{"id":"https://openalex.org/W4311114420","doi":"https://doi.org/10.3233/isb-220253","title":"Modelling speciation: Problems and implications","display_name":"Modelling speciation: Problems and implications","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4311114420","doi":"https://doi.org/10.3233/isb-220253","pmid":"https://pubmed.ncbi.nlm.nih.gov/36502315"},"language":"en","primary_location":{"id":"doi:10.3233/isb-220253","is_oa":true,"landing_page_url":"https://doi.org/10.3233/isb-220253","pdf_url":"https://content.iospress.com:443/download/in-silico-biology/isb220253?id=in-silico-biology%2Fisb220253","source":{"id":"https://openalex.org/S120694666","display_name":"In Silico Biology","issn_l":"1386-6338","issn":["1386-6338","1434-3207"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Silico Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://content.iospress.com:443/download/in-silico-biology/isb220253?id=in-silico-biology%2Fisb220253","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041987387","display_name":"Jonathan Bard","orcid":"https://orcid.org/0000-0002-4422-9726"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jonathan B.L. Bard","raw_affiliation_strings":["Balliol College, University of Oxford, Oxford OX13BJ, UK"],"affiliations":[{"raw_affiliation_string":"Balliol College, University of Oxford, Oxford OX13BJ, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041987387"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":0.1879,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63375817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"15","issue":"1-2","first_page":"23","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.7905179858207703},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6202858686447144},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5968173742294312},{"id":"https://openalex.org/keywords/natural-selection","display_name":"Natural selection","score":0.5826348066329956},{"id":"https://openalex.org/keywords/inheritance","display_name":"Inheritance (genetic algorithm)","score":0.5706580281257629},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5563418865203857},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5483444929122925},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.5030433535575867},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.480480819940567},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4786290228366852},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39737558364868164},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.36091989278793335},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.12260377407073975},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.0933271050453186},{"id":"https://openalex.org/keywords/sociology","display_name":"Sociology","score":0.083962082862854},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.08014565706253052}],"concepts":[{"id":"https://openalex.org/C2776838516","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.7905179858207703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6202858686447144},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5968173742294312},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.5826348066329956},{"id":"https://openalex.org/C2780902518","wikidata":"https://www.wikidata.org/wiki/Q6033780","display_name":"Inheritance (genetic algorithm)","level":3,"score":0.5706580281257629},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5563418865203857},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5483444929122925},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.5030433535575867},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.480480819940567},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4786290228366852},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39737558364868164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36091989278793335},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12260377407073975},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0933271050453186},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.083962082862854},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.08014565706253052},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057231","descriptor_name":"Climate Change","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057231","descriptor_name":"Climate Change","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057231","descriptor_name":"Climate Change","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057231","descriptor_name":"Climate Change","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057231","descriptor_name":"Climate Change","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3233/isb-220253","is_oa":true,"landing_page_url":"https://doi.org/10.3233/isb-220253","pdf_url":"https://content.iospress.com:443/download/in-silico-biology/isb220253?id=in-silico-biology%2Fisb220253","source":{"id":"https://openalex.org/S120694666","display_name":"In Silico Biology","issn_l":"1386-6338","issn":["1386-6338","1434-3207"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Silico Biology","raw_type":"journal-article"},{"id":"pmid:36502315","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36502315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In silico biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10741375","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10741375","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10741375/pdf/isb-15-isb220253.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In Silico Biol","raw_type":"Text"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:8896efd5-e8dd-4f2c-815f-d9bef0dec77e","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jisc Publications Router","raw_type":"http://purl.org/coar/resource_type/c_dcae04bc"}],"best_oa_location":{"id":"doi:10.3233/isb-220253","is_oa":true,"landing_page_url":"https://doi.org/10.3233/isb-220253","pdf_url":"https://content.iospress.com:443/download/in-silico-biology/isb220253?id=in-silico-biology%2Fisb220253","source":{"id":"https://openalex.org/S120694666","display_name":"In Silico Biology","issn_l":"1386-6338","issn":["1386-6338","1434-3207"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Silico Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Climate action","id":"https://metadata.un.org/sdg/13","score":0.7200000286102295}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4311114420.pdf","grobid_xml":"https://content.openalex.org/works/W4311114420.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W240771047","https://openalex.org/W1532683741","https://openalex.org/W1555658038","https://openalex.org/W1558359460","https://openalex.org/W1574291313","https://openalex.org/W1819728079","https://openalex.org/W1964456182","https://openalex.org/W1967829443","https://openalex.org/W1969680007","https://openalex.org/W1980661496","https://openalex.org/W1980850594","https://openalex.org/W1995940437","https://openalex.org/W2009339775","https://openalex.org/W2030638423","https://openalex.org/W2031278222","https://openalex.org/W2044278781","https://openalex.org/W2052061673","https://openalex.org/W2056726501","https://openalex.org/W2060805862","https://openalex.org/W2061177733","https://openalex.org/W2064018179","https://openalex.org/W2067799837","https://openalex.org/W2068751001","https://openalex.org/W2072378334","https://openalex.org/W2091025009","https://openalex.org/W2103892573","https://openalex.org/W2114058116","https://openalex.org/W2115619606","https://openalex.org/W2122530127","https://openalex.org/W2123875750","https://openalex.org/W2124850941","https://openalex.org/W2139137018","https://openalex.org/W2144386534","https://openalex.org/W2147802228","https://openalex.org/W2149943693","https://openalex.org/W2151984197","https://openalex.org/W2166237000","https://openalex.org/W2167637335","https://openalex.org/W2169315800","https://openalex.org/W2174575960","https://openalex.org/W2219314901","https://openalex.org/W2256812860","https://openalex.org/W2277696048","https://openalex.org/W2312744063","https://openalex.org/W2324027308","https://openalex.org/W2346370112","https://openalex.org/W2510652998","https://openalex.org/W2598040098","https://openalex.org/W2737067700","https://openalex.org/W2737687652","https://openalex.org/W2762187001","https://openalex.org/W2765899673","https://openalex.org/W2767023484","https://openalex.org/W2770477936","https://openalex.org/W2782495047","https://openalex.org/W2783450464","https://openalex.org/W2796932341","https://openalex.org/W2797498165","https://openalex.org/W2809508031","https://openalex.org/W2883560622","https://openalex.org/W2909957393","https://openalex.org/W2942193984","https://openalex.org/W2969718750","https://openalex.org/W2971031567","https://openalex.org/W3001061978","https://openalex.org/W3003422837","https://openalex.org/W3044913463","https://openalex.org/W3090727536","https://openalex.org/W3124667933","https://openalex.org/W3174678145","https://openalex.org/W3199213843","https://openalex.org/W3201145195","https://openalex.org/W3205025027","https://openalex.org/W3205057869","https://openalex.org/W3210047912","https://openalex.org/W4200346320","https://openalex.org/W4225396488","https://openalex.org/W4232332012","https://openalex.org/W4233801092","https://openalex.org/W4236161185","https://openalex.org/W4242722048","https://openalex.org/W4250582385","https://openalex.org/W4251560356","https://openalex.org/W4255254201","https://openalex.org/W4281676089","https://openalex.org/W4283525636","https://openalex.org/W4294266209","https://openalex.org/W6634035519","https://openalex.org/W6638520080","https://openalex.org/W6645045626","https://openalex.org/W6667675878","https://openalex.org/W6684423813","https://openalex.org/W6746337845","https://openalex.org/W6758057323","https://openalex.org/W6761900147"],"related_works":["https://openalex.org/W2146397496","https://openalex.org/W2076383445","https://openalex.org/W2136281516","https://openalex.org/W2804435636","https://openalex.org/W4281740518","https://openalex.org/W2025340064","https://openalex.org/W4384665577","https://openalex.org/W2592888218","https://openalex.org/W4231831369","https://openalex.org/W2097774084"],"abstract_inverted_index":{"Darwin's":[0],"and":[1,28,55,110,147,170,213,226,258],"Wallace's":[2],"1859":[3],"explanation":[4],"that":[5,12,88,116,152,176,232,259,278],"novel":[6,281],"speciation":[7,72,111,263],"resulted":[8],"from":[9,100,118,168,266],"natural":[10],"variants":[11,225,282],"had":[13],"been":[14],"subjected":[15],"to":[16,82,102,120,223,256,273,283],"selection":[17,109,234],"was":[18,43],"refined":[19],"over":[20],"the":[21,29,36,45,56,59,68,84,90,105,137,140,154,182,198,217,227,244,251],"next":[22],"150":[23],"years":[24],"as":[25],"genetic":[26,48],"inheritance":[27],"importance":[30],"of":[31,39,47,58,71,92,107,139,184,195,209,230,246],"mutation-induced":[32],"change":[33,49,162],"were":[34],"discovered,":[35],"quantitative":[37],"theory":[38],"evolutionary":[40],"population":[41],"genetics":[42],"produced,":[44],"speed":[46],"in":[50,73,98,181,250],"small":[51],"populations":[52,103],"became":[53,62],"apparent":[54],"ramifications":[57],"DNA":[60],"revolution":[61],"clear.":[63],"This":[64],"paper":[65,204],"first":[66],"discusses":[67],"modern":[69],"view":[70],"its":[74],"historical":[75],"context.":[76],"It":[77,239],"then":[78],"uses":[79],"systems-biology":[80],"approaches":[81],"consider":[83],"many":[85],"complex":[86],"processes":[87,106],"underpin":[89],"production":[91],"a":[93,126,149,185,267],"new":[94,150,186],"species;":[95],"these":[96,210],"extend":[97],"scale":[99,128,211],"genes":[101],"with":[104,160,193],"variation,":[108],"being":[112,164,197],"affected":[113],"by":[114,136,166,190,219],"factors":[115,231],"range":[117,229],"mutation":[119,194,221],"climate":[121],"change.":[122],"Here,":[123],"events":[124,206],"at":[125,178,207],"particular":[127],"level":[129,141,180],"(e.g.":[130,157],"protein":[131],"network":[132],"activity)":[133],"are":[134,253,285],"activated":[135],"output":[138,151],"immediately":[142],"below":[143],"(i.e.":[144],"gene":[145],"expression)":[146],"generate":[148],"activates":[153],"layer":[155],"above":[156],"embryological":[158],"development),":[159],"this":[161],"often":[163],"modulated":[165],"feedback":[167],"higher":[169],"lower":[171],"levels.":[172],"The":[173,203,275],"analysis":[174],"shows":[175],"activity":[177],"each":[179,208],"evolution":[183],"species":[187],"is":[188,243,277],"marked":[189],"stochastic":[191],"activity,":[192],"course":[196],"key":[199],"step":[200],"for":[201,280],"variation.":[202],"examines":[205],"levels":[212],"particularly":[214],"considers":[215],"how":[216],"pathway":[218],"which":[220],"leads":[222],"phenotypic":[224],"wide":[228],"drive":[233],"can":[235],"be":[236,271],"investigated":[237],"computationally.":[238],"concludes":[240],"that,":[241],"such":[242],"complexity":[245],"speciation,":[247],"most":[248],"steps":[249],"process":[252],"currently":[254],"difficult":[255],"model":[257],"predictions":[260],"about":[261],"future":[262],"will,":[264],"apart":[265],"few":[268],"special":[269],"cases,":[270],"hard":[272],"make.":[274],"corollary":[276],"opportunities":[279],"form":[284],"maximised.":[286]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}