{"id":"https://openalex.org/W4414189131","doi":"https://doi.org/10.3389/fbinf.2025.1613136","title":"Discovering biomarkers for chronic sinusitis with nasal polyps: a study integrating bioinformatics analysis and experimental validation of macrophage polarization and metabolism-related genes","display_name":"Discovering biomarkers for chronic sinusitis with nasal polyps: a study integrating bioinformatics analysis and experimental validation of macrophage polarization and metabolism-related genes","publication_year":2025,"publication_date":"2025-09-15","ids":{"openalex":"https://openalex.org/W4414189131","doi":"https://doi.org/10.3389/fbinf.2025.1613136","pmid":"https://pubmed.ncbi.nlm.nih.gov/41030501"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1613136","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1613136","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1613136/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1613136/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089507199","display_name":"Juan Zhou","orcid":"https://orcid.org/0000-0002-1066-1262"},"institutions":[{"id":"https://openalex.org/I4210091843","display_name":"Second People's Hospital of Yunnan Province","ror":"https://ror.org/00c639s42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091843"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Zhou","raw_affiliation_strings":["Department of Otolaryngology, Affliated Hospital of Yunnan University (Second People's Hospital of Yunnan Province, Yunnan Eye Hospital), Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Affliated Hospital of Yunnan University (Second People's Hospital of Yunnan Province, Yunnan Eye Hospital), Kunming, Yunnan, China","institution_ids":["https://openalex.org/I4210091843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332050","display_name":"Huan Wang","orcid":"https://orcid.org/0009-0006-7901-692X"},"institutions":[{"id":"https://openalex.org/I4210091843","display_name":"Second People's Hospital of Yunnan Province","ror":"https://ror.org/00c639s42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091843"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Wang","raw_affiliation_strings":["Department of Otolaryngology, Affliated Hospital of Yunnan University (Second People's Hospital of Yunnan Province, Yunnan Eye Hospital), Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Affliated Hospital of Yunnan University (Second People's Hospital of Yunnan Province, Yunnan Eye Hospital), Kunming, Yunnan, China","institution_ids":["https://openalex.org/I4210091843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100346163","display_name":"Jin Wang","orcid":"https://orcid.org/0000-0002-4924-1716"},"institutions":[{"id":"https://openalex.org/I4210091843","display_name":"Second People's Hospital of Yunnan Province","ror":"https://ror.org/00c639s42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091843"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Wang","raw_affiliation_strings":["Department of Otolaryngology, Affliated Hospital of Yunnan University (Second People's Hospital of Yunnan Province, Yunnan Eye Hospital), Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Affliated Hospital of Yunnan University (Second People's Hospital of Yunnan Province, Yunnan Eye Hospital), Kunming, Yunnan, China","institution_ids":["https://openalex.org/I4210091843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101387934","display_name":"Fuming Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I4210091843","display_name":"Second People's Hospital of Yunnan Province","ror":"https://ror.org/00c639s42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091843"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuming Zhou","raw_affiliation_strings":["Department of Otolaryngology, Affliated Hospital of Yunnan University (Second People's Hospital of Yunnan Province, Yunnan Eye Hospital), Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Affliated Hospital of Yunnan University (Second People's Hospital of Yunnan Province, Yunnan Eye Hospital), Kunming, Yunnan, China","institution_ids":["https://openalex.org/I4210091843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210091843"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29305341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"1613136","last_page":"1613136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.8363000154495239,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.8363000154495239,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"Macrophage polarization","score":0.5802000164985657},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.508899986743927},{"id":"https://openalex.org/keywords/macrophage","display_name":"Macrophage","score":0.41940000653266907},{"id":"https://openalex.org/keywords/chronic-sinusitis","display_name":"Chronic sinusitis","score":0.38429999351501465},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.3831000030040741},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"Pathogenesis","score":0.3804999887943268}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6820999979972839},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.5802000164985657},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.508899986743927},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4912000000476837},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.41940000653266907},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4000999927520752},{"id":"https://openalex.org/C2994554258","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Chronic sinusitis","level":3,"score":0.38429999351501465},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.3831000030040741},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3804999887943268},{"id":"https://openalex.org/C2777768476","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Sinusitis","level":2,"score":0.37389999628067017},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33230000734329224},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.263700008392334},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25529998540878296},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2524000108242035},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.25200000405311584},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.25119999051094055}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fbinf.2025.1613136","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1613136","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1613136/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41030501","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41030501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:99f4d2b89e4e47cd83634e93c9b5d7a9","is_oa":true,"landing_page_url":"https://doaj.org/article/99f4d2b89e4e47cd83634e93c9b5d7a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11285854","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12477252","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12477252","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12477252/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1613136","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1613136","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1613136/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324731","display_name":"Yunnan University","ror":"https://ror.org/0040axw97"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414189131.pdf","grobid_xml":"https://content.openalex.org/works/W4414189131.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1966327575","https://openalex.org/W2001357290","https://openalex.org/W2006617902","https://openalex.org/W2019355936","https://openalex.org/W2022899908","https://openalex.org/W2035618305","https://openalex.org/W2042808167","https://openalex.org/W2047765480","https://openalex.org/W2107277218","https://openalex.org/W2137746159","https://openalex.org/W2140573957","https://openalex.org/W2159707944","https://openalex.org/W2179438025","https://openalex.org/W2406159526","https://openalex.org/W2743925332","https://openalex.org/W2767823698","https://openalex.org/W2898849586","https://openalex.org/W2947836101","https://openalex.org/W3032966939","https://openalex.org/W3094220664","https://openalex.org/W3120796552","https://openalex.org/W3126614195","https://openalex.org/W3159532425","https://openalex.org/W3173931538","https://openalex.org/W3211239814","https://openalex.org/W4206839115","https://openalex.org/W4220858693","https://openalex.org/W4223927553","https://openalex.org/W4281786209","https://openalex.org/W4282597616","https://openalex.org/W4283511977","https://openalex.org/W4283725306","https://openalex.org/W4283819629","https://openalex.org/W4284964174","https://openalex.org/W4289943246","https://openalex.org/W4295185320","https://openalex.org/W4298086799","https://openalex.org/W4309614178","https://openalex.org/W4310828228","https://openalex.org/W4319787482","https://openalex.org/W4324128505","https://openalex.org/W4366770683","https://openalex.org/W4380201713","https://openalex.org/W4381093822","https://openalex.org/W4381435317","https://openalex.org/W4384938635","https://openalex.org/W4386561720","https://openalex.org/W4386979805","https://openalex.org/W4389328270","https://openalex.org/W4389433069","https://openalex.org/W4390175435","https://openalex.org/W4391218134","https://openalex.org/W4394921251","https://openalex.org/W4401590149","https://openalex.org/W4402581409","https://openalex.org/W4405109849","https://openalex.org/W4405131264","https://openalex.org/W4406869095"],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Macrophages":[1],"play":[2],"a":[3,237],"critical":[4],"role":[5,26],"in":[6,27,189,219,302,326,341],"chronic":[7,57],"rhinosinusitis":[8,58],"with":[9,59,102,186,231],"nasal":[10,60],"polyps":[11,61],"(CRSwNP),":[12],"and":[13,42,44,118,122,142,147,178,192,241,260,270,297,314,324,337],"their":[14,25,46],"functional":[15],"imbalance":[16],"may":[17],"cause":[18],"metabolic":[19],"disturbances.":[20],"However,":[21],"the":[22,139,156,169,261,275,291,306],"mechanisms":[23],"of":[24,56,172,239,251,266,294],"CRSwNP":[28,36,303],"remain":[29],"unclear.":[30],"This":[31],"study":[32],"aimed":[33],"to":[34,39,87,93,105,127,153,167,228,281,321],"identify":[35,88],"biomarkers":[37,183,215,225,257,319],"related":[38,92],"macrophage":[40,94,322],"polarization":[41,323],"metabolism,":[43],"elucidate":[45],"molecular":[47],"regulatory":[48],"mechanisms.":[49],"Methods:":[50],"In":[51],"this":[52],"study,":[53],"transcriptomic":[54],"data":[55],"(CRSwNP)":[62],"were":[63,72,99,145,180,226,258,272,299,316],"obtained":[64],"from":[65,308],"public":[66],"databases.":[67],"Differentially":[68],"expressed":[69],"genes":[70,91,96,104],"(DEGs)":[71],"screened":[73],"via":[74],"differential":[75],"expression":[76,149,170,292],"analysis.":[77],"Subsequently,":[78],"weighted":[79],"gene":[80,148],"co-expression":[81],"network":[82],"analysis":[83,211],"(WGCNA)":[84],"was":[85,151,165,234,279],"used":[86,166],"key":[89,253],"module":[90],"polarization-related":[95],"(MP-RGs),":[97],"which":[98],"then":[100],"cross-referenced":[101],"metabolism-related":[103],"screen":[106,129],"for":[107,138,184,247,333],"candidate":[108,131],"genes.":[109,132,174],"After":[110],"that,":[111],"two":[112],"machine":[113],"learning":[114],"methods-least":[115],"absolute":[116],"shrinkage":[117],"selection":[119],"operator":[120],"(LASSO)":[121],"random":[123],"forest":[124],"(RF)-were":[125],"applied":[126],"further":[128],"these":[130,203,214,256],"Receiver":[133],"operating":[134],"characteristic":[135],"(ROC)":[136],"curves":[137],"training":[140,191],"set":[141,144],"validation":[143,150,193],"constructed,":[146],"conducted":[152],"finally":[154],"determine":[155],"biomarkers.":[157,286],"Finally,":[158],"reverse":[159],"transcription-quantitative":[160],"polymerase":[161],"chain":[162],"reaction":[163],"(RT-qPCR)":[164],"verify":[168],"levels":[171,293],"prognostic":[173],"Results:":[175],"ALOX5,":[176,295,312],"HMOX1,":[177,242,296,313],"PLA2G7":[179,298,315],"identified":[181,235,317],"as":[182,236,318],"CRSwNP,":[185],"AUC":[187],">0.7":[188],"both":[190],"sets,":[194],"showing":[195],"strong":[196],"diagnostic":[197,208],"potential.":[198],"A":[199,249],"nomogram,":[200],"built":[201],"on":[202],"three":[204,224,285],"biomarkers,":[205],"exhibited":[206],"superior":[207],"performance.":[209],"Enrichment":[210],"suggested":[212],"that":[213,290],"might":[216],"be":[217,229],"implicated":[218],"immune":[220],"pathways.":[221],"Furthermore,":[222],"all":[223,284],"found":[227,280],"correlated":[230],"asthma.":[232],"Selenium":[233],"co-target":[238],"ALOX5":[240],"presenting":[243],"potential":[244],"therapeutic":[245],"targets":[246],"CRSwNP.":[248,327,342],"total":[250],"10":[252],"miRNAs":[254],"regulating":[255],"identified,":[259],"upstream":[262],"long":[263],"non-coding":[264],"RNAs":[265],"hsa-miR-642a-5p,":[267],"including":[268],"FOXC1":[269,278],"NEAT1,":[271],"predicted.":[273],"Additionally,":[274],"transcription":[276],"factor":[277],"concurrently":[282],"regulate":[283],"RT-qPCR":[287],"results":[288],"validated":[289],"significantly":[300],"elevated":[301],"patients,":[304],"corroborating":[305],"findings":[307,329],"bioinformatics":[309],"analyses.":[310],"Conclusion:":[311],"linked":[320],"metabolism":[325],"These":[328],"offer":[330],"new":[331],"insights":[332],"early":[334],"prevention":[335],"strategies":[336],"clinical":[338],"drug":[339],"development":[340]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
