{"id":"https://openalex.org/W4387875492","doi":"https://doi.org/10.3389/fbinf.2023.1214074","title":"Genome-scale metabolic models consistently predict in vitro characteristics of Corynebacterium striatum","display_name":"Genome-scale metabolic models consistently predict in vitro characteristics of Corynebacterium striatum","publication_year":2023,"publication_date":"2023-10-23","ids":{"openalex":"https://openalex.org/W4387875492","doi":"https://doi.org/10.3389/fbinf.2023.1214074","pmid":"https://pubmed.ncbi.nlm.nih.gov/37936955"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2023.1214074","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2023.1214074","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1214074/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1214074/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066720609","display_name":"Famke B\u00e4uerle","orcid":"https://orcid.org/0000-0003-1387-0251"},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Famke B\u00e4uerle","raw_affiliation_strings":["Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","Department of Computer Science, Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","Interfaculty Institute of Microbiology and Infection Medicine T\u00fcbingen (IMIT), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Computer Science, Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Interfaculty Institute of Microbiology and Infection Medicine T\u00fcbingen (IMIT), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093112412","display_name":"Gwendolyn O. D\u00f6bel","orcid":null},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gwendolyn O. D\u00f6bel","raw_affiliation_strings":["Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","Department of Computer Science, Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Computer Science, Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210115305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078012946","display_name":"Laura Camus","orcid":"https://orcid.org/0000-0003-1335-8901"},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Camus","raw_affiliation_strings":["Cluster of Excellence \"Controlling Microbes to Fight Infections (CMFI)\", Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, T\u00fcbingen, Germany","Interfaculty Institute of Microbiology and Infection Medicine T\u00fcbingen (IMIT), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cluster of Excellence \"Controlling Microbes to Fight Infections (CMFI)\", Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Interfaculty Institute of Microbiology and Infection Medicine T\u00fcbingen (IMIT), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084403633","display_name":"Simon Heilbronner","orcid":"https://orcid.org/0000-0002-6774-2311"},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Simon Heilbronner","raw_affiliation_strings":["Cluster of Excellence \"Controlling Microbes to Fight Infections (CMFI)\", Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","Faculty of Biology, Microbiology, Ludwig Maximilian University of Munich, Munich, Germany","German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, T\u00fcbingen, Germany","Interfaculty Institute of Microbiology and Infection Medicine T\u00fcbingen (IMIT), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cluster of Excellence \"Controlling Microbes to Fight Infections (CMFI)\", Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Faculty of Biology, Microbiology, Ludwig Maximilian University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Interfaculty Institute of Microbiology and Infection Medicine T\u00fcbingen (IMIT), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065854572","display_name":"Andreas Dr\u00e4ger","orcid":"https://orcid.org/0000-0002-1240-5553"},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Dr\u00e4ger","raw_affiliation_strings":["Cluster of Excellence \"Controlling Microbes to Fight Infections (CMFI)\", Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","Department of Computer Science, Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cluster of Excellence \"Controlling Microbes to Fight Infections (CMFI)\", Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI), Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Computer Science, Eberhard Karl University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Partner Site T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210115305"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5065854572","https://openalex.org/A5066720609","https://openalex.org/A5084403633"],"corresponding_institution_ids":["https://openalex.org/I4210115305","https://openalex.org/I8087733","https://openalex.org/I8204097"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.1454,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59439516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"3","issue":null,"first_page":"1214074","last_page":"1214074"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6679694652557373},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6180814504623413},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5293945670127869},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.5221707820892334},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.4951390326023102},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.49024730920791626},{"id":"https://openalex.org/keywords/model-organism","display_name":"Model organism","score":0.48002949357032776},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4773837924003601},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.4563068449497223},{"id":"https://openalex.org/keywords/corynebacterium-glutamicum","display_name":"Corynebacterium glutamicum","score":0.4365244507789612},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.39144957065582275},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.37293529510498047},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3577955961227417},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15645450353622437},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10651594400405884},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09681946039199829}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6679694652557373},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6180814504623413},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5293945670127869},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5221707820892334},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.4951390326023102},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.49024730920791626},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.48002949357032776},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4773837924003601},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.4563068449497223},{"id":"https://openalex.org/C2776260651","wikidata":"https://www.wikidata.org/wiki/Q292314","display_name":"Corynebacterium glutamicum","level":3,"score":0.4365244507789612},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.39144957065582275},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.37293529510498047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3577955961227417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15645450353622437},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10651594400405884},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09681946039199829},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2023.1214074","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2023.1214074","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1214074/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37936955","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37936955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10626998","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10626998","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10626998/pdf/fbinf-03-1214074.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:808689ee433e4453ad44e56a296d1eba","is_oa":true,"landing_page_url":"https://doaj.org/article/808689ee433e4453ad44e56a296d1eba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 3 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2023.1214074","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2023.1214074","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1214074/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.6600000262260437}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311052","display_name":"Deutsches Zentrum f\u00fcr Infektionsforschung","ror":"https://ror.org/028s4q594"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387875492.pdf"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1665355332","https://openalex.org/W1897231799","https://openalex.org/W1943327251","https://openalex.org/W1986399475","https://openalex.org/W1986787331","https://openalex.org/W2014426480","https://openalex.org/W2044935306","https://openalex.org/W2048465561","https://openalex.org/W2085993965","https://openalex.org/W2093385731","https://openalex.org/W2115955917","https://openalex.org/W2122860350","https://openalex.org/W2134221731","https://openalex.org/W2145435867","https://openalex.org/W2185357718","https://openalex.org/W2276489244","https://openalex.org/W2293705795","https://openalex.org/W2559597060","https://openalex.org/W2566306740","https://openalex.org/W2746407896","https://openalex.org/W2749464300","https://openalex.org/W2761502649","https://openalex.org/W2762019694","https://openalex.org/W2783537713","https://openalex.org/W2784783226","https://openalex.org/W2791048175","https://openalex.org/W2795410052","https://openalex.org/W2798209956","https://openalex.org/W2888410600","https://openalex.org/W2945494873","https://openalex.org/W2949418748","https://openalex.org/W2952015518","https://openalex.org/W2987028578","https://openalex.org/W2988361147","https://openalex.org/W3002962092","https://openalex.org/W3003257820","https://openalex.org/W3003280388","https://openalex.org/W3010629926","https://openalex.org/W3014189804","https://openalex.org/W3036988853","https://openalex.org/W3080133182","https://openalex.org/W3081478800","https://openalex.org/W3081775597","https://openalex.org/W3090217015","https://openalex.org/W3090689814","https://openalex.org/W3096828292","https://openalex.org/W3103145119","https://openalex.org/W3155457888","https://openalex.org/W3161160131","https://openalex.org/W3173412145","https://openalex.org/W3192023640","https://openalex.org/W3200565866","https://openalex.org/W3212969645","https://openalex.org/W4214665080","https://openalex.org/W4220663523","https://openalex.org/W4234812893","https://openalex.org/W4280616728","https://openalex.org/W4293473843","https://openalex.org/W4304172344","https://openalex.org/W4306392246","https://openalex.org/W4310779929","https://openalex.org/W4311279271","https://openalex.org/W4313297204","https://openalex.org/W4317479143","https://openalex.org/W4317499868","https://openalex.org/W4319985931","https://openalex.org/W4365135245","https://openalex.org/W4384338858","https://openalex.org/W6773143242"],"related_works":["https://openalex.org/W4223896405","https://openalex.org/W2059629050","https://openalex.org/W2258998699","https://openalex.org/W3013644380","https://openalex.org/W2074740504","https://openalex.org/W1996935079","https://openalex.org/W3210243923","https://openalex.org/W2145833061","https://openalex.org/W1998405066","https://openalex.org/W2171737904"],"abstract_inverted_index":{"Introduction:":[0],"Genome-scale":[1],"metabolic":[2,57,71],"models":[3,58,72,85,121,194],"(GEMs)":[4,73],"are":[5,195],"organism-specific":[6],"knowledge":[7],"bases":[8],"which":[9,167],"can":[10,161,205],"be":[11,206],"used":[12],"to":[13,51,117,125,153],"unravel":[14],"pathogenicity":[15],"or":[16],"improve":[17],"production":[18],"of":[19,28,59,74,108,170],"specific":[20,171],"metabolites":[21],"in":[22,33,34,45,48,122],"biotechnology":[23],"applications.":[24],"However,":[25],"the":[26,90,106,111,128,148,164,179],"validity":[27],"predictions":[29,135],"for":[30,131],"bacterial":[31,155],"proliferation":[32],"vitro":[35,49],"settings":[36],"is":[37,168,183,212],"hardly":[38],"investigated.":[39],"Methods:":[40],"The":[41,133,174,192,208],"present":[42],"work":[43,118],"combines":[44],"silico":[46],"and":[47,53,81,99,124,141,186,200,204],"approaches":[50],"create":[52],"curate":[54],"strain-specific":[55,69],"genome-scale":[56,70],"Corynebacterium":[60],"striatum":[61],".":[62,216],"Results:":[63],"We":[64],"introduce":[65],"five":[66],"newly":[67],"created":[68],"high":[75],"quality,":[76],"satisfying":[77],"all":[78],"contemporary":[79],"standards":[80,130],"requirements.":[82],"All":[83],"these":[84,120],"have":[86],"been":[87],"benchmarked":[88],"using":[89],"community":[91],"standard":[92],"test":[93],"suite":[94],"Metabolic":[95],"Model":[96],"Testing":[97],"(MEMOTE)":[98],"were":[100,136],"validated":[101],"by":[102,138],"laboratory":[103],"experiments.":[104],"For":[105],"curation":[107],"those":[109],"models,":[110],"software":[112,210],"infrastructure":[113],"refineGEMs":[114,211],"was":[115,151],"developed":[116,152],"on":[119,147,163,178],"parallel":[123],"comply":[126],"with":[127,189],"quality":[129],"GEMs.":[132],"model":[134],"confirmed":[137],"experimental":[139],"data":[140],"a":[142,201],"new":[143],"comparison":[144],"metric":[145],"based":[146,177],"doubling":[149],"time":[150],"quantify":[154],"growth.":[156],"Discussion:":[157],"Future":[158],"modeling":[159],"projects":[160],"rely":[162],"proposed":[165],"software,":[166],"independent":[169],"environmental":[172],"conditions.":[173],"validation":[175],"approach":[176],"growth":[180],"rate":[181],"calculation":[182],"now":[184],"accessible":[185],"closely":[187],"aligned":[188],"biological":[190],"questions.":[191],"curated":[193],"freely":[196],"available":[197,213],"via":[198],"BioModels":[199],"GitHub":[202],"repository":[203],"used.":[207],"open-source":[209],"from":[214],"https://github.com/draeger-lab/refinegems":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2023-10-24T00:00:00"}
