{"id":"https://openalex.org/W4413297834","doi":"https://doi.org/10.3389/fbinf.2025.1669236","title":"Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma","display_name":"Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma","publication_year":2025,"publication_date":"2025-08-18","ids":{"openalex":"https://openalex.org/W4413297834","doi":"https://doi.org/10.3389/fbinf.2025.1669236","pmid":"https://pubmed.ncbi.nlm.nih.gov/40901047"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1669236","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1669236","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1669236/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1669236/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086395506","display_name":"Shangyi Luo","orcid":"https://orcid.org/0000-0002-0254-8593"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shangyi Luo","raw_affiliation_strings":["Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou, Fujian, China"],"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418831","display_name":"Li Liu","orcid":"https://orcid.org/0000-0002-5641-446X"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou, Fujian, China"],"affiliations":[{"raw_affiliation_string":"Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112141099","display_name":"Yang Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Sun","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China"],"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046862694","display_name":"Jian Shi","orcid":"https://orcid.org/0000-0001-5802-7116"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Shi","raw_affiliation_strings":["School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039932274","display_name":"Yajing Zhang","orcid":"https://orcid.org/0009-0007-2285-3775"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yajing Zhang","raw_affiliation_strings":["Heilongjiang Province Key Laboratory of Child Development and Genetic Research, Harbin Medical University, Harbin, Heilongjiang, China","Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou, Fujian, China","NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University, Harbin, Heilongjiang, China"],"affiliations":[{"raw_affiliation_string":"Heilongjiang Province Key Laboratory of Child Development and Genetic Research, Harbin Medical University, Harbin, Heilongjiang, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"]},{"raw_affiliation_string":"NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Harbin Medical University, Harbin, Heilongjiang, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5039932274","https://openalex.org/A5046862694"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I156144747","https://openalex.org/I80947539","https://openalex.org/I87780372"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22662691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"1669236","last_page":"1669236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9825999736785889,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.813634991645813},{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.7294222712516785},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.39459389448165894},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3907959461212158},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.355299174785614},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34638649225234985},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.34344086050987244},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33549433946609497},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1389126479625702}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.813634991645813},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.7294222712516785},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.39459389448165894},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3907959461212158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.355299174785614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34638649225234985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34344086050987244},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33549433946609497},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1389126479625702},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fbinf.2025.1669236","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1669236","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1669236/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40901047","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40901047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:e35f90e577a245b985d6961972e98511","is_oa":true,"landing_page_url":"https://doaj.org/article/e35f90e577a245b985d6961972e98511","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11210271","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12399655","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12399655","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12399655/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1669236","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1669236","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1669236/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413297834.pdf"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W2061703796","https://openalex.org/W2069089843","https://openalex.org/W2084806104","https://openalex.org/W2108900994","https://openalex.org/W2124471593","https://openalex.org/W2127712585","https://openalex.org/W2146237899","https://openalex.org/W2324488473","https://openalex.org/W2603489972","https://openalex.org/W2612910794","https://openalex.org/W2625559053","https://openalex.org/W2788142646","https://openalex.org/W2796207838","https://openalex.org/W2949273159","https://openalex.org/W2978708928","https://openalex.org/W2980770033","https://openalex.org/W2982616779","https://openalex.org/W2990323558","https://openalex.org/W2999160028","https://openalex.org/W3010301137","https://openalex.org/W3012668557","https://openalex.org/W3082635810","https://openalex.org/W3128646645","https://openalex.org/W3135937103","https://openalex.org/W3175283754","https://openalex.org/W3199675843","https://openalex.org/W3208472126","https://openalex.org/W4232342538","https://openalex.org/W4294838953","https://openalex.org/W4306759100","https://openalex.org/W4311579386","https://openalex.org/W4311896038","https://openalex.org/W4320856583","https://openalex.org/W4364355552","https://openalex.org/W4387964910","https://openalex.org/W4398170892","https://openalex.org/W4402341090","https://openalex.org/W4407401961"],"related_works":["https://openalex.org/W2417822880","https://openalex.org/W628600844","https://openalex.org/W1570838273","https://openalex.org/W2410885201","https://openalex.org/W2385390897","https://openalex.org/W3172842848","https://openalex.org/W2418745692","https://openalex.org/W2404951810","https://openalex.org/W2800415451","https://openalex.org/W2337719538"],"abstract_inverted_index":{"Our":[0],"study":[1],"reveals":[2],"that":[3],"regional":[4],"transcriptional":[5],"heterogeneity":[6],"within":[7],"tumors":[8],"is":[9],"substantial":[10],"enough":[11],"to":[12],"capture":[13],"survival":[14],"signals,":[15],"and":[16,19],"the":[17],"constructed":[18],"validated":[20],"HCCEvoSig":[21],"provides":[22],"reliable":[23],"prognostic":[24],"information":[25],"for":[26],"HCC":[27],"patients.":[28]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}