{"id":"https://openalex.org/W4409466436","doi":"https://doi.org/10.3389/fbinf.2025.1562596","title":"Identification of novel drug targets and small molecule discovery for MRSA infections","display_name":"Identification of novel drug targets and small molecule discovery for MRSA infections","publication_year":2025,"publication_date":"2025-04-15","ids":{"openalex":"https://openalex.org/W4409466436","doi":"https://doi.org/10.3389/fbinf.2025.1562596","pmid":"https://pubmed.ncbi.nlm.nih.gov/40303563"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1562596","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1562596","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1562596/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1562596/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106401264","display_name":"Nandha Kumar Subramani","orcid":null},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Nandha Kumar Subramani","raw_affiliation_strings":["School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016444065","display_name":"Subhashree Venugopal","orcid":"https://orcid.org/0000-0001-7713-5737"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhashree Venugopal","raw_affiliation_strings":["School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India","institution_ids":["https://openalex.org/I876193797"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5106401264"],"corresponding_institution_ids":["https://openalex.org/I876193797"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":8.0879,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.97505605,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"5","issue":null,"first_page":"1562596","last_page":"1562596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virulence","display_name":"Virulence","score":0.7754859924316406},{"id":"https://openalex.org/keywords/vancomycin","display_name":"Vancomycin","score":0.7200624942779541},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.5294473171234131},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"Methicillin-resistant Staphylococcus aureus","score":0.5176863670349121},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.4539780616760254},{"id":"https://openalex.org/keywords/flavonoid","display_name":"Flavonoid","score":0.44728487730026245},{"id":"https://openalex.org/keywords/virulence-factor","display_name":"Virulence factor","score":0.43041083216667175},{"id":"https://openalex.org/keywords/catechin","display_name":"Catechin","score":0.4267692565917969},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4244758188724518},{"id":"https://openalex.org/keywords/lipid-ii","display_name":"Lipid II","score":0.42312535643577576},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.41336938738822937},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3153529167175293},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.27876904606819153},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.22048845887184143},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.21573984622955322},{"id":"https://openalex.org/keywords/polyphenol","display_name":"Polyphenol","score":0.2095785140991211},{"id":"https://openalex.org/keywords/antioxidant","display_name":"Antioxidant","score":0.14563703536987305},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08959388732910156},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.08936309814453125},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07028830051422119}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7754859924316406},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.7200624942779541},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5294473171234131},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.5176863670349121},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4539780616760254},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.44728487730026245},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.43041083216667175},{"id":"https://openalex.org/C2779431889","wikidata":"https://www.wikidata.org/wiki/Q415007","display_name":"Catechin","level":4,"score":0.4267692565917969},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4244758188724518},{"id":"https://openalex.org/C2780183148","wikidata":"https://www.wikidata.org/wiki/Q21099571","display_name":"Lipid II","level":4,"score":0.42312535643577576},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41336938738822937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3153529167175293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27876904606819153},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22048845887184143},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.21573984622955322},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.2095785140991211},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.14563703536987305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08959388732910156},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08936309814453125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07028830051422119},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1562596","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1562596","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1562596/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40303563","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40303563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:0ea1fcd453c84e49b6ecb59010b17f27","is_oa":true,"landing_page_url":"https://doaj.org/article/0ea1fcd453c84e49b6ecb59010b17f27","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12037569","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12037569","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1562596","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1562596","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1562596/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.5799999833106995}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4409466436.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W562504","https://openalex.org/W1965517743","https://openalex.org/W1979790785","https://openalex.org/W1992192767","https://openalex.org/W2080948893","https://openalex.org/W2097606916","https://openalex.org/W2131044539","https://openalex.org/W2134967712","https://openalex.org/W2162792752","https://openalex.org/W2169678694","https://openalex.org/W2560776032","https://openalex.org/W2568617656","https://openalex.org/W2739691438","https://openalex.org/W2746592319","https://openalex.org/W2793515214","https://openalex.org/W2793873332","https://openalex.org/W2804822363","https://openalex.org/W2942853171","https://openalex.org/W2980822327","https://openalex.org/W3082710850","https://openalex.org/W3085737697","https://openalex.org/W3097378887","https://openalex.org/W3157356791","https://openalex.org/W3181242121","https://openalex.org/W3188686653","https://openalex.org/W3197806189","https://openalex.org/W3202287440","https://openalex.org/W3215508572","https://openalex.org/W4211032563","https://openalex.org/W4214516091","https://openalex.org/W4284990487","https://openalex.org/W4289936604","https://openalex.org/W4295204163","https://openalex.org/W4308834893","https://openalex.org/W4312177281","https://openalex.org/W4312195067","https://openalex.org/W4315488180","https://openalex.org/W4318395099","https://openalex.org/W4324145929","https://openalex.org/W4367050591","https://openalex.org/W4378070678","https://openalex.org/W4386259256","https://openalex.org/W4386347549","https://openalex.org/W4386758612","https://openalex.org/W4388615774","https://openalex.org/W4388944994","https://openalex.org/W4399753945","https://openalex.org/W4401521261","https://openalex.org/W4402010657","https://openalex.org/W7052092799"],"related_works":["https://openalex.org/W3011335140","https://openalex.org/W2177308390","https://openalex.org/W2975863253","https://openalex.org/W2605052975","https://openalex.org/W2026584619","https://openalex.org/W2102230668","https://openalex.org/W2020869136","https://openalex.org/W1980145079","https://openalex.org/W2146325980","https://openalex.org/W2143933546"],"abstract_inverted_index":{"These":[0],"potential":[1],"findings":[2],"revealed":[3],"that":[4,25],"heme":[5],"response":[6],"regulator":[7],"R":[8],"as":[9,21],"a":[10],"promising":[11],"therapeutic":[12,23],"target":[13,26],"while":[14],"the":[15],"flavonoid":[16],"compound":[17],"catechin":[18],"could":[19],"act":[20],"alternative":[22],"inhibitor":[24],"MRSA":[27],"infections.":[28]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}