{"id":"https://openalex.org/W4319787294","doi":"https://doi.org/10.3389/fbinf.2023.1117271","title":"Multi-omics of extracellular vesicles: An integrative representation of functional mediators and perspectives on lung disease study","display_name":"Multi-omics of extracellular vesicles: An integrative representation of functional mediators and perspectives on lung disease study","publication_year":2023,"publication_date":"2023-02-09","ids":{"openalex":"https://openalex.org/W4319787294","doi":"https://doi.org/10.3389/fbinf.2023.1117271","pmid":"https://pubmed.ncbi.nlm.nih.gov/36844931"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2023.1117271","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2023.1117271","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1117271/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1117271/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070870604","display_name":"Yuexing Liu","orcid":"https://orcid.org/0000-0003-4369-1131"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuexing Liu","raw_affiliation_strings":["Guangzhou Laboratory, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Laboratory, Guangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008280608","display_name":"Yixue Li","orcid":"https://orcid.org/0000-0002-1198-7176"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yixue Li","raw_affiliation_strings":["Guangzhou Laboratory, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Laboratory, Guangzhou, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026321844","display_name":"Tao Zeng","orcid":"https://orcid.org/0000-0002-0295-3994"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Zeng","raw_affiliation_strings":["Guangzhou Laboratory, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Laboratory, Guangzhou, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1900,"currency":"USD","value_usd":2125},"apc_paid":{"value":1900,"currency":"USD","value_usd":2125},"fwci":1.5936,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.82762798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"3","issue":null,"first_page":"1117271","last_page":"1117271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microvesicles","display_name":"Microvesicles","score":0.757384181022644},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6551166772842407},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"Extracellular vesicles","score":0.6068193316459656},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5741956233978271},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5458777546882629},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33535295724868774},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2769728899002075},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.22858905792236328},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10872113704681396},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10617578029632568}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.757384181022644},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6551166772842407},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.6068193316459656},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5741956233978271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5458777546882629},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33535295724868774},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2769728899002075},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.22858905792236328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10872113704681396},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10617578029632568},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2023.1117271","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2023.1117271","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1117271/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36844931","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36844931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9947558","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9947558","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9947558/pdf/fbinf-03-1117271.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a0b3b348c054438098ddec8109c6b0a7","is_oa":true,"landing_page_url":"https://doaj.org/article/a0b3b348c054438098ddec8109c6b0a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 3 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2023.1117271","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2023.1117271","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2023.1117271/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5660135745","display_name":null,"funder_award_id":"2022YFF1202100","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5970925000","display_name":"\u57fa\u4e8e\u751f\u7269\u5927\u6570\u636e\u7684\u5206\u5b50\u7f51\u7edc\u5206\u578b\u7684\u6a21\u578b\u53ca\u7b97\u6cd5\u7814\u7a76","funder_award_id":"11871456","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6044760167","display_name":null,"funder_award_id":"2017SHZDZX01","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319787294.pdf"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1500925570","https://openalex.org/W2560371760","https://openalex.org/W2567639438","https://openalex.org/W2790335960","https://openalex.org/W2928087086","https://openalex.org/W3046071390","https://openalex.org/W3047253843","https://openalex.org/W3103498083","https://openalex.org/W3108804544","https://openalex.org/W3113349068","https://openalex.org/W3137790535","https://openalex.org/W3152370785","https://openalex.org/W3154523717","https://openalex.org/W3155703470","https://openalex.org/W3168638757","https://openalex.org/W3177080725","https://openalex.org/W3183922152","https://openalex.org/W3192067290","https://openalex.org/W3195287719","https://openalex.org/W3197711498","https://openalex.org/W3198011172","https://openalex.org/W3204671147","https://openalex.org/W3204789385","https://openalex.org/W3206223527","https://openalex.org/W3210598828","https://openalex.org/W3217068506","https://openalex.org/W4200006438","https://openalex.org/W4200144217","https://openalex.org/W4200236068","https://openalex.org/W4200439253","https://openalex.org/W4200525770","https://openalex.org/W4205571336","https://openalex.org/W4206609166","https://openalex.org/W4206781704","https://openalex.org/W4207063191","https://openalex.org/W4214518289","https://openalex.org/W4220706419","https://openalex.org/W4220903131","https://openalex.org/W4220915864","https://openalex.org/W4220990074","https://openalex.org/W4220999566","https://openalex.org/W4221093274","https://openalex.org/W4221133969","https://openalex.org/W4223443779","https://openalex.org/W4224215508","https://openalex.org/W4224311399","https://openalex.org/W4281657073","https://openalex.org/W4284884324","https://openalex.org/W4291184123","https://openalex.org/W4298006197","https://openalex.org/W4302287440","https://openalex.org/W4307939590","https://openalex.org/W4308726171","https://openalex.org/W4311849792","https://openalex.org/W4313424416"],"related_works":["https://openalex.org/W2004257346","https://openalex.org/W4224608758","https://openalex.org/W4381617892","https://openalex.org/W3128768115","https://openalex.org/W2560295122","https://openalex.org/W4224325546","https://openalex.org/W4378176405","https://openalex.org/W3188041304","https://openalex.org/W2247699313","https://openalex.org/W2890709780"],"abstract_inverted_index":{"carrying":[0],"diverse":[1],"biological":[2,85],"signals":[3],"from":[4],"one":[5],"cell":[6],"type":[7],"or":[8,27],"tissue":[9],"to":[10,22,51,78],"another.":[11],"EVs":[12,33,129,148],"play":[13],"roles":[14],"as":[15,41],"communication":[16,101,114],"messengers":[17],"of":[18,37,62,83,109,133,141,144],"the":[19,60,105,118,131,142],"intercellular":[20],"network":[21],"mediate":[23],"different":[24],"physiological":[25],"activities":[26],"pathological":[28],"changes.":[29],"In":[30],"particular,":[31],"most":[32],"are":[34,49,76],"natural":[35],"carriers":[36],"functional":[38],"cargo":[39,97],"such":[40],"DNA,":[42],"RNA,":[43],"and":[44,46,67,73,86,92,107,111,121,135,149],"proteins,":[45],"thus":[47],"they":[48],"relevant":[50],"advancing":[52],"personalized":[53],"targeted":[54],"therapies":[55],"in":[56,130],"clinical":[57],"practice.":[58],"For":[59],"application":[61],"EVs,":[63,110],"novel":[64],"bioinformatic":[65,139],"models":[66],"methods":[68],"based":[69],"on":[70,147],"high-throughput":[71],"technologies":[72],"multi-omics":[74,134],"data":[75],"required":[77],"provide":[79],"a":[80],"deeper":[81],"understanding":[82],"their":[84,150],"biomedical":[87],"characteristics.":[88],"These":[89],"include":[90],"qualitative":[91],"quantitative":[93],"representation":[94],"for":[95,103,116],"identifying":[96],"markers,":[98],"local":[99],"cellular":[100],"inference":[102],"tracing":[104],"origin":[106],"production":[108],"distant":[112],"organ":[113],"reconstruction":[115],"targeting":[117],"influential":[119],"microenvironment":[120],"transferable":[122],"activators.":[123],"Thus,":[124],"this":[125],"perspective":[126],"paper":[127],"introduces":[128],"context":[132],"provides":[136],"an":[137],"integrative":[138],"viewpoint":[140],"state":[143],"current":[145],"research":[146],"applications.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
