{"id":"https://openalex.org/W4401824268","doi":"https://doi.org/10.3233/shti240737","title":"Privacy-Preserving Workflow for the Cross-Border Federated Analysis of Clinical Data","display_name":"Privacy-Preserving Workflow for the Cross-Border Federated Analysis of Clinical Data","publication_year":2024,"publication_date":"2024-08-22","ids":{"openalex":"https://openalex.org/W4401824268","doi":"https://doi.org/10.3233/shti240737","pmid":"https://pubmed.ncbi.nlm.nih.gov/39176524"},"language":"en","primary_location":{"id":"doi:10.3233/shti240737","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti240737","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI240737","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI240737","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036825905","display_name":"Miroslav Puskaric","orcid":"https://orcid.org/0000-0003-2487-8822"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Miroslav Puskaric","raw_affiliation_strings":["HLRS, University of Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HLRS, University of Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055726071","display_name":"Balasubramanian Chandramouli","orcid":"https://orcid.org/0000-0002-6837-4709"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Balasubramanian Chandramouli","raw_affiliation_strings":["HPC Department, CINECA Consorzio Interuniversitario, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HPC Department, CINECA Consorzio Interuniversitario, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021729674","display_name":"Thomas Osmo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210091683","display_name":"Centre Informatique National de l'Enseignement Sup\u00e9rieur","ror":"https://ror.org/00gnrwz95","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210091683"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Osmo","raw_affiliation_strings":["CINES Centre Informatique National de l\u2019Enseignement Sup\u00e9rieur, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CINES Centre Informatique National de l\u2019Enseignement Sup\u00e9rieur, France","institution_ids":["https://openalex.org/I4210091683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034436939","display_name":"Roy Gusinow","orcid":"https://orcid.org/0000-0002-0044-2613"},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roy Gusinow","raw_affiliation_strings":["Life and Medical Sciences Institute, University of Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life and Medical Sciences Institute, University of Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086305084","display_name":"Chiara Dellacasa","orcid":"https://orcid.org/0000-0002-8123-1737"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiara Dellacasa","raw_affiliation_strings":["HPC Department, CINECA Consorzio Interuniversitario, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HPC Department, CINECA Consorzio Interuniversitario, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050858475","display_name":"Elisa Rossi","orcid":"https://orcid.org/0000-0001-5767-7256"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisa Rossi","raw_affiliation_strings":["HPC Department, CINECA Consorzio Interuniversitario, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HPC Department, CINECA Consorzio Interuniversitario, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074382090","display_name":"Salvatore Cataudella","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvatore Cataudella","raw_affiliation_strings":["HPC Department, CINECA Consorzio Interuniversitario, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HPC Department, CINECA Consorzio Interuniversitario, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005623010","display_name":"Anna G\u00f3rska","orcid":"https://orcid.org/0000-0003-3305-8711"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna G\u00f3rska","raw_affiliation_strings":["Department of Diagnostics and Public Health, University of Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostics and Public Health, University of Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023671416","display_name":"Eugenia Rinaldi","orcid":"https://orcid.org/0000-0003-0343-6400"},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eugenia Rinaldi","raw_affiliation_strings":["Berlin Institute of Health (BIH), Charit\u00e9, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin Institute of Health (BIH), Charit\u00e9, Germany","institution_ids":["https://openalex.org/I4210139777"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5036825905"],"corresponding_institution_ids":["https://openalex.org/I100066346"],"apc_list":null,"apc_paid":null,"fwci":1.4887,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.83244128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"316","issue":null,"first_page":"1637","last_page":"1641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10764","display_name":"Privacy-Preserving Technologies in Data","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10764","display_name":"Privacy-Preserving Technologies in Data","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10761","display_name":"Vehicular Ad Hoc Networks (VANETs)","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.8511315584182739},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7128773331642151},{"id":"https://openalex.org/keywords/usability","display_name":"Usability","score":0.712719202041626},{"id":"https://openalex.org/keywords/harmonization","display_name":"Harmonization","score":0.6084340810775757},{"id":"https://openalex.org/keywords/security-analysis","display_name":"Security analysis","score":0.5270664691925049},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.453535795211792},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.425799697637558},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.42105960845947266},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3892980217933655},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.3614856004714966},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.3380308151245117}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.8511315584182739},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7128773331642151},{"id":"https://openalex.org/C170130773","wikidata":"https://www.wikidata.org/wiki/Q216378","display_name":"Usability","level":2,"score":0.712719202041626},{"id":"https://openalex.org/C2779962950","wikidata":"https://www.wikidata.org/wiki/Q5659376","display_name":"Harmonization","level":2,"score":0.6084340810775757},{"id":"https://openalex.org/C38369872","wikidata":"https://www.wikidata.org/wiki/Q7445009","display_name":"Security analysis","level":2,"score":0.5270664691925049},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.453535795211792},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.425799697637558},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.42105960845947266},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3892980217933655},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.3614856004714966},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.3380308151245117},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003219","descriptor_name":"Confidentiality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003219","descriptor_name":"Confidentiality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003219","descriptor_name":"Confidentiality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003219","descriptor_name":"Confidentiality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016494","descriptor_name":"Computer Security","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016494","descriptor_name":"Computer Security","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016494","descriptor_name":"Computer Security","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016494","descriptor_name":"Computer Security","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti240737","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti240737","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI240737","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:39176524","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39176524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti240737","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti240737","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI240737","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.6000000238418579,"display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4401824268.pdf"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2128349406","https://openalex.org/W4289783200","https://openalex.org/W4302018437","https://openalex.org/W4386268613"],"related_works":["https://openalex.org/W2006073222","https://openalex.org/W2488916264","https://openalex.org/W2323573032","https://openalex.org/W4389670110","https://openalex.org/W2429057255","https://openalex.org/W2187546663","https://openalex.org/W148745890","https://openalex.org/W2611942503","https://openalex.org/W4315621326","https://openalex.org/W2899790217"],"abstract_inverted_index":{"The":[0,85,106,124],"motivation":[1],"behind":[2],"this":[3],"research":[4,46],"is":[5,51,88,171],"to":[6,65,165,173,184],"perform":[7],"a":[8,37,120,148],"privacy-preserving":[9],"analysis":[10,35,41,59,87,102,113,122,152,157],"of":[11,24,70,79,103,129,146],"data":[12,40,80,86,112,151,178,189],"located":[13],"at":[14],"remote":[15],"sites":[16],"and":[17,36,54,75,97,136,154,181,188],"in":[18,82],"different":[19],"jurisdictions":[20],"with":[21,119,177],"no":[22],"possibility":[23],"sharing":[25],"individual-level":[26],"information.":[27],"Here,":[28],"we":[29],"present":[30,62],"key":[31],"findings":[32],"from":[33],"requirements":[34,175],"resulting":[38],"federated":[39,150],"workflow":[42,107],"built":[43],"using":[44,90],"open-source":[45],"software,":[47],"where":[48],"patient-level":[49,160],"information":[50],"securely":[52],"stored":[53],"never":[55],"exposed":[56],"during":[57],"the":[58,68,71,77,83,91,116,130,139,144],"process.":[60],"We":[61,73,142],"additional":[63],"improvements":[64],"further":[66],"strengthen":[67],"security":[69],"workflow.":[72],"emphasize":[74],"showcase":[76],"use":[78],"harmonization":[81],"analysis.":[84,168],"done":[89],"R":[92],"language":[93],"for":[94,100],"statistical":[95],"computing":[96],"DataSHIELD":[98],"libraries":[99],"non-disclosive":[101],"sensitive":[104],"data.":[105],"was":[108],"validated":[109],"against":[110],"two":[111],"scenarios,":[114],"confirming":[115],"results":[117,163],"obtained":[118],"centralized":[121,166],"approach.":[123],"clinical":[125],"datasets":[126],"are":[127],"part":[128],"large":[131],"Pan-European":[132],"SARS-Cov-2":[133],"cohort,":[134],"collected":[135],"managed":[137],"by":[138],"ORCHESTRA":[140],"project.":[141],"demonstrate":[143],"viability":[145],"establishing":[147],"cross-border":[149],"framework":[153],"conducting":[155],"an":[156],"without":[158],"exposing":[159],"information,":[161],"achieving":[162],"equivalent":[164],"non-secure":[167],"However,":[169],"it":[170],"vital":[172],"ensure":[174],"associated":[176],"harmonization,":[179],"anonymization":[180],"IT":[182],"infrastructure":[183],"maintain":[185],"availability,":[186],"usability":[187],"security.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-04T08:30:34.212998","created_date":"2025-10-10T00:00:00"}