{"id":"https://openalex.org/W4413051877","doi":"https://doi.org/10.3233/shti251301","title":"Hypertension Decoded: What 367,000 Real-World Cases Tell Us About Adolescents and Young Adults","display_name":"Hypertension Decoded: What 367,000 Real-World Cases Tell Us About Adolescents and Young Adults","publication_year":2025,"publication_date":"2025-08-07","ids":{"openalex":"https://openalex.org/W4413051877","doi":"https://doi.org/10.3233/shti251301","pmid":"https://pubmed.ncbi.nlm.nih.gov/40776318"},"language":"en","primary_location":{"id":"doi:10.3233/shti251301","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti251301","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3233/shti251301","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093787744","display_name":"Kseniia Sholokhova","orcid":"https://orcid.org/0000-0002-1014-2446"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kseniia Sholokhova","raw_affiliation_strings":["Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-1014-2446","affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058108838","display_name":"Hsuan\u2010Chia Yang","orcid":"https://orcid.org/0000-0001-9198-0697"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsuan-Chia Yang","raw_affiliation_strings":["Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-9198-0697","affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112623798","display_name":"Yu\u2010Chuan Li","orcid":"https://orcid.org/0000-0001-6497-4232"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chuan Li","raw_affiliation_strings":["Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-6497-4232","affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5093787744"],"corresponding_institution_ids":["https://openalex.org/I47519274"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44396706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"329","issue":null,"first_page":"1964","last_page":"1965"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9710000157356262,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9710000157356262,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.9610000252723694,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.932200014591217,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervention","display_name":"Intervention (counseling)","score":0.5821104049682617},{"id":"https://openalex.org/keywords/young-adult","display_name":"Young adult","score":0.577424168586731},{"id":"https://openalex.org/keywords/window-of-opportunity","display_name":"Window of opportunity","score":0.5096137523651123},{"id":"https://openalex.org/keywords/hazard","display_name":"Hazard","score":0.5046895742416382},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4920782446861267},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4837660789489746},{"id":"https://openalex.org/keywords/hazard-ratio","display_name":"Hazard ratio","score":0.43949031829833984},{"id":"https://openalex.org/keywords/gerontology","display_name":"Gerontology","score":0.4225574731826782},{"id":"https://openalex.org/keywords/pediatrics","display_name":"Pediatrics","score":0.3997464179992676},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.33557939529418945},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.24989601969718933},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09981599450111389},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.07396972179412842}],"concepts":[{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5821104049682617},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.577424168586731},{"id":"https://openalex.org/C2778363899","wikidata":"https://www.wikidata.org/wiki/Q23900955","display_name":"Window of opportunity","level":2,"score":0.5096137523651123},{"id":"https://openalex.org/C49261128","wikidata":"https://www.wikidata.org/wiki/Q1132455","display_name":"Hazard","level":2,"score":0.5046895742416382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4920782446861267},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4837660789489746},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.43949031829833984},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4225574731826782},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3997464179992676},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33557939529418945},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.24989601969718933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09981599450111389},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07396972179412842},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C79403827","wikidata":"https://www.wikidata.org/wiki/Q3988","display_name":"Real-time computing","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti251301","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti251301","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:40776318","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40776318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti251301","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti251301","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W64073120","https://openalex.org/W1760666711","https://openalex.org/W2073407767","https://openalex.org/W2348606523","https://openalex.org/W2071282189","https://openalex.org/W2152968221","https://openalex.org/W4299792440","https://openalex.org/W2265524420","https://openalex.org/W2087437514","https://openalex.org/W2087430539"],"abstract_inverted_index":{"While":[0],"the":[1,12,14,18,39,46,87,106],"evidence":[2,15],"of":[3,6,16,20,27,49,72,89,105],"damaging":[4],"effects":[5],"hypertension":[7,50],"is":[8,29,96],"widely":[9],"present":[10],"in":[11,38],"literature,":[13],"how":[17],"time":[19],"index":[21],"event":[22],"influences":[23],"future":[24],"health":[25,47],"burden":[26],"individuals":[28],"less":[30],"prevalent.":[31],"By":[32],"using":[33],"data":[34],"from":[35],"367,809":[36],"patients":[37],"TriNetX":[40],"global":[41],"collaborative":[42],"network,":[43],"we":[44,120],"compared":[45,82],"burdens":[48],"initiated":[51],"during":[52],"adolescence":[53],"and":[54,67,92,113,128],"young":[55,84],"adulthood.":[56],"Our":[57],"analysis":[58],"revealed":[59],"that":[60],"adolescents":[61],"face":[62],"a":[63,68,79,97,101],"30.9%":[64],"higher":[65],"risk":[66],"17.6%":[69],"greater":[70],"hazard":[71],"severe":[73],"comorbidities,":[74],"measured":[75],"by":[76,114],"CCI,":[77],"within":[78],"five-year":[80],"window":[81],"to":[83,110,122],"adults,":[85],"highlighting":[86],"importance":[88],"earlier":[90],"detection":[91],"intervention.":[93],"This":[94],"work":[95],"preliminary":[98],"step":[99],"toward":[100],"more":[102],"comprehensive":[103],"understanding":[104],"disease":[107],"trajectories":[108],"linked":[109],"early-onset":[111],"hypertension,":[112],"shedding":[115],"light":[116],"on":[117],"this":[118],"issue,":[119],"hope":[121],"raise":[123],"awareness":[124],"among":[125],"patients,":[126],"caregivers,":[127],"policymakers.":[129]},"counts_by_year":[],"updated_date":"2025-12-28T23:10:05.387466","created_date":"2025-10-10T00:00:00"}