{"id":"https://openalex.org/W4412686049","doi":"https://doi.org/10.3389/fbinf.2025.1599098","title":"Integrative machine learning and bioinformatics analysis to identify cellular senescence-related genes and potential therapeutic targets in ulcerative colitis and colorectal cancer","display_name":"Integrative machine learning and bioinformatics analysis to identify cellular senescence-related genes and potential therapeutic targets in ulcerative colitis and colorectal cancer","publication_year":2025,"publication_date":"2025-07-28","ids":{"openalex":"https://openalex.org/W4412686049","doi":"https://doi.org/10.3389/fbinf.2025.1599098","pmid":"https://pubmed.ncbi.nlm.nih.gov/40791849"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1599098","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1599098","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1599098/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1599098/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077505607","display_name":"Tianle Xue","orcid":null},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tianle Xue","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yunpeng Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yunpeng Chen","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109739832","display_name":"Xiaomeng Li","orcid":null},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xiaomeng Li","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101699535","display_name":"Zhi\u2010Xiang Zhou","orcid":"https://orcid.org/0000-0002-9366-0248"},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zhixiang Zhou","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042326787","display_name":"Qiyang Chen","orcid":"https://orcid.org/0000-0002-7804-8835"},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Qiyang Chen","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I181647926"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5077505607"],"corresponding_institution_ids":["https://openalex.org/I181647926"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2026539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"1599098","last_page":"1599098"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.980400025844574,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"Ulcerative colitis","score":0.8197269439697266},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.7605868577957153},{"id":"https://openalex.org/keywords/senescence","display_name":"Senescence","score":0.5925413370132446},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5606222152709961},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.5114561319351196},{"id":"https://openalex.org/keywords/colitis","display_name":"Colitis","score":0.4966750741004944},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4932984411716461},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4364873766899109},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29010334610939026},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.20251944661140442},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.14806607365608215},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14214980602264404}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8197269439697266},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7605868577957153},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5925413370132446},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5606222152709961},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5114561319351196},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4966750741004944},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4932984411716461},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4364873766899109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29010334610939026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20251944661140442},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14806607365608215},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14214980602264404}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1599098","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1599098","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1599098/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40791849","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40791849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:509a24a7dc714685a0fac9c7c4c72185","is_oa":true,"landing_page_url":"https://doaj.org/article/509a24a7dc714685a0fac9c7c4c72185","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12336176","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12336176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1599098","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1599098","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1599098/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4412686049.pdf"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1774257523","https://openalex.org/W1966327575","https://openalex.org/W1977301755","https://openalex.org/W1977982136","https://openalex.org/W1981538589","https://openalex.org/W2007534521","https://openalex.org/W2043232337","https://openalex.org/W2076433751","https://openalex.org/W2107665951","https://openalex.org/W2146512944","https://openalex.org/W2154149568","https://openalex.org/W2169353806","https://openalex.org/W2177605184","https://openalex.org/W2295124130","https://openalex.org/W2302003756","https://openalex.org/W2337307831","https://openalex.org/W2405484961","https://openalex.org/W2566227895","https://openalex.org/W2605674430","https://openalex.org/W2617184869","https://openalex.org/W2778455075","https://openalex.org/W2782216561","https://openalex.org/W2792605105","https://openalex.org/W2900523370","https://openalex.org/W2949821018","https://openalex.org/W2975349219","https://openalex.org/W2976543836","https://openalex.org/W3014402470","https://openalex.org/W3035710011","https://openalex.org/W3043996204","https://openalex.org/W3048264855","https://openalex.org/W3048754226","https://openalex.org/W3084409266","https://openalex.org/W3088630585","https://openalex.org/W3111260423","https://openalex.org/W3157583556","https://openalex.org/W3158265593","https://openalex.org/W3167095581","https://openalex.org/W3172239804","https://openalex.org/W3175752499","https://openalex.org/W3176078083","https://openalex.org/W3209170136","https://openalex.org/W4223500612","https://openalex.org/W4223559494","https://openalex.org/W4226455352","https://openalex.org/W4283268279","https://openalex.org/W4285236391","https://openalex.org/W4290704612","https://openalex.org/W4293747103","https://openalex.org/W4294865413","https://openalex.org/W4296445205","https://openalex.org/W4310046092","https://openalex.org/W4313531686","https://openalex.org/W4319923857","https://openalex.org/W4322769008","https://openalex.org/W4361298490","https://openalex.org/W4361298924","https://openalex.org/W4379966941","https://openalex.org/W4385164119","https://openalex.org/W4385262369","https://openalex.org/W4385270799","https://openalex.org/W4385699293","https://openalex.org/W4386392487","https://openalex.org/W4387744129","https://openalex.org/W4387904333","https://openalex.org/W4387996474","https://openalex.org/W4391568951","https://openalex.org/W4391842138","https://openalex.org/W4392926472","https://openalex.org/W4396898615","https://openalex.org/W4396907470","https://openalex.org/W4398208496","https://openalex.org/W4399331281","https://openalex.org/W4409424143"],"related_works":["https://openalex.org/W2378399001","https://openalex.org/W2381376498","https://openalex.org/W2393318770","https://openalex.org/W2369056725","https://openalex.org/W4385147599","https://openalex.org/W3151390891","https://openalex.org/W2391150797","https://openalex.org/W4224234790","https://openalex.org/W2363553858","https://openalex.org/W2363311716"],"abstract_inverted_index":{"This":[0],"study":[1],"provides":[2],"novel":[3],"insights":[4],"into":[5],"the":[6,13,34],"molecular":[7],"interplay":[8],"between":[9],"cellular":[10],"senescence":[11],"and":[12],"UC-to-CRC":[14],"transition.":[15],"The":[16],"identified":[17],"biomarkers":[18],"not":[19],"only":[20],"offer":[21],"strong":[22],"diagnostic":[23],"potential":[24],"but":[25],"also":[26],"represent":[27],"promising":[28],"targets":[29],"for":[30,36],"therapeutic":[31],"intervention,":[32],"paving":[33],"way":[35],"improved":[37],"clinical":[38],"management":[39],"of":[40],"UC-associated":[41],"CRC.":[42]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
