{"id":"https://openalex.org/W3164310021","doi":"https://doi.org/10.3233/shti210138","title":"Potential Role of Clinical Trial Eligibility Criteria in Electronic Phenotyping","display_name":"Potential Role of Clinical Trial Eligibility Criteria in Electronic Phenotyping","publication_year":2021,"publication_date":"2021-05-27","ids":{"openalex":"https://openalex.org/W3164310021","doi":"https://doi.org/10.3233/shti210138","mag":"3164310021","pmid":"https://pubmed.ncbi.nlm.nih.gov/34042723"},"language":"en","primary_location":{"id":"doi:10.3233/shti210138","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210138","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210138","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210138","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082966346","display_name":"Zhehuan Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhehuan Chen","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458789","display_name":"Hao Liu","orcid":"https://orcid.org/0000-0002-1975-1272"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056634699","display_name":"Alex Butler","orcid":null},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Butler","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015201397","display_name":"Anna Ostropolets","orcid":"https://orcid.org/0000-0002-0847-6682"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Ostropolets","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009604048","display_name":"Chunhua Weng","orcid":"https://orcid.org/0000-0002-9624-0214"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chunhua Weng","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, NY, USA","Corresponding Author, Department of Biomedical Informatics, Columbia University, 622 West 168th Street, PH-20, Room 407, New York, NY 10032, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Corresponding Author, Department of Biomedical Informatics, Columbia University, 622 West 168th Street, PH-20, Room 407, New York, NY 10032, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009604048"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.5224,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5987069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"281","issue":null,"first_page":"148","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.9473999738693237,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10215","display_name":"Semantic Web and Ontologies","score":0.9449999928474426,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.7114158272743225},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.6259087324142456},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"Clinical phenotype","score":0.5081131458282471},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.48555442690849304},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.4807824492454529},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.4248316287994385},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.27403196692466736},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.21110263466835022},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19130995869636536},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13009119033813477},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11990347504615784},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09112614393234253}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7114158272743225},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6259087324142456},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.5081131458282471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48555442690849304},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4807824492454529},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4248316287994385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27403196692466736},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21110263466835022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19130995869636536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13009119033813477},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11990347504615784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09112614393234253}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004581","descriptor_name":"Electronics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004581","descriptor_name":"Electronics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004581","descriptor_name":"Electronics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti210138","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210138","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210138","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:34042723","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34042723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti210138","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210138","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210138","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1684742011","display_name":null,"funder_award_id":"UL1TR001873","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G5922379911","display_name":null,"funder_award_id":"5R01LM009886-11","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G6091063704","display_name":null,"funder_award_id":"R01LM009886-11","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G6819462749","display_name":null,"funder_award_id":"5R01LM009886","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G682085659","display_name":null,"funder_award_id":"R01LM009886","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3164310021.pdf","grobid_xml":"https://content.openalex.org/works/W3164310021.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2064337796","https://openalex.org/W2973950617"],"related_works":["https://openalex.org/W3164771895","https://openalex.org/W2604464132","https://openalex.org/W29071608","https://openalex.org/W2161088626","https://openalex.org/W3029893540","https://openalex.org/W2314682585","https://openalex.org/W2313584493","https://openalex.org/W2135667114","https://openalex.org/W2110968082","https://openalex.org/W3122747281"],"abstract_inverted_index":{"2,719":[0],"distinctive":[1,12],"phenotyping":[2,84],"variables":[3],"from":[4],"176":[5],"electronic":[6],"phenotypes":[7,61],"were":[8],"compared":[9],"with":[10],"57,150":[11],"clinical":[13,47,79],"trial":[14,48,80],"eligibility":[15,49,81],"criteria":[16,82],"concepts":[17],"to":[18,46,53],"assess":[19],"the":[20,54,63,75],"phenotype":[21,34,43],"knowledge":[22],"overlap":[23],"between":[24],"them.":[25],"We":[26],"observed":[27],"a":[28,37],"high":[29],"percentage":[30,39],"(69.5%)":[31],"of":[32,41,77,90],"eMERGE":[33,60],"features":[35,44],"and":[36,62,87],"lower":[38],"(47.6%)":[40],"OHDSI":[42,69],"matched":[45],"criteria,":[50],"possibly":[51],"due":[52],"relative":[55,64],"emphasis":[56,65],"on":[57,66],"specificity":[58],"for":[59,68,83,93],"sensitivity":[67],"phenotypes.":[70],"The":[71],"study":[72],"results":[73],"show":[74],"potential":[76],"reusing":[78],"feature":[85],"selection":[86],"moderate":[88],"benefits":[89],"using":[91],"them":[92],"local":[94],"cohort":[95],"query":[96],"implementation.":[97]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-15T09:29:46.208133","created_date":"2025-10-10T00:00:00"}