{"id":"https://openalex.org/W4413971003","doi":"https://doi.org/10.3233/shti251419","title":"ProvideQ: A Web-Based Knowledge Platform for Assessing Preanalytical Influences on Biomolecules in Biospecimens.","display_name":"ProvideQ: A Web-Based Knowledge Platform for Assessing Preanalytical Influences on Biomolecules in Biospecimens.","publication_year":2025,"publication_date":"2025-09-03","ids":{"openalex":"https://openalex.org/W4413971003","doi":"https://doi.org/10.3233/shti251419","pmid":"https://pubmed.ncbi.nlm.nih.gov/40899562"},"language":"en","primary_location":{"id":"pmid:40899562","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40899562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null},"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119533918","display_name":"Sven Bichtemann","orcid":null},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sven Bichtemann","raw_affiliation_strings":["Hannover Unified Biobank (HUB), Medizinische Hochschule Hannover, Carl Neuberg Str.1, 30625 Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Unified Biobank (HUB), Medizinische Hochschule Hannover, Carl Neuberg Str.1, 30625 Hannover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042665334","display_name":"Oliver J. Bott","orcid":"https://orcid.org/0000-0002-8823-5247"},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Johannes Bott","raw_affiliation_strings":["Institute for Applied Data Science Hannover DATA|H, University of Applied Sciences and Arts, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Applied Data Science Hannover DATA|H, University of Applied Sciences and Arts, Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016974201","display_name":"Johanna Apfel-Starke","orcid":"https://orcid.org/0000-0001-7068-1508"},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johanna Apfel-Starke","raw_affiliation_strings":["Institute for Applied Data Science Hannover DATA|H, University of Applied Sciences and Arts, Hannover, Germany","MHH Information Technology, Medizinische Hochschule Hannover, Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Applied Data Science Hannover DATA|H, University of Applied Sciences and Arts, Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]},{"raw_affiliation_string":"MHH Information Technology, Medizinische Hochschule Hannover, Hannover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119533919","display_name":"Vicky Scholz","orcid":null},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vicky Scholz","raw_affiliation_strings":["Hannover Unified Biobank (HUB), Medizinische Hochschule Hannover, Carl Neuberg Str.1, 30625 Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Unified Biobank (HUB), Medizinische Hochschule Hannover, Carl Neuberg Str.1, 30625 Hannover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071033298","display_name":"Thomas Illig","orcid":"https://orcid.org/0000-0003-4284-5389"},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Illig","raw_affiliation_strings":["Hannover Unified Biobank (HUB), Medizinische Hochschule Hannover, Carl Neuberg Str.1, 30625 Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Unified Biobank (HUB), Medizinische Hochschule Hannover, Carl Neuberg Str.1, 30625 Hannover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":null,"display_name":"Sara Haag","orcid":null},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210152261","display_name":"Intelligent Transport Systems Niedersachsen","ror":"https://ror.org/05xyrf554","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210152261"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sara Haag","raw_affiliation_strings":["Hannover Unified Biobank (HUB), Medizinische Hochschule Hannover, Carl Neuberg Str.1, 30625 Hannover","Translationsallianz in Niedersachsen (TRAIN), Feodor-Lynen-Stra\u00dfe 7, 30625 Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Unified Biobank (HUB), Medizinische Hochschule Hannover, Carl Neuberg Str.1, 30625 Hannover","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Translationsallianz in Niedersachsen (TRAIN), Feodor-Lynen-Stra\u00dfe 7, 30625 Hannover","institution_ids":["https://openalex.org/I4210152261"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5119533918"],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19511716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"331","issue":null,"first_page":"386","last_page":"394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.23199999332427979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.23199999332427979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.07079999893903732,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5947496294975281},{"id":"https://openalex.org/keywords/web-application","display_name":"Web application","score":0.4613831639289856},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.41022390127182007},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.31938689947128296}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5947496294975281},{"id":"https://openalex.org/C118643609","wikidata":"https://www.wikidata.org/wiki/Q189210","display_name":"Web application","level":2,"score":0.4613831639289856},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.41022390127182007},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.31938689947128296}],"mesh":[{"descriptor_ui":"D000073623","descriptor_name":"Pre-Analytical Phase","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000073623","descriptor_name":"Pre-Analytical Phase","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018070","descriptor_name":"Biological Specimen Banks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018070","descriptor_name":"Biological Specimen Banks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:40899562","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40899562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Preanalytical":[1],"factors":[2,140],"significantly":[3],"impact":[4],"the":[5,12,22,84,129,143,149],"stability":[6],"of":[7,14,24,75,135,145],"biomolecules":[8],"in":[9,121],"biospecimens,":[10],"affecting":[11],"reliability":[13],"biomedical":[15],"research":[16,41,146],"and":[17,30,68,99,105,111,123,131],"diagnostics.":[18],"This":[19],"paper":[20],"presents":[21],"development":[23],"ProvideQ":[25,108],"(Database":[26],"for":[27,58,72],"pre-analytical":[28,139],"variability":[29],"biospecimen":[31],"quality),":[32],"a":[33,54,94,118],"web-based":[34],"platform":[35],"designed":[36],"to":[37,40,141],"centralize":[38],"access":[39],"findings":[42],"on":[43,48,138],"these":[44],"influences.":[45],"METHODS:":[46],"Building":[47],"an":[49,61,90,100],"initial":[50],"prototype,":[51],"we":[52],"implemented":[53],"validated":[55],"criteria":[56],"catalog":[57],"data":[59,92],"quality,":[60],"efficient":[62],"search":[63],"system":[64],"handling":[65],"incomplete":[66],"inputs,":[67],"SPREC":[69],"4.0":[70],"integration":[71],"standardized":[73],"coding":[74],"preanalytical":[76],"variables.":[77],"User":[78],"feedback":[79],"from":[80],"usability":[81],"tests":[82],"enhanced":[83],"platform's":[85],"interface.":[86],"RESULTS:":[87],"Results":[88],"include":[89,127],"improved":[91],"model,":[93],"Python-based":[95],"literature":[96],"import":[97,144],"module,":[98],"intuitive":[101],"frontend":[102],"using":[103],"Next.js":[104],"React.":[106],"CONCLUSION:":[107],"supports":[109],"analyte-":[110],"sample-centric":[112],"searches,":[113],"demonstrating":[114],"its":[115],"potential":[116],"as":[117],"valuable":[119],"tool":[120],"biobanking":[122],"research.":[124],"Future":[125],"enhancements":[126],"expanding":[128],"database":[130],"integrating":[132],"AI-driven":[133],"analytics":[134],"scientific":[136],"publications":[137],"facilitate":[142],"results":[147],"into":[148],"platform.":[150]},"counts_by_year":[],"updated_date":"2026-04-28T06:04:28.489925","created_date":"2025-10-10T00:00:00"}