{"id":"https://openalex.org/W4408873419","doi":"https://doi.org/10.3389/fbinf.2025.1544800","title":"Streptomyces sp. VITGV156 secondary metabolite binds pathogenic protein PBP2a and Beta-lactamase","display_name":"Streptomyces sp. VITGV156 secondary metabolite binds pathogenic protein PBP2a and Beta-lactamase","publication_year":2025,"publication_date":"2025-03-26","ids":{"openalex":"https://openalex.org/W4408873419","doi":"https://doi.org/10.3389/fbinf.2025.1544800","pmid":"https://pubmed.ncbi.nlm.nih.gov/40206635"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1544800","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1544800","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1544800/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1544800/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116603179","display_name":"Veilumuthu Pattapulavar","orcid":null},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Veilumuthu Pattapulavar","raw_affiliation_strings":["Department of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116811403","display_name":"Sathiyabama Ramanujam","orcid":null},"institutions":[{"id":"https://openalex.org/I65220239","display_name":"Karpagam Academy of Higher Education","ror":"https://ror.org/00ssvzv66","country_code":"IN","type":"education","lineage":["https://openalex.org/I65220239"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sathiyabama Ramanujam","raw_affiliation_strings":["Department of Science and Humanities, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"Department of Science and Humanities, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India","institution_ids":["https://openalex.org/I65220239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004852403","display_name":"Manisha R. Shah","orcid":"https://orcid.org/0000-0002-0704-9224"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manisha Shah","raw_affiliation_strings":["Department of Bio-Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India"],"affiliations":[{"raw_affiliation_string":"Department of Bio-Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102004243","display_name":"Muthu Kumar Thirunavukkarasu","orcid":"https://orcid.org/0000-0001-8021-222X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muthu Kumar Thirunavukkarasu","raw_affiliation_strings":["School of Sciences and Humanities, SR University, Warangal, Telangana, India"],"affiliations":[{"raw_affiliation_string":"School of Sciences and Humanities, SR University, Warangal, Telangana, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101864088","display_name":"Sivakumar Arumugam","orcid":"https://orcid.org/0000-0001-8834-8834"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sivakumar Arumugam","raw_affiliation_strings":["Department of Bio-Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India"],"affiliations":[{"raw_affiliation_string":"Department of Bio-Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ramanathan Karuppasamy","orcid":null},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramanathan Karuppasamy","raw_affiliation_strings":["Department of Biotechnology, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017390077","display_name":"Antony V. Samrot","orcid":"https://orcid.org/0000-0001-9536-0567"},"institutions":[{"id":"https://openalex.org/I4210121274","display_name":"Manipal University College Malaysia","ror":"https://ror.org/02z88n164","country_code":"MY","type":"education","lineage":["https://openalex.org/I4210121274"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Antony V. Samrot","raw_affiliation_strings":["Department of Microbiology, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia","institution_ids":["https://openalex.org/I4210121274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011846048","display_name":"K. Deepasree","orcid":null},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. Deepasree","raw_affiliation_strings":["Department of Integrative Biology, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India"],"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016444065","display_name":"Subhashree Venugopal","orcid":"https://orcid.org/0000-0001-7713-5737"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhashree Venugopal","raw_affiliation_strings":["Department of Integrative Biology, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India"],"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048792738","display_name":"J. Godwin Christopher","orcid":"https://orcid.org/0000-0002-9328-983X"},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"John Godwin Christopher","raw_affiliation_strings":["Department of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India","institution_ids":["https://openalex.org/I876193797"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5048792738"],"corresponding_institution_ids":["https://openalex.org/I876193797"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":2.4902,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.8699614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"5","issue":null,"first_page":"1544800","last_page":"1544800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.6723398566246033},{"id":"https://openalex.org/keywords/antimicrobial","display_name":"Antimicrobial","score":0.5314542055130005},{"id":"https://openalex.org/keywords/secondary-metabolite","display_name":"Secondary metabolite","score":0.49256259202957153},{"id":"https://openalex.org/keywords/adme","display_name":"ADME","score":0.49218741059303284},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47151127457618713},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.45450904965400696},{"id":"https://openalex.org/keywords/secondary-metabolism","display_name":"Secondary metabolism","score":0.43800145387649536},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.42734280228614807},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3978993594646454},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.2940157949924469},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.27085864543914795},{"id":"https://openalex.org/keywords/biosynthesis","display_name":"Biosynthesis","score":0.19612562656402588},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.18003243207931519},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.16226139664649963},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15013709664344788}],"concepts":[{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.6723398566246033},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5314542055130005},{"id":"https://openalex.org/C2777347573","wikidata":"https://www.wikidata.org/wiki/Q522244","display_name":"Secondary metabolite","level":3,"score":0.49256259202957153},{"id":"https://openalex.org/C69366308","wikidata":"https://www.wikidata.org/wiki/Q2272286","display_name":"ADME","level":3,"score":0.49218741059303284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47151127457618713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45450904965400696},{"id":"https://openalex.org/C2777157883","wikidata":"https://www.wikidata.org/wiki/Q3360529","display_name":"Secondary metabolism","level":4,"score":0.43800145387649536},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.42734280228614807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3978993594646454},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2940157949924469},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.27085864543914795},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.19612562656402588},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18003243207931519},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16226139664649963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15013709664344788},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1544800","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1544800","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1544800/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40206635","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40206635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a9c9cc11fe7c47faacdcdc004e1754fd","is_oa":true,"landing_page_url":"https://doaj.org/article/a9c9cc11fe7c47faacdcdc004e1754fd","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11979255","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11979255","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1544800","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1544800","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1544800/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4408873419.pdf"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W64438412","https://openalex.org/W1513678377","https://openalex.org/W1867142858","https://openalex.org/W1979754402","https://openalex.org/W1986322731","https://openalex.org/W1995304732","https://openalex.org/W1995510650","https://openalex.org/W2029082748","https://openalex.org/W2052567202","https://openalex.org/W2083104750","https://openalex.org/W2103517584","https://openalex.org/W2127096898","https://openalex.org/W2143200335","https://openalex.org/W2162854463","https://openalex.org/W2163184780","https://openalex.org/W2171716692","https://openalex.org/W2178324140","https://openalex.org/W2416695193","https://openalex.org/W2568617656","https://openalex.org/W2576924213","https://openalex.org/W2727419071","https://openalex.org/W2785455203","https://openalex.org/W2799524357","https://openalex.org/W2803753687","https://openalex.org/W2877507873","https://openalex.org/W2892097685","https://openalex.org/W2892276868","https://openalex.org/W2898293688","https://openalex.org/W2924306915","https://openalex.org/W2944645675","https://openalex.org/W2964458079","https://openalex.org/W2977469515","https://openalex.org/W3018076926","https://openalex.org/W3021428226","https://openalex.org/W3113703065","https://openalex.org/W3124639514","https://openalex.org/W3126693634","https://openalex.org/W3147328417","https://openalex.org/W3156456685","https://openalex.org/W3161596995","https://openalex.org/W3170752557","https://openalex.org/W3204218092","https://openalex.org/W4210603860","https://openalex.org/W4210743324","https://openalex.org/W4213459687","https://openalex.org/W4225361514","https://openalex.org/W4307058238","https://openalex.org/W4307190168","https://openalex.org/W4312048455","https://openalex.org/W4367301620","https://openalex.org/W4376871742","https://openalex.org/W4382814985","https://openalex.org/W4382993701","https://openalex.org/W4391131438","https://openalex.org/W4392137905","https://openalex.org/W4399295897","https://openalex.org/W6646737114"],"related_works":["https://openalex.org/W2036012616","https://openalex.org/W4293221075","https://openalex.org/W2443036239","https://openalex.org/W2938607100","https://openalex.org/W3030716531","https://openalex.org/W2015381774","https://openalex.org/W4388722323","https://openalex.org/W2609970963","https://openalex.org/W3040659072","https://openalex.org/W3048064645"],"abstract_inverted_index":{"The":[0,20],"genomic":[1],"and":[2,26,42,52],"bioactive":[3,27],"analysis":[4],"of":[5,16,22],"<i>Streptomyces</i>":[6],"sp.":[7],"VITGV156":[8],"highlights":[9],"its":[10,31],"potential":[11],"as":[12],"a":[13],"valuable":[14],"source":[15],"novel":[17],"antimicrobial":[18],"agents.":[19],"identification":[21],"unique":[23],"biosynthetic":[24],"genes":[25],"secondary":[28],"metabolites":[29],"suggests":[30],"possible":[32],"application":[33],"in":[34,43],"combating":[35],"multidrug-resistant":[36],"pathogens.":[37],"Further":[38],"studies,":[39],"including":[40],"purification":[41],"vivo":[44],"testing,":[45],"are":[46],"necessary":[47],"to":[48],"validate":[49],"these":[50],"findings":[51],"explore":[53],"their":[54],"therapeutic":[55],"potential.":[56]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-03-27T00:00:00"}