{"id":"https://openalex.org/W4416956277","doi":"https://doi.org/10.3389/fbinf.2025.1695217","title":"Subtractive genomic approach to uncover novel drug targets in Salmonella typhimurium and computational screening of food-based polyphenols as inhibitors","display_name":"Subtractive genomic approach to uncover novel drug targets in Salmonella typhimurium and computational screening of food-based polyphenols as inhibitors","publication_year":2025,"publication_date":"2025-12-03","ids":{"openalex":"https://openalex.org/W4416956277","doi":"https://doi.org/10.3389/fbinf.2025.1695217","pmid":"https://pubmed.ncbi.nlm.nih.gov/41415625"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1695217","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1695217","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1695217/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1695217/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078596094","display_name":"Mohammed Naveez Valathoor","orcid":"https://orcid.org/0000-0001-8901-9602"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohammed Naveez Valathoor","raw_affiliation_strings":["Department of Bio Medical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"Department of Bio Medical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016444065","display_name":"Subhashree Venugopal","orcid":"https://orcid.org/0000-0001-7713-5737"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhashree Venugopal","raw_affiliation_strings":["Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052422280","display_name":"Anand Prem Rajan","orcid":"https://orcid.org/0000-0001-5659-0386"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anand Prem Rajan","raw_affiliation_strings":["Department of Bio Medical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"Department of Bio Medical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India","institution_ids":["https://openalex.org/I876193797"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052422280"],"corresponding_institution_ids":["https://openalex.org/I876193797"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":1.4014,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.85285466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"5","issue":null,"first_page":"1695217","last_page":"1695217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12653","display_name":"Cyclization and Aryne Chemistry","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/druggability","display_name":"Druggability","score":0.8881999850273132},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5156999826431274},{"id":"https://openalex.org/keywords/polyphenol","display_name":"Polyphenol","score":0.4577000141143799},{"id":"https://openalex.org/keywords/salmonella","display_name":"Salmonella","score":0.39250001311302185},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.35499998927116394},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.2987000048160553}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.8881999850273132},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5526000261306763},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5156999826431274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4837999939918518},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.4577000141143799},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.39250001311302185},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.35499998927116394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3084000051021576},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C150799807","wikidata":"https://www.wikidata.org/wiki/Q374081","display_name":"Subtractive color","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28200000524520874},{"id":"https://openalex.org/C196436469","wikidata":"https://www.wikidata.org/wiki/Q6587700","display_name":"Suppression subtractive hybridization","level":5,"score":0.2768000066280365},{"id":"https://openalex.org/C2779607309","wikidata":"https://www.wikidata.org/wiki/Q2264864","display_name":"Salmonella enterica","level":4,"score":0.2727000117301941},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26579999923706055},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C2777494893","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Approved drug","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2590999901294708}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1695217","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1695217","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1695217/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41415625","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41415625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:417a254100b642a1a4edc676e80538da","is_oa":true,"landing_page_url":"https://doaj.org/article/417a254100b642a1a4edc676e80538da","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12710465","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12710465/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1695217","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1695217","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1695217/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322838","display_name":"VIT University","ror":"https://ror.org/00qzypv28"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416956277.pdf","grobid_xml":"https://content.openalex.org/works/W4416956277.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1981737096","https://openalex.org/W2012853202","https://openalex.org/W2029446881","https://openalex.org/W2041791898","https://openalex.org/W2053904909","https://openalex.org/W2064456974","https://openalex.org/W2070753604","https://openalex.org/W2100190412","https://openalex.org/W2101997581","https://openalex.org/W2108052469","https://openalex.org/W2138271600","https://openalex.org/W2169678694","https://openalex.org/W2171268876","https://openalex.org/W2612518316","https://openalex.org/W2749939966","https://openalex.org/W2921372701","https://openalex.org/W2946442314","https://openalex.org/W3002370709","https://openalex.org/W3094213757","https://openalex.org/W3124387327","https://openalex.org/W3202287440","https://openalex.org/W3206934844","https://openalex.org/W3213313190","https://openalex.org/W4213235558","https://openalex.org/W4288434000","https://openalex.org/W4292164655","https://openalex.org/W4295204163","https://openalex.org/W4296777868","https://openalex.org/W4303943903","https://openalex.org/W4308181764","https://openalex.org/W4320856211","https://openalex.org/W4322504811","https://openalex.org/W4360826956","https://openalex.org/W4362617416","https://openalex.org/W4380080057","https://openalex.org/W4386283616","https://openalex.org/W4386421162","https://openalex.org/W4388538238","https://openalex.org/W4391155152","https://openalex.org/W4392718480","https://openalex.org/W4399325088","https://openalex.org/W4400390698","https://openalex.org/W4402011896","https://openalex.org/W4402847492","https://openalex.org/W4409466436","https://openalex.org/W4414230499"],"related_works":[],"abstract_inverted_index":{"This":[0],"study":[1],"validates":[2],"MurG":[3],"as":[4,14],"a":[5,15,26],"druggable":[6],"target":[7],"in":[8],"<i>S.":[9],"typhimurium</i>":[10],"and":[11],"identifies":[12],"6-prenylnaringenin":[13,24],"potent":[16],"inhibitor.":[17],"With":[18],"computational":[19],"metrics":[20],"superior":[21],"to":[22,40],"ciprofloxacin,":[23],"is":[25,38],"promising":[27],"lead":[28],"compound":[29],"for":[30],"developing":[31],"new":[32],"anti-Salmonella":[33],"therapeutics.":[34],"Future":[35],"experimental":[36],"validation":[37],"required":[39],"confirm":[41],"these":[42],"<i>in":[43],"silico</i>":[44],"findings.":[45]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-12-03T00:00:00"}
