{"id":"https://openalex.org/W7126056712","doi":"https://doi.org/10.3389/fbinf.2026.1755664","title":"Benchmarking multiple gene ontology enrichment tools reveals high biological significance, ranking, and stringency heterogeneity among datasets","display_name":"Benchmarking multiple gene ontology enrichment tools reveals high biological significance, ranking, and stringency heterogeneity among datasets","publication_year":2026,"publication_date":"2026-01-29","ids":{"openalex":"https://openalex.org/W7126056712","doi":"https://doi.org/10.3389/fbinf.2026.1755664","pmid":"https://pubmed.ncbi.nlm.nih.gov/41694332"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2026.1755664","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1755664","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1755664/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1755664/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124199812","display_name":"F\u00e1bio Henrique Schuster de Oliveira","orcid":null},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I94328231","display_name":"University of Rio Grande and Rio Grande Community College","ror":"https://ror.org/02sghbs34","country_code":"US","type":"education","lineage":["https://openalex.org/I94328231"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"F\u00e1bio Henrique Schuster de Oliveira","raw_affiliation_strings":["Laboratory of DNA Repair and Aging, Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul"],"affiliations":[{"raw_affiliation_string":"Laboratory of DNA Repair and Aging, Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul","institution_ids":["https://openalex.org/I130442723","https://openalex.org/I94328231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124277069","display_name":"Felipe Acker Gomes","orcid":null},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I94328231","display_name":"University of Rio Grande and Rio Grande Community College","ror":"https://ror.org/02sghbs34","country_code":"US","type":"education","lineage":["https://openalex.org/I94328231"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Felipe Acker Gomes","raw_affiliation_strings":["Laboratory of DNA Repair and Aging, Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul"],"affiliations":[{"raw_affiliation_string":"Laboratory of DNA Repair and Aging, Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul","institution_ids":["https://openalex.org/I130442723","https://openalex.org/I94328231"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081162394","display_name":"Bruno C\u00e9sar Feltes","orcid":"https://orcid.org/0000-0002-2825-8295"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I94328231","display_name":"University of Rio Grande and Rio Grande Community College","ror":"https://ror.org/02sghbs34","country_code":"US","type":"education","lineage":["https://openalex.org/I94328231"]}],"countries":["BR","US"],"is_corresponding":true,"raw_author_name":"Bruno C\u00e9sar Feltes","raw_affiliation_strings":["Laboratory of DNA Repair and Aging, Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul"],"affiliations":[{"raw_affiliation_string":"Laboratory of DNA Repair and Aging, Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul","institution_ids":["https://openalex.org/I130442723","https://openalex.org/I94328231"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081162394"],"corresponding_institution_ids":["https://openalex.org/I130442723","https://openalex.org/I94328231"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19100034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":"1755664","last_page":"1755664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.7523999810218811},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.6376000046730042},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.6035000085830688},{"id":"https://openalex.org/keywords/ontology","display_name":"Ontology","score":0.5824999809265137},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.45419999957084656},{"id":"https://openalex.org/keywords/prioritization","display_name":"Prioritization","score":0.41679999232292175},{"id":"https://openalex.org/keywords/semantics","display_name":"Semantics (computer science)","score":0.41280001401901245}],"concepts":[{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.7523999810218811},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6618000268936157},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.6376000046730042},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.6035000085830688},{"id":"https://openalex.org/C25810664","wikidata":"https://www.wikidata.org/wiki/Q44325","display_name":"Ontology","level":2,"score":0.5824999809265137},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.47679999470710754},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4729999899864197},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.45419999957084656},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C184337299","wikidata":"https://www.wikidata.org/wiki/Q1437428","display_name":"Semantics (computer science)","level":2,"score":0.41280001401901245},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.4032000005245209},{"id":"https://openalex.org/C130318100","wikidata":"https://www.wikidata.org/wiki/Q2268914","display_name":"Semantic similarity","level":2,"score":0.3765000104904175},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3174000084400177},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3156999945640564},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.29760000109672546},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C105565629","wikidata":"https://www.wikidata.org/wiki/Q1248292","display_name":"Gene prediction","level":4,"score":0.27619999647140503},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.26249998807907104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2026.1755664","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1755664","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1755664/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41694332","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41694332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11701721","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12894344","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12894344","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12894344/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2026.1755664","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1755664","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1755664/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1837441638","display_name":null,"funder_award_id":"FAPERGS","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3331681876","display_name":null,"funder_award_id":"CAPES","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G5139334624","display_name":null,"funder_award_id":"Coordena\u00e7\u00e3o","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G7361910657","display_name":null,"funder_award_id":"24/2551-0001277-0","funder_id":"https://openalex.org/F4320322502","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul"},{"id":"https://openalex.org/G963174003","display_name":null,"funder_award_id":"de Aperfei\u00e7","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322502","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","ror":"https://ror.org/05k49za97"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7126056712.pdf","grobid_xml":"https://content.openalex.org/works/W7126056712.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1637271240","https://openalex.org/W1783384641","https://openalex.org/W1848567445","https://openalex.org/W1981307375","https://openalex.org/W2002850151","https://openalex.org/W2010457001","https://openalex.org/W2018340043","https://openalex.org/W2027895157","https://openalex.org/W2045949302","https://openalex.org/W2070050178","https://openalex.org/W2076735582","https://openalex.org/W2084533385","https://openalex.org/W2096586490","https://openalex.org/W2103017472","https://openalex.org/W2110065044","https://openalex.org/W2128049108","https://openalex.org/W2130410032","https://openalex.org/W2138255346","https://openalex.org/W2145825942","https://openalex.org/W2146512944","https://openalex.org/W2158217645","https://openalex.org/W2169589032","https://openalex.org/W2171030481","https://openalex.org/W2214074259","https://openalex.org/W2235123180","https://openalex.org/W2845591014","https://openalex.org/W2912198494","https://openalex.org/W2917101543","https://openalex.org/W2950458545","https://openalex.org/W2957376989","https://openalex.org/W2962704265","https://openalex.org/W2979832776","https://openalex.org/W2997022986","https://openalex.org/W3004747635","https://openalex.org/W4200556126","https://openalex.org/W4220684489","https://openalex.org/W4220831425","https://openalex.org/W4226103421","https://openalex.org/W4286716053","https://openalex.org/W4294216483","https://openalex.org/W4323036511","https://openalex.org/W4372332501","https://openalex.org/W4388539829","https://openalex.org/W4388539880","https://openalex.org/W4392393171","https://openalex.org/W4399139716","https://openalex.org/W4400735087","https://openalex.org/W4403479110","https://openalex.org/W4403597791","https://openalex.org/W6944546543"],"related_works":[],"abstract_inverted_index":{"Functional":[0],"enrichment":[1,69,93,103,129,347],"analysis":[2],"(FEA)":[3],"provides":[4],"biological":[5,64,89,114,219,255],"meaning":[6],"from":[7],"lists":[8],"of":[9,40,66,122,182,195,221,228,235,283,287,343],"differentially":[10],"expressed":[11],"genes":[12,172],"and":[13,26,105,143,153,160,170,193,207,211,232,266,285,349],"proteins":[14],"obtained":[15],"through":[16],"omics":[17],"experiments.":[18],"FEA":[19,77,242,356],"tools":[20,70,104,130,197,280,290,348],"can":[21],"employ":[22],"numerous":[23],"statistical":[24],"methods":[25,44],"rely":[27],"on":[28,82,87,199,245],"different":[29],"pathway":[30,57],"databases.":[31],"In":[32],"this":[33],"sense,":[34],"Overrepresentation":[35],"Analysis":[36],"(ORA)":[37],"is":[38,51,71],"one":[39],"the":[41,53,63,88,97,112,120,180,186,191,196,200,204,208,218,222,226,233,241,254,263,269,310,314,320,340,344],"most":[42,54],"popular":[43,100,127],"to":[45,79,178,251,312,319],"perform":[46],"FEA.":[47,60],"Gene":[48,164],"Ontology":[49],"(GO)":[50],"arguably":[52],"widely":[55],"used":[56],"knowledgebase":[58],"in":[59,76,92,281,294],"Hence,":[61],"benchmarking":[62,355],"accuracy":[65,115,194],"ORA-based":[67,101],"GO":[68,102,128,230,346],"crucial.":[72],"Nevertheless,":[73],"benchmark":[74],"studies":[75],"tend":[78],"focus":[80],"excessively":[81],"performance-based":[83],"metrics":[84,215],"rather":[85],"than":[86,331],"information":[90],"contained":[91],"results.":[94,288],"To":[95],"identify":[96],"differences":[98],"between":[99,203],"provide":[106,336],"data":[107,353],"that":[108,216,309],"brings":[109],"insights":[110,338],"into":[111,339],"tools'":[113,270],"and,":[116],"thus,":[117],"better":[118],"suits":[119],"application":[121],"FEA,":[123],"we":[124,189,239,307],"tested":[125],"12":[126],"(i.e.,":[131],"DAVID,":[132],"PANTHER,":[133],"WebGestalt,":[134],"Enrichr,":[135],"ShinyGO,":[136],"limma,":[137],"topGO,":[138],"GOstats,":[139],"clusterProfiler,":[140],"g:Profiler,":[141],"ClueGO,":[142],"BiNGO)":[144],"with":[145,166,326],"randomized":[146],"datasets":[147,156],"as":[148,157,225,302],"negative":[149],"controls,":[150,159],"a":[151,154],"target-oriented":[152],"hallmark":[155],"positive":[158],"an":[161],"experiment-derived":[162],"dataset.":[163],"sets":[165],"500,":[167],"200,":[168],"100,":[169],"50":[171],"were":[173],"built":[174],"for":[175,354],"each":[176,259],"dataset":[177],"investigate":[179],"impact":[181],"input":[183,303],"sizes.":[184],"Using":[185],"control":[187],"datasets,":[188],"calculated":[190],"FPR":[192],"based":[198,244],"semantic":[201,247],"similarity":[202],"enriched":[205,229,315],"terms":[206,231,282],"target":[209,236,296],"ontologies":[210,316],"assessed":[212],"overlooked,":[213],"insightful":[214],"reflect":[217],"informativeness":[220,284],"results,":[223],"such":[224],"specificity":[227],"prioritization":[234],"ontologies.":[237],"Additionally,":[238,306],"clustered":[240],"results":[243,271,335],"term":[246],"similarity,":[248],"enabling":[249],"us":[250],"directly":[252],"compare":[253],"profiles":[256],"generated":[257],"by":[258],"tool.":[260],"Despite":[261],"employing":[262],"same":[264],"method":[265],"functional":[267],"database,":[268],"diverged":[272],"significantly.":[273],"Our":[274],"findings":[275],"reveal":[276],"considerable":[277],"variation":[278],"among":[279],"interpretability":[286],"Some":[289],"demonstrated":[291],"strong":[292],"capabilities":[293],"prioritizing":[295],"pathways,":[297],"while":[298],"others":[299],"struggled,":[300],"especially":[301],"size":[304],"increased.":[305],"observed":[308],"degree":[311],"which":[313],"are":[317],"related":[318],"expected":[321],"targets":[322],"varies":[323],"across":[324],"tools,":[325],"some":[327],"being":[328],"more":[329],"conservative":[330],"others.":[332],"Together,":[333],"these":[334],"powerful":[337],"performance":[341],"characteristics":[342],"analyzed":[345],"yield":[350],"new,":[351],"relevant":[352],"tools.":[357]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2026-01-30T00:00:00"}
