{"id":"https://openalex.org/W4213446872","doi":"https://doi.org/10.3389/fbinf.2022.821861","title":"Applications and Comparison of Dimensionality Reduction Methods for Microbiome Data","display_name":"Applications and Comparison of Dimensionality Reduction Methods for Microbiome Data","publication_year":2022,"publication_date":"2022-02-24","ids":{"openalex":"https://openalex.org/W4213446872","doi":"https://doi.org/10.3389/fbinf.2022.821861","pmid":"https://pubmed.ncbi.nlm.nih.gov/36304280"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2022.821861","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2022.821861","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2022.821861/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2022.821861/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000137125","display_name":"George Armstrong","orcid":"https://orcid.org/0000-0002-1061-3295"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Armstrong","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, United States","Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States"],"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043464127","display_name":"Gibraan Rahman","orcid":"https://orcid.org/0000-0002-8843-0229"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gibraan Rahman","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, United States","Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States"],"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067810319","display_name":"Cameron Martino","orcid":"https://orcid.org/0000-0001-9334-1258"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210150894","display_name":"Jacobs (United States)","ror":"https://ror.org/05pmj3x43","country_code":"US","type":"company","lineage":["https://openalex.org/I4210150894"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cameron Martino","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, United States","Center for Microbiome Innovation, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA, United States","Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States"],"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Center for Microbiome Innovation, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210150894"]},{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022461817","display_name":"Daniel McDonald","orcid":"https://orcid.org/0000-0003-0876-9060"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel McDonald","raw_affiliation_strings":["Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101532298","display_name":"Antonio Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-5900-3965"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Gonzalez","raw_affiliation_strings":["Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075832074","display_name":"Gal Mishne","orcid":"https://orcid.org/0000-0002-5287-3626"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gal Mishne","raw_affiliation_strings":["Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, United States","Hal\u0131c\u0131o\u011flu Data Science Institute, University of California, San Diego, La Jolla, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Hal\u0131c\u0131o\u011flu Data Science Institute, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033881627","display_name":"Rob Knight","orcid":"https://orcid.org/0000-0002-0975-9019"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rob Knight","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States","Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, United States","Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5033881627"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210133661"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":4.6023,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.96114943,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"2","issue":null,"first_page":"821861","last_page":"821861"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.8026160001754761},{"id":"https://openalex.org/keywords/principle-of-compositionality","display_name":"Principle of compositionality","score":0.7012124061584473},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7010233402252197},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.6260656714439392},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.5312032103538513},{"id":"https://openalex.org/keywords/normality","display_name":"Normality","score":0.4971063435077667},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.49427247047424316},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4544239342212677},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4273717403411865},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4199420213699341},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.39453238248825073},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1669899821281433},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15122023224830627},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11431115865707397},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.0731167197227478}],"concepts":[{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.8026160001754761},{"id":"https://openalex.org/C121375916","wikidata":"https://www.wikidata.org/wiki/Q936559","display_name":"Principle of compositionality","level":2,"score":0.7012124061584473},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7010233402252197},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6260656714439392},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.5312032103538513},{"id":"https://openalex.org/C2776157432","wikidata":"https://www.wikidata.org/wiki/Q1375683","display_name":"Normality","level":2,"score":0.4971063435077667},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.49427247047424316},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4544239342212677},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4273717403411865},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4199420213699341},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.39453238248825073},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1669899821281433},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15122023224830627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11431115865707397},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0731167197227478},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2022.821861","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2022.821861","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2022.821861/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36304280","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36304280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:27ed972fb2724b03bc457a9ac7c1a916","is_oa":true,"landing_page_url":"https://doaj.org/article/27ed972fb2724b03bc457a9ac7c1a916","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 2 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9580878","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9580878","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2022.821861","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2022.821861","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbinf.2022.821861/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2053563072","display_name":null,"funder_award_id":"CRISP","funder_id":"https://openalex.org/F4320306087","funder_display_name":"Semiconductor Research Corporation"},{"id":"https://openalex.org/G3820508793","display_name":null,"funder_award_id":"DP1AT010885","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6384937221","display_name":null,"funder_award_id":"U19AG063744","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6567865259","display_name":null,"funder_award_id":"U24CA248454","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7406030291","display_name":null,"funder_award_id":"CRISP","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G953843664","display_name":null,"funder_award_id":"2038509","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306087","display_name":"Semiconductor Research Corporation","ror":"https://ror.org/047z4n946"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4213446872.pdf","grobid_xml":"https://content.openalex.org/works/W4213446872.grobid-xml"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W571770348","https://openalex.org/W1484864026","https://openalex.org/W1523266228","https://openalex.org/W1565234293","https://openalex.org/W1604938182","https://openalex.org/W1902027874","https://openalex.org/W1968105193","https://openalex.org/W1984284869","https://openalex.org/W1985197139","https://openalex.org/W2000259070","https://openalex.org/W2001141328","https://openalex.org/W2008194879","https://openalex.org/W2029207056","https://openalex.org/W2034710843","https://openalex.org/W2051322058","https://openalex.org/W2053186076","https://openalex.org/W2056279562","https://openalex.org/W2066011810","https://openalex.org/W2067045493","https://openalex.org/W2067537975","https://openalex.org/W2079477813","https://openalex.org/W2080283023","https://openalex.org/W2105937617","https://openalex.org/W2108303460","https://openalex.org/W2108718991","https://openalex.org/W2127175247","https://openalex.org/W2127602818","https://openalex.org/W2128769815","https://openalex.org/W2130731460","https://openalex.org/W2131186249","https://openalex.org/W2145664556","https://openalex.org/W2152825437","https://openalex.org/W2156718197","https://openalex.org/W2162088497","https://openalex.org/W2164583936","https://openalex.org/W2166562121","https://openalex.org/W2167941657","https://openalex.org/W2170024099","https://openalex.org/W2187089797","https://openalex.org/W2190487303","https://openalex.org/W2302539953","https://openalex.org/W2316237173","https://openalex.org/W2334043242","https://openalex.org/W2347104163","https://openalex.org/W2409427249","https://openalex.org/W2520725961","https://openalex.org/W2529206757","https://openalex.org/W2537693456","https://openalex.org/W2542768043","https://openalex.org/W2572771096","https://openalex.org/W2588997555","https://openalex.org/W2590974468","https://openalex.org/W2592244930","https://openalex.org/W2592367925","https://openalex.org/W2593591803","https://openalex.org/W2622073354","https://openalex.org/W2737507131","https://openalex.org/W2760357344","https://openalex.org/W2766358903","https://openalex.org/W2767431605","https://openalex.org/W2767554904","https://openalex.org/W2767933740","https://openalex.org/W2769542288","https://openalex.org/W2769839254","https://openalex.org/W2804309380","https://openalex.org/W2890526629","https://openalex.org/W2891216882","https://openalex.org/W2892206041","https://openalex.org/W2899495835","https://openalex.org/W2902636332","https://openalex.org/W2902652978","https://openalex.org/W2914348147","https://openalex.org/W2915311012","https://openalex.org/W2924089816","https://openalex.org/W2950612336","https://openalex.org/W2951061751","https://openalex.org/W2963276645","https://openalex.org/W2969973950","https://openalex.org/W2972909756","https://openalex.org/W2989747508","https://openalex.org/W2996147503","https://openalex.org/W2998369522","https://openalex.org/W3003742251","https://openalex.org/W3005127469","https://openalex.org/W3006148598","https://openalex.org/W3011209653","https://openalex.org/W3016087356","https://openalex.org/W3022006686","https://openalex.org/W3081657721","https://openalex.org/W3091376159","https://openalex.org/W3102089015","https://openalex.org/W3105146463","https://openalex.org/W3109541743","https://openalex.org/W3111059807","https://openalex.org/W3111747080","https://openalex.org/W3112561157","https://openalex.org/W3121420839","https://openalex.org/W3122222197","https://openalex.org/W3126757510","https://openalex.org/W3127452014","https://openalex.org/W3129896128","https://openalex.org/W3163440514","https://openalex.org/W3164133171","https://openalex.org/W3177046243","https://openalex.org/W3197037991","https://openalex.org/W3204834823","https://openalex.org/W3211228774","https://openalex.org/W4205366374","https://openalex.org/W4221116063","https://openalex.org/W4234309721","https://openalex.org/W4246354968","https://openalex.org/W6634974784","https://openalex.org/W6754796332","https://openalex.org/W6788968379"],"related_works":["https://openalex.org/W1995622179","https://openalex.org/W1484111231","https://openalex.org/W4391160746","https://openalex.org/W1552543208","https://openalex.org/W2074396517","https://openalex.org/W2166963679","https://openalex.org/W2187269125","https://openalex.org/W1641615907","https://openalex.org/W3089231081","https://openalex.org/W2093956241"],"abstract_inverted_index":{"Dimensionality":[0],"reduction":[1,41],"techniques":[2,120],"are":[3,64],"a":[4],"key":[5],"component":[6],"of":[7,46,61,74,103],"most":[8],"microbiome":[9,19,47],"studies,":[10],"providing":[11],"both":[12],"the":[13,22,36,43,58,72,90,96,101,107],"ability":[14,108],"to":[15,84,109],"tractably":[16],"visualize":[17],"complex":[18],"datasets":[20],"and":[21,52,69,113],"starting":[23],"point":[24],"for":[25,38,66,92],"additional,":[26],"more":[27,125],"formal,":[28],"statistical":[29],"analyses.":[30,129],"In":[31],"this":[32,56],"review,":[33],"we":[34],"discuss":[35],"motivation":[37],"applying":[39],"dimensionality":[40,67],"techniques,":[42],"special":[44],"characteristics":[45],"data":[48],"such":[49],"as":[50,115,117],"sparsity":[51],"compositionality":[53],"that":[54,63,121],"make":[55],"difficult,":[57],"different":[59],"categories":[60],"strategies":[62],"available":[65],"reduction,":[68],"examples":[70],"from":[71],"literature":[73],"how":[75],"they":[76],"have":[77],"been":[78],"successfully":[79],"applied":[80,124],"(together":[81],"with":[82,106],"pitfalls":[83],"avoid).":[85],"We":[86],"conclude":[87],"by":[88],"describing":[89],"need":[91],"further":[93],"development":[94],"in":[95,98,127],"field,":[97],"particular":[99],"combining":[100],"power":[102],"phylogenetic":[104],"analysis":[105],"handle":[110],"sparsity,":[111],"compositionality,":[112],"non-normality,":[114],"well":[116],"discussing":[118],"current":[119],"should":[122],"be":[123],"widely":[126],"future":[128]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-16T09:10:04.655348","created_date":"2025-10-10T00:00:00"}