{"id":"https://openalex.org/W4402246801","doi":"https://doi.org/10.3389/fbinf.2024.1424202","title":"PhIP-Seq: methods, applications and challenges","display_name":"PhIP-Seq: methods, applications and challenges","publication_year":2024,"publication_date":"2024-09-04","ids":{"openalex":"https://openalex.org/W4402246801","doi":"https://doi.org/10.3389/fbinf.2024.1424202","pmid":"https://pubmed.ncbi.nlm.nih.gov/39295784"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2024.1424202","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2024.1424202","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2024.1424202/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2024.1424202/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034946608","display_name":"Ziru Huang","orcid":"https://orcid.org/0009-0006-2380-3676"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziru Huang","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031746959","display_name":"Samarappuli Mudiyanselage Savini Gunarathne","orcid":null},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Samarappuli Mudiyanselage Savini Gunarathne","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343172","display_name":"Wenwen Liu","orcid":"https://orcid.org/0000-0002-6119-9784"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwen Liu","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101966458","display_name":"Yuwei Zhou","orcid":"https://orcid.org/0000-0002-9786-8441"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuwei Zhou","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035675066","display_name":"Yuqing Jiang","orcid":"https://orcid.org/0000-0002-4202-3038"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Jiang","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015927716","display_name":"Shiqi Li","orcid":"https://orcid.org/0000-0003-3160-5582"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shiqi Li","raw_affiliation_strings":["School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113431605","display_name":"Jian Huang","orcid":"https://orcid.org/0000-0003-2661-816X"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210134419","display_name":"Neusoft (China)","ror":"https://ror.org/02zc84r97","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210134419"]},{"id":"https://openalex.org/I4400573292","display_name":"Chengdu Neusoft University","ror":"https://ror.org/04p9p1r69","country_code":null,"type":"education","lineage":["https://openalex.org/I4400573292"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Huang","raw_affiliation_strings":["School of Healthcare Technology, Chengdu Neusoft University, Chengdu, China","School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"School of Healthcare Technology, Chengdu Neusoft University, Chengdu, China","institution_ids":["https://openalex.org/I4210134419","https://openalex.org/I4400573292"]},{"raw_affiliation_string":"School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5015927716","https://openalex.org/A5113431605"],"corresponding_institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210134419","https://openalex.org/I4400573292"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":2.3252,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.8867086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"4","issue":null,"first_page":"1424202","last_page":"1424202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5562472939491272},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4840918779373169},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.41345980763435364},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3895415663719177},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32541483640670776},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2283325493335724}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5562472939491272},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4840918779373169},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.41345980763435364},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3895415663719177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32541483640670776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2283325493335724},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2024.1424202","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2024.1424202","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2024.1424202/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39295784","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39295784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11408297","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11408297","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11408297/pdf/fbinf-04-1424202.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f8ab76fca97b4ba7b6c73b00c0d68da3","is_oa":true,"landing_page_url":"https://doaj.org/article/f8ab76fca97b4ba7b6c73b00c0d68da3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 4 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2024.1424202","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2024.1424202","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2024.1424202/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G6713167077","display_name":null,"funder_award_id":"62071099 62371112","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G774013373","display_name":null,"funder_award_id":"62371112","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G965811515","display_name":null,"funder_award_id":"62071099","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323292","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4402246801.pdf"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W1014714876","https://openalex.org/W1900892538","https://openalex.org/W1974931279","https://openalex.org/W1985921653","https://openalex.org/W1998702086","https://openalex.org/W2004216886","https://openalex.org/W2057363338","https://openalex.org/W2070360032","https://openalex.org/W2086195230","https://openalex.org/W2096441981","https://openalex.org/W2097874743","https://openalex.org/W2122210493","https://openalex.org/W2124985265","https://openalex.org/W2178408458","https://openalex.org/W2272459766","https://openalex.org/W2332669903","https://openalex.org/W2532684607","https://openalex.org/W2550055437","https://openalex.org/W2581899071","https://openalex.org/W2749679400","https://openalex.org/W2757558138","https://openalex.org/W2799193166","https://openalex.org/W2890891844","https://openalex.org/W2921997068","https://openalex.org/W2942717816","https://openalex.org/W2953728338","https://openalex.org/W2981275313","https://openalex.org/W2994799044","https://openalex.org/W3011155739","https://openalex.org/W3025141660","https://openalex.org/W3030201038","https://openalex.org/W3032729016","https://openalex.org/W3046348643","https://openalex.org/W3087845968","https://openalex.org/W3091214020","https://openalex.org/W3121746107","https://openalex.org/W3125785493","https://openalex.org/W3126303430","https://openalex.org/W3157704466","https://openalex.org/W3157834780","https://openalex.org/W3160102114","https://openalex.org/W3160449499","https://openalex.org/W3163926470","https://openalex.org/W3186269282","https://openalex.org/W3186809114","https://openalex.org/W3197453979","https://openalex.org/W3205303641","https://openalex.org/W4200044480","https://openalex.org/W4200217775","https://openalex.org/W4206917016","https://openalex.org/W4213105197","https://openalex.org/W4221132542","https://openalex.org/W4224310802","https://openalex.org/W4226149440","https://openalex.org/W4229028232","https://openalex.org/W4246569265","https://openalex.org/W4280565378","https://openalex.org/W4281646402","https://openalex.org/W4282553951","https://openalex.org/W4284694839","https://openalex.org/W4285296517","https://openalex.org/W4285391968","https://openalex.org/W4290977073","https://openalex.org/W4292686948","https://openalex.org/W4293240488","https://openalex.org/W4294938724","https://openalex.org/W4295817771","https://openalex.org/W4295926033","https://openalex.org/W4296843408","https://openalex.org/W4307426052","https://openalex.org/W4307687256","https://openalex.org/W4308683205","https://openalex.org/W4309244578","https://openalex.org/W4311550620","https://openalex.org/W4312084929","https://openalex.org/W4317722351","https://openalex.org/W4317788233","https://openalex.org/W4320800886","https://openalex.org/W4320856678","https://openalex.org/W4361006991","https://openalex.org/W4365509847","https://openalex.org/W4366990441","https://openalex.org/W4375947256","https://openalex.org/W4375947513","https://openalex.org/W4378085029","https://openalex.org/W4379743194","https://openalex.org/W4380450207","https://openalex.org/W4382395620","https://openalex.org/W4386895811","https://openalex.org/W4386960364","https://openalex.org/W4386979696","https://openalex.org/W4388452269","https://openalex.org/W4389131630","https://openalex.org/W4389478651","https://openalex.org/W4389935790","https://openalex.org/W4390038776","https://openalex.org/W4390577990","https://openalex.org/W4391839137","https://openalex.org/W4391998003","https://openalex.org/W4392763058","https://openalex.org/W4394962458"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Phage-immunoprecipitation":[0],"sequencing":[1],"(PhIP-Seq)":[2],"technology":[3,20,69],"is":[4,106],"an":[5,110],"innovative,":[6],"high-throughput":[7],"antibody":[8,17],"detection":[9],"method.":[10],"It":[11],"enables":[12],"comprehensive":[13],"analysis":[14],"of":[15,45,57,64,87],"individual":[16],"profiles.":[18],"This":[19],"shows":[21],"great":[22],"potential,":[23],"particularly":[24],"in":[25,38,94,115],"exploring":[26],"disease":[27,125],"mechanisms":[28],"and":[29,52,74,85,89,97,103,122,128],"immune":[30],"responses.":[31],"Currently,":[32],"PhIP-Seq":[33,68,88,105],"has":[34,75],"been":[35],"successfully":[36],"applied":[37],"various":[39],"fields,":[40],"such":[41],"as":[42],"the":[43,62,82],"exploration":[44],"biomarkers":[46],"for":[47,77,124],"autoimmune":[48],"diseases,":[49],"vaccine":[50],"development,":[51],"allergen":[53],"detection.":[54],"A":[55],"variety":[56],"bioinformatics":[58],"tools":[59],"have":[60],"facilitated":[61],"development":[63],"this":[65],"process.":[66],"However,":[67],"still":[70],"faces":[71],"many":[72],"challenges":[73,86],"room":[76],"improvement.":[78],"Here,":[79],"we":[80],"review":[81],"methods,":[83],"applications,":[84],"discuss":[90],"its":[91],"future":[92,116],"directions":[93],"immunological":[95],"research":[96],"clinical":[98],"applications.":[99],"With":[100],"continuous":[101],"progress":[102],"optimization,":[104],"expected":[107],"to":[108],"play":[109],"even":[111],"more":[112],"important":[113],"role":[114],"biomedical":[117],"research,":[118],"providing":[119],"new":[120],"ideas":[121],"methods":[123],"prevention,":[126],"diagnosis,":[127],"treatment.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}