{"id":"https://openalex.org/W4281480694","doi":"https://doi.org/10.3233/shti220490","title":"Implementation of Gene Expression Profiles in the HL7 FHIR Standard","display_name":"Implementation of Gene Expression Profiles in the HL7 FHIR Standard","publication_year":2022,"publication_date":"2022-05-25","ids":{"openalex":"https://openalex.org/W4281480694","doi":"https://doi.org/10.3233/shti220490","pmid":"https://pubmed.ncbi.nlm.nih.gov/35612112"},"language":"en","primary_location":{"id":"doi:10.3233/shti220490","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti220490","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI220490","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI220490","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075084280","display_name":"Florian Auer","orcid":"https://orcid.org/0000-0002-5320-8900"},"institutions":[{"id":"https://openalex.org/I179225836","display_name":"University of Augsburg","ror":"https://ror.org/03p14d497","country_code":"DE","type":"education","lineage":["https://openalex.org/I179225836"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Florian Auer","raw_affiliation_strings":["IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"],"affiliations":[{"raw_affiliation_string":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany","institution_ids":["https://openalex.org/I179225836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029030657","display_name":"Zhibek Abdykalykova","orcid":"https://orcid.org/0000-0002-8017-5913"},"institutions":[{"id":"https://openalex.org/I179225836","display_name":"University of Augsburg","ror":"https://ror.org/03p14d497","country_code":"DE","type":"education","lineage":["https://openalex.org/I179225836"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zhibek Abdykalykova","raw_affiliation_strings":["IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"],"affiliations":[{"raw_affiliation_string":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany","institution_ids":["https://openalex.org/I179225836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036358389","display_name":"Dominik M\u00fcller","orcid":"https://orcid.org/0000-0003-0838-9885"},"institutions":[{"id":"https://openalex.org/I179225836","display_name":"University of Augsburg","ror":"https://ror.org/03p14d497","country_code":"DE","type":"education","lineage":["https://openalex.org/I179225836"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik M\u00fcller","raw_affiliation_strings":["IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"],"affiliations":[{"raw_affiliation_string":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany","institution_ids":["https://openalex.org/I179225836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010964383","display_name":"Frank Kr\u00e4mer","orcid":"https://orcid.org/0000-0002-2857-7122"},"institutions":[{"id":"https://openalex.org/I179225836","display_name":"University of Augsburg","ror":"https://ror.org/03p14d497","country_code":"DE","type":"education","lineage":["https://openalex.org/I179225836"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Kramer","raw_affiliation_strings":["IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany"],"affiliations":[{"raw_affiliation_string":"IT-Infrastructure for Translational Medical Research, University of Augsburg, Germany","institution_ids":["https://openalex.org/I179225836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075084280"],"corresponding_institution_ids":["https://openalex.org/I179225836"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11785493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"294","issue":null,"first_page":"417","last_page":"418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5502136945724487},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5478982925415039},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48215338587760925},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4727369546890259},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.46997159719467163},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.4396810829639435},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.4313771724700928},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.423218697309494},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.41351810097694397},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33674734830856323},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.319354772567749},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24998241662979126},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.14440199732780457}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5502136945724487},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5478982925415039},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48215338587760925},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4727369546890259},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46997159719467163},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.4396810829639435},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4313771724700928},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.423218697309494},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.41351810097694397},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33674734830856323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.319354772567749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24998241662979126},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.14440199732780457}],"mesh":[{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057208","descriptor_name":"Health Level Seven","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057208","descriptor_name":"Health Level Seven","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057208","descriptor_name":"Health Level Seven","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3233/shti220490","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti220490","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI220490","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:35612112","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35612112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null},{"id":"pmh:oai:uni-augsburg.opus-bayern.de:96106","is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-961064","pdf_url":null,"source":{"id":"https://openalex.org/S4306400930","display_name":"OPUS (Augsburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I119916105","host_organization_name":"Augsburg University","host_organization_lineage":["https://openalex.org/I119916105"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:bookpart"}],"best_oa_location":{"id":"doi:10.3233/shti220490","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti220490","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI220490","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[{"score":0.6800000071525574,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281480694.pdf","grobid_xml":"https://content.openalex.org/works/W4281480694.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2137713250","https://openalex.org/W2154109625","https://openalex.org/W2626036098","https://openalex.org/W2751687090"],"related_works":["https://openalex.org/W2053053668","https://openalex.org/W1531528770","https://openalex.org/W3032874291","https://openalex.org/W262379139","https://openalex.org/W2112336316","https://openalex.org/W2417887690","https://openalex.org/W2392221252","https://openalex.org/W2782128209","https://openalex.org/W2439513411","https://openalex.org/W2773571775"],"abstract_inverted_index":{"Gene":[0],"expression":[1,28,44],"profiles":[2,45],"can":[3,64],"capture":[4],"significant":[5],"molecular":[6,23,78],"differences":[7],"paving":[8],"the":[9,54,75],"way":[10],"toward":[11],"precision":[12],"medicine.":[13],"However,":[14],"clinical":[15,83],"standards":[16],"like":[17],"FHIR":[18,55,62],"only":[19],"provide":[20,38],"encoding":[21],"of":[22,42,46,53,77],"sequence":[24],"variations,":[25],"even":[26],"so,":[27],"patterns":[29],"are":[30],"equally":[31],"important":[32],"for":[33,74],"decision":[34,69],"making.":[35],"Here":[36],"we":[37],"an":[39,51],"exemplary":[40],"implementation":[41],"gene":[43],"a":[47],"microarray":[48],"analysis":[49],"using":[50],"adaption":[52],"Genomics":[56],"extension.":[57],"Our":[58],"results":[59],"demonstrate":[60],"how":[61],"resources":[63],"be":[65],"facilitated":[66],"in":[67,81],"bioinformatics-based":[68],"support":[70],"systems":[71],"or":[72],"used":[73],"aggregation":[76],"genetics":[79],"data":[80],"multi-center":[82],"trials.":[84]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}