{"id":"https://openalex.org/W7161958505","doi":"https://doi.org/10.3233/shti260399","title":"Practical Implications for Using Laboratory Data: Research over Federated Networks","display_name":"Practical Implications for Using Laboratory Data: Research over Federated Networks","publication_year":2026,"publication_date":"2026-05-21","ids":{"openalex":"https://openalex.org/W7161958505","doi":"https://doi.org/10.3233/shti260399","pmid":"https://pubmed.ncbi.nlm.nih.gov/42175072"},"language":"en","primary_location":{"id":"doi:10.3233/shti260399","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti260399","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3233/shti260399","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028841766","display_name":"David Rubio Ruiz","orcid":"https://orcid.org/0000-0003-1880-8019"},"institutions":[{"id":"https://openalex.org/I4210166233","display_name":"TriNetX (United States)","ror":"https://ror.org/05skpc353","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166233"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"David Rubio Ruiz","raw_affiliation_strings":["Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain","TriNetX, LLC, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-1880-8019","affiliations":[{"raw_affiliation_string":"Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]},{"raw_affiliation_string":"TriNetX, LLC, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210166233"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091979947","display_name":"A\u00edda Mu\u00f1oz Monjas","orcid":"https://orcid.org/0000-0003-4504-9775"},"institutions":[{"id":"https://openalex.org/I4210166233","display_name":"TriNetX (United States)","ror":"https://ror.org/05skpc353","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166233"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"A\u00edda Mu\u00f1oz Monjas","raw_affiliation_strings":["Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain","TriNetX, LLC, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4504-9775","affiliations":[{"raw_affiliation_string":"Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]},{"raw_affiliation_string":"TriNetX, LLC, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210166233"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136650267","display_name":"Paula Bermejo Bernardo","orcid":"https://orcid.org/0009-0007-5253-5321"},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Bermejo Bernardo","raw_affiliation_strings":["Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"],"raw_orcid":"https://orcid.org/0009-0007-5253-5321","affiliations":[{"raw_affiliation_string":"Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136661100","display_name":"David Perez-Rey","orcid":"https://orcid.org/0000-0002-9021-2597"},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Perez-Rey","raw_affiliation_strings":["Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9021-2597","affiliations":[{"raw_affiliation_string":"Biomedical Informatics Group, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069368979","display_name":"Matvey B. Palchuk","orcid":"https://orcid.org/0000-0002-7737-8752"},"institutions":[{"id":"https://openalex.org/I4210166233","display_name":"TriNetX (United States)","ror":"https://ror.org/05skpc353","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166233"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matvey B. Palchuk","raw_affiliation_strings":["TriNetX, LLC, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-7737-8752","affiliations":[{"raw_affiliation_string":"TriNetX, LLC, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210166233"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66808252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"336","issue":null,"first_page":"1252","last_page":"1256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.22499999403953552,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.22499999403953552,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.09989999979734421,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.09880000352859497,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/standardization","display_name":"Standardization","score":0.8300999999046326},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.6071000099182129},{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.5873000025749207},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.5235000252723694},{"id":"https://openalex.org/keywords/work","display_name":"Work (physics)","score":0.40139999985694885},{"id":"https://openalex.org/keywords/data-modeling","display_name":"Data modeling","score":0.37619999051094055},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.3587999939918518},{"id":"https://openalex.org/keywords/semantic-data-model","display_name":"Semantic data model","score":0.3513999879360199}],"concepts":[{"id":"https://openalex.org/C188087704","wikidata":"https://www.wikidata.org/wiki/Q369577","display_name":"Standardization","level":2,"score":0.8300999999046326},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7366999983787537},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.6071000099182129},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.6019999980926514},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.5873000025749207},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5235000252723694},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.40139999985694885},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37779998779296875},{"id":"https://openalex.org/C67186912","wikidata":"https://www.wikidata.org/wiki/Q367664","display_name":"Data modeling","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.3587999939918518},{"id":"https://openalex.org/C90312973","wikidata":"https://www.wikidata.org/wiki/Q7449052","display_name":"Semantic data model","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.34119999408721924},{"id":"https://openalex.org/C189950617","wikidata":"https://www.wikidata.org/wiki/Q937228","display_name":"Property (philosophy)","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C92446256","wikidata":"https://www.wikidata.org/wiki/Q3306762","display_name":"Data validation","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2712000012397766},{"id":"https://openalex.org/C3017977704","wikidata":"https://www.wikidata.org/wiki/Q18745135","display_name":"Health data","level":3,"score":0.26919999718666077},{"id":"https://openalex.org/C100463513","wikidata":"https://www.wikidata.org/wiki/Q5227322","display_name":"Data model (GIS)","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C3019952477","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Health records","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.26489999890327454},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.25760000944137573},{"id":"https://openalex.org/C3020144179","wikidata":"https://www.wikidata.org/wiki/Q10871684","display_name":"Electronic health record","level":3,"score":0.2540999948978424},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.25110000371932983}],"mesh":[{"descriptor_ui":"D000098407","descriptor_name":"Federated Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002984","descriptor_name":"Clinical Laboratory Information Systems","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D002984","descriptor_name":"Clinical Laboratory Information Systems","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D002984","descriptor_name":"Clinical Laboratory Information Systems","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D002984","descriptor_name":"Clinical Laboratory Information Systems","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D003195","descriptor_name":"Computer Communication Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039703","descriptor_name":"Logical Observation Identifiers Names and Codes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti260399","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti260399","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:42175072","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42175072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3233/shti260399","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti260399","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[{"score":0.5542244911193848,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"INTRODUCTION:":[0],"Semantic":[1],"standardization":[2],"is":[3,101],"essential,":[4],"but":[5],"not":[6],"sufficient,":[7],"to":[8,103],"enable":[9],"research":[10,56,112],"over":[11,113],"real-world":[12,115],"data":[13,20,43,50,99],"networks.":[14],"Even":[15],"when":[16],"harmonized,":[17],"differences":[18],"in":[19],"availability,":[21,88],"granularity,":[22],"and":[23,34,45,86,93,111],"clinical":[24,114],"practice":[25],"can":[26],"introduce":[27],"subtle":[28],"biases":[29,105],"that":[30],"affect":[31],"downstream":[32],"analyses":[33],"AI":[35,108],"model":[36,109],"development.":[37],"METHODS:":[38],"This":[39],"work":[40],"explores":[41],"laboratory":[42],"availability":[44],"testing":[46],"practices":[47],"using":[48,64],"LOINC-coded":[49],"from":[51,70],"TriNetX,":[52],"a":[53],"global":[54],"federated":[55],"network.":[57],"Significant":[58],"LOINC":[59],"part":[60],"variations":[61],"were":[62,78],"identified":[63],"statistical":[65],"dispersion":[66],"assessment.":[67],"RESULTS:":[68],"Data":[69],"172":[71],"healthcare":[72],"institutions":[73],"was":[74],"evaluated.":[75],"Representative":[76],"examples":[77],"further":[79],"analysed":[80],"demonstrating":[81],"the":[82],"relevance":[83],"of":[84],"specimen":[85],"method":[87],"as":[89,91],"well":[90],"property":[92],"component":[94],"country-specific":[95],"differences.":[96],"CONCLUSIONS:":[97],"Acknowledging":[98],"variability":[100],"key":[102],"minimizing":[104],"introduced":[106],"during":[107],"development":[110],"data.":[116]},"counts_by_year":[],"updated_date":"2026-07-18T07:39:51.176621","created_date":"2026-05-22T00:00:00"}
