{"id":"https://openalex.org/W4407230074","doi":"https://doi.org/10.3389/fbinf.2025.1499255","title":"Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications","display_name":"Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications","publication_year":2025,"publication_date":"2025-02-06","ids":{"openalex":"https://openalex.org/W4407230074","doi":"https://doi.org/10.3389/fbinf.2025.1499255","pmid":"https://pubmed.ncbi.nlm.nih.gov/39996053"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1499255","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1499255","pdf_url":null,"source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fbinf.2025.1499255","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116182141","display_name":"Miriam E. L. Gakpey","orcid":null},"institutions":[{"id":"https://openalex.org/I4210091910","display_name":"Noguchi Memorial Institute for Medical Research","ror":"https://ror.org/00f1qr933","country_code":"GH","type":"nonprofit","lineage":["https://openalex.org/I138690464","https://openalex.org/I4210091910"]},{"id":"https://openalex.org/I138690464","display_name":"University of Ghana","ror":"https://ror.org/01r22mr83","country_code":"GH","type":"education","lineage":["https://openalex.org/I138690464"]}],"countries":["GH"],"is_corresponding":true,"raw_author_name":"Miriam E. L. Gakpey","raw_affiliation_strings":["Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana","institution_ids":["https://openalex.org/I4210091910","https://openalex.org/I138690464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116182143","display_name":"Shadrack A. Aidoo","orcid":null},"institutions":[{"id":"https://openalex.org/I138690464","display_name":"University of Ghana","ror":"https://ror.org/01r22mr83","country_code":"GH","type":"education","lineage":["https://openalex.org/I138690464"]},{"id":"https://openalex.org/I4210091910","display_name":"Noguchi Memorial Institute for Medical Research","ror":"https://ror.org/00f1qr933","country_code":"GH","type":"nonprofit","lineage":["https://openalex.org/I138690464","https://openalex.org/I4210091910"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Shadrack A. Aidoo","raw_affiliation_strings":["Department of Virology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"],"affiliations":[{"raw_affiliation_string":"Department of Virology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana","institution_ids":["https://openalex.org/I4210091910","https://openalex.org/I138690464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099011482","display_name":"Toheeb A. Jumah","orcid":null},"institutions":[{"id":"https://openalex.org/I4210131560","display_name":"Universit\u00e9 Mohammed VI Polytechnique","ror":"https://ror.org/03xc55g68","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210131560"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Toheeb A. Jumah","raw_affiliation_strings":["School of Collective Intelligence, University Mohammed VI Polytechnic, Rabat, Morocco"],"affiliations":[{"raw_affiliation_string":"School of Collective Intelligence, University Mohammed VI Polytechnic, Rabat, Morocco","institution_ids":["https://openalex.org/I4210131560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067967023","display_name":"George W. Hanson","orcid":"https://orcid.org/0000-0001-5792-8836"},"institutions":[{"id":"https://openalex.org/I138690464","display_name":"University of Ghana","ror":"https://ror.org/01r22mr83","country_code":"GH","type":"education","lineage":["https://openalex.org/I138690464"]},{"id":"https://openalex.org/I4210091910","display_name":"Noguchi Memorial Institute for Medical Research","ror":"https://ror.org/00f1qr933","country_code":"GH","type":"nonprofit","lineage":["https://openalex.org/I138690464","https://openalex.org/I4210091910"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"George Hanson","raw_affiliation_strings":["Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"],"affiliations":[{"raw_affiliation_string":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana","institution_ids":["https://openalex.org/I4210091910","https://openalex.org/I138690464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116182144","display_name":"Siyabonga Msipa","orcid":null},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Siyabonga Msipa","raw_affiliation_strings":["Department of Integrative Biomedical Science, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"],"affiliations":[{"raw_affiliation_string":"Department of Integrative Biomedical Science, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110460095","display_name":"Florence N. Mbaoji","orcid":null},"institutions":[{"id":"https://openalex.org/I11892038","display_name":"University of Nigeria","ror":"https://ror.org/01sn1yx84","country_code":"NG","type":"education","lineage":["https://openalex.org/I11892038"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Florence N. Mbaoji","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu, Nigeria"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu, Nigeria","institution_ids":["https://openalex.org/I11892038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061684359","display_name":"Omonijo Bukola","orcid":null},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Omonijo Bukola","raw_affiliation_strings":["Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomosho, Oyo, Nigeria"],"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomosho, Oyo, Nigeria","institution_ids":["https://openalex.org/I45230691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116182145","display_name":"Palesa C. Tjale","orcid":null},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Palesa C. Tjale","raw_affiliation_strings":["Department of Computational Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113606511","display_name":"Mamadou Sangar\u00e9","orcid":"https://orcid.org/0000-0002-8300-8205"},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Mamadou Sangare","raw_affiliation_strings":["African Center of Excellence in Bioinformatics (ACE-B), University of Science, Techniques and Technologies of Bamako (USTTB), Bamako, Mali","Center of Excellence in Bioinformatics and Data Science, University of Science Techniques and Technologies of Bamako (USTTB), Bamako, Mali"],"affiliations":[{"raw_affiliation_string":"African Center of Excellence in Bioinformatics (ACE-B), University of Science, Techniques and Technologies of Bamako (USTTB), Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]},{"raw_affiliation_string":"Center of Excellence in Bioinformatics and Data Science, University of Science Techniques and Technologies of Bamako (USTTB), Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116182142","display_name":"Hedia Tebourbi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162466","display_name":"Centre of Biotechnology of Sfax","ror":"https://ror.org/05acynk65","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210162466"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hedia Tebourbi","raw_affiliation_strings":["Pathophysiology, Food and Biomolecules Laboratory, Higher Institute of Biotechnology of Sidi Thabet, Sidi Thabet, Tunisia"],"affiliations":[{"raw_affiliation_string":"Pathophysiology, Food and Biomolecules Laboratory, Higher Institute of Biotechnology of Sidi Thabet, Sidi Thabet, Tunisia","institution_ids":["https://openalex.org/I4210162466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091587560","display_name":"Olaitan I. Awe","orcid":"https://orcid.org/0000-0002-4257-3611"},"institutions":[{"id":"https://openalex.org/I148561064","display_name":"African Institute for Mathematical Sciences","ror":"https://ror.org/02f9k5d27","country_code":"ZA","type":"education","lineage":["https://openalex.org/I148561064"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Olaitan I. Awe","raw_affiliation_strings":["African Society for Bioinformatics and Computational Biology, Cape Town, South Africa"],"affiliations":[{"raw_affiliation_string":"African Society for Bioinformatics and Computational Biology, Cape Town, South Africa","institution_ids":["https://openalex.org/I148561064"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5116182141"],"corresponding_institution_ids":["https://openalex.org/I138690464","https://openalex.org/I4210091910"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":9.262,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.98202964,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"5","issue":null,"first_page":"1499255","last_page":"1499255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorbinil","display_name":"Sorbinil","score":0.9650840163230896},{"id":"https://openalex.org/keywords/aldose-reductase","display_name":"Aldose reductase","score":0.9538478851318359},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6905596852302551},{"id":"https://openalex.org/keywords/aldose-reductase-inhibitor","display_name":"Aldose reductase inhibitor","score":0.6887109279632568},{"id":"https://openalex.org/keywords/lipinskis-rule-of-five","display_name":"Lipinski's rule of five","score":0.6122100353240967},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.6034367084503174},{"id":"https://openalex.org/keywords/sorbitol","display_name":"Sorbitol","score":0.5910413265228271},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.4831692576408386},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.4683726727962494},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.44482147693634033},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.44268545508384705},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4410945773124695},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.34121453762054443},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.3291071951389313},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.27628952264785767},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2071896493434906}],"concepts":[{"id":"https://openalex.org/C2776614240","wikidata":"https://www.wikidata.org/wiki/Q1259458","display_name":"Sorbinil","level":5,"score":0.9650840163230896},{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.9538478851318359},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6905596852302551},{"id":"https://openalex.org/C2777374081","wikidata":"https://www.wikidata.org/wiki/Q4713968","display_name":"Aldose reductase inhibitor","level":4,"score":0.6887109279632568},{"id":"https://openalex.org/C41847442","wikidata":"https://www.wikidata.org/wiki/Q916723","display_name":"Lipinski's rule of five","level":4,"score":0.6122100353240967},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6034367084503174},{"id":"https://openalex.org/C2776779347","wikidata":"https://www.wikidata.org/wiki/Q245280","display_name":"Sorbitol","level":2,"score":0.5910413265228271},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4831692576408386},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4683726727962494},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.44482147693634033},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.44268545508384705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4410945773124695},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34121453762054443},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3291071951389313},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.27628952264785767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2071896493434906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1499255","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1499255","pdf_url":null,"source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39996053","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39996053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11848289","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11848289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cfe665b5d8224ca38b2602c5269e158d","is_oa":true,"landing_page_url":"https://doaj.org/article/cfe665b5d8224ca38b2602c5269e158d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1499255","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1499255","pdf_url":null,"source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1501568305","https://openalex.org/W1526677948","https://openalex.org/W1543947130","https://openalex.org/W1570500995","https://openalex.org/W1887624773","https://openalex.org/W1965866394","https://openalex.org/W1968319881","https://openalex.org/W1969996239","https://openalex.org/W1971849220","https://openalex.org/W1979915001","https://openalex.org/W1981737096","https://openalex.org/W1982728268","https://openalex.org/W1987612487","https://openalex.org/W1992922019","https://openalex.org/W1997872815","https://openalex.org/W2009867031","https://openalex.org/W2010424368","https://openalex.org/W2011697200","https://openalex.org/W2014858249","https://openalex.org/W2027605161","https://openalex.org/W2036765328","https://openalex.org/W2036927874","https://openalex.org/W2039478311","https://openalex.org/W2047482528","https://openalex.org/W2050027039","https://openalex.org/W2058149456","https://openalex.org/W2060433756","https://openalex.org/W2065326103","https://openalex.org/W2066746672","https://openalex.org/W2069087197","https://openalex.org/W2073605475","https://openalex.org/W2087658344","https://openalex.org/W2090632754","https://openalex.org/W2101181377","https://openalex.org/W2108344016","https://openalex.org/W2125306830","https://openalex.org/W2129434797","https://openalex.org/W2130479394","https://openalex.org/W2134967712","https://openalex.org/W2154789716","https://openalex.org/W2166976731","https://openalex.org/W2169678694","https://openalex.org/W2171553260","https://openalex.org/W2335807821","https://openalex.org/W2422106236","https://openalex.org/W2490619433","https://openalex.org/W2558316923","https://openalex.org/W2593436234","https://openalex.org/W2651157417","https://openalex.org/W2741290399","https://openalex.org/W2783351753","https://openalex.org/W2788915030","https://openalex.org/W2797855269","https://openalex.org/W2804489204","https://openalex.org/W2811379301","https://openalex.org/W2885936768","https://openalex.org/W2888936354","https://openalex.org/W2900141214","https://openalex.org/W2906611342","https://openalex.org/W2911420827","https://openalex.org/W2912371425","https://openalex.org/W2914734348","https://openalex.org/W2947955632","https://openalex.org/W2956851576","https://openalex.org/W2970686092","https://openalex.org/W3013426051","https://openalex.org/W3083358089","https://openalex.org/W3119700671","https://openalex.org/W3126491695","https://openalex.org/W3149063413","https://openalex.org/W3162775003","https://openalex.org/W3165240135","https://openalex.org/W3189606566","https://openalex.org/W3199671153","https://openalex.org/W3202490969","https://openalex.org/W4211216582","https://openalex.org/W4224290264","https://openalex.org/W4281297157","https://openalex.org/W4281837039","https://openalex.org/W4283315282","https://openalex.org/W4283775188","https://openalex.org/W4291701399","https://openalex.org/W4293064106","https://openalex.org/W4313122153","https://openalex.org/W4313480321","https://openalex.org/W4318294165","https://openalex.org/W4321610320","https://openalex.org/W4323034264","https://openalex.org/W4361211770","https://openalex.org/W4375953875","https://openalex.org/W4383703956","https://openalex.org/W4385728738","https://openalex.org/W4386306060","https://openalex.org/W4386629396","https://openalex.org/W4386789713","https://openalex.org/W4388615774","https://openalex.org/W4389203329","https://openalex.org/W4391132740","https://openalex.org/W4391151526","https://openalex.org/W4392401766","https://openalex.org/W4393214873","https://openalex.org/W4395004944","https://openalex.org/W4400483688","https://openalex.org/W4403341384","https://openalex.org/W4404701405","https://openalex.org/W4404869484","https://openalex.org/W4405736928","https://openalex.org/W4405764229","https://openalex.org/W4406228454"],"related_works":["https://openalex.org/W2040669208","https://openalex.org/W2358600802","https://openalex.org/W2027015359","https://openalex.org/W2093080751","https://openalex.org/W2018093451","https://openalex.org/W2163029824","https://openalex.org/W2133543344","https://openalex.org/W79620260","https://openalex.org/W2411150516","https://openalex.org/W1994695197"],"abstract_inverted_index":{"This":[0],"study":[1],"highlighted":[2],"the":[3,13,26,29,33],"potential":[4],"inhibitory":[5],"activity":[6],"of":[7,32],"5":[8],"compounds":[9],"that":[10],"belong":[11],"to":[12,42,55],"African":[14],"region:":[15],"(+)-Pipoxide,":[16],"Zinc000095485961,":[17],"Naamidine":[18],"A,":[19],"(-)-Pipoxide,":[20],"and":[21,51],"1,6-di-o-p-hydroxybenzoyl-beta-d-glucopyranoside.":[22],"These":[23],"molecules":[24],"inhibiting":[25],"aldose":[27],"reductase,":[28],"key":[30],"enzyme":[31],"polyol":[34],"pathway,":[35],"can":[36],"be":[37],"developed":[38],"as":[39],"therapeutic":[40],"agents":[41],"manage":[43],"diabetic":[44],"complications.":[45],"However,":[46],"we":[47],"recommend":[48],"<i>in":[49,52],"vitro</i>":[50],"vivo</i>":[53],"studies":[54],"confirm":[56],"our":[57],"findings.":[58]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
