{"id":"https://openalex.org/W7116046925","doi":"https://doi.org/10.3389/fbinf.2025.1735106","title":"Network-based insights into miR-30a-5p-mediated regulation and EGCG targeting in triple-negative breast cancer","display_name":"Network-based insights into miR-30a-5p-mediated regulation and EGCG targeting in triple-negative breast cancer","publication_year":2025,"publication_date":"2025-12-19","ids":{"openalex":"https://openalex.org/W7116046925","doi":"https://doi.org/10.3389/fbinf.2025.1735106","pmid":"https://pubmed.ncbi.nlm.nih.gov/41487287"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1735106","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1735106","pdf_url":null,"source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fbinf.2025.1735106","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Loganathan Chandramani Priya Dharshini","orcid":null},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Loganathan Chandramani Priya Dharshini","raw_affiliation_strings":["Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"last","author":{"id":null,"display_name":"Abul Kalam Azad Mandal","orcid":null},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abul Kalam Azad Mandal","raw_affiliation_strings":["Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India","institution_ids":["https://openalex.org/I876193797"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I876193797"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60683801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"1735106","last_page":"1735106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.7095999717712402,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.7095999717712402,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.07209999859333038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5792999863624573},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3481000065803528},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.2703999876976013},{"id":"https://openalex.org/keywords/rational-design","display_name":"Rational design","score":0.2556999921798706}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5792999863624573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5674999952316284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49470001459121704},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3481000065803528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2736999988555908},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2703999876976013},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25999999046325684},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24879999458789825}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1735106","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1735106","pdf_url":null,"source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41487287","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41487287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:58a7040827c842599e19bf0fe9adb690","is_oa":true,"landing_page_url":"https://doaj.org/article/58a7040827c842599e19bf0fe9adb690","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12757378","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12757378/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1735106","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1735106","pdf_url":null,"source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1839791863","https://openalex.org/W1915224590","https://openalex.org/W1984168218","https://openalex.org/W1992840397","https://openalex.org/W2000068858","https://openalex.org/W2013676093","https://openalex.org/W2074316698","https://openalex.org/W2101979288","https://openalex.org/W2103912979","https://openalex.org/W2111495238","https://openalex.org/W2114057457","https://openalex.org/W2123500593","https://openalex.org/W2159675211","https://openalex.org/W2171268876","https://openalex.org/W2301874383","https://openalex.org/W2616807206","https://openalex.org/W2738153741","https://openalex.org/W2752803900","https://openalex.org/W2763467492","https://openalex.org/W2767981580","https://openalex.org/W2770070152","https://openalex.org/W2886699530","https://openalex.org/W2906940574","https://openalex.org/W2938119865","https://openalex.org/W2944545583","https://openalex.org/W2946657092","https://openalex.org/W2970358232","https://openalex.org/W2993347499","https://openalex.org/W2997022986","https://openalex.org/W3006029259","https://openalex.org/W3026764315","https://openalex.org/W3033869790","https://openalex.org/W3090705945","https://openalex.org/W3092260414","https://openalex.org/W3128200801","https://openalex.org/W3128219246","https://openalex.org/W3150953736","https://openalex.org/W3183242014","https://openalex.org/W3184531291","https://openalex.org/W3207499161","https://openalex.org/W4221003204","https://openalex.org/W4292415327","https://openalex.org/W4296777868","https://openalex.org/W4308834893","https://openalex.org/W4313515595","https://openalex.org/W4315647946","https://openalex.org/W4319017146","https://openalex.org/W4376872535","https://openalex.org/W4382468321","https://openalex.org/W4383820630","https://openalex.org/W4384071336","https://openalex.org/W4386223335","https://openalex.org/W4394752105","https://openalex.org/W4400390698","https://openalex.org/W4401729903","https://openalex.org/W4402217489","https://openalex.org/W4404656064","https://openalex.org/W4404729270","https://openalex.org/W4406312924","https://openalex.org/W4410286988","https://openalex.org/W4412438190","https://openalex.org/W4413972190","https://openalex.org/W4414356987"],"related_works":[],"abstract_inverted_index":{"The":[0,20],"results":[1],"emphasizes":[2],"that":[3,12],"EGCG":[4],"has":[5],"strong":[6],"binding":[7],"affinity":[8],"towards":[9],"YWHAZ,":[10],"revealing":[11],"miR-30a-EGCG":[13],"targets":[14],"TNBC":[15,28],"synergistically":[16],"through":[17],"cell-cycle-mediated":[18],"pathways.":[19],"findings":[21],"give":[22],"rational":[23],"support":[24],"for":[25],"miRNA-guided":[26],"phytochemical-based":[27],"therapeutic":[29],"development.":[30]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-12-19T00:00:00"}