{"id":"https://openalex.org/W4323309784","doi":"https://doi.org/10.3389/fbinf.2023.1120370","title":"Before and after AlphaFold2: An overview of protein structure prediction","display_name":"Before and after AlphaFold2: An overview of protein structure prediction","publication_year":2023,"publication_date":"2023-02-28","ids":{"openalex":"https://openalex.org/W4323309784","doi":"https://doi.org/10.3389/fbinf.2023.1120370","pmid":"https://pubmed.ncbi.nlm.nih.gov/36926275"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2023.1120370","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2023.1120370","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1120370/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1120370/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060313675","display_name":"Let\u00edcia M. F. Bertoline","orcid":"https://orcid.org/0009-0008-6029-5759"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Let\u00edcia M. F. Bertoline","raw_affiliation_strings":["Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"],"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048517462","display_name":"Ang\u00e9lica N. Lima","orcid":null},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ang\u00e9lica N. Lima","raw_affiliation_strings":["Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"],"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088604083","display_name":"Jos\u00e9 Eduardo Krieger","orcid":"https://orcid.org/0000-0001-5464-1792"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jose E. Krieger","raw_affiliation_strings":["Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"],"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087996341","display_name":"Samantha K. Teixeira","orcid":"https://orcid.org/0000-0001-9534-2174"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Samantha K. Teixeira","raw_affiliation_strings":["Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"],"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060313675"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":41.0349,"has_fulltext":true,"cited_by_count":267,"citation_normalized_percentile":{"value":0.99906209,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"3","issue":null,"first_page":"1120370","last_page":"1120370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uniprot","display_name":"UniProt","score":0.7811609506607056},{"id":"https://openalex.org/keywords/casp","display_name":"CASP","score":0.7122732400894165},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.676774263381958},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.602564811706543},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.602207601070404},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5298768281936646},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5045994520187378},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"Protein function prediction","score":0.4777504503726959},{"id":"https://openalex.org/keywords/protein-structure-database","display_name":"Protein structure database","score":0.4676268696784973},{"id":"https://openalex.org/keywords/protein-tertiary-structure","display_name":"Protein tertiary structure","score":0.4319896697998047},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.41665852069854736},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.36865824460983276},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3640791177749634},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29577013850212097},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.08822482824325562}],"concepts":[{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.7811609506607056},{"id":"https://openalex.org/C66153294","wikidata":"https://www.wikidata.org/wiki/Q899291","display_name":"CASP","level":4,"score":0.7122732400894165},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.676774263381958},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.602564811706543},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.602207601070404},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5298768281936646},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5045994520187378},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.4777504503726959},{"id":"https://openalex.org/C136475424","wikidata":"https://www.wikidata.org/wiki/Q7251500","display_name":"Protein structure database","level":4,"score":0.4676268696784973},{"id":"https://openalex.org/C75599170","wikidata":"https://www.wikidata.org/wiki/Q898483","display_name":"Protein tertiary structure","level":2,"score":0.4319896697998047},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41665852069854736},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.36865824460983276},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3640791177749634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29577013850212097},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.08822482824325562},{"id":"https://openalex.org/C41584329","wikidata":"https://www.wikidata.org/wiki/Q175902","display_name":"Sequence database","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2023.1120370","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2023.1120370","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1120370/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36926275","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36926275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10011655","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10011655","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10011655/pdf/fbinf-03-1120370.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:223ae697af404cf7ac017898b15e8f8c","is_oa":true,"landing_page_url":"https://doaj.org/article/223ae697af404cf7ac017898b15e8f8c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 3 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2023.1120370","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2023.1120370","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1120370/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1950316668","display_name":null,"funder_award_id":"CAPES","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G2286822848","display_name":null,"funder_award_id":"2018-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3331681876","display_name":null,"funder_award_id":"CAPES","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3572101131","display_name":null,"funder_award_id":"2014/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3601516360","display_name":null,"funder_award_id":"Brazil","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4273621698","display_name":null,"funder_award_id":"PROEX","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4600047395","display_name":null,"funder_award_id":"FAPESP","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G4956284797","display_name":null,"funder_award_id":"14/50889-7","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5079005330","display_name":null,"funder_award_id":"support","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G5139334624","display_name":null,"funder_award_id":"Coordena\u00e7\u00e3o","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G5232205019","display_name":null,"funder_award_id":"2014/50889-7","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G6111631661","display_name":null,"funder_award_id":"Pesquisa","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G692611148","display_name":null,"funder_award_id":"Brazil","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G6997603433","display_name":null,"funder_award_id":"169192/2018-0","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G7123744472","display_name":null,"funder_award_id":"465586/2014-7","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G8281023383","display_name":null,"funder_award_id":"20214/50889-7","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G8733947178","display_name":null,"funder_award_id":"2018-0","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G963174003","display_name":null,"funder_award_id":"de Aperfei\u00e7","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4323309784.pdf"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1988385727","https://openalex.org/W2038561883","https://openalex.org/W2063916063","https://openalex.org/W2086211870","https://openalex.org/W2118200955","https://openalex.org/W2119619424","https://openalex.org/W2129434797","https://openalex.org/W2139279375","https://openalex.org/W2144483796","https://openalex.org/W2160544342","https://openalex.org/W2171559274","https://openalex.org/W2398896914","https://openalex.org/W2616928092","https://openalex.org/W2792555433","https://openalex.org/W2980272550","https://openalex.org/W2997234557","https://openalex.org/W2999044305","https://openalex.org/W3166142427","https://openalex.org/W3171039768","https://openalex.org/W3172825434","https://openalex.org/W3177828909","https://openalex.org/W3179412555","https://openalex.org/W3187563093","https://openalex.org/W3195375135","https://openalex.org/W3199799076","https://openalex.org/W3201523286","https://openalex.org/W3201869122","https://openalex.org/W3203459683","https://openalex.org/W3205208140","https://openalex.org/W3211795435","https://openalex.org/W3215498386","https://openalex.org/W4206002704","https://openalex.org/W4206344191","https://openalex.org/W4206940890","https://openalex.org/W4220824576","https://openalex.org/W4223956519","https://openalex.org/W4225552973","https://openalex.org/W4226027101","https://openalex.org/W4280575706","https://openalex.org/W4281291878","https://openalex.org/W4281790889","https://openalex.org/W4283122993","https://openalex.org/W4285392187","https://openalex.org/W4285594705","https://openalex.org/W4286500588","https://openalex.org/W4290725230","https://openalex.org/W4294719209","https://openalex.org/W4297235560","https://openalex.org/W4306888844","https://openalex.org/W4306951126","https://openalex.org/W4309148342","https://openalex.org/W4309153596","https://openalex.org/W4310058955","https://openalex.org/W4313367649","https://openalex.org/W4327550249","https://openalex.org/W4327566741","https://openalex.org/W6802033083"],"related_works":["https://openalex.org/W2118200955","https://openalex.org/W2771582859","https://openalex.org/W3109006384","https://openalex.org/W2316191393","https://openalex.org/W2952660917","https://openalex.org/W2044565516","https://openalex.org/W2470147982","https://openalex.org/W4385568297","https://openalex.org/W2065993463","https://openalex.org/W1963026959"],"abstract_inverted_index":{"Three-dimensional":[0],"protein":[1,30,47,66,100,125,133,140,150,194],"structure":[2,101,141,195],"is":[3,12,38,108],"directly":[4],"correlated":[5],"with":[6,54,102,172],"its":[7,10,111,166],"function":[8,143],"and":[9,18,22,52,142,198],"determination":[11],"critical":[13],"to":[14,64,86,130,170],"understanding":[15],"biological":[16],"processes":[17],"addressing":[19],"human":[20],"health":[21],"life":[23],"science":[24],"problems":[25],"in":[26,50,114,193],"general.":[27],"Although":[28],"new":[29,121],"structures":[31,67],"are":[32],"experimentally":[33],"obtained":[34],"over":[35],"time,":[36],"there":[37],"still":[39],"a":[40,72],"large":[41],"difference":[42],"between":[43],"the":[44,78,92,115,132,137,191],"number":[45],"of":[46,94,139,165,190],"sequences":[48],"placed":[49],"Uniprot":[51],"those":[53],"resolved":[55],"tertiary":[56],"structure.":[57],"In":[58,77,183],"this":[59,184],"context,":[60],"studies":[61],"have":[62,83,128],"emerged":[63],"predict":[65,171],"by":[68],"methods":[69,82,122,155],"based":[70,123],"on":[71,124,149],"template":[73],"or":[74],"free":[75],"modeling.":[76],"last":[79],"years,":[80],"different":[81],"been":[84],"combined":[85],"overcome":[87],"their":[88],"individual":[89],"limitations,":[90,167],"until":[91],"emergence":[93],"AlphaFold2,":[95],"which":[96],"demonstrated":[97],"that":[98],"predicting":[99],"high":[103,173],"accuracy":[104,174],"at":[105],"unprecedented":[106],"scale":[107],"possible.":[109],"Despite":[110],"current":[112],"impact":[113],"field,":[116],"AlphaFold2":[117,159,200],"has":[118],"limitations.":[119],"Recently,":[120],"language":[126],"models":[127],"promised":[129],"revolutionize":[131],"structural":[134],"biology":[135],"allowing":[136],"discovery":[138],"only":[144],"from":[145,180],"evolutionary":[146],"patterns":[147],"present":[148],"sequence.":[151],"Even":[152],"though":[153],"these":[154],"do":[156],"not":[157],"reach":[158],"accuracy,":[160],"they":[161],"already":[162],"covered":[163],"some":[164],"being":[168],"able":[169],"more":[175],"than":[176],"200":[177],"million":[178],"proteins":[179],"metagenomic":[181],"databases.":[182],"mini-review,":[185],"we":[186],"provide":[187],"an":[188],"overview":[189],"breakthroughs":[192],"prediction":[196],"before":[197],"after":[199],"emergence.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":112},{"year":2024,"cited_by_count":89},{"year":2023,"cited_by_count":46}],"updated_date":"2026-03-31T07:56:22.981413","created_date":"2025-10-10T00:00:00"}
