{"id":"https://openalex.org/W7140286242","doi":"https://doi.org/10.3389/fbinf.2026.1719700","title":"Boolean network and meshless simulations for the comparison of transport and reaction mechanisms arising in one-short tri-exponential and uniform infusion electrochemotherapeutic treatments","display_name":"Boolean network and meshless simulations for the comparison of transport and reaction mechanisms arising in one-short tri-exponential and uniform infusion electrochemotherapeutic treatments","publication_year":2026,"publication_date":"2026-03-25","ids":{"openalex":"https://openalex.org/W7140286242","doi":"https://doi.org/10.3389/fbinf.2026.1719700","pmid":"https://pubmed.ncbi.nlm.nih.gov/41958709"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2026.1719700","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1719700","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1719700/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1719700/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086464746","display_name":"Fabi\u00e1n Mauricio V\u00e9lez Salazar","orcid":"https://orcid.org/0000-0002-7299-5970"},"institutions":[{"id":"https://openalex.org/I4210094719","display_name":"Instituci\u00f3n Universitaria Pascual Bravo","ror":"https://ror.org/00s1b0733","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210094719"]}],"countries":["CO"],"is_corresponding":true,"raw_author_name":"Fabi\u00e1n Mauricio V\u00e9lez Salazar","raw_affiliation_strings":["Grupo de Investigaci\u00f3n e Innovaci\u00f3n Ambiental (GIIAM), Instituci\u00f3n Universitaria Pascual Bravo"],"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n e Innovaci\u00f3n Ambiental (GIIAM), Instituci\u00f3n Universitaria Pascual Bravo","institution_ids":["https://openalex.org/I4210094719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130587779","display_name":"Iv\u00e1n David Pati\u00f1o Arcila","orcid":null},"institutions":[{"id":"https://openalex.org/I4210094719","display_name":"Instituci\u00f3n Universitaria Pascual Bravo","ror":"https://ror.org/00s1b0733","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210094719"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Iv\u00e1n David Pati\u00f1o Arcila","raw_affiliation_strings":["Grupo de Investigaci\u00f3n e Innovaci\u00f3n Ambiental (GIIAM), Instituci\u00f3n Universitaria Pascual Bravo"],"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n e Innovaci\u00f3n Ambiental (GIIAM), Instituci\u00f3n Universitaria Pascual Bravo","institution_ids":["https://openalex.org/I4210094719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130580272","display_name":"Ismael E. Rivera Madrid","orcid":null},"institutions":[{"id":"https://openalex.org/I4210094719","display_name":"Instituci\u00f3n Universitaria Pascual Bravo","ror":"https://ror.org/00s1b0733","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210094719"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Ismael E. Rivera Madrid","raw_affiliation_strings":["Instituci\u00f3n Universitaria Pascual Bravo"],"affiliations":[{"raw_affiliation_string":"Instituci\u00f3n Universitaria Pascual Bravo","institution_ids":["https://openalex.org/I4210094719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048301328","display_name":"M.R. Fulla","orcid":null},"institutions":[{"id":"https://openalex.org/I36243813","display_name":"Universidad Nacional de Colombia","ror":"https://ror.org/059yx9a68","country_code":"CO","type":"education","lineage":["https://openalex.org/I36243813"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Marlon Rinc\u00f3n Fulla","raw_affiliation_strings":["Grupo en Modelaci\u00f3n Computacional de Sistemas Mec\u00e1nico-Cu\u00e1nticos, Universidad Nacional de Colombia"],"affiliations":[{"raw_affiliation_string":"Grupo en Modelaci\u00f3n Computacional de Sistemas Mec\u00e1nico-Cu\u00e1nticos, Universidad Nacional de Colombia","institution_ids":["https://openalex.org/I36243813"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086464746"],"corresponding_institution_ids":["https://openalex.org/I4210094719"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70009116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":"1719700","last_page":"1719700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.7989000082015991,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.7989000082015991,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.04960000142455101,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrochemotherapy","display_name":"Electrochemotherapy","score":0.6815000176429749},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.40630000829696655},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.3928999900817871},{"id":"https://openalex.org/keywords/dissociation","display_name":"Dissociation (chemistry)","score":0.3919999897480011},{"id":"https://openalex.org/keywords/lymphatic-system","display_name":"Lymphatic system","score":0.38109999895095825},{"id":"https://openalex.org/keywords/drug-administration","display_name":"Drug administration","score":0.3675999939441681},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.36739999055862427},{"id":"https://openalex.org/keywords/electroporation","display_name":"Electroporation","score":0.3646000027656555},{"id":"https://openalex.org/keywords/minification","display_name":"Minification","score":0.3634999990463257}],"concepts":[{"id":"https://openalex.org/C2777108052","wikidata":"https://www.wikidata.org/wiki/Q3137263","display_name":"Electrochemotherapy","level":4,"score":0.6815000176429749},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.47040000557899475},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.4174000024795532},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.40630000829696655},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.40290001034736633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40290001034736633},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.3928999900817871},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.3919999897480011},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3869999945163727},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.38109999895095825},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.37940001487731934},{"id":"https://openalex.org/C2987276129","wikidata":"https://www.wikidata.org/wiki/Q12140","display_name":"Drug administration","level":2,"score":0.3675999939441681},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.36739999055862427},{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.3646000027656555},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3637000024318695},{"id":"https://openalex.org/C147764199","wikidata":"https://www.wikidata.org/wiki/Q6865248","display_name":"Minification","level":2,"score":0.3634999990463257},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3626999855041504},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.3621000051498413},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3521000146865845},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.350600004196167},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.3467000126838684},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.3248000144958496},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.31290000677108765},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.30979999899864197},{"id":"https://openalex.org/C60799052","wikidata":"https://www.wikidata.org/wiki/Q46221","display_name":"Electric field","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.29919999837875366},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.29760000109672546},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2971999943256378},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.28600001335144043},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.28529998660087585},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.2827000021934509},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.2734000086784363},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.2687999904155731}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2026.1719700","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1719700","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1719700/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41958709","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41958709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:b3910249c7404afe8a476275b227fb87","is_oa":true,"landing_page_url":"https://doaj.org/article/b3910249c7404afe8a476275b227fb87","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 6 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13057505","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13057505/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2026.1719700","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2026.1719700","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1719700/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.71670001745224,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7140286242.pdf","grobid_xml":"https://content.openalex.org/works/W7140286242.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W67938392","https://openalex.org/W1573339040","https://openalex.org/W1963568344","https://openalex.org/W1963580598","https://openalex.org/W1963943534","https://openalex.org/W1967217835","https://openalex.org/W1969399579","https://openalex.org/W1972286416","https://openalex.org/W1974755626","https://openalex.org/W1975823711","https://openalex.org/W1977198605","https://openalex.org/W1978550123","https://openalex.org/W1982435395","https://openalex.org/W1983474189","https://openalex.org/W1986125200","https://openalex.org/W1986451670","https://openalex.org/W1986781659","https://openalex.org/W1988447698","https://openalex.org/W1990983926","https://openalex.org/W1999629847","https://openalex.org/W2004952803","https://openalex.org/W2006202974","https://openalex.org/W2010638294","https://openalex.org/W2011649403","https://openalex.org/W2020732140","https://openalex.org/W2022137585","https://openalex.org/W2026761507","https://openalex.org/W2028437938","https://openalex.org/W2033739909","https://openalex.org/W2044469114","https://openalex.org/W2045225530","https://openalex.org/W2047256102","https://openalex.org/W2047719364","https://openalex.org/W2048556470","https://openalex.org/W2053789233","https://openalex.org/W2053847699","https://openalex.org/W2080729606","https://openalex.org/W2082498763","https://openalex.org/W2084478449","https://openalex.org/W2092347097","https://openalex.org/W2094626068","https://openalex.org/W2104204014","https://openalex.org/W2106066793","https://openalex.org/W2116576002","https://openalex.org/W2117727989","https://openalex.org/W2121830723","https://openalex.org/W2123431502","https://openalex.org/W2124278065","https://openalex.org/W2128348744","https://openalex.org/W2138460990","https://openalex.org/W2143203694","https://openalex.org/W2144000788","https://openalex.org/W2149974024","https://openalex.org/W2154294370","https://openalex.org/W2164878073","https://openalex.org/W2166917168","https://openalex.org/W2167437179","https://openalex.org/W2172034196","https://openalex.org/W2215362688","https://openalex.org/W2244438291","https://openalex.org/W2252874512","https://openalex.org/W2271801128","https://openalex.org/W2319351536","https://openalex.org/W2407145072","https://openalex.org/W2409969331","https://openalex.org/W2604599343","https://openalex.org/W2618794160","https://openalex.org/W2767780867","https://openalex.org/W2773535565","https://openalex.org/W2791109629","https://openalex.org/W2807663612","https://openalex.org/W2890209544","https://openalex.org/W2892194894","https://openalex.org/W2917550741","https://openalex.org/W2953870718","https://openalex.org/W2963062456","https://openalex.org/W2980539172","https://openalex.org/W2996931039","https://openalex.org/W3012124203","https://openalex.org/W3036203402","https://openalex.org/W3038075946","https://openalex.org/W3141506875","https://openalex.org/W3206036721","https://openalex.org/W3214366605","https://openalex.org/W4234914173","https://openalex.org/W4242302409","https://openalex.org/W4243464787","https://openalex.org/W4294884779","https://openalex.org/W4361199454","https://openalex.org/W4384562446","https://openalex.org/W4384626474","https://openalex.org/W4388880083","https://openalex.org/W4389475408","https://openalex.org/W4405208565","https://openalex.org/W4407245985","https://openalex.org/W4413138540"],"related_works":[],"abstract_inverted_index":{"Drug":[0],"administration":[1],"via":[2],"the":[3,48,64,71,91,103,128,139,156,190,210,217,221,246,249,270,273,277,401,451,457,460,464,469,483,493,499],"bloodstream":[4,72],"involves":[5],"some":[6],"transport":[7,462,488],"and":[8,27,32,34,118,122,145,166,199,227,243,363,396,414,429,466,503,515],"reaction":[9],"mechanisms":[10,500],"(":[11,52,95,182,202,286,326,368,408],"<mml:math":[12,38,53,74,96,104,142,146,157,174,183,203,250,283,287,297,307,317,327,339,351,364,369,387,403,409,415,426,430,453,472,510],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mrow><mml:mi>R</mml:mi>":[13,39,105,158,251,388],"<mml:mi>T</mml:mi>":[14,40,106,159,252,389],"<mml:mi>M</mml:mi>":[15,41,107,253],"<mml:mi>s</mml:mi></mml:mrow>":[16,42,108,162,177,254,336,348,360,392,406],"</mml:math>":[17,43,56,86,98,109,144,154,163,178,187,207,255,285,295,305,315,325,337,349,361,367,377,393,407,413,419,428,438,455,480,512],"),":[18,188,208,316,362],"such":[19],"as":[20,67,69],"extravasation,":[21],"perfusion":[22],"along":[23],"blood":[24],"vessels,":[25],"transmembrane":[26,461],"interstitial":[28],"transport,":[29],"protein":[30],"dissociation":[31,504],"association,":[33],"lymphatic":[35],"drainage.":[36],"These":[37],"can":[44,100,398],"be":[45],"influenced":[46],"by":[47,70,258,509],"type":[49],"of":[50,141,260,272,276,282,425,471,486,498,501],"pharmacokinetic":[51,447],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mrow><mml:mi>P</mml:mi>":[54,175,365,404],"<mml:mi>K</mml:mi></mml:mrow>":[55,186,206,366,376,412,418],")":[57,99,378,420],"profile":[58],"used":[59],"for":[60,171,421],"drug":[61,191,211],"delivery":[62],"in":[63,124,169,463],"circulatory":[65],"system,":[66],"well":[68],"velocity":[73],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\">":[75,147,318,431,473],"<mml:mrow>":[76],"<mml:mfenced>":[77],"<mml:mrow><mml:msub><mml:mi>\u03bb</mml:mi>":[78,148,319,432,474],"<mml:mrow><mml:mi>i</mml:mi>":[79,149,320,433,475],"<mml:mi>n</mml:mi>":[80,150,321,434,476],"<mml:mi>l</mml:mi></mml:mrow>":[81,151,322,435,477],"</mml:msub>":[82,152,323,436,478],"</mml:mrow>":[83,85,153,324,437,479],"</mml:mfenced>":[84],".":[87,439],"In":[88,127,449],"electroporated":[89],"tissues,":[90],"electric":[92],"field":[93],"magnitude":[94],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mrow><mml:mi>E</mml:mi></mml:mrow>":[97,143,284,427,454,511],"also":[101,481],"affect":[102],"because":[110],"it":[111],"brings":[112],"about":[113],"vessel":[114,119],"vasoconstriction,":[115],"cell":[116],"membrane":[117],"wall":[120],"electro-permeabilization,":[121],"changes":[123],"tissue":[125],"porosity.":[126],"present":[129],"work,":[130],"in-house":[131],"computational":[132],"tools":[133],"are":[134,231,379,443],"employed":[135],"to":[136],"examine":[137],"how":[138],"combination":[140],"influences":[155,492],"<mml:msup><mml:mi>M</mml:mi>":[160,390],"<mml:mo>'</mml:mo></mml:msup>":[161,391],"existence,":[164,394],"interaction,":[165,395],"rates":[167,397],"arising":[168],"electrochemotherapy":[170],"two":[172,402],"different":[173],"<mml:mi>K</mml:mi>":[176,372,405],":":[179],"One-short":[180],"tri-exponential":[181],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mrow><mml:mi>T</mml:mi>":[184,370,410],"<mml:mi>P</mml:mi>":[185,205,371,375,411,417],"where":[189,209],"concentration":[192,212,278],"decreases":[193],"exponentially":[194],"after":[195],"a":[196,237,261,422],"one-short":[197],"infusion,":[198],"one":[200],"uniform":[201,459],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mrow><mml:mi>U</mml:mi>":[204,416],"is":[213,256,267,505],"kept":[214],"constant":[215],"during":[216],"whole":[218],"treatment.":[219],"First,":[220],"ratios":[222],"between":[223,248,400,445],"extracellular,":[224],"free":[225],"intracellular,":[226],"bound":[228],"intracellular":[229],"concentrations":[230],"obtained":[232],"from":[233],"numerical":[234],"simulations":[235],"with":[236],"meshless":[238],"code":[239],"previously":[240],"developed,":[241],"calibrated,":[242],"validated.":[244],"Subsequently,":[245],"interaction":[247],"investigated":[257],"means":[259],"Boolean":[262],"model":[263],"presented":[264],"here":[265],"that":[266,386],"based":[268],"on":[269],"comparison":[271],"spatio-temporal":[274],"evolution":[275],"ratios.":[279],"Several":[280],"combinations":[281],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mrow><mml:mn>0</mml:mn>":[288],"<mml:mtext>":[289,299,309],"</mml:mtext>":[290,300,310],"<mml:mi>k</mml:mi>":[291,301,311],"<mml:mi>V</mml:mi>":[292,302,312],"<mml:mo>/</mml:mo>":[293,303,313,335,347,359],"<mml:mi>m</mml:mi></mml:mrow>":[294,304,314],";":[296,306,338,350],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mrow><mml:mn>46</mml:mn>":[298],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mrow><mml:mn>70</mml:mn>":[308],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mrow><mml:mn>1</mml:mn>":[328,340,352],"<mml:mo>\u00d7</mml:mo>":[329,341,353],"<mml:msup><mml:mn>10</mml:mn>":[330,342,354],"<mml:mrow><mml:mo>-</mml:mo>":[331,343,355],"<mml:mn>4</mml:mn></mml:mrow>":[332],"</mml:msup>":[333,345,357],"<mml:mi>m</mml:mi>":[334,346,358],"<mml:mn>3</mml:mn></mml:mrow>":[344],"<mml:mn>2</mml:mn></mml:mrow>":[356],"<mml:mtext>and</mml:mtext>":[373],"<mml:mi>U</mml:mi>":[374],"tested.":[380],"The":[381,496],"<i>in":[382],"silico</i>":[383],"findings":[384],"indicate":[385],"vary":[399],"specific":[423],"permutation":[424],"Nevertheless,":[440],"common":[441],"features":[442],"identified":[444],"these":[446],"profiles.":[448],"general,":[450],"lower":[452],",":[456],"more":[458],"radial":[465,484],"axial":[467,494],"direction;":[468],"decrease":[470],"improves":[482],"homogeneity":[485],"this":[487],"mechanism":[489],"but":[490],"negatively":[491],"uniformity.":[495],"uniformity":[497],"association":[502],"only":[506],"altered":[507],"monotonously":[508],"(V\u00e9lez":[513],"Salazar":[514],"Pati\u00f1o":[516],"Arcila,":[517],"2025).":[518]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2026-03-26T00:00:00"}
