{"id":"https://openalex.org/W4410477866","doi":"https://doi.org/10.3389/fbinf.2025.1575790","title":"Integrative multi-omics study identifies sex-specific molecular signatures and immune modulation in bladder cancer","display_name":"Integrative multi-omics study identifies sex-specific molecular signatures and immune modulation in bladder cancer","publication_year":2025,"publication_date":"2025-05-19","ids":{"openalex":"https://openalex.org/W4410477866","doi":"https://doi.org/10.3389/fbinf.2025.1575790","pmid":"https://pubmed.ncbi.nlm.nih.gov/40458476"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1575790","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1575790","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1575790/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1575790/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100602401","display_name":"Yizhou Wang","orcid":"https://orcid.org/0000-0002-9378-745X"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yizhou Wang","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084570095","display_name":"Priyanka Bhandary","orcid":"https://orcid.org/0000-0002-6962-9638"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Bhandary","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109163188","display_name":"Kevin Griffin","orcid":null},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Griffin","raw_affiliation_strings":["Department of Medicine and Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA, United States","Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Medicine and Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032971510","display_name":"Jason H. Moore","orcid":"https://orcid.org/0000-0002-5015-1099"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason H. Moore","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031905569","display_name":"Xue Li","orcid":"https://orcid.org/0000-0001-9520-517X"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xue Li","raw_affiliation_strings":["Department of Medicine and Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA, United States","Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Medicine and Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076732420","display_name":"Zhiping Paul Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhiping Paul Wang","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5031905569","https://openalex.org/A5076732420"],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":7.1462,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.96938884,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"5","issue":null,"first_page":"1575790","last_page":"1575790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"Bladder cancer","score":0.631523072719574},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6171005368232727},{"id":"https://openalex.org/keywords/immune-modulation","display_name":"Immune modulation","score":0.5683860778808594},{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.55077064037323},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5037912726402283},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4233548939228058},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4213281273841858},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38695618510246277},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.20636406540870667},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17450520396232605}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.631523072719574},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6171005368232727},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.5683860778808594},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.55077064037323},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5037912726402283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4233548939228058},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4213281273841858},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38695618510246277},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20636406540870667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17450520396232605}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1575790","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1575790","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1575790/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40458476","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40458476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:c029c81b3b55457d9c9db7af21f55943","is_oa":true,"landing_page_url":"https://doaj.org/article/c029c81b3b55457d9c9db7af21f55943","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12127366","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12127366","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1575790","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1575790","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1575790/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410477866.pdf"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1476363707","https://openalex.org/W1587440546","https://openalex.org/W1967758891","https://openalex.org/W1976385056","https://openalex.org/W1978777696","https://openalex.org/W1988838227","https://openalex.org/W2017598170","https://openalex.org/W2023023921","https://openalex.org/W2027630547","https://openalex.org/W2039311888","https://openalex.org/W2064503485","https://openalex.org/W2083716686","https://openalex.org/W2101722671","https://openalex.org/W2114031931","https://openalex.org/W2115156555","https://openalex.org/W2132759801","https://openalex.org/W2150405576","https://openalex.org/W2160587188","https://openalex.org/W2176394836","https://openalex.org/W2196987736","https://openalex.org/W2291633071","https://openalex.org/W2589780548","https://openalex.org/W2607211817","https://openalex.org/W2736730167","https://openalex.org/W2742795257","https://openalex.org/W2755507863","https://openalex.org/W2766331571","https://openalex.org/W2790879859","https://openalex.org/W2795989238","https://openalex.org/W2801400022","https://openalex.org/W2810464703","https://openalex.org/W2896737957","https://openalex.org/W2909448282","https://openalex.org/W2910682475","https://openalex.org/W2910727202","https://openalex.org/W2935064944","https://openalex.org/W2952331527","https://openalex.org/W2965027567","https://openalex.org/W2980082898","https://openalex.org/W3012478583","https://openalex.org/W3012802534","https://openalex.org/W3016662185","https://openalex.org/W3025651971","https://openalex.org/W3082377769","https://openalex.org/W3084601559","https://openalex.org/W3108227758","https://openalex.org/W3120399356","https://openalex.org/W3132288715","https://openalex.org/W3208706270","https://openalex.org/W4205354551","https://openalex.org/W4207005453","https://openalex.org/W4214480352","https://openalex.org/W4220896278","https://openalex.org/W4223909987","https://openalex.org/W4284712897","https://openalex.org/W4284975205","https://openalex.org/W4285266962","https://openalex.org/W4290616347","https://openalex.org/W4309314698","https://openalex.org/W4315778645","https://openalex.org/W4362692393","https://openalex.org/W4384385587","https://openalex.org/W4385687295","https://openalex.org/W4385986528","https://openalex.org/W4386410563"],"related_works":["https://openalex.org/W177137871","https://openalex.org/W4292302930","https://openalex.org/W4386960635","https://openalex.org/W2594649246","https://openalex.org/W2924366642","https://openalex.org/W3184567430","https://openalex.org/W2582143511","https://openalex.org/W2386061805","https://openalex.org/W2518191767","https://openalex.org/W3195112886"],"abstract_inverted_index":{"These":[0],"findings":[1],"provide":[2],"new":[3],"insights":[4],"into":[5],"the":[6,18],"molecular":[7],"basis":[8],"of":[9],"sex":[10],"differences":[11],"in":[12],"bladder":[13],"cancer":[14],"and":[15,23,30],"could":[16],"pave":[17],"way":[19],"for":[20],"more":[21],"personalized":[22],"effective":[24],"therapeutic":[25],"strategies":[26],"tailored":[27],"to":[28],"male":[29],"female":[31],"patients.":[32]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
