{"id":"https://openalex.org/W4382631281","doi":"https://doi.org/10.3233/shti230479","title":"An Artificial Intelligence-Based Diagnostic System for Acute Lymphoblastic Leukemia Detection","display_name":"An Artificial Intelligence-Based Diagnostic System for Acute Lymphoblastic Leukemia Detection","publication_year":2023,"publication_date":"2023-06-29","ids":{"openalex":"https://openalex.org/W4382631281","doi":"https://doi.org/10.3233/shti230479","pmid":"https://pubmed.ncbi.nlm.nih.gov/37387013"},"language":"en","primary_location":{"id":"doi:10.3233/shti230479","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti230479","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI230479","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI230479","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012516611","display_name":"Yousra El Alaoui","orcid":"https://orcid.org/0000-0002-7389-2789"},"institutions":[{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I92528248","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05","country_code":"QA","type":"funder","lineage":["https://openalex.org/I92528248"]}],"countries":["QA"],"is_corresponding":true,"raw_author_name":"Yousra El Alaoui","raw_affiliation_strings":["College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839","https://openalex.org/I92528248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020913417","display_name":"Regina Padmanabhan","orcid":"https://orcid.org/0000-0001-9448-6950"},"institutions":[{"id":"https://openalex.org/I92528248","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05","country_code":"QA","type":"funder","lineage":["https://openalex.org/I92528248"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Regina Padmanabhan","raw_affiliation_strings":["College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839","https://openalex.org/I92528248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040213636","display_name":"Adel Elomri","orcid":"https://orcid.org/0000-0003-1605-9800"},"institutions":[{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I92528248","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05","country_code":"QA","type":"funder","lineage":["https://openalex.org/I92528248"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Adel Elomri","raw_affiliation_strings":["College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839","https://openalex.org/I92528248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010196813","display_name":"Marwa Qaraqe","orcid":"https://orcid.org/0000-0003-0767-2478"},"institutions":[{"id":"https://openalex.org/I92528248","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05","country_code":"QA","type":"funder","lineage":["https://openalex.org/I92528248"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Marwa K. Qaraqe","raw_affiliation_strings":["College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839","https://openalex.org/I92528248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036313621","display_name":"Halima El Omri","orcid":"https://orcid.org/0000-0002-8299-3733"},"institutions":[{"id":"https://openalex.org/I49828101","display_name":"Hamad Medical Corporation","ror":"https://ror.org/02zwb6n98","country_code":"QA","type":"nonprofit","lineage":["https://openalex.org/I49828101"]},{"id":"https://openalex.org/I4210118835","display_name":"National Center for Cancer Care and Research","ror":"https://ror.org/02d4f9f51","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210118835","https://openalex.org/I49828101"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Halima El Omri","raw_affiliation_strings":["Medical Oncology-Hematology Department, National Centre for Cancer Care and Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"Medical Oncology-Hematology Department, National Centre for Cancer Care and Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar","institution_ids":["https://openalex.org/I4210118835","https://openalex.org/I49828101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081321939","display_name":"Ruba Y. Taha","orcid":"https://orcid.org/0000-0002-7941-5342"},"institutions":[{"id":"https://openalex.org/I4210118835","display_name":"National Center for Cancer Care and Research","ror":"https://ror.org/02d4f9f51","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210118835","https://openalex.org/I49828101"]},{"id":"https://openalex.org/I49828101","display_name":"Hamad Medical Corporation","ror":"https://ror.org/02zwb6n98","country_code":"QA","type":"nonprofit","lineage":["https://openalex.org/I49828101"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Ruba Yasin Taha","raw_affiliation_strings":["Medical Oncology-Hematology Department, National Centre for Cancer Care and Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"Medical Oncology-Hematology Department, National Centre for Cancer Care and Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar","institution_ids":["https://openalex.org/I4210118835","https://openalex.org/I49828101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5012516611"],"corresponding_institution_ids":["https://openalex.org/I4210144839","https://openalex.org/I92528248"],"apc_list":null,"apc_paid":null,"fwci":2.3864,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.928821,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"305","issue":null,"first_page":"265","last_page":"268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9620000123977661,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.8078304529190063},{"id":"https://openalex.org/keywords/lymphoblastic-leukemia","display_name":"Lymphoblastic Leukemia","score":0.8057925701141357},{"id":"https://openalex.org/keywords/hyperparameter","display_name":"Hyperparameter","score":0.7865101099014282},{"id":"https://openalex.org/keywords/decision-tree","display_name":"Decision tree","score":0.639051079750061},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6120019555091858},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5977222919464111},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5865087509155273},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5643064975738525},{"id":"https://openalex.org/keywords/hyperparameter-optimization","display_name":"Hyperparameter optimization","score":0.521282434463501},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.41246798634529114},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3821227550506592},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20579564571380615},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.2027980387210846},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12293732166290283},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.08418631553649902}],"concepts":[{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.8078304529190063},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.8057925701141357},{"id":"https://openalex.org/C8642999","wikidata":"https://www.wikidata.org/wiki/Q4171168","display_name":"Hyperparameter","level":2,"score":0.7865101099014282},{"id":"https://openalex.org/C84525736","wikidata":"https://www.wikidata.org/wiki/Q831366","display_name":"Decision tree","level":2,"score":0.639051079750061},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6120019555091858},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5977222919464111},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5865087509155273},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5643064975738525},{"id":"https://openalex.org/C10485038","wikidata":"https://www.wikidata.org/wiki/Q48996162","display_name":"Hyperparameter optimization","level":3,"score":0.521282434463501},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.41246798634529114},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3821227550506592},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20579564571380615},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2027980387210846},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12293732166290283},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.08418631553649902}],"mesh":[{"descriptor_ui":"D000093743","descriptor_name":"Random Forest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093743","descriptor_name":"Random Forest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093743","descriptor_name":"Random Forest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti230479","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti230479","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI230479","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:37387013","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37387013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti230479","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti230479","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI230479","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.7400000095367432}],"awards":[{"id":"https://openalex.org/G2894603144","display_name":null,"funder_award_id":"NPRP12S-","funder_id":"https://openalex.org/F4320332753","funder_display_name":"Qatar National Research Fund"},{"id":"https://openalex.org/G6064236338","display_name":null,"funder_award_id":"NPRP12S-0219-190108","funder_id":"https://openalex.org/F4320332753","funder_display_name":"Qatar National Research Fund"}],"funders":[{"id":"https://openalex.org/F4320309815","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05"},{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"},{"id":"https://openalex.org/F4320332753","display_name":"Qatar National Research Fund","ror":"https://ror.org/01svaqq28"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4382631281.pdf"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1978761216","https://openalex.org/W1987776395","https://openalex.org/W1995806857","https://openalex.org/W2156354701","https://openalex.org/W2163913032","https://openalex.org/W2971541566","https://openalex.org/W2982391067","https://openalex.org/W3096847176","https://openalex.org/W3115044335","https://openalex.org/W3213077079","https://openalex.org/W4213121506","https://openalex.org/W4233503153","https://openalex.org/W4237318738","https://openalex.org/W4240429504","https://openalex.org/W4285077021"],"related_works":["https://openalex.org/W4322775603","https://openalex.org/W4362544620","https://openalex.org/W3096565539","https://openalex.org/W3090711245","https://openalex.org/W4295309597","https://openalex.org/W4323902652","https://openalex.org/W4312707991","https://openalex.org/W4210825373","https://openalex.org/W4307632867","https://openalex.org/W4383911948"],"abstract_inverted_index":{"This":[0],"study":[1],"suggests":[2],"a":[3,20,41,51],"novel":[4],"Acute":[5],"Lymphoblastic":[6],"Leukemia":[7],"(ALL)":[8],"diagnostic":[9],"model,":[10],"built":[11],"solely":[12],"on":[13],"complete":[14],"blood":[15],"count":[16],"(CBC)":[17],"records.":[18,93],"Using":[19],"dataset":[21],"comprised":[22],"of":[23,26,73],"CBC":[24],"records":[25],"86":[27,30],"ALL":[28,89],"and":[29,64,84],"control":[31],"patients":[32],"respectively,":[33],"we":[34],"identified":[35],"the":[36,71,74],"most":[37],"ALL-specific":[38],"parameters":[39],"using":[40,60,91],"feature":[42],"selection":[43],"approach.":[44],"Next,":[45],"Grid":[46],"Search-based":[47],"hyperparameter":[48],"tuning":[49],"with":[50],"five-fold":[52],"cross-validation":[53],"scheme":[54],"was":[55],"adopted":[56],"to":[57],"build":[58],"classifiers":[59],"Random":[61,85],"Forest,":[62],"XGBoost,":[63],"Decision":[65,79],"Tree":[66,80],"algorithms.":[67],"A":[68],"comparison":[69],"between":[70],"performances":[72],"three":[75],"models":[76],"demonstrates":[77],"that":[78],"classifier":[81],"outperformed":[82],"XGBoost":[83],"Forest":[86],"algorithms":[87],"in":[88],"detection":[90],"CBC-based":[92]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}