{"id":"https://openalex.org/W7139137357","doi":"https://doi.org/10.3389/fbinf.2026.1779654","title":"Designing and immuno-informatics evaluation of a multi-epitope vaccine targeting lipoprotein A-4\u2032-phosphatase (LpxF) for Helicobacter pylori infection control","display_name":"Designing and immuno-informatics evaluation of a multi-epitope vaccine targeting lipoprotein A-4\u2032-phosphatase (LpxF) for Helicobacter pylori infection control","publication_year":2026,"publication_date":"2026-03-18","ids":{"openalex":"https://openalex.org/W7139137357","doi":"https://doi.org/10.3389/fbinf.2026.1779654","pmid":"https://pubmed.ncbi.nlm.nih.gov/41929239"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2026.1779654","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1779654","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1779654/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1779654/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046211003","display_name":"Pavan Gollapalli","orcid":"https://orcid.org/0000-0002-7252-1564"},"institutions":[{"id":"https://openalex.org/I1333540553","display_name":"Nitte University","ror":"https://ror.org/029nydt37","country_code":"IN","type":"education","lineage":["https://openalex.org/I1333540553"]},{"id":"https://openalex.org/I60324483","display_name":"K S Hegde Medical Academy","ror":"https://ror.org/02p74z057","country_code":"IN","type":"education","lineage":["https://openalex.org/I60324483"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Pavan Gollapalli","raw_affiliation_strings":["Nitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Centre for Bioinformatics","Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Department of Bioinformatics and Biostatistics, Paneer Campus"],"affiliations":[{"raw_affiliation_string":"Nitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Centre for Bioinformatics","institution_ids":["https://openalex.org/I60324483"]},{"raw_affiliation_string":"Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Department of Bioinformatics and Biostatistics, Paneer Campus","institution_ids":["https://openalex.org/I1333540553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5129887907","display_name":"Tamizh Selvan Gnanasekaran","orcid":null},"institutions":[{"id":"https://openalex.org/I60324483","display_name":"K S Hegde Medical Academy","ror":"https://ror.org/02p74z057","country_code":"IN","type":"education","lineage":["https://openalex.org/I60324483"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tamizh Selvan Gnanasekaran","raw_affiliation_strings":["Nitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Central Research Laboratory"],"affiliations":[{"raw_affiliation_string":"Nitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Central Research Laboratory","institution_ids":["https://openalex.org/I60324483"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046211003"],"corresponding_institution_ids":["https://openalex.org/I1333540553","https://openalex.org/I60324483"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63885879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":"1779654","last_page":"1779654"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.5516999959945679},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5468000173568726},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.5246999859809875},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5077000260353088},{"id":"https://openalex.org/keywords/reverse-vaccinology","display_name":"Reverse vaccinology","score":0.49300000071525574},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.39089998602867126},{"id":"https://openalex.org/keywords/adjuvant","display_name":"Adjuvant","score":0.3896999955177307},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.38179999589920044}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5516999959945679},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5468000173568726},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5246999859809875},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5077000260353088},{"id":"https://openalex.org/C2781152039","wikidata":"https://www.wikidata.org/wiki/Q7318278","display_name":"Reverse vaccinology","level":4,"score":0.49300000071525574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4627000093460083},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4625000059604645},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39089998602867126},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.3896999955177307},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.38179999589920044},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.36980000138282776},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.3662000000476837},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.357699990272522},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.33880001306533813},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3361000120639801},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.31529998779296875},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.30320000648498535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2973000109195709},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.275299996137619},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25839999318122864},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.2549999952316284}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2026.1779654","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1779654","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1779654/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41929239","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41929239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:7b2c2f30162c4e9a8a4df3f6ecadebd9","is_oa":true,"landing_page_url":"https://doaj.org/article/7b2c2f30162c4e9a8a4df3f6ecadebd9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 6 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13039028","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13039028/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2026.1779654","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1779654","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1779654/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7228550910949707,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7139137357.pdf","grobid_xml":"https://content.openalex.org/works/W7139137357.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1058646234","https://openalex.org/W1420654867","https://openalex.org/W1503364994","https://openalex.org/W1531182450","https://openalex.org/W1569628965","https://openalex.org/W1630068686","https://openalex.org/W1689761783","https://openalex.org/W1796772814","https://openalex.org/W1948562438","https://openalex.org/W1965255999","https://openalex.org/W1966641706","https://openalex.org/W1975061369","https://openalex.org/W1991542542","https://openalex.org/W1992192767","https://openalex.org/W1993792235","https://openalex.org/W1995744610","https://openalex.org/W2001330064","https://openalex.org/W2004361545","https://openalex.org/W2004465286","https://openalex.org/W2005604534","https://openalex.org/W2009650104","https://openalex.org/W2012625502","https://openalex.org/W2014274241","https://openalex.org/W2030675030","https://openalex.org/W2035014358","https://openalex.org/W2036478186","https://openalex.org/W2051101891","https://openalex.org/W2055043387","https://openalex.org/W2059062189","https://openalex.org/W2059385530","https://openalex.org/W2073927369","https://openalex.org/W2074512572","https://openalex.org/W2079505521","https://openalex.org/W2080876451","https://openalex.org/W2083157454","https://openalex.org/W2087996087","https://openalex.org/W2093845596","https://openalex.org/W2094754630","https://openalex.org/W2102023232","https://openalex.org/W2102818658","https://openalex.org/W2102993309","https://openalex.org/W2105422109","https://openalex.org/W2107247090","https://openalex.org/W2110298304","https://openalex.org/W2114335580","https://openalex.org/W2119497560","https://openalex.org/W2119614619","https://openalex.org/W2121277457","https://openalex.org/W2122779464","https://openalex.org/W2130655121","https://openalex.org/W2133579817","https://openalex.org/W2140953817","https://openalex.org/W2147210428","https://openalex.org/W2151932306","https://openalex.org/W2152065574","https://openalex.org/W2154273408","https://openalex.org/W2154792548","https://openalex.org/W2156345326","https://openalex.org/W2160397907","https://openalex.org/W2161257366","https://openalex.org/W2161441796","https://openalex.org/W2162726394","https://openalex.org/W2162792752","https://openalex.org/W2164237791","https://openalex.org/W2169069488","https://openalex.org/W2169716006","https://openalex.org/W2171249995","https://openalex.org/W2171295581","https://openalex.org/W2199203801","https://openalex.org/W2407247987","https://openalex.org/W2520439500","https://openalex.org/W2557496587","https://openalex.org/W2572080171","https://openalex.org/W2607377760","https://openalex.org/W2748460808","https://openalex.org/W2751128104","https://openalex.org/W2751476102","https://openalex.org/W2767891136","https://openalex.org/W2789781012","https://openalex.org/W2795628761","https://openalex.org/W2802312498","https://openalex.org/W2802402702","https://openalex.org/W2881320234","https://openalex.org/W2898389621","https://openalex.org/W2898402099","https://openalex.org/W2903418377","https://openalex.org/W2910775131","https://openalex.org/W2912167200","https://openalex.org/W2914280503","https://openalex.org/W2914602426","https://openalex.org/W2918075940","https://openalex.org/W2941112903","https://openalex.org/W2946512810","https://openalex.org/W2971215527","https://openalex.org/W2972594981","https://openalex.org/W2999364275","https://openalex.org/W2999790763","https://openalex.org/W3007974386","https://openalex.org/W3044165763","https://openalex.org/W3091932546","https://openalex.org/W3101256226","https://openalex.org/W3119780302","https://openalex.org/W3124429364","https://openalex.org/W3163160118","https://openalex.org/W3196959202","https://openalex.org/W4234317413","https://openalex.org/W4235859326","https://openalex.org/W4244736178","https://openalex.org/W4307862924","https://openalex.org/W4386976919","https://openalex.org/W4392167319","https://openalex.org/W4399525404","https://openalex.org/W4401817942","https://openalex.org/W4404941892","https://openalex.org/W4414656709"],"related_works":[],"abstract_inverted_index":{"Based":[0],"on":[1],"these":[2],"computational":[3],"findings,":[4],"the":[5,22,26,32],"designed":[6],"MEV":[7],"shows":[8],"significant":[9],"promise":[10],"for":[11],"establishing":[12],"protective":[13],"immunity":[14],"against":[15],"<i>H.":[16],"pylori</i>.":[17],"The":[18],"multi-epitope":[19],"approach":[20],"addresses":[21],"challenges":[23],"posed":[24],"by":[25],"bacterium's":[27],"resilient":[28],"nature.":[29],"However,":[30],"while":[31],"in":[33,55],"silico":[34],"results":[35],"are":[36,45],"encouraging,":[37],"further":[38],"<i>in":[39,42],"vitro</i>":[40],"and":[41,50],"vivo</i>":[43],"investigations":[44],"required":[46],"to":[47],"fully":[48],"comprehend":[49],"validate":[51],"its":[52],"immune-protective":[53],"efficacy":[54],"biological":[56],"systems.":[57]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2026-03-20T00:00:00"}