{"id":"https://openalex.org/W4281851318","doi":"https://doi.org/10.3389/fbinf.2022.847629","title":"DNA Methylation, Aging, and Cancer Risk: A Mini-Review","display_name":"DNA Methylation, Aging, and Cancer Risk: A Mini-Review","publication_year":2022,"publication_date":"2022-06-02","ids":{"openalex":"https://openalex.org/W4281851318","doi":"https://doi.org/10.3389/fbinf.2022.847629","pmid":"https://pubmed.ncbi.nlm.nih.gov/36304336"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2022.847629","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2022.847629","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2022.847629/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2022.847629/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103136870","display_name":"Larry Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry Chen","raw_affiliation_strings":["Computational and Systems Biology Program, University of California, Los Angeles, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Systems Biology Program, University of California, Los Angeles, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103153387","display_name":"Patricia A. Ganz","orcid":"https://orcid.org/0000-0002-1841-4143"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia A. Ganz","raw_affiliation_strings":["Department of Health Policy and Management, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States","Division of Hematology-Oncology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Policy and Management, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018583135","display_name":"Mary E. Sehl","orcid":"https://orcid.org/0000-0003-2301-0562"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary E. Sehl","raw_affiliation_strings":["Department of Computational Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, United States","Division of Hematology-Oncology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, United States","institution_ids":[]},{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018583135"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":2.4563,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.89402341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"2","issue":null,"first_page":"847629","last_page":"847629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9606999754905701,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.9544000029563904,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.8710707426071167},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7998663187026978},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6402225494384766},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.6059591174125671},{"id":"https://openalex.org/keywords/genome-instability","display_name":"Genome instability","score":0.5741683840751648},{"id":"https://openalex.org/keywords/somatic-cell","display_name":"Somatic cell","score":0.5704476833343506},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5550075173377991},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4367574155330658},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.36596769094467163},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.3455390930175781},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3347170948982239},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31905198097229004},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.23320850729942322},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16720232367515564},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12109988927841187}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8710707426071167},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7998663187026978},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6402225494384766},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6059591174125671},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5741683840751648},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5704476833343506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5550075173377991},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4367574155330658},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36596769094467163},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3455390930175781},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3347170948982239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31905198097229004},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23320850729942322},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16720232367515564},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12109988927841187}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2022.847629","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2022.847629","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2022.847629/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36304336","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36304336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:f67b079c1d6f41e9a679d7f0352e2ec1","is_oa":false,"landing_page_url":"https://doaj.org/article/f67b079c1d6f41e9a679d7f0352e2ec1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 2 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9580889","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9580889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2022.847629","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2022.847629","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2022.847629/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320311413","display_name":"Susan G. Komen","ror":"https://ror.org/02nadbe75"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281851318.pdf","grobid_xml":"https://content.openalex.org/works/W4281851318.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1556996865","https://openalex.org/W1850198354","https://openalex.org/W1965262464","https://openalex.org/W1974047233","https://openalex.org/W1998516698","https://openalex.org/W2008978345","https://openalex.org/W2052629634","https://openalex.org/W2080644309","https://openalex.org/W2095174508","https://openalex.org/W2112365416","https://openalex.org/W2117692326","https://openalex.org/W2121091193","https://openalex.org/W2124407126","https://openalex.org/W2126525177","https://openalex.org/W2127196115","https://openalex.org/W2153424791","https://openalex.org/W2154881878","https://openalex.org/W2158805742","https://openalex.org/W2159144282","https://openalex.org/W2167021978","https://openalex.org/W2171346943","https://openalex.org/W2255969727","https://openalex.org/W2341474791","https://openalex.org/W2356710107","https://openalex.org/W2403874820","https://openalex.org/W2416801689","https://openalex.org/W2421283105","https://openalex.org/W2528967511","https://openalex.org/W2529317472","https://openalex.org/W2529664418","https://openalex.org/W2557295976","https://openalex.org/W2590469096","https://openalex.org/W2592878201","https://openalex.org/W2598804691","https://openalex.org/W2606865793","https://openalex.org/W2725163236","https://openalex.org/W2770929780","https://openalex.org/W2773327522","https://openalex.org/W2785550069","https://openalex.org/W2883262856","https://openalex.org/W2889199419","https://openalex.org/W2912654909","https://openalex.org/W2917830189","https://openalex.org/W2947965693","https://openalex.org/W2949100461","https://openalex.org/W2952093052","https://openalex.org/W2956136191","https://openalex.org/W2965994767","https://openalex.org/W2969128479","https://openalex.org/W2980419056","https://openalex.org/W2980520436","https://openalex.org/W2980665731","https://openalex.org/W2983046534","https://openalex.org/W2994754234","https://openalex.org/W3007728540","https://openalex.org/W3012152443","https://openalex.org/W3111314674","https://openalex.org/W3139234365","https://openalex.org/W3164927336","https://openalex.org/W3167889335","https://openalex.org/W3200825592","https://openalex.org/W4226102911","https://openalex.org/W6769456228"],"related_works":["https://openalex.org/W2902329290","https://openalex.org/W2051467864","https://openalex.org/W2139872319","https://openalex.org/W2096764255","https://openalex.org/W2052355316","https://openalex.org/W2046964473","https://openalex.org/W2107880877","https://openalex.org/W2151182744","https://openalex.org/W2024490794","https://openalex.org/W1998349112"],"abstract_inverted_index":{"Accumulation":[0],"of":[1,9,28,38,53,77,91,107],"somatic":[2],"mutations":[3],"and":[4,12,20,40,42,72,74],"genomic":[5],"instability":[6],"are":[7],"hallmarks":[8],"both":[10],"aging":[11,68],"cancer.":[13,55,108],"Epigenetic":[14],"alterations":[15],"occur":[16],"across":[17],"cell":[18],"types":[19],"tissues":[21,103],"with":[22,51],"advancing":[23],"age.":[24],"DNA":[25],"methylation-based":[26],"estimates":[27],"biologic":[29],"age":[30],"can":[31],"predict":[32,82],"important":[33],"age-related":[34],"outcomes,":[35],"including":[36,85],"risk":[37,52,106],"frailty":[39],"mortality,":[41],"most":[43],"recently":[44],"have":[45],"been":[46],"shown":[47],"to":[48,63],"be":[49],"associated":[50],"developing":[54],"In":[56],"this":[57],"mini-review,":[58],"we":[59],"examine":[60],"pathways":[61],"known":[62],"exhibit":[64],"altered":[65],"methylation":[66,89,98],"in":[67],"tissues,":[69],"pre-malignant":[70],"lesions,":[71],"tumors":[73],"review":[75],"methodologies":[76],"epigenetic":[78],"clocks":[79],"that":[80],"reliably":[81],"cancer":[83],"risk,":[84],"those":[86,97],"derived":[87],"from":[88,100],"studies":[90],"peripheral":[92],"blood,":[93],"as":[94,96],"well":[95],"levels":[99],"within":[101],"the":[102],"at":[104],"high":[105]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":8}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
