{"id":"https://openalex.org/W3165400810","doi":"https://doi.org/10.3233/shti210168","title":"Challenges in Building of Deep Learning Models for Glioblastoma Segmentation: Evidence from Clinical Data","display_name":"Challenges in Building of Deep Learning Models for Glioblastoma Segmentation: Evidence from Clinical Data","publication_year":2021,"publication_date":"2021-05-27","ids":{"openalex":"https://openalex.org/W3165400810","doi":"https://doi.org/10.3233/shti210168","mag":"3165400810","pmid":"https://pubmed.ncbi.nlm.nih.gov/34042753"},"language":"en","primary_location":{"id":"doi:10.3233/shti210168","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210168","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210168","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210168","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024966193","display_name":"Anvar Kurmukov","orcid":"https://orcid.org/0000-0001-6754-4211"},"institutions":[{"id":"https://openalex.org/I118501908","display_name":"National Research University Higher School of Economics","ror":"https://ror.org/055f7t516","country_code":"RU","type":"education","lineage":["https://openalex.org/I118501908"]},{"id":"https://openalex.org/I4210107660","display_name":"Institute for Information Transmission Problems","ror":"https://ror.org/013w2d378","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210107660"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anvar Kurmukov","raw_affiliation_strings":["Higher School of Economics \u2013 National Research University, Moscow, Russia","Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Higher School of Economics \u2013 National Research University, Moscow, Russia","institution_ids":["https://openalex.org/I118501908"]},{"raw_affiliation_string":"Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Moscow, Russia","institution_ids":["https://openalex.org/I4210107660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112668197","display_name":"Aleksandra Dalechina","orcid":null},"institutions":[{"id":"https://openalex.org/I4210122729","display_name":"Burdenko Neurosurgery Institute","ror":"https://ror.org/02t1t6n83","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210122729"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Aleksandra Dalechina","raw_affiliation_strings":["N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","N. N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","institution_ids":["https://openalex.org/I4210122729"]},{"raw_affiliation_string":"N. N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","institution_ids":["https://openalex.org/I4210122729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019286324","display_name":"Talgat Saparov","orcid":null},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]},{"id":"https://openalex.org/I4210107660","display_name":"Institute for Information Transmission Problems","ror":"https://ror.org/013w2d378","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210107660"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Talgat Saparov","raw_affiliation_strings":["Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Moscow, Russia","Moscow Institute of Physics and Technology, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Moscow, Russia","institution_ids":["https://openalex.org/I4210107660"]},{"raw_affiliation_string":"Moscow Institute of Physics and Technology, Moscow, Russia","institution_ids":["https://openalex.org/I153845743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000964051","display_name":"Mikhail Belyaev","orcid":"https://orcid.org/0000-0002-2776-5316"},"institutions":[{"id":"https://openalex.org/I125989756","display_name":"Skolkovo Institute of Science and Technology","ror":"https://ror.org/03f9nc143","country_code":"RU","type":"education","lineage":["https://openalex.org/I125989756"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mikhail Belyaev","raw_affiliation_strings":["Skolkovo Institute of Science and Technology, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skolkovo Institute of Science and Technology, Moscow, Russia","institution_ids":["https://openalex.org/I125989756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069502958","display_name":"S V Zolotova","orcid":"https://orcid.org/0000-0001-8893-3830"},"institutions":[{"id":"https://openalex.org/I4210122729","display_name":"Burdenko Neurosurgery Institute","ror":"https://ror.org/02t1t6n83","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210122729"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Svetlana Zolotova","raw_affiliation_strings":["N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","N. N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","institution_ids":["https://openalex.org/I4210122729"]},{"raw_affiliation_string":"N. N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","institution_ids":["https://openalex.org/I4210122729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050188051","display_name":"Andrey Golanov","orcid":"https://orcid.org/0000-0002-0976-4547"},"institutions":[{"id":"https://openalex.org/I4210122729","display_name":"Burdenko Neurosurgery Institute","ror":"https://ror.org/02t1t6n83","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210122729"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrey Golanov","raw_affiliation_strings":["N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","N. N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","institution_ids":["https://openalex.org/I4210122729"]},{"raw_affiliation_string":"N. N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","institution_ids":["https://openalex.org/I4210122729"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009652227","display_name":"\u0410. \u0410. \u041d\u0438\u043a\u043e\u043b\u0430\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0003-2419-544X"},"institutions":[{"id":"https://openalex.org/I4210122729","display_name":"Burdenko Neurosurgery Institute","ror":"https://ror.org/02t1t6n83","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210122729"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna Nikolaeva","raw_affiliation_strings":["N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","N. N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","institution_ids":["https://openalex.org/I4210122729"]},{"raw_affiliation_string":"N. N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia","institution_ids":["https://openalex.org/I4210122729"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5112668197"],"corresponding_institution_ids":["https://openalex.org/I4210122729"],"apc_list":null,"apc_paid":null,"fwci":0.9022,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75365445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"281","issue":null,"first_page":"298","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.850964367389679},{"id":"https://openalex.org/keywords/dice","display_name":"Dice","score":0.7130491137504578},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6868879795074463},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6823738813400269},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6019765734672546},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.4851142168045044},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4270590543746948},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.32181790471076965},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1829773187637329},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.15607070922851562},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.09078264236450195}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.850964367389679},{"id":"https://openalex.org/C22029948","wikidata":"https://www.wikidata.org/wiki/Q45089","display_name":"Dice","level":2,"score":0.7130491137504578},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6868879795074463},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6823738813400269},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6019765734672546},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4851142168045044},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4270590543746948},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32181790471076965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1829773187637329},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.15607070922851562},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.09078264236450195},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti210168","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210168","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210168","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:34042753","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34042753","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti210168","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210168","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210168","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2934504215","display_name":null,"funder_award_id":"18-29-","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G4057298281","display_name":null,"funder_award_id":"18-29-01054","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"}],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3165400810.pdf","grobid_xml":"https://content.openalex.org/works/W3165400810.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1641498739","https://openalex.org/W1901129140","https://openalex.org/W2773960327","https://openalex.org/W2889822862","https://openalex.org/W2900298334","https://openalex.org/W2928374940","https://openalex.org/W2972042851","https://openalex.org/W3021686348","https://openalex.org/W3090460762"],"related_works":["https://openalex.org/W3104750253","https://openalex.org/W3021239166","https://openalex.org/W4366341510","https://openalex.org/W2390936256","https://openalex.org/W2483429559","https://openalex.org/W2016385589","https://openalex.org/W2009559548","https://openalex.org/W2906397153","https://openalex.org/W2385445039","https://openalex.org/W4380075502"],"abstract_inverted_index":{"In":[0],"this":[1],"article,":[2],"we":[3],"compare":[4],"the":[5,24,35,41,87],"performance":[6,75],"of":[7,47,76],"a":[8,100,107],"state-of-the-art":[9],"segmentation":[10,18,77],"network":[11],"(UNet)":[12],"on":[13,34,80],"two":[14],"different":[15],"glioblastoma":[16],"(GB)":[17],"datasets.":[19],"Our":[20],"experiments":[21],"show":[22],"that":[23,99],"same":[25],"training":[26],"procedure":[27],"yields":[28],"almost":[29],"twice":[30],"as":[31],"bad":[32],"results":[33],"retrospective":[36],"clinical":[37,95],"data":[38,44],"compared":[39],"to":[40,90,112],"BraTS":[42],"challenge":[43],"(in":[45],"terms":[46],"Dice":[48],"score).":[49],"We":[50,97],"discuss":[51],"possible":[52],"reasons":[53],"for":[54],"such":[55],"an":[56],"outcome,":[57],"including":[58],"inter-rater":[59],"variability":[60,63],"and":[61,70],"high":[62,74],"in":[64,94],"magnetic":[65],"resonance":[66],"imaging":[67,82],"(MRI)":[68],"scanners":[69],"scanner":[71],"settings.":[72,96],"The":[73],"models,":[78],"demonstrated":[79],"preselected":[81],"data,":[83],"does":[84],"not":[85],"bring":[86],"community":[88],"closer":[89],"using":[91],"these":[92],"algorithms":[93],"believe":[98],"clinically":[101],"applicable":[102],"deep":[103],"learning":[104],"architecture":[105],"requires":[106],"shift":[108],"from":[109],"unified":[110],"datasets":[111],"heterogeneous":[113],"data.":[114]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}