{"id":"https://openalex.org/W4413040100","doi":"https://doi.org/10.3233/shti250809","title":"Standardized Epilepsy Data Collection and Analysis Leveraging the Four Dimensional Epilepsy Classification (4D-EC) Framework","display_name":"Standardized Epilepsy Data Collection and Analysis Leveraging the Four Dimensional Epilepsy Classification (4D-EC) Framework","publication_year":2025,"publication_date":"2025-08-07","ids":{"openalex":"https://openalex.org/W4413040100","doi":"https://doi.org/10.3233/shti250809","pmid":"https://pubmed.ncbi.nlm.nih.gov/40775827"},"language":"en","primary_location":{"id":"doi:10.3233/shti250809","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti250809","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3233/shti250809","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015141736","display_name":"Katrina Prantzalos","orcid":"https://orcid.org/0000-0003-4009-2950"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katrina Prantzalos","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065956783","display_name":"Pedram Golnari","orcid":"https://orcid.org/0000-0002-2154-1645"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedram Golnari","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027803900","display_name":"Dipak Prasad Upadhyaya","orcid":"https://orcid.org/0000-0001-9068-5450"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipak Upadhyaya","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064226405","display_name":"Suraj Thyagaraj","orcid":"https://orcid.org/0000-0001-9150-1967"},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"funder","lineage":["https://openalex.org/I2799343972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suraj Thyagaraj","raw_affiliation_strings":["Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056999559","display_name":"Guadalupe Fernandez-BacaVaca","orcid":"https://orcid.org/0000-0002-7842-0553"},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"funder","lineage":["https://openalex.org/I2799343972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guadalupe Fernandez-Bacavaca","raw_affiliation_strings":["Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036696155","display_name":"Hans O. L\u00fcders","orcid":"https://orcid.org/0000-0002-8123-9931"},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"funder","lineage":["https://openalex.org/I2799343972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans Luders","raw_affiliation_strings":["Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050196876","display_name":"Satya S. Sahoo","orcid":"https://orcid.org/0000-0001-9190-4256"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satya S. Sahoo","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5015141736"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":15.1188,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.9846981,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"329","issue":null,"first_page":"98","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9828000068664551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.9513999819755554,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.7622170448303223},{"id":"https://openalex.org/keywords/informatics","display_name":"Informatics","score":0.6638694405555725},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.6345273852348328},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5997958183288574},{"id":"https://openalex.org/keywords/terminology","display_name":"Terminology","score":0.5576552152633667},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.37515413761138916},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3654285967350006},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.13343095779418945},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.11537683010101318}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7622170448303223},{"id":"https://openalex.org/C191630685","wikidata":"https://www.wikidata.org/wiki/Q4027615","display_name":"Informatics","level":2,"score":0.6638694405555725},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.6345273852348328},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5997958183288574},{"id":"https://openalex.org/C547195049","wikidata":"https://www.wikidata.org/wiki/Q1725664","display_name":"Terminology","level":2,"score":0.5576552152633667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37515413761138916},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3654285967350006},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.13343095779418945},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11537683010101318},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003625","descriptor_name":"Data Collection","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D003625","descriptor_name":"Data Collection","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009626","descriptor_name":"Terminology as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009626","descriptor_name":"Terminology as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti250809","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti250809","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:40775827","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40775827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti250809","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti250809","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.4300000071525574}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2350593162","https://openalex.org/W2390350206","https://openalex.org/W1969477129","https://openalex.org/W2921208823","https://openalex.org/W2353483812","https://openalex.org/W2131808775","https://openalex.org/W2130038259","https://openalex.org/W2360756181","https://openalex.org/W2374093222","https://openalex.org/W2359533638"],"abstract_inverted_index":{"Epilepsy":[0,61],"requires":[1],"accurate":[2],"diagnosis":[3],"through":[4],"systematic":[5],"classification":[6,30,35,63],"of":[7,77,83,117,139,146],"patients":[8],"for":[9,18,64],"effective":[10],"treatment,":[11],"targeted":[12],"therapeutic":[13],"interventions,":[14],"and":[15,45,56,66,98,115,129,137],"structured":[16],"research":[17],"enhanced":[19],"patient":[20,111],"care.":[21],"Over":[22],"the":[23,27,54,57,75,78,81,90,104,144],"past":[24],"few":[25],"decades,":[26],"four-dimensional":[28],"epilepsy":[29],"(4D-EC)":[31],"that":[32],"includes":[33],"seizure":[34],"based":[36],"exclusively":[37],"on":[38],"ictal":[39],"symptomatology":[40],"has":[41,92],"been":[42],"widely":[43],"adopted":[44],"tested.":[46],"Recent":[47],"studies":[48],"have":[49],"defined":[50],"a":[51,84],"mapping":[52],"between":[53],"4D-EC":[55,91,106],"International":[58],"League":[59],"Against":[60],"(ILAE)":[62],"seizures":[65],"epilepsies":[67],"(ILAE-EC),":[68],"which":[69,149],"is":[70,150],"likely":[71],"to":[72,88,109],"further":[73],"advance":[74],"adoption":[76],"4D-EC.":[79],"However,":[80],"absence":[82],"dedicated":[85],"informatics":[86,107],"platform":[87],"implement":[89],"limited":[93],"its":[94],"widespread":[95],"clinical":[96,134],"implementation":[97],"educational":[99],"use.":[100],"Therefore,":[101],"we":[102],"developed":[103],"first":[105],"tool":[108,122],"facilitate":[110],"data":[112],"reporting,":[113],"analysis,":[114],"training":[116,138],"new":[118],"investigators.":[119],"Our":[120,141],"web-based":[121],"incorporates":[123],"standardized":[124],"terminology,":[125],"dynamic":[126],"user-driven":[127],"workflows,":[128],"automated":[130],"summary":[131],"generation,":[132],"enhancing":[133],"decision":[135],"support":[136],"epileptologists.":[140],"work":[142],"presents":[143],"development":[145],"this":[147],"application,":[148],"accessible":[151],"at":[152],"https://bmhinformatics.case.edu/epilepsy4d/.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}