{"id":"https://openalex.org/W4410447998","doi":"https://doi.org/10.3233/shti250402","title":"From Normal to Optimal: Investigating Metabolic and Inflammatory Parameters as Predictors of Survival in Locally Advanced Cervical Cancer","display_name":"From Normal to Optimal: Investigating Metabolic and Inflammatory Parameters as Predictors of Survival in Locally Advanced Cervical Cancer","publication_year":2025,"publication_date":"2025-05-15","ids":{"openalex":"https://openalex.org/W4410447998","doi":"https://doi.org/10.3233/shti250402","pmid":"https://pubmed.ncbi.nlm.nih.gov/40380512"},"language":"en","primary_location":{"id":"doi:10.3233/shti250402","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti250402","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI250402","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI250402","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106681930","display_name":"Mayra Roxana Elwes","orcid":"https://orcid.org/0009-0005-9454-7174"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mayra Elwes","raw_affiliation_strings":["Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001094349","display_name":"Bhanu Prasanna Koppolu","orcid":null},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bhanu Prasanna Koppolu","raw_affiliation_strings":["Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010844718","display_name":"Carminia Lapuz","orcid":"https://orcid.org/0000-0003-2596-1353"},"institutions":[{"id":"https://openalex.org/I4210158799","display_name":"Olivia Newton-John Cancer Wellness & Research Centre","ror":"https://ror.org/04t908e09","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210158799"]},{"id":"https://openalex.org/I4210163497","display_name":"Austin Health","ror":"https://ror.org/05dbj6g52","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163497"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Carminia Lapuz","raw_affiliation_strings":["Radiation Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Australia","institution_ids":["https://openalex.org/I4210158799","https://openalex.org/I4210163497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017249382","display_name":"Mark Tacey","orcid":"https://orcid.org/0000-0002-6318-3911"},"institutions":[{"id":"https://openalex.org/I4210158799","display_name":"Olivia Newton-John Cancer Wellness & Research Centre","ror":"https://ror.org/04t908e09","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210158799"]},{"id":"https://openalex.org/I4210163497","display_name":"Austin Health","ror":"https://ror.org/05dbj6g52","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163497"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark Tacey","raw_affiliation_strings":["Radiation Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Australia","institution_ids":["https://openalex.org/I4210158799","https://openalex.org/I4210163497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068698535","display_name":"Simone Marnitz","orcid":"https://orcid.org/0000-0001-6739-7768"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simone Marnitz","raw_affiliation_strings":["Radiation Oncology, Vosspalais Private Clinic, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Vosspalais Private Clinic, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067635650","display_name":"Oya Beyan","orcid":"https://orcid.org/0000-0001-7611-3501"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oya Beyan","raw_affiliation_strings":["Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026834736","display_name":"Maike Trommer","orcid":"https://orcid.org/0000-0003-2864-4273"},"institutions":[{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maike Trommer","raw_affiliation_strings":["Department of Radiation Oncology, Cyberknife and Radiotherapy, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Cyberknife and Radiotherapy, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210153755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047693689","display_name":"Ekaterina Kutafina","orcid":"https://orcid.org/0000-0002-3430-5123"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ekaterina Kutafina","raw_affiliation_strings":["Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20418848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"327","issue":null,"first_page":"572","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9684000015258789,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"Cervical cancer","score":0.6800158023834229},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5738111138343811},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.47343042492866516},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4421897530555725},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.43896815180778503},{"id":"https://openalex.org/keywords/cancer-survival","display_name":"Cancer survival","score":0.42991384863853455}],"concepts":[{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.6800158023834229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5738111138343811},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47343042492866516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4421897530555725},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43896815180778503},{"id":"https://openalex.org/C3020167199","wikidata":"https://www.wikidata.org/wiki/Q5031455","display_name":"Cancer survival","level":3,"score":0.42991384863853455}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti250402","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti250402","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI250402","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:40380512","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40380512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3233/shti250402","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti250402","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI250402","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2761004381","display_name":"NFDI4DS  NFDI f\u00fcr Datenwissenschaften und K\u00fcnstliche Intelligenz","funder_award_id":"460234259","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410447998.pdf","grobid_xml":"https://content.openalex.org/works/W4410447998.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966504330","https://openalex.org/W1979139803","https://openalex.org/W2037631372","https://openalex.org/W4252436151","https://openalex.org/W2030889776","https://openalex.org/W2316082485","https://openalex.org/W936491529","https://openalex.org/W2595667203","https://openalex.org/W2238700386","https://openalex.org/W3105707221"],"abstract_inverted_index":{"Cervical":[0],"cancer":[1,7],"is":[2],"the":[3,15,28,34,39,55,69,75,81,93,102,110,125],"third":[4],"most":[5],"common":[6],"in":[8,21,99,124],"women,":[9],"and":[10],"recent":[11],"studies":[12],"have":[13],"highlighted":[14],"importance":[16],"of":[17,30,41,61,68,96,113,127],"body":[18,118],"composition":[19],"markers":[20],"predicting":[22],"patient":[23],"outcomes.":[24],"We":[25,49],"build":[26],"upon":[27],"data":[29],"83":[31],"patients":[32],"from":[33],"Uterus-11":[35],"study,":[36],"to":[37,45,53,78,91,101,130],"explore":[38],"relation":[40],"pairwise":[42],"feature":[43],"combinations":[44,57],"long-term":[46],"progression-free":[47],"survival.":[48],"propose":[50],"a":[51],"framework":[52],"identify":[54],"parameter":[56],"with":[58],"pre-defined":[59],"thresholds":[60,77],"\"normal":[62],"range\"":[63],"which":[64],"provide":[65],"good":[66],"separation":[67,82],"survival":[70],"group.":[71],"Further,":[72],"we":[73],"optimize":[74],"pair-wise":[76],"further":[79],"improve":[80,92],"measured":[83],"by":[84],"F1":[85],"scores.":[86],"This":[87],"approach":[88],"allowed":[89],"us":[90],"statistical":[94],"significance":[95],"hazard":[97],"ratios":[98],"comparison":[100],"previous":[103],"studies.":[104],"The":[105],"optimization":[106],"results":[107],"suggest":[108],"that":[109],"normal":[111],"ranges":[112],"well-established":[114],"biomarkers":[115],"such":[116],"as":[117],"mass":[119],"index":[120],"could":[121],"be":[122],"shifted":[123],"context":[126],"specific":[128],"diseases":[129],"achieve":[131],"optimal":[132],"outcome.":[133]},"counts_by_year":[],"updated_date":"2026-08-22T07:34:49.880490","created_date":"2025-10-10T00:00:00"}
