{"id":"https://openalex.org/W3164585366","doi":"https://doi.org/10.3233/shti210314","title":"Digital Health in the Management of Pediatric Growth Hormone Therapy \u2013 10 Years of Developments","display_name":"Digital Health in the Management of Pediatric Growth Hormone Therapy \u2013 10 Years of Developments","publication_year":2021,"publication_date":"2021-05-27","ids":{"openalex":"https://openalex.org/W3164585366","doi":"https://doi.org/10.3233/shti210314","mag":"3164585366","pmid":"https://pubmed.ncbi.nlm.nih.gov/34042809"},"language":"en","primary_location":{"id":"doi:10.3233/shti210314","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210314","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210314","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090580951","display_name":"Ekaterina Koledova","orcid":"https://orcid.org/0000-0003-2572-9052"},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ekaterina Koledova","raw_affiliation_strings":["Endocrinology Global Medical Affairs, Merck KGaA, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Global Medical Affairs, Merck KGaA, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011253090","display_name":"Quentin Le Masne","orcid":"https://orcid.org/0000-0001-7120-130X"},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Quentin Le Masne","raw_affiliation_strings":["Connected Health & Devices, Ares Trading SA, Eysins, Switzerland, an affiliate of Merck KGaA, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connected Health & Devices, Ares Trading SA, Eysins, Switzerland, an affiliate of Merck KGaA, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103975761","display_name":"Amalia Spataru","orcid":null},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210122261","display_name":"Swiss Data Science Center","ror":"https://ror.org/02hdt9m26","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4210122261","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Amalia Spataru","raw_affiliation_strings":["Swiss Data Science Center, ETH Zurich and EPFL, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Data Science Center, ETH Zurich and EPFL, Switzerland","institution_ids":["https://openalex.org/I4210122261","https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005926611","display_name":"Merat Bagha","orcid":"https://orcid.org/0000-0002-5870-1358"},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Merat Bagha","raw_affiliation_strings":["Tiba Medical Inc., Beaverton, OR, USA","affiliate of Merck KGaA, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tiba Medical Inc., Beaverton, OR, USA","institution_ids":[]},{"raw_affiliation_string":"affiliate of Merck KGaA, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090352030","display_name":"David R. Dixon","orcid":"https://orcid.org/0000-0002-1047-1709"},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Dixon","raw_affiliation_strings":["Endocrinology Global Medical Affairs, Merck KGaA, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Global Medical Affairs, Merck KGaA, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090580951"],"corresponding_institution_ids":["https://openalex.org/I164928964"],"apc_list":null,"apc_paid":null,"fwci":24.6345,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.99355923,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"281","issue":null,"first_page":"926","last_page":"930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12823","display_name":"Adolescent and Pediatric Healthcare","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11446","display_name":"Mobile Health and mHealth Applications","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telehealth","display_name":"Telehealth","score":0.7570970058441162},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"Growth hormone","score":0.5900363922119141},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4672750234603882},{"id":"https://openalex.org/keywords/anxiety","display_name":"Anxiety","score":0.45855849981307983},{"id":"https://openalex.org/keywords/cloud-computing","display_name":"Cloud computing","score":0.4360361397266388},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.42170417308807373},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.41926059126853943},{"id":"https://openalex.org/keywords/telemedicine","display_name":"Telemedicine","score":0.3032640814781189},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.26585686206817627},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.16132554411888123},{"id":"https://openalex.org/keywords/hormone","display_name":"Hormone","score":0.14936870336532593},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14203080534934998},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.12990063428878784}],"concepts":[{"id":"https://openalex.org/C2781050511","wikidata":"https://www.wikidata.org/wiki/Q46994","display_name":"Telehealth","level":4,"score":0.7570970058441162},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.5900363922119141},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4672750234603882},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.45855849981307983},{"id":"https://openalex.org/C79974875","wikidata":"https://www.wikidata.org/wiki/Q483639","display_name":"Cloud computing","level":2,"score":0.4360361397266388},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.42170417308807373},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.41926059126853943},{"id":"https://openalex.org/C2779891985","wikidata":"https://www.wikidata.org/wiki/Q46994","display_name":"Telemedicine","level":3,"score":0.3032640814781189},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26585686206817627},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16132554411888123},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14936870336532593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14203080534934998},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.12990063428878784},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3233/shti210314","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210314","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210314","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:34042809","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34042809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/510853","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/510853","pdf_url":"http://hdl.handle.net/20.500.11850/510853","source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Studies in Health Technology and Informatics, 281","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"doi:10.3929/ethz-b-000510853","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000510853","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.3233/shti210314","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210314","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210314","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311647","display_name":"Merck KGaA","ror":"https://ror.org/04b2dty93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3164585366.pdf","grobid_xml":"https://content.openalex.org/works/W3164585366.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2122538510","https://openalex.org/W2198491249","https://openalex.org/W2379349040","https://openalex.org/W2771133002","https://openalex.org/W2807556183","https://openalex.org/W2830414615","https://openalex.org/W2898288062","https://openalex.org/W3045858594","https://openalex.org/W3046024755","https://openalex.org/W3113244651","https://openalex.org/W3157344487"],"related_works":["https://openalex.org/W3170020535","https://openalex.org/W2970477638","https://openalex.org/W2912378903","https://openalex.org/W3134723546","https://openalex.org/W4389781895","https://openalex.org/W2410804002","https://openalex.org/W4308006235","https://openalex.org/W1483331398","https://openalex.org/W3181210348","https://openalex.org/W3185086095"],"abstract_inverted_index":{"Growth":[0],"hormone":[1],"administration":[2],"is":[3],"approved":[4],"for":[5,200],"use":[6],"in":[7,14],"a":[8,49,152,168],"number":[9],"of":[10,29,42,145],"growth":[11,17,109,170,203],"failure":[12],"conditions":[13],"children.":[15],"Optimal":[16],"outcome":[18],"requires":[19],"continuous":[20],"daily":[21],"injections":[22],"over":[23,155],"many":[24],"years,":[25,157],"leading":[26],"to":[27,48,71,80,83,99,107,129,148],"problems":[28],"persistence":[30,178],"and":[31,44,68,89,92,102,116,136,158,179,205],"adherence":[32,65,163,180],"with":[33,66,167,181,202],"therapy.":[34],"The":[35,73,111],"easypod\u2122":[36,118,140,186],"connect":[37,141,187],"ecosystem":[38,82,128],"enables":[39],"electronic":[40],"monitoring":[41],"injection":[43],"dose":[45],"history,":[46],"transmitted":[47],"secure":[50],"cloud":[51],"database":[52],"via":[53,184],"the":[54,81,117,127,185],"internet":[55],"or":[56],"cellular":[57],"networks.":[58],"Thus,":[59],"healthcare":[60,105],"providers":[61,106],"can":[62,87],"easily":[63],"monitor":[64],"therapy":[67,183],"be":[69,149],"alerted":[70],"problems.":[72],"growlink\u2122":[74,95],"patient":[75,112],"app":[76,122],"has":[77],"been":[78],"added":[79],"provide":[84],"solutions":[85,194],"that":[86,161,176,195],"engage":[88],"educate":[90],"patients":[91,98],"their":[93],"families/caregivers.":[94],"also":[96],"allows":[97],"self-report":[100],"height":[101],"weight,":[103],"enabling":[104],"track":[108],"progression.":[110],"support":[113,130],"program,":[114],"TuiTek":[115],"Augmented":[119],"Reality":[120],"(AR)":[121],"are":[123,192],"being":[124],"developed":[125],"within":[126],"telehealth":[131],"services,":[132],"increase":[133],"disease":[134],"awareness":[135],"reduce":[137],"therapy-related":[138],"anxiety.":[139],"provides":[142],"objective":[143],"assessments":[144],"adherence,":[146],"shown":[147],"maintained":[150],"at":[151],"high":[153],"level":[154],"several":[156],"analyses":[159],"showed":[160],"increased":[162],"was":[164],"significantly":[165],"associated":[166],"better":[169],"outcome.":[171],"Studies":[172],"have":[173],"identified":[174],"factors":[175],"influence":[177],"GH":[182],"ecosystem.":[188],"These":[189],"novel":[190],"technologies":[191],"generating":[193],"enable":[196],"data-driven":[197],"personalized":[198],"care":[199],"children":[201],"disorders":[204],"optimize":[206],"long-term":[207],"clinical":[208],"outcomes.":[209]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}