{"id":"https://openalex.org/W4412100260","doi":"https://doi.org/10.3389/fbinf.2025.1566162","title":"Using deep neural networks and LASSO regression to predict miRNA expression changes based on mRNA data","display_name":"Using deep neural networks and LASSO regression to predict miRNA expression changes based on mRNA data","publication_year":2025,"publication_date":"2025-07-08","ids":{"openalex":"https://openalex.org/W4412100260","doi":"https://doi.org/10.3389/fbinf.2025.1566162","pmid":"https://pubmed.ncbi.nlm.nih.gov/40698341"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1566162","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1566162","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1566162/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1566162/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068079731","display_name":"Franz L. B\u00f6ge","orcid":null},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franz Leonard B\u00f6ge","raw_affiliation_strings":["Institute for Animal Genomics, University of Veterinary Medicine Hannover Foundation, Hannover, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Animal Genomics, University of Veterinary Medicine Hannover Foundation, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091597117","display_name":"Helena U. Zacharias","orcid":"https://orcid.org/0000-0003-3633-1330"},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I94509681","display_name":"Technische Universit\u00e4t Braunschweig","ror":"https://ror.org/010nsgg66","country_code":"DE","type":"education","lineage":["https://openalex.org/I94509681"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helena U. Zacharias","raw_affiliation_strings":["Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School, Hannover Medical School, Hannover, Germany"],"affiliations":[{"raw_affiliation_string":"Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795","https://openalex.org/I94509681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085954168","display_name":"Stefanie Becker","orcid":"https://orcid.org/0000-0003-1207-8924"},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie C. Becker","raw_affiliation_strings":["Institute of Parasitology, University of Veterinary Medicine Hannover Foundation, Hannover, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Parasitology, University of Veterinary Medicine Hannover Foundation, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018032600","display_name":"Klaus Jung","orcid":"https://orcid.org/0000-0001-9955-748X"},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Klaus Jung","raw_affiliation_strings":["Institute for Animal Genomics, University of Veterinary Medicine Hannover Foundation, Hannover, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Animal Genomics, University of Veterinary Medicine Hannover Foundation, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018032600"],"corresponding_institution_ids":["https://openalex.org/I189991"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22333786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"1566162","last_page":"1566162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.6940279006958008},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.5608108043670654},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5581445097923279},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5065480470657349},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4938991665840149},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4809107780456543},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.46997231245040894},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.412497341632843},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3809010684490204},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3409460186958313},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3388691246509552},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33531683683395386},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2556275427341461},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18708032369613647},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18384087085723877},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13382691144943237}],"concepts":[{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.6940279006958008},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.5608108043670654},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5581445097923279},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5065480470657349},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4938991665840149},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4809107780456543},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.46997231245040894},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.412497341632843},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3809010684490204},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3409460186958313},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3388691246509552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33531683683395386},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2556275427341461},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18708032369613647},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18384087085723877},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13382691144943237},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1566162","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1566162","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1566162/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40698341","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40698341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:263a23f3fa5c46b8934f5bdc0505bc96","is_oa":true,"landing_page_url":"https://doaj.org/article/263a23f3fa5c46b8934f5bdc0505bc96","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11091696","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12279838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1566162","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1566162","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1566162/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4412100260.pdf"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W282221905","https://openalex.org/W349163361","https://openalex.org/W1964904043","https://openalex.org/W1972898510","https://openalex.org/W2013282470","https://openalex.org/W2038622868","https://openalex.org/W2046611619","https://openalex.org/W2109227959","https://openalex.org/W2128985829","https://openalex.org/W2135046866","https://openalex.org/W2137526110","https://openalex.org/W2138664009","https://openalex.org/W2143091387","https://openalex.org/W2146512944","https://openalex.org/W2149748804","https://openalex.org/W2163263839","https://openalex.org/W2167742986","https://openalex.org/W2208438326","https://openalex.org/W2341128841","https://openalex.org/W2418706671","https://openalex.org/W2588839509","https://openalex.org/W2785792383","https://openalex.org/W2811212358","https://openalex.org/W2891816174","https://openalex.org/W2918283874","https://openalex.org/W3094015473","https://openalex.org/W3100788068","https://openalex.org/W3159614651","https://openalex.org/W3165233449","https://openalex.org/W3184975152","https://openalex.org/W3191661929","https://openalex.org/W3213224786","https://openalex.org/W4200003890","https://openalex.org/W4200062847","https://openalex.org/W4205089140","https://openalex.org/W4210643453","https://openalex.org/W4213420809","https://openalex.org/W4225369431","https://openalex.org/W4252328106","https://openalex.org/W4254867250","https://openalex.org/W4293192215","https://openalex.org/W4297157124","https://openalex.org/W4387344289","https://openalex.org/W4399793343","https://openalex.org/W4400323905","https://openalex.org/W4401327032","https://openalex.org/W4406569944","https://openalex.org/W4410642310","https://openalex.org/W6611713518"],"related_works":["https://openalex.org/W4256576576","https://openalex.org/W3090384609","https://openalex.org/W3194013178","https://openalex.org/W2737319532","https://openalex.org/W4392896533","https://openalex.org/W2062945643","https://openalex.org/W4249086404","https://openalex.org/W1515021623","https://openalex.org/W3155171010","https://openalex.org/W2119862467"],"abstract_inverted_index":{"Overall,":[0],"cross-omics":[1],"prediction":[2],"of":[3,15],"expression":[4,18],"profiles":[5],"appears":[6],"possible,":[7],"even":[8],"with":[9],"some":[10],"correlations":[11],"on":[12],"the":[13,16],"Level":[14],"differential":[17],"analysis.":[19]},"counts_by_year":[],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}