{"id":"https://openalex.org/W4292133584","doi":"https://doi.org/10.3233/shti220802","title":"Secure Multi-Party Computation Based Distributed Feasibility Queries \u2013 A HiGHmed Use Case","display_name":"Secure Multi-Party Computation Based Distributed Feasibility Queries \u2013 A HiGHmed Use Case","publication_year":2022,"publication_date":"2022-08-17","ids":{"openalex":"https://openalex.org/W4292133584","doi":"https://doi.org/10.3233/shti220802","pmid":"https://pubmed.ncbi.nlm.nih.gov/36073487"},"language":"en","primary_location":{"id":"doi:10.3233/shti220802","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti220802","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI220802","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI220802","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102997914","display_name":"Reto Wettstein","orcid":"https://orcid.org/0000-0003-3612-8658"},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Reto Wettstein","raw_affiliation_strings":["Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057389420","display_name":"Tobias Kussel","orcid":"https://orcid.org/0000-0002-9731-7666"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Kussel","raw_affiliation_strings":["Computational Biology & Simulation, Technical University Darmstadt, Darmstadt, Germany"],"affiliations":[{"raw_affiliation_string":"Computational Biology & Simulation, Technical University Darmstadt, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088713583","display_name":"Hauke Hund","orcid":null},"institutions":[{"id":"https://openalex.org/I41121874","display_name":"Heilbronn University","ror":"https://ror.org/04g5gcg95","country_code":"DE","type":"education","lineage":["https://openalex.org/I41121874"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hauke Hund","raw_affiliation_strings":["GECKO Institute, Heilbronn University of Applied Sciences, Heilbronn, Germany"],"affiliations":[{"raw_affiliation_string":"GECKO Institute, Heilbronn University of Applied Sciences, Heilbronn, Germany","institution_ids":["https://openalex.org/I41121874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010820385","display_name":"Christian Fegeler","orcid":"https://orcid.org/0000-0001-5581-7155"},"institutions":[{"id":"https://openalex.org/I41121874","display_name":"Heilbronn University","ror":"https://ror.org/04g5gcg95","country_code":"DE","type":"education","lineage":["https://openalex.org/I41121874"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Fegeler","raw_affiliation_strings":["GECKO Institute, Heilbronn University of Applied Sciences, Heilbronn, Germany"],"affiliations":[{"raw_affiliation_string":"GECKO Institute, Heilbronn University of Applied Sciences, Heilbronn, Germany","institution_ids":["https://openalex.org/I41121874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002071945","display_name":"Martin Dugas","orcid":"https://orcid.org/0000-0001-9740-0788"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Dugas","raw_affiliation_strings":["Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063890041","display_name":"Kay Hamacher","orcid":"https://orcid.org/0000-0002-6921-8345"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kay Hamacher","raw_affiliation_strings":["Computational Biology & Simulation, Technical University Darmstadt, Darmstadt, Germany"],"affiliations":[{"raw_affiliation_string":"Computational Biology & Simulation, Technical University Darmstadt, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102997914"],"corresponding_institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"],"apc_list":null,"apc_paid":null,"fwci":1.7114,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.86795002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"296","issue":null,"first_page":"41","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10237","display_name":"Cryptography and Data Security","score":0.9088000059127808,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10237","display_name":"Cryptography and Data Security","score":0.9088000059127808,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7260183095932007},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.47761625051498413},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.46721306443214417},{"id":"https://openalex.org/keywords/trusted-third-party","display_name":"Trusted third party","score":0.4227117598056793},{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.4175020158290863},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.4157341718673706},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.38801276683807373},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.32225412130355835},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.3047664165496826},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.14381396770477295}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7260183095932007},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.47761625051498413},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.46721306443214417},{"id":"https://openalex.org/C139089976","wikidata":"https://www.wikidata.org/wiki/Q2142273","display_name":"Trusted third party","level":2,"score":0.4227117598056793},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.4175020158290863},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4157341718673706},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.38801276683807373},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.32225412130355835},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.3047664165496826},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.14381396770477295},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3233/shti220802","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti220802","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI220802","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:36073487","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36073487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:134082","is_oa":false,"landing_page_url":"http://tubiblio.ulb.tu-darmstadt.de/134082/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artikel"}],"best_oa_location":{"id":"doi:10.3233/shti220802","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti220802","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI220802","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[{"score":0.5299999713897705,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G2755971928","display_name":null,"funder_award_id":"CROSSING/236615297","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3634552206","display_name":null,"funder_award_id":"SFB 1119 CROSSING/236615297","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4158655670","display_name":null,"funder_award_id":"SFB 1119","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4269364176","display_name":null,"funder_award_id":"236615297","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G5106512922","display_name":null,"funder_award_id":"Deutsche Forschungsgemeinschaft (DFG","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5644826747","display_name":null,"funder_award_id":"01ZZ1802","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G6024419964","display_name":null,"funder_award_id":"Deutsche Forschungsgemeinschaft (DFG)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6052429835","display_name":null,"funder_award_id":"(DFG)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6343502828","display_name":null,"funder_award_id":"236615297","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8417898881","display_name":null,"funder_award_id":"1119 CROSSING/236615297","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8523583147","display_name":null,"funder_award_id":"SFB 1119 CROSSING","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8880105035","display_name":null,"funder_award_id":"01ZZ1802G","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292133584.pdf","grobid_xml":"https://content.openalex.org/works/W4292133584.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1480225633","https://openalex.org/W2027471022","https://openalex.org/W2076157564","https://openalex.org/W2088492763","https://openalex.org/W2119046301","https://openalex.org/W2746922071","https://openalex.org/W2801702159","https://openalex.org/W2883427794","https://openalex.org/W2885961219","https://openalex.org/W2892370045","https://openalex.org/W3081553330","https://openalex.org/W3083828464","https://openalex.org/W3164327632","https://openalex.org/W3164494622","https://openalex.org/W6628587945"],"related_works":["https://openalex.org/W2623347760","https://openalex.org/W4285814174","https://openalex.org/W4293872997","https://openalex.org/W2126703991","https://openalex.org/W2116602925","https://openalex.org/W2982101747","https://openalex.org/W2411662051","https://openalex.org/W4376872641","https://openalex.org/W2418991883","https://openalex.org/W2065059003"],"abstract_inverted_index":{"The":[0,27,190,210],"integration":[1],"of":[2,39,169,194],"routine":[3],"medical":[4],"care":[5],"data":[6,18,57,70,77,140,149],"into":[7],"research":[8,67,89],"endeavors":[9],"promises":[10],"great":[11],"value.":[12],"However,":[13,132],"access":[14],"to":[15,55,97,204],"this":[16,113],"extra-domain":[17],"is":[19,45,78,96,198],"constrained":[20],"by":[21,35],"numerous":[22],"technical":[23],"and":[24,41,159,213],"legal":[25],"requirements.":[26],"German":[28],"Medical":[29,51],"Informatics":[30],"Initiative":[31],"(MII)":[32],"-":[33,44],"initiated":[34],"the":[36,116,122,166,195,205],"Federal":[37],"Ministry":[38],"Research":[40],"Education":[42],"(BMBF)":[43],"making":[46],"progress":[47],"in":[48,59,81],"setting":[49],"up":[50],"Data":[52,207],"Integration":[53],"Centers":[54],"consolidate":[56],"stored":[58],"clinical":[60],"primary":[61],"information":[62],"systems.":[63],"Unfortunately,":[64],"for":[65,88,112,121,128,148],"many":[66],"questions":[68],"cross-organizational":[69],"sources":[71],"are":[72,146],"required,":[73],"as":[74,156,163,165,200],"one":[75],"organization's":[76],"insufficient,":[79],"especially":[80],"rare":[82],"disease":[83],"research.":[84],"A":[85],"first":[86],"step,":[87],"projects":[90],"exploring":[91],"possible":[92],"multi-centric":[93],"study":[94],"designs,":[95],"perform":[98,126],"a":[99,103,175,201],"feasibility":[100,119,179],"query,":[101],"i.e.,":[102],"cohort":[104],"size":[105],"calculation":[106],"transcending":[107],"organizational":[108],"boundaries.":[109],"Existing":[110],"solutions":[111],"problem,":[114],"like":[115],"previously":[117],"introduced":[118],"process":[120,181,203],"MII's":[123],"HiGHmed":[124,206],"consortium,":[125],"well":[127,164],"most":[129],"use":[130,135],"cases.":[131],"there":[133],"exist":[134],"cases":[136],"where":[137],"neither":[138],"centralized":[139],"repositories,":[141],"nor":[142],"Trusted":[143,187],"Third":[144,188],"Parties":[145],"acceptable":[147],"aggregation.":[150],"Based":[151],"on":[152],"open":[153,191],"standards,":[154],"such":[155],"BPMN":[157],"2.0":[158],"HL7":[160],"FHIR":[161],"R4,":[162],"cryptographic":[167],"techniques":[168],"secure":[170],"Multi-Party":[171],"Computation,":[172],"we":[173],"introduce":[174],"fully":[176],"automated,":[177],"decentral":[178],"query":[180],"without":[182],"any":[183],"central":[184],"component":[185],"or":[186],"Party.":[189],"source":[192],"implementation":[193],"proposed":[196],"solution":[197],"intended":[199],"plugin":[202],"Sharing":[208],"Framework.":[209],"process's":[211],"concept":[212],"underlying":[214],"algorithms":[215],"can":[216],"also":[217],"be":[218],"used":[219],"independently.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}