{"id":"https://openalex.org/W4403138758","doi":"https://doi.org/10.3389/fbinf.2024.1463001","title":"Discovery of plasma biomarkers related to blood-brain barrier dysregulation in Alzheimer\u2019s disease","display_name":"Discovery of plasma biomarkers related to blood-brain barrier dysregulation in Alzheimer\u2019s disease","publication_year":2024,"publication_date":"2024-10-04","ids":{"openalex":"https://openalex.org/W4403138758","doi":"https://doi.org/10.3389/fbinf.2024.1463001","pmid":"https://pubmed.ncbi.nlm.nih.gov/39429696"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2024.1463001","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2024.1463001","pdf_url":null,"source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fbinf.2024.1463001","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110790780","display_name":"Yuet Ruh Dan","orcid":"https://orcid.org/0000-0002-9592-2758"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yuet Ruh Dan","raw_affiliation_strings":["Bioinformatics Institute, A*STAR, Singapore, Singapore","School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute, A*STAR, Singapore, Singapore","institution_ids":["https://openalex.org/I4210148498","https://openalex.org/I115228651"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077836921","display_name":"Keng\u2010Hwee Chiam","orcid":"https://orcid.org/0000-0002-8987-8463"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Keng-Hwee Chiam","raw_affiliation_strings":["Bioinformatics Institute, A*STAR, Singapore, Singapore","School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute, A*STAR, Singapore, Singapore","institution_ids":["https://openalex.org/I4210148498","https://openalex.org/I115228651"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077836921"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I172675005","https://openalex.org/I4210148498"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.6282,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70920358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"4","issue":null,"first_page":"1463001","last_page":"1463001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.47049999237060547,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.47049999237060547,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.17499999701976776,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"Neuroinflammation","score":0.765378475189209},{"id":"https://openalex.org/keywords/blood\u2013brain-barrier","display_name":"Blood\u2013brain barrier","score":0.6728195548057556},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.652668297290802},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5819083452224731},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5722148418426514},{"id":"https://openalex.org/keywords/diagnostic-biomarker","display_name":"Diagnostic biomarker","score":0.5084185004234314},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"Amyloid beta","score":0.5019512176513672},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4343881905078888},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.41540640592575073},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4051814079284668},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38510429859161377},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.3806625008583069},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3697270154953003},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.33651500940322876},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.292374849319458},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.26089340448379517},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.18114620447158813},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.17947715520858765},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1015835702419281}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.765378475189209},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.6728195548057556},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.652668297290802},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5819083452224731},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5722148418426514},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.5084185004234314},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.5019512176513672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4343881905078888},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.41540640592575073},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4051814079284668},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38510429859161377},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.3806625008583069},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3697270154953003},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33651500940322876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.292374849319458},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26089340448379517},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18114620447158813},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17947715520858765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1015835702419281}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2024.1463001","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2024.1463001","pdf_url":null,"source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39429696","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39429696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11487119","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11487119","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d48149ecfa214c66b643e21a5218496f","is_oa":true,"landing_page_url":"https://doaj.org/article/d48149ecfa214c66b643e21a5218496f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 4 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2024.1463001","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2024.1463001","pdf_url":null,"source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1474309979","https://openalex.org/W1563064469","https://openalex.org/W1832678746","https://openalex.org/W1979169292","https://openalex.org/W1988122824","https://openalex.org/W2002753890","https://openalex.org/W2003827559","https://openalex.org/W2005010112","https://openalex.org/W2006617902","https://openalex.org/W2034430748","https://openalex.org/W2054686729","https://openalex.org/W2058571175","https://openalex.org/W2064186732","https://openalex.org/W2090710011","https://openalex.org/W2090747948","https://openalex.org/W2107665951","https://openalex.org/W2114789645","https://openalex.org/W2116707508","https://openalex.org/W2122328291","https://openalex.org/W2123959697","https://openalex.org/W2130116522","https://openalex.org/W2134623786","https://openalex.org/W2156665896","https://openalex.org/W2165249364","https://openalex.org/W2314634699","https://openalex.org/W2398295983","https://openalex.org/W2415637550","https://openalex.org/W2550934658","https://openalex.org/W2616922646","https://openalex.org/W2618794795","https://openalex.org/W2735466792","https://openalex.org/W2737166034","https://openalex.org/W2786608785","https://openalex.org/W2788507110","https://openalex.org/W2799913710","https://openalex.org/W2888111243","https://openalex.org/W2901092742","https://openalex.org/W2965717703","https://openalex.org/W2969396388","https://openalex.org/W2979384131","https://openalex.org/W2991414673","https://openalex.org/W2992151131","https://openalex.org/W2998139612","https://openalex.org/W3008633917","https://openalex.org/W3028711203","https://openalex.org/W3039975419","https://openalex.org/W3046275966","https://openalex.org/W3110609137","https://openalex.org/W3112436101","https://openalex.org/W3126632828","https://openalex.org/W3153514526","https://openalex.org/W3159530258","https://openalex.org/W3164268272","https://openalex.org/W4207008211","https://openalex.org/W4210381047","https://openalex.org/W4211166256","https://openalex.org/W4212913626","https://openalex.org/W4213366162","https://openalex.org/W4220819957","https://openalex.org/W4220977870","https://openalex.org/W4296796569","https://openalex.org/W4309561526","https://openalex.org/W4312088343","https://openalex.org/W4362520601","https://openalex.org/W4376642451","https://openalex.org/W4378980630","https://openalex.org/W4384942725","https://openalex.org/W4389303262","https://openalex.org/W4390742876","https://openalex.org/W4391743929","https://openalex.org/W6610017368"],"related_works":["https://openalex.org/W4390463473","https://openalex.org/W2807379694","https://openalex.org/W4221075899","https://openalex.org/W163337889","https://openalex.org/W4386839975","https://openalex.org/W3206087933","https://openalex.org/W2154580547","https://openalex.org/W1534920339","https://openalex.org/W2013256337","https://openalex.org/W1969082909"],"abstract_inverted_index":{"Introduction:":[0],"Blood-based":[1],"biomarkers":[2,14],"are":[3],"quantitative,":[4],"non-invasive":[5],"diagnostic":[6],"tools.":[7],"This":[8],"study":[9],"aimed":[10],"to":[11,54,129],"identify":[12,131],"candidate":[13],"for":[15,40],"Alzheimer's":[16],"disease":[17,137],"(AD)":[18],"using":[19,24],"publicly":[20],"available":[21],"omics":[22],"datasets,":[23],"the":[25,146,152],"hypothesis":[26],"that":[27],"with":[28,65,134],"blood-brain":[29,153],"barrier":[30],"dysfunction":[31],"in":[32,99,106],"AD,":[33],"brain-synthesized":[34],"proteins":[35,79],"can":[36],"leak":[37],"into":[38],"plasma":[39,47],"detection.":[41],"Methods:":[42],"Differential":[43],"abundance":[44],"results":[45],"of":[46,58,117,136,148],"and":[48,68,84,95,139],"brain":[49,73],"proteomic":[50],"datasets":[51],"were":[52,97],"integrated":[53],"obtain":[55],"a":[56,124],"list":[57],"potential":[59],"biomarkers.":[60],"Biological":[61],"validity":[62],"was":[63],"investigated":[64],"intercellular":[66],"communication":[67],"gene":[69],"regulatory":[70],"analyses":[71],"on":[72],"single-cell":[74],"transcriptomics":[75],"data.":[76],"Results:":[77],"Five":[78],"(APOD,":[80,92],"B2M,":[81,93],"CFH,":[82],"CLU,":[83,94],"C3)":[85,96],"fit":[86],"biomarker":[87],"criteria.":[88],"4":[89],"corresponding":[90],"transcripts":[91],"overexpressed":[98],"AD":[100,132],"astrocytes,":[101],"mediated":[102],"by":[103],"AD-related":[104],"dysregulations":[105],"transcription":[107],"factors":[108],"regulating":[109],"neuroinflammation.":[110],"Additionally,":[111],"CLU":[112],"specifically":[113],"induced":[114],"downstream":[115],"expression":[116],"neuronal":[118],"death":[119],"genes.":[120],"Discussion:":[121],"In":[122],"conclusion,":[123],"5-protein":[125],"panel":[126],"is":[127],"shown":[128],"effectively":[130],"patients,":[133],"evidence":[135],"specificity":[138],"biological":[140],"validity.":[141],"Future":[142],"research":[143],"should":[144],"investigate":[145],"mechanism":[147],"protein":[149],"leakage":[150],"through":[151],"barrier.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-30T09:15:22.047038","created_date":"2025-10-10T00:00:00"}
