{"id":"https://openalex.org/W4408675244","doi":"https://doi.org/10.3389/fbinf.2025.1491735","title":"Divergent evolution of low-complexity regions in the vertebrate CPEB protein family","display_name":"Divergent evolution of low-complexity regions in the vertebrate CPEB protein family","publication_year":2025,"publication_date":"2025-03-20","ids":{"openalex":"https://openalex.org/W4408675244","doi":"https://doi.org/10.3389/fbinf.2025.1491735","pmid":"https://pubmed.ncbi.nlm.nih.gov/40182702"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1491735","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1491735","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1491735/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1491735/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038175504","display_name":"Serena Vaglietti","orcid":"https://orcid.org/0000-0002-7660-0761"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Serena Vaglietti","raw_affiliation_strings":["\"Rita Levi-Montalcini\" Department of Neuroscience, University of Turin, Turin, Italy"],"affiliations":[{"raw_affiliation_string":"\"Rita Levi-Montalcini\" Department of Neuroscience, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001519996","display_name":"Stefania Boggio Bozzo","orcid":null},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Boggio Bozzo","raw_affiliation_strings":["\"Rita Levi-Montalcini\" Department of Neuroscience, University of Turin, Turin, Italy"],"affiliations":[{"raw_affiliation_string":"\"Rita Levi-Montalcini\" Department of Neuroscience, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066547068","display_name":"Mirella Ghirardi","orcid":null},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mirella Ghirardi","raw_affiliation_strings":["\"Rita Levi-Montalcini\" Department of Neuroscience, University of Turin, Turin, Italy"],"affiliations":[{"raw_affiliation_string":"\"Rita Levi-Montalcini\" Department of Neuroscience, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083243484","display_name":"Ferdinando Fiumara","orcid":"https://orcid.org/0000-0003-0715-7863"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ferdinando Fiumara","raw_affiliation_strings":["\"Rita Levi-Montalcini\" Department of Neuroscience, University of Turin, Turin, Italy"],"affiliations":[{"raw_affiliation_string":"\"Rita Levi-Montalcini\" Department of Neuroscience, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038175504"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":2.1731,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.86154131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"5","issue":null,"first_page":"1491735","last_page":"1491735"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8068627119064331},{"id":"https://openalex.org/keywords/vertebrate","display_name":"Vertebrate","score":0.6076804399490356},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5887055397033691},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5318025946617126},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"Gene duplication","score":0.5317698121070862},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.4744875431060791},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.46354052424430847},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.43606826663017273},{"id":"https://openalex.org/keywords/polyadenylation","display_name":"Polyadenylation","score":0.4342595636844635},{"id":"https://openalex.org/keywords/clade","display_name":"Clade","score":0.43137413263320923},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40893977880477905},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.4009479582309723},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.20649296045303345},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.20230633020401}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8068627119064331},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.6076804399490356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5887055397033691},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5318025946617126},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5317698121070862},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.4744875431060791},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46354052424430847},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.43606826663017273},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.4342595636844635},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.43137413263320923},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40893977880477905},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.4009479582309723},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.20649296045303345},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.20230633020401}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1491735","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1491735","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1491735/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40182702","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40182702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:872cd536ed8e421391115a102673baf2","is_oa":true,"landing_page_url":"https://doaj.org/article/872cd536ed8e421391115a102673baf2","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11965684","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11965684","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1491735","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1491735","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1491735/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.44999998807907104,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324041","display_name":"Universit\u00e0 degli Studi di Torino","ror":"https://ror.org/048tbm396"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4408675244.pdf"},"referenced_works_count":108,"referenced_works":["https://openalex.org/W68124440","https://openalex.org/W177750526","https://openalex.org/W1580522653","https://openalex.org/W1616451653","https://openalex.org/W1854617463","https://openalex.org/W1903318724","https://openalex.org/W1912455695","https://openalex.org/W1965403470","https://openalex.org/W1968185788","https://openalex.org/W1971095698","https://openalex.org/W1986196866","https://openalex.org/W1994947657","https://openalex.org/W1997928221","https://openalex.org/W1998113180","https://openalex.org/W2008781962","https://openalex.org/W2010961953","https://openalex.org/W2013756663","https://openalex.org/W2019480782","https://openalex.org/W2023043020","https://openalex.org/W2029592830","https://openalex.org/W2032469042","https://openalex.org/W2034610575","https://openalex.org/W2034767282","https://openalex.org/W2039329450","https://openalex.org/W2044730187","https://openalex.org/W2046231927","https://openalex.org/W2048146797","https://openalex.org/W2048975947","https://openalex.org/W2057071452","https://openalex.org/W2057715520","https://openalex.org/W2060013127","https://openalex.org/W2072654650","https://openalex.org/W2097532103","https://openalex.org/W2097838377","https://openalex.org/W2098444377","https://openalex.org/W2106046434","https://openalex.org/W2106801137","https://openalex.org/W2106811293","https://openalex.org/W2107158607","https://openalex.org/W2110189539","https://openalex.org/W2110927099","https://openalex.org/W2119651404","https://openalex.org/W2124296475","https://openalex.org/W2127322768","https://openalex.org/W2127472975","https://openalex.org/W2132629607","https://openalex.org/W2135039550","https://openalex.org/W2137307693","https://openalex.org/W2138906088","https://openalex.org/W2139995722","https://openalex.org/W2140794408","https://openalex.org/W2143387960","https://openalex.org/W2143704763","https://openalex.org/W2145400088","https://openalex.org/W2145779714","https://openalex.org/W2153391836","https://openalex.org/W2153452535","https://openalex.org/W2230438766","https://openalex.org/W2513727910","https://openalex.org/W2555542882","https://openalex.org/W2560461065","https://openalex.org/W2565431933","https://openalex.org/W2593862218","https://openalex.org/W2604308930","https://openalex.org/W2749545656","https://openalex.org/W2792129356","https://openalex.org/W2799953103","https://openalex.org/W2801412154","https://openalex.org/W2810866092","https://openalex.org/W2884082692","https://openalex.org/W2884588713","https://openalex.org/W2889721864","https://openalex.org/W2968219122","https://openalex.org/W2979393734","https://openalex.org/W3011713314","https://openalex.org/W3017333675","https://openalex.org/W3044319154","https://openalex.org/W3093868212","https://openalex.org/W3134553760","https://openalex.org/W3143253488","https://openalex.org/W3147419222","https://openalex.org/W3157923161","https://openalex.org/W3162714996","https://openalex.org/W3164053338","https://openalex.org/W3165128934","https://openalex.org/W3193864919","https://openalex.org/W4206228991","https://openalex.org/W4225261147","https://openalex.org/W4234389510","https://openalex.org/W4238346383","https://openalex.org/W4251751280","https://openalex.org/W4281729735","https://openalex.org/W4281790889","https://openalex.org/W4292240717","https://openalex.org/W4292640607","https://openalex.org/W4295261310","https://openalex.org/W4311475743","https://openalex.org/W4318577400","https://openalex.org/W4363645570","https://openalex.org/W4363677213","https://openalex.org/W4367677484","https://openalex.org/W4379768828","https://openalex.org/W4387035586","https://openalex.org/W4387967709","https://openalex.org/W4391542412","https://openalex.org/W4393317567","https://openalex.org/W4394738782","https://openalex.org/W4399518101"],"related_works":["https://openalex.org/W1976007281","https://openalex.org/W195216885","https://openalex.org/W1968152888","https://openalex.org/W2081082232","https://openalex.org/W4205787488","https://openalex.org/W2041389612","https://openalex.org/W2082559221","https://openalex.org/W2159433765","https://openalex.org/W2005709378","https://openalex.org/W2009274685"],"abstract_inverted_index":{"The":[0,40,92],"<i>cytoplasmic":[1],"polyadenylation":[2],"element-binding":[3],"proteins</i>":[4],"(CPEBs)":[5],"are":[6,43],"a":[7,244],"family":[8],"of":[9,61,84,89,115,170,225,241],"translational":[10],"regulators":[11],"involved":[12],"in":[13,82,195,204,227,232,248],"multiple":[14],"biological":[15],"processes,":[16],"including":[17,49,252],"memory-related":[18],"synaptic":[19],"plasticity.":[20],"In":[21],"vertebrates,":[22],"four":[23,76,149,186],"paralogous":[24,77],"genes":[25],"(CPEB1-4)":[26],"encode":[27],"proteins":[28,79,188],"with":[29],"phylogenetically":[30],"conserved":[31],"C-terminal":[32],"RNA-binding":[33],"domains":[34],"and":[35,55,66,87,118,128,136,143,153,197,207,222,235],"variable":[36],"N-terminal":[37],"regions":[38,47],"(NTRs).":[39],"CPEB":[41,78,151,187,229],"NTRs":[42,94],"characterized":[44],"by":[45,202],"low-complexity":[46],"(LCRs),":[48],"homopolymeric":[50],"amino":[51],"acid":[52],"repeats":[53],"(AARs),":[54],"have":[56,96],"been":[57],"identified":[58],"as":[59,243],"mediators":[60],"liquid-liquid":[62],"phase":[63],"separation":[64],"(LLPS)":[65],"prion-like":[67,246],"aggregation.":[68],"After":[69],"their":[70,104,119,129,157,205],"appearance":[71],"following":[72],"gene":[73],"duplication,":[74],"the":[75,113,148,179,185,220,228,239],"functionally":[80],"diverged":[81],"terms":[83],"activation":[85],"mechanisms":[86],"modes":[88],"mRNA":[90],"binding.":[91],"paralog-specific":[93,192],"may":[95],"contributed":[97],"substantially":[98],"to":[99,166,176,210],"such":[100],"functional":[101,131,223],"diversification":[102],"but":[103],"evolutionary":[105,158,193],"history":[106],"remains":[107],"largely":[108,208],"unexplored.":[109],"Here,":[110],"we":[111],"traced":[112],"evolution":[114,224],"vertebrate":[116,180,250],"CPEBs":[117],"LCRs/AARs":[120,206],"focusing":[121],"on":[122,133,219],"primary":[123],"sequence":[124],"composition,":[125],"complexity,":[126],"repetitiveness,":[127],"possible":[130],"impact":[132],"LLPS":[134],"propensity":[135],"prion-likeness.":[137],"We":[138,182],"initially":[139],"defined":[140],"these":[141],"composition-":[142,196],"function-related":[144,198],"quantitative":[145,234],"parameters":[146],"for":[147],"human":[150],"paralogs":[152],"then":[154],"systematically":[155],"analyzed":[156],"variation":[159,203],"across":[160],"more":[161],"than":[162],"500":[163],"species":[164],"belonging":[165],"nine":[167],"major":[168],"clades":[169],"different":[171],"stem":[172,212],"age,":[173],"from":[174],"Chondrichthyes":[175],"Euarchontoglires,":[177],"along":[178],"lineage.":[181],"found":[183],"that":[184],"display":[189],"highly":[190],"divergent,":[191],"trends":[194],"parameters,":[199],"primarily":[200],"driven":[201],"related":[209],"clade":[211],"ages.":[213],"These":[214],"findings":[215],"shed":[216],"new":[217],"light":[218],"molecular":[221],"LCRs":[226],"protein":[230,247],"family,":[231],"both":[233],"qualitative":[236],"terms,":[237],"highlighting":[238],"emergence":[240],"CPEB2":[242],"proline-rich":[245],"younger":[249],"clades,":[251],"Primates.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}