{"id":"https://openalex.org/W4404611977","doi":"https://doi.org/10.3233/shti241068","title":"Leveraging Cancer Therapy Peptide Data: A Case Study on Machine Learning Application in Accelerating Cancer Research","display_name":"Leveraging Cancer Therapy Peptide Data: A Case Study on Machine Learning Application in Accelerating Cancer Research","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4404611977","doi":"https://doi.org/10.3233/shti241068","pmid":"https://pubmed.ncbi.nlm.nih.gov/39575785"},"language":"en","primary_location":{"id":"doi:10.3233/shti241068","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti241068","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI241068","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI241068","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003484641","display_name":"Georgios Feretzakis","orcid":"https://orcid.org/0000-0002-3597-1187"},"institutions":[{"id":"https://openalex.org/I231025917","display_name":"Hellenic Open University","ror":"https://ror.org/02kq26x23","country_code":"GR","type":"education","lineage":["https://openalex.org/I231025917"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Feretzakis","raw_affiliation_strings":["School of Science and Technology, Hellenic Open University, Patras, Greece"],"raw_orcid":"https://orcid.org/0000-0002-3597-1187","affiliations":[{"raw_affiliation_string":"School of Science and Technology, Hellenic Open University, Patras, Greece","institution_ids":["https://openalex.org/I231025917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010771476","display_name":"\u0391\u03b8\u03b1\u03bd\u03ac\u03c3\u03b9\u03bf\u03c2 \u0391\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03bf\u03c5","orcid":"https://orcid.org/0000-0001-6679-3590"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Athanasios Anastasiou","raw_affiliation_strings":["Biomedical Engineering Laboratory, National Technical University of Athens, Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0001-6679-3590","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Laboratory, National Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033143489","display_name":"Stavros Pitoglou","orcid":"https://orcid.org/0000-0002-5309-4683"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stavros Pitoglou","raw_affiliation_strings":["Computer Solutions SA, Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0002-5309-4683","affiliations":[{"raw_affiliation_string":"Computer Solutions SA, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086837749","display_name":"Aikaterini Sakagianni","orcid":"https://orcid.org/0000-0002-3199-9158"},"institutions":[{"id":"https://openalex.org/I2800888565","display_name":"Sismanoglio General Hospital","ror":"https://ror.org/057cm0m66","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800888565"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Aikaterini Sakagianni","raw_affiliation_strings":["Sismanogleio General Hospital, Marousi, Greece"],"raw_orcid":"https://orcid.org/0000-0002-3199-9158","affiliations":[{"raw_affiliation_string":"Sismanogleio General Hospital, Marousi, Greece","institution_ids":["https://openalex.org/I2800888565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012136672","display_name":"Zoi Rakopoulou","orcid":null},"institutions":[{"id":"https://openalex.org/I2800888565","display_name":"Sismanoglio General Hospital","ror":"https://ror.org/057cm0m66","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800888565"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Zoi Rakopoulou","raw_affiliation_strings":["Sismanogleio General Hospital, Marousi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sismanogleio General Hospital, Marousi, Greece","institution_ids":["https://openalex.org/I2800888565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093313000","display_name":"Konstantinos Kalodanis","orcid":"https://orcid.org/0000-0003-2456-9261"},"institutions":[{"id":"https://openalex.org/I32762134","display_name":"Harokopio University of Athens","ror":"https://ror.org/02k5gp281","country_code":"GR","type":"education","lineage":["https://openalex.org/I32762134"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos Kalodanis","raw_affiliation_strings":["Harokopio University of Athens, Kallithea, Greece"],"raw_orcid":"https://orcid.org/0000-0003-2456-9261","affiliations":[{"raw_affiliation_string":"Harokopio University of Athens, Kallithea, Greece","institution_ids":["https://openalex.org/I32762134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045237177","display_name":"Vasileios Kaldis","orcid":"https://orcid.org/0000-0001-6416-2293"},"institutions":[{"id":"https://openalex.org/I2800888565","display_name":"Sismanoglio General Hospital","ror":"https://ror.org/057cm0m66","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800888565"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasileios Kaldis","raw_affiliation_strings":["Sismanogleio General Hospital, Marousi, Greece"],"raw_orcid":"https://orcid.org/0000-0001-6416-2293","affiliations":[{"raw_affiliation_string":"Sismanogleio General Hospital, Marousi, Greece","institution_ids":["https://openalex.org/I2800888565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036319147","display_name":"Evgenia Paxinou","orcid":"https://orcid.org/0000-0002-9910-8569"},"institutions":[{"id":"https://openalex.org/I231025917","display_name":"Hellenic Open University","ror":"https://ror.org/02kq26x23","country_code":"GR","type":"education","lineage":["https://openalex.org/I231025917"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evgenia Paxinou","raw_affiliation_strings":["School of Science and Technology, Hellenic Open University, Patras, Greece"],"raw_orcid":"https://orcid.org/0000-0002-9910-8569","affiliations":[{"raw_affiliation_string":"School of Science and Technology, Hellenic Open University, Patras, Greece","institution_ids":["https://openalex.org/I231025917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068179203","display_name":"Dimitris Kalles","orcid":"https://orcid.org/0000-0003-0364-5966"},"institutions":[{"id":"https://openalex.org/I231025917","display_name":"Hellenic Open University","ror":"https://ror.org/02kq26x23","country_code":"GR","type":"education","lineage":["https://openalex.org/I231025917"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitris Kalles","raw_affiliation_strings":["School of Science and Technology, Hellenic Open University, Patras, Greece"],"raw_orcid":"https://orcid.org/0000-0003-0364-5966","affiliations":[{"raw_affiliation_string":"School of Science and Technology, Hellenic Open University, Patras, Greece","institution_ids":["https://openalex.org/I231025917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085113815","display_name":"Vassilios S. Verykios","orcid":"https://orcid.org/0000-0002-9758-0819"},"institutions":[{"id":"https://openalex.org/I231025917","display_name":"Hellenic Open University","ror":"https://ror.org/02kq26x23","country_code":"GR","type":"education","lineage":["https://openalex.org/I231025917"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vassilios S. Verykios","raw_affiliation_strings":["School of Science and Technology, Hellenic Open University, Patras, Greece"],"raw_orcid":"https://orcid.org/0000-0002-9758-0819","affiliations":[{"raw_affiliation_string":"School of Science and Technology, Hellenic Open University, Patras, Greece","institution_ids":["https://openalex.org/I231025917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5010771476"],"corresponding_institution_ids":["https://openalex.org/I174458059"],"apc_list":null,"apc_paid":null,"fwci":4.044,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.94184608,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"321","issue":null,"first_page":"84","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6605201959609985},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6177384853363037},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5454046726226807},{"id":"https://openalex.org/keywords/categorization","display_name":"Categorization","score":0.5104633569717407},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.48136216402053833},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.46918487548828125},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"Cancer therapy","score":0.4452548623085022},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21671131253242493},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07780086994171143}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6605201959609985},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6177384853363037},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5454046726226807},{"id":"https://openalex.org/C94124525","wikidata":"https://www.wikidata.org/wiki/Q912550","display_name":"Categorization","level":2,"score":0.5104633569717407},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.48136216402053833},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.46918487548828125},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4452548623085022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21671131253242493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07780086994171143}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti241068","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti241068","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI241068","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:39575785","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39575785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti241068","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti241068","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI241068","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4404611977.pdf"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1537066827","https://openalex.org/W1966447062","https://openalex.org/W1977556410","https://openalex.org/W2101234009","https://openalex.org/W2150593711","https://openalex.org/W2295124130","https://openalex.org/W2905810301","https://openalex.org/W2999417355","https://openalex.org/W3111045787","https://openalex.org/W4212959738","https://openalex.org/W4399013224"],"related_works":["https://openalex.org/W2165912799","https://openalex.org/W2735662278","https://openalex.org/W2382615723","https://openalex.org/W4311804456","https://openalex.org/W1987484445","https://openalex.org/W2623658258","https://openalex.org/W2143413548","https://openalex.org/W1969219540","https://openalex.org/W2370459448","https://openalex.org/W4285386966"],"abstract_inverted_index":{"This":[0],"study":[1],"leverages":[2],"the":[3,15,71,82,96,104,108,112,117],"DCTPep":[4],"database,":[5],"a":[6,79],"comprehensive":[7],"repository":[8],"of":[9,17,84,98,111,119],"cancer":[10,22,35,123],"therapy":[11,36],"peptides,":[12],"to":[13,33,102,116],"explore":[14],"application":[16],"machine":[18],"learning":[19],"in":[20],"accelerating":[21],"research.":[23],"We":[24],"applied":[25],"Principal":[26],"Component":[27],"Analysis":[28],"(PCA)":[29],"and":[30,63,95,106],"K-means":[31],"clustering":[32,105],"categorize":[34],"peptides":[37],"based":[38],"on":[39,92],"their":[40],"physicochemical":[41],"properties.":[42],"Our":[43],"analysis":[44],"identified":[45],"three":[46],"distinct":[47],"clusters,":[48],"each":[49],"characterized":[50],"by":[51],"unique":[52],"features":[53],"such":[54],"as":[55],"sequence":[56],"length,":[57],"isoelectric":[58],"point":[59],"(pI),":[60],"net":[61],"charge,":[62],"mass.":[64],"These":[65],"findings":[66],"provide":[67],"valuable":[68],"insights":[69],"into":[70],"key":[72],"properties":[73],"that":[74],"influence":[75],"peptide":[76],"efficacy,":[77],"offering":[78],"foundation":[80],"for":[81],"design":[83],"new":[85],"therapeutic":[86],"peptides.":[87],"Future":[88],"work":[89],"will":[90],"focus":[91],"experimental":[93],"validation":[94],"integration":[97],"additional":[99],"data":[100],"sources":[101],"refine":[103],"enhance":[107],"predictive":[109],"power":[110],"model,":[113],"ultimately":[114],"contributing":[115],"development":[118],"more":[120],"effective":[121],"peptide-based":[122],"treatments.":[124]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
