{"id":"https://openalex.org/W4407555536","doi":"https://doi.org/10.3389/fbinf.2025.1533983","title":"Unlocking the potential of in silico approach in designing antibodies against SARS-CoV-2","display_name":"Unlocking the potential of in silico approach in designing antibodies against SARS-CoV-2","publication_year":2025,"publication_date":"2025-02-13","ids":{"openalex":"https://openalex.org/W4407555536","doi":"https://doi.org/10.3389/fbinf.2025.1533983","pmid":"https://pubmed.ncbi.nlm.nih.gov/40017562"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1533983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1533983","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1533983/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1533983/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114207866","display_name":"Tasshitra R. Subramaniam","orcid":null},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Tasshitra Subramaniam","raw_affiliation_strings":["Biomedical Engineering and Health Sciences Department, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering and Health Sciences Department, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017986891","display_name":"Siti Aisyah Mualif","orcid":"https://orcid.org/0000-0001-6742-3364"},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Siti Aisyah Mualif","raw_affiliation_strings":["Advanced Diagnostics and Progressive Human Care, Biomedical Engineering and Health Sciences Department, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia","Biomedical Engineering and Health Sciences Department, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia"],"affiliations":[{"raw_affiliation_string":"Advanced Diagnostics and Progressive Human Care, Biomedical Engineering and Health Sciences Department, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]},{"raw_affiliation_string":"Biomedical Engineering and Health Sciences Department, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047121335","display_name":"Weng Howe Chan","orcid":"https://orcid.org/0000-0003-0612-3661"},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Weng Howe Chan","raw_affiliation_strings":["Faculty of Computing, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia"],"affiliations":[{"raw_affiliation_string":"Faculty of Computing, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059659621","display_name":"Khairul Bariyyah Abd Halim","orcid":null},"institutions":[{"id":"https://openalex.org/I4164984","display_name":"International Islamic University Malaysia","ror":"https://ror.org/03s9hs139","country_code":"MY","type":"education","lineage":["https://openalex.org/I4164984"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Khairul Bariyyah Abd Halim","raw_affiliation_strings":["Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, Malaysia","Research Unit for Bioinformatics and Computational Biology (RUBIC), Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, Malaysia"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, Malaysia","institution_ids":["https://openalex.org/I4164984"]},{"raw_affiliation_string":"Research Unit for Bioinformatics and Computational Biology (RUBIC), Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, Malaysia","institution_ids":["https://openalex.org/I4164984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017986891"],"corresponding_institution_ids":["https://openalex.org/I4576418"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":2.4405,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.86249379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"5","issue":null,"first_page":"1533983","last_page":"1533983"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8134493827819824},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.5555744171142578},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.5382295846939087},{"id":"https://openalex.org/keywords/safeguarding","display_name":"Safeguarding","score":0.5343460440635681},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4753924608230591},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.467840313911438},{"id":"https://openalex.org/keywords/pandemic","display_name":"Pandemic","score":0.45375868678092957},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43060582876205444},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27726712822914124},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.24147140979766846},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24104788899421692},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.18860343098640442},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.1481161117553711}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8134493827819824},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5555744171142578},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5382295846939087},{"id":"https://openalex.org/C2776743756","wikidata":"https://www.wikidata.org/wiki/Q5097921","display_name":"Safeguarding","level":2,"score":0.5343460440635681},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4753924608230591},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.467840313911438},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.45375868678092957},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43060582876205444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27726712822914124},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24147140979766846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24104788899421692},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.18860343098640442},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1481161117553711},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fbinf.2025.1533983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1533983","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1533983/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40017562","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40017562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:generic.eprints.org:123805","is_oa":true,"landing_page_url":null,"pdf_url":"http://irep.iium.edu.my/123805/8/123805_Unlocking%20the%20potential_Scopus.pdf","source":{"id":"https://openalex.org/S4306400713","display_name":"The International Islamic University Malaysia Repository (The International Islamic University Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4164984","host_organization_name":"International Islamic University Malaysia","host_organization_lineage":["https://openalex.org/I4164984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:pubmedcentral.nih.gov:11865036","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11865036","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11865036/pdf/fbinf-05-1533983.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cc3b0bdfdd1a47aa8cc8e5ab64458019","is_oa":true,"landing_page_url":"https://doaj.org/article/cc3b0bdfdd1a47aa8cc8e5ab64458019","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1533983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1533983","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1533983/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.550000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407555536.pdf","grobid_xml":"https://content.openalex.org/works/W4407555536.grobid-xml"},"referenced_works_count":133,"referenced_works":["https://openalex.org/W1484092314","https://openalex.org/W1855237549","https://openalex.org/W1872459230","https://openalex.org/W1966041739","https://openalex.org/W1969407832","https://openalex.org/W1981021420","https://openalex.org/W1982481323","https://openalex.org/W1982679430","https://openalex.org/W2005140643","https://openalex.org/W2019691413","https://openalex.org/W2029667189","https://openalex.org/W2030522563","https://openalex.org/W2060809301","https://openalex.org/W2065283382","https://openalex.org/W2075460992","https://openalex.org/W2101375662","https://openalex.org/W2132262459","https://openalex.org/W2133712572","https://openalex.org/W2147993766","https://openalex.org/W2153983456","https://openalex.org/W2154135618","https://openalex.org/W2171268876","https://openalex.org/W2474661075","https://openalex.org/W2572080171","https://openalex.org/W2739999456","https://openalex.org/W2743395618","https://openalex.org/W2899341761","https://openalex.org/W2940763506","https://openalex.org/W2945172910","https://openalex.org/W2972674028","https://openalex.org/W2974982237","https://openalex.org/W2980681402","https://openalex.org/W2981124539","https://openalex.org/W2994449811","https://openalex.org/W2995502823","https://openalex.org/W3003657470","https://openalex.org/W3009199988","https://openalex.org/W3017045680","https://openalex.org/W3020409391","https://openalex.org/W3024091762","https://openalex.org/W3027630905","https://openalex.org/W3033035693","https://openalex.org/W3038984769","https://openalex.org/W3048109295","https://openalex.org/W3089439163","https://openalex.org/W3091822454","https://openalex.org/W3106608798","https://openalex.org/W3106972875","https://openalex.org/W3108975412","https://openalex.org/W3110098045","https://openalex.org/W3112867477","https://openalex.org/W3113435490","https://openalex.org/W3117549579","https://openalex.org/W3125686621","https://openalex.org/W3137229984","https://openalex.org/W3158544128","https://openalex.org/W3161380845","https://openalex.org/W3163488943","https://openalex.org/W3166262177","https://openalex.org/W3166352703","https://openalex.org/W3183931249","https://openalex.org/W3187474504","https://openalex.org/W3195375135","https://openalex.org/W3196609471","https://openalex.org/W3197623424","https://openalex.org/W3201869122","https://openalex.org/W3202951415","https://openalex.org/W3208583661","https://openalex.org/W3212079140","https://openalex.org/W3215498386","https://openalex.org/W4200315607","https://openalex.org/W4205100034","https://openalex.org/W4205927326","https://openalex.org/W4206311027","https://openalex.org/W4206365084","https://openalex.org/W4207077414","https://openalex.org/W4211045835","https://openalex.org/W4213149192","https://openalex.org/W4220738744","https://openalex.org/W4221092123","https://openalex.org/W4221120989","https://openalex.org/W4221140111","https://openalex.org/W4225285785","https://openalex.org/W4225575973","https://openalex.org/W4225974076","https://openalex.org/W4235848672","https://openalex.org/W4236072577","https://openalex.org/W4282924213","https://openalex.org/W4283258959","https://openalex.org/W4285392187","https://openalex.org/W4287447177","https://openalex.org/W4292450768","https://openalex.org/W4293198902","https://openalex.org/W4296035370","https://openalex.org/W4307280721","https://openalex.org/W4307593309","https://openalex.org/W4309420179","https://openalex.org/W4311271652","https://openalex.org/W4312141234","https://openalex.org/W4312392534","https://openalex.org/W4313397207","https://openalex.org/W4319596267","https://openalex.org/W4320717226","https://openalex.org/W4321112414","https://openalex.org/W4321788270","https://openalex.org/W4362510922","https://openalex.org/W4362579800","https://openalex.org/W4366692324","https://openalex.org/W4366991204","https://openalex.org/W4367054712","https://openalex.org/W4367680230","https://openalex.org/W4379768875","https://openalex.org/W4380761328","https://openalex.org/W4381278943","https://openalex.org/W4384662277","https://openalex.org/W4385654864","https://openalex.org/W4385950555","https://openalex.org/W4386713035","https://openalex.org/W4387899566","https://openalex.org/W4390727868","https://openalex.org/W4390742285","https://openalex.org/W4391145040","https://openalex.org/W4391265541","https://openalex.org/W4391685139","https://openalex.org/W4392015576","https://openalex.org/W4392745541","https://openalex.org/W4393235402","https://openalex.org/W4399053249","https://openalex.org/W4399491411","https://openalex.org/W4402066505","https://openalex.org/W4404743845","https://openalex.org/W6629186764","https://openalex.org/W6852853001"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2935909890","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W1531601525","https://openalex.org/W2374550342"],"abstract_inverted_index":{"Antibodies":[0],"are":[1,101],"naturally":[2],"produced":[3,21],"safeguarding":[4],"proteins":[5],"that":[6],"the":[7,31,44,70],"immune":[8],"system":[9],"generates":[10],"to":[11,25,48,157,172,194],"fight":[12],"against":[13,83],"invasive":[14],"invaders.":[15],"For":[16],"centuries,":[17],"they":[18],"have":[19,40,169],"been":[20],"artificially":[22],"and":[23,51,81,92,98,104,114,134,149,175,188],"utilized":[24],"eradicate":[26],"various":[27],"infectious":[28],"diseases.":[29],"Given":[30],"ongoing":[32],"threat":[33],"posed":[34],"by":[35,88,190],"COVID-19":[36],"pandemics":[37],"worldwide,":[38],"antibodies":[39,77,100,168,185],"become":[41],"one":[42],"of":[43,54,72,165],"most":[45],"promising":[46],"treatments":[47],"prevent":[49],"infection":[50],"save":[52],"millions":[53],"lives.":[55],"Currently,":[56],"<i>in":[57,107,144,166],"silico</i>":[58,108],"techniques":[59,75],"provide":[60],"an":[61],"innovative":[62],"approach":[63,109],"for":[64,96,117,153,200],"developing":[65,99],"antibodies,":[66,120],"which":[67],"significantly":[68],"impacts":[69],"formulation":[71],"antibodies.":[73],"These":[74],"develop":[76,183],"with":[78,124],"great":[79],"specificity":[80],"potency":[82],"diseases":[84],"such":[85],"as":[86],"SARS-CoV-2":[87,184],"using":[89],"computational":[90,198],"tools":[91],"algorithms.":[93],"Conventional":[94],"methods":[95],"designing":[97],"frequently":[102],"costly":[103],"time-consuming.":[105],"However,":[106],"offers":[110],"a":[111,137,162],"contemporary,":[112],"effective,":[113],"economical":[115],"paradigm":[116],"creating":[118],"next-generation":[119],"especially":[121],"in":[122,127],"accordance":[123],"recent":[125],"developments":[126],"bioinformatics.":[128],"By":[129],"utilizing":[130],"multiple":[131],"antibody":[132,139,151,201],"databases":[133],"high-throughput":[135],"approaches,":[136],"unique":[138],"construct":[140],"can":[141],"be":[142],"designed":[143],"silico</i>,":[145],"facilitating":[146],"accurate,":[147],"reliable,":[148],"secure":[150],"development":[152],"human":[154],"use.":[155],"Compared":[156],"their":[158],"traditionally":[159],"developed":[160],"equivalents,":[161],"large":[163],"number":[164],"silico</i>-designed":[167],"advanced":[170],"swiftly":[171],"clinical":[173],"trials":[174],"became":[176],"accessible":[177],"sooner.":[178],"This":[179],"article":[180],"helps":[181],"researchers":[182],"more":[186],"quickly":[187],"affordably":[189],"giving":[191],"them":[192],"access":[193],"current":[195],"information":[196],"on":[197],"approaches":[199],"creation.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}