265,298],"MAL071,":[63],"against":[66,149,286],"patent":[67],"parasitemia":[68],"ranged":[69],"from":[70],"44%":[71],"87%":[73],"across":[74,164],"studies":[75],"arms":[77],"(each":[78],"study":[79],"included":[80],"a":[81,99,113,133,269,276],"standard":[82,159,167,218],"arm":[84,97,161,169],"with":[85,98,208],"three":[86],"doses":[88],"delivered":[89],"four-week-intervals,":[91],"as":[92,94,125,127,198,235,278,280],"well":[93,126,279],"an":[95],"alternative":[96,172],"modified":[100],"version":[101],"this":[103,242],"regimen).":[104],"each":[106],"trial,":[107],"immunogenicity":[109],"was":[110],"interrogated":[111],"using":[112],"broad":[114],"range":[115],"immunological":[117],"assays,":[118],"assessing":[119],"cellular":[120],"humoral":[122],"parameters":[124],"gene":[128],"expression.":[129],"Here,":[130],"we":[131],"used":[132],"predictive":[134,201],"modeling":[135],"framework":[136],"identify":[138],"biomarkers":[140],"measured":[141],"at":[142],"day-of-challenge":[143],"predict":[146],"sterile":[147],"infection.":[151],"Using":[152],"cross-validation":[153],"on":[154],"data":[156],"(either":[157],"alone,":[162],"or":[163],"both":[165,296],"arm),":[173,220],"top-performing":[174,221],"univariate":[175,222,253],"models":[176,223,251],"identified":[177,225],"variables":[178,205,226],"related":[179,227],"Fc":[181,229,299],"effector":[182,230,300],"functions":[183,231,301],"titer":[185,297],"antibodies":[187,234,285],"bind":[189],"central":[192],"repeat":[193],"region":[194],"(NANP6)":[195],"CSP":[197],"most":[200],"variables;":[202],"all":[203],"NANP6-related":[204],"consistently":[206],"associated":[207],"protection.":[209],"cross-study":[211],"prediction":[212,247],"analyses":[213],"MAL071":[215],"outcomes":[216],"(the":[217],"again":[224],"NANP6-targeting":[233],"highly":[236],"predictive.":[237],"We":[238],"found":[239],"little":[240],"benefit-with":[241],"dataset-in":[243],"terms":[244],"improved":[246],"accuracy":[248],"bivariate":[250],"vs.":[252],"models.":[254],"These":[255],"findings":[256,274],"await":[257],"validation":[258],"children":[260],"living":[261],"malaria-endemic":[263],"regions,":[264],"vaccinees":[267],"administered":[268],"fourth":[270],"dose.":[272],"Our":[273],"support":[275],"\"quality":[277],"quantity\"":[281],"hypothesis":[282],"RTS,S/AS01-elicited":[284],"NANP6,":[287],"implying":[288],"clinical":[292],"should":[294],"assess":[295],"anti-NANP6":[303],"antibodies.":[304]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
