{"id":"https://openalex.org/W4391229433","doi":"https://doi.org/10.3233/shti231008","title":"Introducing a Comprehensive Score of Systemic Anticancer Treatment Relevance","display_name":"Introducing a Comprehensive Score of Systemic Anticancer Treatment Relevance","publication_year":2024,"publication_date":"2024-01-25","ids":{"openalex":"https://openalex.org/W4391229433","doi":"https://doi.org/10.3233/shti231008","pmid":"https://pubmed.ncbi.nlm.nih.gov/38269846"},"language":"en","primary_location":{"id":"doi:10.3233/shti231008","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3233/shti231008","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI231008","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI231008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024959372","display_name":"Travis Zack","orcid":"https://orcid.org/0000-0002-1620-6455"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis Zack","raw_affiliation_strings":["University of California, San Francisco, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-1620-6455","affiliations":[{"raw_affiliation_string":"University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044194506","display_name":"Jeremy L. Warner","orcid":"https://orcid.org/0000-0002-2851-7242"},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210151747","display_name":"Lifespan","ror":"https://ror.org/04yt1rh21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremy L. Warner","raw_affiliation_strings":["Brown University and Lifespan Cancer Institute, Providence, RI, USA"],"raw_orcid":"https://orcid.org/0000-0002-2851-7242","affiliations":[{"raw_affiliation_string":"Brown University and Lifespan Cancer Institute, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210151747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044194506"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210151747"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0372093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"310","issue":null,"first_page":"464","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.8097538948059082},{"id":"https://openalex.org/keywords/guideline","display_name":"Guideline","score":0.6877610683441162},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.545131266117096},{"id":"https://openalex.org/keywords/complement","display_name":"Complement (music)","score":0.43489837646484375},{"id":"https://openalex.org/keywords/clinical-significance","display_name":"Clinical significance","score":0.4162774682044983},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36352550983428955},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.3319801688194275},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1537863314151764},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.152750164270401},{"id":"https://openalex.org/keywords/political-science","display_name":"Political science","score":0.10292083024978638}],"concepts":[{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.8097538948059082},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.6877610683441162},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.545131266117096},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.43489837646484375},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4162774682044983},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36352550983428955},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3319801688194275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1537863314151764},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.152750164270401},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.10292083024978638},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007743","descriptor_name":"Labor, Obstetric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007743","descriptor_name":"Labor, Obstetric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007743","descriptor_name":"Labor, Obstetric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007743","descriptor_name":"Labor, Obstetric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012108","descriptor_name":"Research Personnel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012108","descriptor_name":"Research Personnel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012108","descriptor_name":"Research Personnel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012108","descriptor_name":"Research Personnel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3233/shti231008","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3233/shti231008","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI231008","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:38269846","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38269846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10909246","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10909246","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10909246/pdf/nihms-1962470.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stud Health Technol Inform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3233/shti231008","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3233/shti231008","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI231008","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[{"score":0.5,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G378733189","display_name":null,"funder_award_id":"CA265879","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7141122533","display_name":null,"funder_award_id":"U24 CA265879","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391229433.pdf","grobid_xml":"https://content.openalex.org/works/W4391229433.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1529414772","https://openalex.org/W2058015212","https://openalex.org/W2138542336","https://openalex.org/W2328999771","https://openalex.org/W2492574990","https://openalex.org/W3016280944","https://openalex.org/W3210269332","https://openalex.org/W4220833748","https://openalex.org/W4225935538"],"related_works":["https://openalex.org/W2339422290","https://openalex.org/W2397653702","https://openalex.org/W4233871529","https://openalex.org/W2338818750","https://openalex.org/W2365451219","https://openalex.org/W2415869793","https://openalex.org/W4211072166","https://openalex.org/W28723353","https://openalex.org/W4231104876","https://openalex.org/W2441306059"],"abstract_inverted_index":{"Treatment":[0],"patterns":[1],"in":[2,106,138],"systemic":[3],"anticancer":[4],"therapy":[5],"(SACT)":[6],"are":[7,24],"extremely":[8,28],"varied":[9],"and":[10,30,61,124],"complex.":[11],"While":[12],"professional":[13,83],"society":[14,84],"guidelines":[15,23,40],"exist":[16],"that":[17,99,113],"suggest":[18],"recommended":[19],"treatment":[20,45],"strategies,":[21],"these":[22,49],"produced":[25],"through":[26],"an":[27],"laborious":[29],"sometimes":[31],"opaque":[32],"manual":[33],"process,":[34],"making":[35],"it":[36],"impossible":[37],"for":[38,131],"such":[39],"to":[41,67],"cover":[42],"all":[43],"relevant":[44],"scenarios.":[46],"To":[47],"complement":[48],"manually":[50],"curated":[51],"guidelines,":[52],"we":[53],"leveraged":[54],"a":[55,69,74],"database":[56],"of":[57,94,121],"5818":[58],"clinical":[59,132],"trials":[60],"7012":[62],"supporting":[63],"references":[64],"from":[65],"1943-present":[66],"calculate":[68],"quantifiable":[70],"\"relevance":[71],"score\".":[72],"In":[73],"pilot":[75],"evaluation,":[76],"this":[77,100,114],"score":[78,101],"was":[79],"strongly":[80],"associated":[81],"with":[82],"guideline":[85],"recommendations,":[86],"while":[87],"also":[88,102],"providing":[89],"relevance":[90,120],"information":[91],"on":[92],"thousands":[93],"additional":[95],"therapies.":[96],"We":[97,111],"show":[98],"accurately":[103],"illustrates":[104],"trends":[105],"SACT":[107,122],"adoption":[108],"over":[109],"time.":[110],"foresee":[112],"score,":[115],"which":[116],"comprehensively":[117],"evaluates":[118],"the":[119],"overall":[123],"by":[125],"cancer":[126],"subtype,":[127],"will":[128],"have":[129],"utility":[130],"practitioners":[133],"as":[134,136],"well":[135],"researchers":[137],"real-world":[139],"data.":[140]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}