{"id":"https://openalex.org/W7134844650","doi":"https://doi.org/10.3389/fbinf.2026.1756081","title":"Network pharmacology refined with non-ubiquity and decoy-controlled molecular docking reveals insights into Moringa oleifera phytochemicals targeting insulin resistance","display_name":"Network pharmacology refined with non-ubiquity and decoy-controlled molecular docking reveals insights into Moringa oleifera phytochemicals targeting insulin resistance","publication_year":2026,"publication_date":"2026-03-10","ids":{"openalex":"https://openalex.org/W7134844650","doi":"https://doi.org/10.3389/fbinf.2026.1756081","pmid":"https://pubmed.ncbi.nlm.nih.gov/41884708"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2026.1756081","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1756081","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1756081/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1756081/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5128662837","display_name":"Armi Katrina Santos-Enriquez","orcid":null},"institutions":[{"id":"https://openalex.org/I19722","display_name":"Ateneo de Manila University","ror":"https://ror.org/053kevk63","country_code":"PH","type":"education","lineage":["https://openalex.org/I19722"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":true,"raw_author_name":"Armi Katrina Santos-Enriquez","raw_affiliation_strings":["Department of Chemistry, School of Science and Engineering, Ateneo De Manila University","Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science and Engineering, Ateneo De Manila University","institution_ids":["https://openalex.org/I19722"]},{"raw_affiliation_string":"Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila","institution_ids":["https://openalex.org/I5791819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054872617","display_name":"Fabian M. Dayrit","orcid":"https://orcid.org/0000-0002-4811-9583"},"institutions":[{"id":"https://openalex.org/I19722","display_name":"Ateneo de Manila University","ror":"https://ror.org/053kevk63","country_code":"PH","type":"education","lineage":["https://openalex.org/I19722"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Fabian M. Dayrit","raw_affiliation_strings":["Department of Chemistry, School of Science and Engineering, Ateneo De Manila University"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science and Engineering, Ateneo De Manila University","institution_ids":["https://openalex.org/I19722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038482555","display_name":"Armando Jerome De Jesus","orcid":null},"institutions":[{"id":"https://openalex.org/I19722","display_name":"Ateneo de Manila University","ror":"https://ror.org/053kevk63","country_code":"PH","type":"education","lineage":["https://openalex.org/I19722"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Armando Jerome de Jesus","raw_affiliation_strings":["Department of Chemistry, School of Science and Engineering, Ateneo De Manila University"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science and Engineering, Ateneo De Manila University","institution_ids":["https://openalex.org/I19722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077218981","display_name":"Nina Rosario L. Rojas","orcid":"https://orcid.org/0000-0002-0334-8235"},"institutions":[{"id":"https://openalex.org/I19722","display_name":"Ateneo de Manila University","ror":"https://ror.org/053kevk63","country_code":"PH","type":"education","lineage":["https://openalex.org/I19722"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Nina Rosario L. Rojas","raw_affiliation_strings":["Department of Chemistry, School of Science and Engineering, Ateneo De Manila University"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science and Engineering, Ateneo De Manila University","institution_ids":["https://openalex.org/I19722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5128662837"],"corresponding_institution_ids":["https://openalex.org/I19722","https://openalex.org/I5791819"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.53320467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":"1756081","last_page":"1756081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12721","display_name":"Moringa oleifera research and applications","score":0.944100022315979,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12721","display_name":"Moringa oleifera research and applications","score":0.944100022315979,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13792","display_name":"Morinda citrifolia extract uses","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"Insulin resistance","score":0.6643999814987183},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5985000133514404},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"Insulin receptor","score":0.565500020980835},{"id":"https://openalex.org/keywords/phytochemical","display_name":"Phytochemical","score":0.38589999079704285},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.3808000087738037},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"Rosiglitazone","score":0.36649999022483826},{"id":"https://openalex.org/keywords/peroxisome","display_name":"Peroxisome","score":0.34439998865127563},{"id":"https://openalex.org/keywords/prenylation","display_name":"Prenylation","score":0.32820001244544983}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6643999814987183},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5985000133514404},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.565500020980835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5264000296592712},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4569999873638153},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4072999954223633},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.38589999079704285},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3808000087738037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36739999055862427},{"id":"https://openalex.org/C2780152017","wikidata":"https://www.wikidata.org/wiki/Q424771","display_name":"Rosiglitazone","level":3,"score":0.36649999022483826},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.34439998865127563},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.32820001244544983},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C2780152424","wikidata":"https://www.wikidata.org/wiki/Q4826062","display_name":"AutoDock","level":4,"score":0.2890999913215637},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2818000018596649},{"id":"https://openalex.org/C2777864359","wikidata":"https://www.wikidata.org/wiki/Q5090466","display_name":"Chemical genetics","level":3,"score":0.275299996137619},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2026.1756081","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1756081","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1756081/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41884708","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41884708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:3794c3545981427f89fc20eca1f3518b","is_oa":true,"landing_page_url":"https://doaj.org/article/3794c3545981427f89fc20eca1f3518b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 6 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13008888","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13008888/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2026.1756081","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1756081","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1756081/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323581","display_name":"Ateneo de Manila University","ror":"https://ror.org/053kevk63"},{"id":"https://openalex.org/F4320324410","display_name":"University of the Philippines","ror":"https://ror.org/02hqkr514"},{"id":"https://openalex.org/F4320337407","display_name":"Division of Human Resource Development","ror":"https://ror.org/03mamvh39"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7134844650.pdf","grobid_xml":"https://content.openalex.org/works/W7134844650.grobid-xml"},"referenced_works_count":167,"referenced_works":["https://openalex.org/W173542192","https://openalex.org/W268737201","https://openalex.org/W1541486667","https://openalex.org/W1544009106","https://openalex.org/W1606947757","https://openalex.org/W1734276011","https://openalex.org/W1950371468","https://openalex.org/W1968319881","https://openalex.org/W1968375269","https://openalex.org/W1969176330","https://openalex.org/W1969544008","https://openalex.org/W1972130027","https://openalex.org/W1978804351","https://openalex.org/W1979107282","https://openalex.org/W1979299825","https://openalex.org/W1983644298","https://openalex.org/W1984137975","https://openalex.org/W1984995076","https://openalex.org/W1992582633","https://openalex.org/W1999356728","https://openalex.org/W2003801493","https://openalex.org/W2006617902","https://openalex.org/W2013260905","https://openalex.org/W2019219544","https://openalex.org/W2024139795","https://openalex.org/W2037294472","https://openalex.org/W2039478311","https://openalex.org/W2041880968","https://openalex.org/W2044800918","https://openalex.org/W2068968795","https://openalex.org/W2069478010","https://openalex.org/W2070613674","https://openalex.org/W2074473216","https://openalex.org/W2077691407","https://openalex.org/W2083138678","https://openalex.org/W2084282266","https://openalex.org/W2089050551","https://openalex.org/W2090460655","https://openalex.org/W2093224552","https://openalex.org/W2102466686","https://openalex.org/W2102768305","https://openalex.org/W2104761334","https://openalex.org/W2105668062","https://openalex.org/W2116286641","https://openalex.org/W2118339171","https://openalex.org/W2126839635","https://openalex.org/W2130303892","https://openalex.org/W2130479394","https://openalex.org/W2132569719","https://openalex.org/W2132629607","https://openalex.org/W2134967712","https://openalex.org/W2135888592","https://openalex.org/W2138906820","https://openalex.org/W2144795270","https://openalex.org/W2152575748","https://openalex.org/W2152760742","https://openalex.org/W2155122816","https://openalex.org/W2159675211","https://openalex.org/W2160315579","https://openalex.org/W2164567015","https://openalex.org/W2164698543","https://openalex.org/W2168582474","https://openalex.org/W2169678694","https://openalex.org/W2189666223","https://openalex.org/W2204695023","https://openalex.org/W2261741354","https://openalex.org/W2287735258","https://openalex.org/W2343879804","https://openalex.org/W2396930286","https://openalex.org/W2474747771","https://openalex.org/W2480943605","https://openalex.org/W2505666436","https://openalex.org/W2560438932","https://openalex.org/W2562122613","https://openalex.org/W2565769207","https://openalex.org/W2565858590","https://openalex.org/W2577596804","https://openalex.org/W2588615357","https://openalex.org/W2593436234","https://openalex.org/W2769250691","https://openalex.org/W2769987609","https://openalex.org/W2781618922","https://openalex.org/W2789725535","https://openalex.org/W2793435470","https://openalex.org/W2800013319","https://openalex.org/W2889030242","https://openalex.org/W2894868541","https://openalex.org/W2895949704","https://openalex.org/W2897020020","https://openalex.org/W2898063183","https://openalex.org/W2904085801","https://openalex.org/W2907111532","https://openalex.org/W2918843079","https://openalex.org/W2919231240","https://openalex.org/W2946412700","https://openalex.org/W2949305189","https://openalex.org/W2952036143","https://openalex.org/W2959795248","https://openalex.org/W2962439985","https://openalex.org/W2971148593","https://openalex.org/W2976376641","https://openalex.org/W2983166786","https://openalex.org/W2990309084","https://openalex.org/W2995953683","https://openalex.org/W2996087077","https://openalex.org/W3003235895","https://openalex.org/W3003265560","https://openalex.org/W3033229556","https://openalex.org/W3084144806","https://openalex.org/W3088794572","https://openalex.org/W3090647677","https://openalex.org/W3108227107","https://openalex.org/W3109646171","https://openalex.org/W3115660798","https://openalex.org/W3118695441","https://openalex.org/W3118758188","https://openalex.org/W3126031592","https://openalex.org/W3131395202","https://openalex.org/W3156169848","https://openalex.org/W3168436232","https://openalex.org/W3184764232","https://openalex.org/W3185970161","https://openalex.org/W4200341852","https://openalex.org/W4200402021","https://openalex.org/W4205134630","https://openalex.org/W4205576161","https://openalex.org/W4210781284","https://openalex.org/W4225373799","https://openalex.org/W4229032121","https://openalex.org/W4237095724","https://openalex.org/W4282941214","https://openalex.org/W4285009802","https://openalex.org/W4286488124","https://openalex.org/W4292668725","https://openalex.org/W4295038096","https://openalex.org/W4296741060","https://openalex.org/W4306913084","https://openalex.org/W4307468223","https://openalex.org/W4308834893","https://openalex.org/W4309506674","https://openalex.org/W4315620073","https://openalex.org/W4317702955","https://openalex.org/W4321515288","https://openalex.org/W4322486512","https://openalex.org/W4322505937","https://openalex.org/W4361264515","https://openalex.org/W4364377249","https://openalex.org/W4372332501","https://openalex.org/W4380841460","https://openalex.org/W4382459062","https://openalex.org/W4385463106","https://openalex.org/W4385769748","https://openalex.org/W4387164156","https://openalex.org/W4387435884","https://openalex.org/W4388615774","https://openalex.org/W4389101175","https://openalex.org/W4390561755","https://openalex.org/W4391997341","https://openalex.org/W4394987508","https://openalex.org/W4399589545","https://openalex.org/W4399978594","https://openalex.org/W4400094315","https://openalex.org/W4400120249","https://openalex.org/W4400999955","https://openalex.org/W4402441283","https://openalex.org/W4407175019","https://openalex.org/W4407919921"],"related_works":[],"abstract_inverted_index":{"<i>Moringa":[0],"oleifera</i>":[1,23,185,225],"phytochemicals":[2,24,115,172,324],"were":[3,33,43,119,128,173,206],"predicted":[4,65,120,125,237],"to":[5,54,131,163,165,176],"target":[6,63],"insulin":[7,55,95,181,228,247,261],"resistance":[8,56,182,248,262],"proteins":[9],"using":[10,69,121,134,198,302],"a":[11,166],"modified":[12],"network":[13,195,212,297,315],"pharmacology":[14,316],"and":[15,29,37,59,61,108,148,157,243,269,275,284,292,308,331],"molecular":[16],"docking":[17,306],"approach.":[18],"Two":[19],"hundred":[20],"ninety":[21],"<i>M.":[22,184,224],"with":[25,51,116,151,154,236,246],"their":[26],"aglycones,":[27],"acetylase":[28],"myrosinase":[30],"degradation":[31],"products":[32],"compiled":[34],"from":[35,45,57,186],"literature":[36],"phytochemical":[38],"databases.":[39],"Nine":[40],"protein":[41],"targets":[42,118,208],"identified":[44],"the":[46,62,117,178,233],"intersection":[47],"of":[48,114,140,183,188,300,311,333],"gene":[49],"lists":[50],"high":[52,240],"relevance":[53],"GeneCards":[58],"DisGeNET":[60],"genes":[64],"by":[66],"reverse":[67],"screening":[68],"Swiss":[70],"Target":[71],"Prediction:":[72],"protein-tyrosine":[73],"phosphatase":[74],"1B":[75],"(PTPN1),":[76],"11-beta-hydroxysteroid":[77],"dehydrogenase":[78],"1":[79],"(HSD11B1),":[80],"peroxisome":[81,86],"proliferator-activated":[82,87],"receptor":[83,88,96],"\u03b1":[84,101],"(PPAR\u03b1),":[85],"\u03b3":[89],"(PPAR\u03b3),":[90],"PI3-kinase":[91],"p85-alpha":[92],"subunit":[93],"(PIK3R1),":[94],"(INSR),":[97],"tumor":[98],"necrosis":[99],"factor":[100],"(TNF-\u03b1),":[102],"endothelial":[103],"nitric":[104],"oxide":[105],"synthase":[106],"(eNOS)":[107],"hepatic":[109,204],"lipase":[110],"(LIPC).":[111],"Binding":[112],"affinities":[113,127,142],"Autodock":[122],"Vina.":[123],"The":[124,191],"binding":[126,141,245],"classified":[129],"according":[130],"calculated":[132],"thresholds":[133,304],"receiver":[135],"operating":[136],"characteristic":[137],"(ROC)":[138],"calculations":[139],"of:":[143],"(a)":[144],"binders":[145],"(annotated":[146],"drugs":[147],"other":[149,189],"molecules":[150],"known":[152],"interaction":[153,194],"each":[155],"target),":[156],"(b)":[158],"decoys":[159],"(molecules":[160],"not":[161],"expected":[162],"bind":[164],"specific":[167],"target).":[168],"In":[169],"addition,":[170],"ubiquitous":[171],"filtered":[174],"out":[175],"differentiate":[177],"effect":[179],"on":[180,210,217],"that":[187,222],"plants.":[190],"resulting":[192],"phytochemical-protein":[193],"was":[196],"visualized":[197],"Cytoscape.":[199],"All":[200],"mentioned":[201],"targets,":[202,249,301],"except":[203],"lipase,":[205],"key":[207,322],"based":[209],"various":[211],"centrality":[213,298],"measures.":[214],"Previous":[215],"studies":[216],"murine":[218],"models":[219],"have":[220],"shown":[221],"isothiocyanate-rich":[223],"extracts":[226],"ameliorate":[227],"resistance.":[229],"Using":[230],"our":[231,313],"approach,":[232],"following":[234],"phytochemicals,":[235,312],"moderate":[238],"bioavailability,":[239],"GI":[241],"absorption,":[242],"probable":[244],"are":[250],"recommended":[251],"for":[252,260,305,329],"further":[253],"<i>in":[254,257],"vivo</i>":[255],"or":[256],"vitro</i>":[258],"validation":[259],"activity:":[263],"boldione":[264],"(a":[265,280],"steroid);":[266],"aurantiamide":[267,270],"acetate":[268],"(peptide":[271],"derivatives);":[272,289],"O-ethyl-[(3,4-dihydroxyphenyl)methyl]":[273],"carbamothioate":[274,277],"O-methyl-N-[(4-hydroxyphenyl)methyl]":[276],"(thiocarbamates);":[278],"4\u03b1,6\u03b1-dihydroxyeudesman-8\u03b2,12-olide":[279],"sesquiterpenoid);":[281],"sanleng":[282],"acid":[283,286,288],"tianshic":[285],"(fatty":[287],"2',5,5',7-tetrahydroxyflavone;":[290],"2',3,5,7-tetrahydroxyflavone;":[291],"6-hydroxykaempferol":[293],"(flavonoids).":[294],"By":[295],"combining":[296],"measures":[299],"ROC-derived":[303],"energies,":[307],"considering":[309],"ubiquity":[310],"refined":[314],"approach":[317],"may":[318],"aid":[319],"in":[320],"discovering":[321],"bioactive":[323],"as":[325],"potential":[326],"chemical":[327],"markers":[328],"standardization":[330],"differentiation":[332],"an":[334],"herbal":[335],"drug.":[336]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2026-03-11T00:00:00"}
